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Protein

Polyadenylate-binding protein-interacting protein 2B

Gene

PAIP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.1 Publication

GO - Molecular functioni

  • translation repressor activity, nucleic acid binding Source: HGNC

GO - Biological processi

  • negative regulation of translational initiation Source: HGNC

Keywordsi

Molecular functionRepressor
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 2B
Short name:
PABP-interacting protein 2B
Short name:
PAIP-2B
Short name:
Poly(A)-binding protein-interacting protein 2B
Gene namesi
Name:PAIP2B
Synonyms:KIAA1155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000124374.8.
HGNCiHGNC:29200. PAIP2B.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124374.
PharmGKBiPA162398595.

Polymorphism and mutation databases

BioMutaiPAIP2B.
DMDMi166977703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172941 – 123Polyadenylate-binding protein-interacting protein 2BAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Post-translational modificationi

Ubiquitinated in vitro.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ9ULR5.
MaxQBiQ9ULR5.
PaxDbiQ9ULR5.
PeptideAtlasiQ9ULR5.
PRIDEiQ9ULR5.

PTM databases

iPTMnetiQ9ULR5.
PhosphoSitePlusiQ9ULR5.

Expressioni

Tissue specificityi

Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis.1 Publication

Gene expression databases

BgeeiENSG00000124374.
CleanExiHS_PAIP2B.
GenevisibleiQ9ULR5. HS.

Organism-specific databases

HPAiHPA046784.
HPA072371.

Interactioni

Subunit structurei

Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus).1 Publication

Protein-protein interaction databases

BioGridi134843. 10 interactors.
ELMiQ9ULR5.
STRINGi9606.ENSP00000244221.

Structurei

3D structure databases

ProteinModelPortaliQ9ULR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAIP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW9I. Eukaryota.
ENOG4111Z4B. LUCA.
GeneTreeiENSGT00390000017284.
HOGENOMiHOG000008098.
HOVERGENiHBG053493.
InParanoidiQ9ULR5.
OMAiSMANTSP.
OrthoDBiEOG091G1372.
PhylomeDBiQ9ULR5.
TreeFamiTF326855.

Family and domain databases

InterProiView protein in InterPro
IPR009818. Ataxin-2_C.
PfamiView protein in Pfam
PF07145. PAM2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ULR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGSNMANTS PSVKSKEDQG LSGHDEKENP FAEYMWMENE EDFNRQVEEE
60 70 80 90 100
LQEQDFLDRC FQEMLDEEDQ DWFIPSRDLP QAMGQLQQQL NGLSVSEGHD
110 120
SEDILSKSNL NPDAKEFIPG EKY
Length:123
Mass (Da):14,237
Last modified:February 5, 2008 - v2
Checksum:iD1C85F950BD651C3
GO

Sequence cautioni

The sequence BAA86469 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032981 mRNA. Translation: BAA86469.1. Different initiation.
CCDSiCCDS46322.1.
RefSeqiNP_065192.1. NM_020459.1.
XP_005264367.1. XM_005264310.3.
XP_005264368.1. XM_005264311.4.
XP_011531145.1. XM_011532843.2.
UniGeneiHs.416735.

Genome annotation databases

EnsembliENST00000244221; ENSP00000244221; ENSG00000124374.
GeneIDi400961.
KEGGihsa:400961.
UCSCiuc002shu.3. human.

Similar proteinsi

Entry informationi

Entry nameiPAI2B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 27, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families