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Protein

Potassium voltage-gated channel subfamily S member 2

Gene

KCNS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.16. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 2
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 2
Voltage-gated potassium channel subunit Kv9.2
Gene namesi
Name:KCNS2
Synonyms:KIAA1144
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6301. KCNS2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 184184CytoplasmicBy similarityAdd
BLAST
Transmembranei185 – 20622Helical; Name=Segment S1By similarityAdd
BLAST
Topological domaini207 – 22519ExtracellularBy similarityAdd
BLAST
Transmembranei226 – 24823Helical; Name=Segment S2By similarityAdd
BLAST
Topological domaini249 – 25911CytoplasmicBy similarityAdd
BLAST
Transmembranei260 – 28021Helical; Name=Segment S3By similarityAdd
BLAST
Topological domaini281 – 29010ExtracellularBy similarity
Transmembranei291 – 31121Helical; Voltage-sensor; Name=Segment S4By similarityAdd
BLAST
Topological domaini312 – 32615CytoplasmicBy similarityAdd
BLAST
Transmembranei327 – 34822Helical; Name=Segment S5By similarityAdd
BLAST
Topological domaini349 – 36113ExtracellularBy similarityAdd
BLAST
Intramembranei362 – 37312Helical; Name=Pore helixBy similarityAdd
BLAST
Intramembranei374 – 3818By similarity
Topological domaini382 – 3887ExtracellularBy similarity
Transmembranei389 – 41729Helical; Name=Segment S6By similarityAdd
BLAST
Topological domaini418 – 47760CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30079.

Chemistry

ChEMBLiCHEMBL2362996.

Polymorphism and mutation databases

BioMutaiKCNS2.
DMDMi24418481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Potassium voltage-gated channel subfamily S member 2PRO_0000054084Add
BLAST

Proteomic databases

PaxDbiQ9ULS6.
PeptideAtlasiQ9ULS6.
PRIDEiQ9ULS6.

PTM databases

iPTMnetiQ9ULS6.
PhosphoSiteiQ9ULS6.

Expressioni

Gene expression databases

BgeeiENSG00000156486.
CleanExiHS_KCNS2.
GenevisibleiQ9ULS6. HS.

Organism-specific databases

HPAiHPA051417.

Interactioni

Subunit structurei

Heterotetramer with KCNB1 and KCNB2. Does not form homomultimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10323864,EBI-743099

Protein-protein interaction databases

BioGridi109989. 1 interaction.
IntActiQ9ULS6. 1 interaction.
STRINGi9606.ENSP00000287042.

Structurei

3D structure databases

ProteinModelPortaliQ9ULS6.
SMRiQ9ULS6. Positions 15-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi374 – 3796Selectivity filterBy similarity

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9ULS6.
KOiK04932.
OMAiAQREFYF.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ9ULS6.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ULS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH
60 70 80 90 100
SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS
110 120 130 140 150
FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE
160 170 180 190 200
ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS ILSILVVMGS
210 220 230 240 250
IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP
260 270 280 290 300
DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM
310 320 330 340 350
RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI
360 370 380 390 400
EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL
410 420 430 440 450
VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH
460 470
KVKSLMASLT NMSRSSPSEL SLNDSLR
Length:477
Mass (Da):54,237
Last modified:October 25, 2002 - v2
Checksum:iF231AD99EC02EB46
GO

Sequence cautioni

The sequence BAA86458 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032970 mRNA. Translation: BAA86458.1. Different initiation.
AK293096 mRNA. Translation: BAF85785.1.
CH471060 Genomic DNA. Translation: EAW91780.1.
BC027932 mRNA. Translation: AAH27932.1.
BC034778 mRNA. Translation: AAH34778.1.
CCDSiCCDS6279.1.
RefSeqiNP_065748.1. NM_020697.3.
UniGeneiHs.388045.

Genome annotation databases

EnsembliENST00000287042; ENSP00000287042; ENSG00000156486.
ENST00000521839; ENSP00000430712; ENSG00000156486.
GeneIDi3788.
KEGGihsa:3788.
UCSCiuc003yin.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032970 mRNA. Translation: BAA86458.1. Different initiation.
AK293096 mRNA. Translation: BAF85785.1.
CH471060 Genomic DNA. Translation: EAW91780.1.
BC027932 mRNA. Translation: AAH27932.1.
BC034778 mRNA. Translation: AAH34778.1.
CCDSiCCDS6279.1.
RefSeqiNP_065748.1. NM_020697.3.
UniGeneiHs.388045.

3D structure databases

ProteinModelPortaliQ9ULS6.
SMRiQ9ULS6. Positions 15-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109989. 1 interaction.
IntActiQ9ULS6. 1 interaction.
STRINGi9606.ENSP00000287042.

Chemistry

ChEMBLiCHEMBL2362996.

Protein family/group databases

TCDBi1.A.1.2.16. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ9ULS6.
PhosphoSiteiQ9ULS6.

Polymorphism and mutation databases

BioMutaiKCNS2.
DMDMi24418481.

Proteomic databases

PaxDbiQ9ULS6.
PeptideAtlasiQ9ULS6.
PRIDEiQ9ULS6.

Protocols and materials databases

DNASUi3788.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287042; ENSP00000287042; ENSG00000156486.
ENST00000521839; ENSP00000430712; ENSG00000156486.
GeneIDi3788.
KEGGihsa:3788.
UCSCiuc003yin.4. human.

Organism-specific databases

CTDi3788.
GeneCardsiKCNS2.
HGNCiHGNC:6301. KCNS2.
HPAiHPA051417.
MIMi602906. gene.
neXtProtiNX_Q9ULS6.
PharmGKBiPA30079.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ9ULS6.
KOiK04932.
OMAiAQREFYF.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ9ULS6.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNS2.
GenomeRNAii3788.
PROiQ9ULS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156486.
CleanExiHS_KCNS2.
GenevisibleiQ9ULS6. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNS2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULS6
Secondary accession number(s): A8KAN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.