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Protein

Polyadenylate-binding protein-interacting protein 2B

Gene

PAIP2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail.1 Publication

GO - Molecular functioni

  • translation repressor activity, nucleic acid binding Source: HGNC

GO - Biological processi

  • negative regulation of translational initiation Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein-interacting protein 2B
Short name:
PABP-interacting protein 2B
Short name:
PAIP-2B
Short name:
Poly(A)-binding protein-interacting protein 2B
Gene namesi
Name:PAIP2B
Synonyms:KIAA1155
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29200. PAIP2B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398595.

Polymorphism and mutation databases

BioMutaiPAIP2B.
DMDMi166977703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Polyadenylate-binding protein-interacting protein 2BPRO_0000317294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Post-translational modificationi

Ubiquitinated in vitro.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ9ULR5.
MaxQBiQ9ULR5.
PaxDbiQ9ULR5.
PeptideAtlasiQ9ULR5.
PRIDEiQ9ULR5.

PTM databases

iPTMnetiQ9ULR5.

Expressioni

Tissue specificityi

Expressed in brain, cervix, heart, liver, ovary, kidney, prostate and testis.1 Publication

Gene expression databases

BgeeiQ9ULR5.
CleanExiHS_PAIP2B.
GenevisibleiQ9ULR5. HS.

Organism-specific databases

HPAiHPA046784.

Interactioni

Subunit structurei

Interacts (via central acidic portion and C-terminus) with PABPC1 (via the second and third RRM domains and the C-terminus).1 Publication

Protein-protein interaction databases

BioGridi134843. 9 interactions.
STRINGi9606.ENSP00000244221.

Structurei

3D structure databases

ProteinModelPortaliQ9ULR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAIP2 family.Curated

Phylogenomic databases

eggNOGiENOG410IW9I. Eukaryota.
ENOG4111Z4B. LUCA.
GeneTreeiENSGT00390000017284.
HOGENOMiHOG000008098.
HOVERGENiHBG053493.
InParanoidiQ9ULR5.
OMAiSMANTSP.
OrthoDBiEOG7PCJK0.
PhylomeDBiQ9ULR5.
TreeFamiTF326855.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
[Graphical view]
PfamiPF07145. PAM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGSNMANTS PSVKSKEDQG LSGHDEKENP FAEYMWMENE EDFNRQVEEE
60 70 80 90 100
LQEQDFLDRC FQEMLDEEDQ DWFIPSRDLP QAMGQLQQQL NGLSVSEGHD
110 120
SEDILSKSNL NPDAKEFIPG EKY
Length:123
Mass (Da):14,237
Last modified:February 5, 2008 - v2
Checksum:iD1C85F950BD651C3
GO

Sequence cautioni

The sequence BAA86469.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032981 mRNA. Translation: BAA86469.1. Different initiation.
CCDSiCCDS46322.1.
RefSeqiNP_065192.1. NM_020459.1.
XP_005264367.1. XM_005264310.2.
XP_005264368.1. XM_005264311.3.
XP_011531145.1. XM_011532843.1.
UniGeneiHs.416735.

Genome annotation databases

EnsembliENST00000244221; ENSP00000244221; ENSG00000124374.
GeneIDi400961.
KEGGihsa:400961.
UCSCiuc002shu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032981 mRNA. Translation: BAA86469.1. Different initiation.
CCDSiCCDS46322.1.
RefSeqiNP_065192.1. NM_020459.1.
XP_005264367.1. XM_005264310.2.
XP_005264368.1. XM_005264311.3.
XP_011531145.1. XM_011532843.1.
UniGeneiHs.416735.

3D structure databases

ProteinModelPortaliQ9ULR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134843. 9 interactions.
STRINGi9606.ENSP00000244221.

PTM databases

iPTMnetiQ9ULR5.

Polymorphism and mutation databases

BioMutaiPAIP2B.
DMDMi166977703.

Proteomic databases

EPDiQ9ULR5.
MaxQBiQ9ULR5.
PaxDbiQ9ULR5.
PeptideAtlasiQ9ULR5.
PRIDEiQ9ULR5.

Protocols and materials databases

DNASUi400961.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244221; ENSP00000244221; ENSG00000124374.
GeneIDi400961.
KEGGihsa:400961.
UCSCiuc002shu.3. human.

Organism-specific databases

CTDi400961.
GeneCardsiPAIP2B.
HGNCiHGNC:29200. PAIP2B.
HPAiHPA046784.
MIMi611018. gene.
neXtProtiNX_Q9ULR5.
PharmGKBiPA162398595.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW9I. Eukaryota.
ENOG4111Z4B. LUCA.
GeneTreeiENSGT00390000017284.
HOGENOMiHOG000008098.
HOVERGENiHBG053493.
InParanoidiQ9ULR5.
OMAiSMANTSP.
OrthoDBiEOG7PCJK0.
PhylomeDBiQ9ULR5.
TreeFamiTF326855.

Miscellaneous databases

ChiTaRSiPAIP2B. human.
GenomeRNAii400961.
PROiQ9ULR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULR5.
CleanExiHS_PAIP2B.
GenevisibleiQ9ULR5. HS.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
[Graphical view]
PfamiPF07145. PAM2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B."
    Berlanga J.J., Baass A., Sonenberg N.
    RNA 12:1556-1568(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PABPC1, TISSUE SPECIFICITY, UBIQUITINATION.
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPAI2B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 6, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.