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Q9ULR3

- PPM1H_HUMAN

UniProt

Q9ULR3 - PPM1H_HUMAN

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Protein

Protein phosphatase 1H

Gene

PPM1H

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1H (EC:3.1.3.16)
Gene namesi
Name:PPM1H
Synonyms:ARHCL1, KIAA1157, URCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18583. PPM1H.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Protein phosphatase 1HPRO_0000286603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei124 – 1241Phosphoserine2 Publications
Modified residuei211 – 2111Phosphoserine2 Publications
Modified residuei221 – 2211Phosphoserine1 Publication
Modified residuei224 – 2241Phosphothreonine1 Publication
Modified residuei422 – 4221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ULR3.
PaxDbiQ9ULR3.
PRIDEiQ9ULR3.

PTM databases

PhosphoSiteiQ9ULR3.

Expressioni

Gene expression databases

BgeeiQ9ULR3.
CleanExiHS_PPM1H.
GenevestigatoriQ9ULR3.

Organism-specific databases

HPAiCAB020694.

Interactioni

Protein-protein interaction databases

BioGridi121530. 2 interactions.
IntActiQ9ULR3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9ULR3.
SMRiQ9ULR3. Positions 248-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 507371PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00530000063231.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ9ULR3.
KOiK17503.
OMAiERTVYNI.
OrthoDBiEOG7F511J.
PhylomeDBiQ9ULR3.
TreeFamiTF314700.

Family and domain databases

Gene3Di3.60.40.10. 4 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9ULR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTRVKSAVA NFMGGIMAGS SGSEHGGGSC GGSDLPLRFP YGRPEFLGLS
60 70 80 90 100
QDEVECSADH IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV
110 120 130 140 150
LTVKKKAGAV TSTPNRNSSK RRSSLPNGEG LQLKENSESE GVSCHYWSLF
160 170 180 190 200
DGHAGSGAAV VASRLLQHHI TEQLQDIVDI LKNSAVLPPT CLGEEPENTP
210 220 230 240 250
ANSRTLTRAA SLRGGVGAPG SPSTPPTRFF TEKKIPHECL VIGALESAFK
260 270 280 290 300
EMDLQIERER SSYNISGGCT ALIVICLLGK LYVANAGDSR AIIIRNGEII
310 320 330 340 350
PMSSEFTPET ERQRLQYLAF MQPHLLGNEF THLEFPRRVQ RKELGKKMLY
360 370 380 390 400
RDFNMTGWAY KTIEDEDLKF PLIYGEGKKA RVMATIGVTR GLGDHDLKVH
410 420 430 440 450
DSNIYIKPFL SSAPEVRIYD LSKYDHGSDD VLILATDGLW DVLSNEEVAE
460 470 480 490 500
AITQFLPNCD PDDPHRYTLA AQDLVMRARG VLKDRGWRIS NDRLGSGDDI
510
SVYVIPLIHG NKLS
Length:514
Mass (Da):56,448
Last modified:May 15, 2007 - v2
Checksum:i9348C6AC3D74D1B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771A → V in AAI57844. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB084258 mRNA. Translation: BAG16181.1.
AC023359 Genomic DNA. No translation available.
AC025264 Genomic DNA. No translation available.
AC048341 Genomic DNA. No translation available.
AC078814 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97112.1.
BC157843 mRNA. Translation: AAI57844.1.
AB032983 mRNA. Translation: BAA86471.1.
CCDSiCCDS44934.1.
RefSeqiNP_065751.1. NM_020700.1.
UniGeneiHs.435479.

Genome annotation databases

EnsembliENST00000228705; ENSP00000228705; ENSG00000111110.
GeneIDi57460.
KEGGihsa:57460.
UCSCiuc001srk.3. human.

Polymorphism databases

DMDMi147721250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB084258 mRNA. Translation: BAG16181.1 .
AC023359 Genomic DNA. No translation available.
AC025264 Genomic DNA. No translation available.
AC048341 Genomic DNA. No translation available.
AC078814 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97112.1 .
BC157843 mRNA. Translation: AAI57844.1 .
AB032983 mRNA. Translation: BAA86471.1 .
CCDSi CCDS44934.1.
RefSeqi NP_065751.1. NM_020700.1.
UniGenei Hs.435479.

3D structure databases

ProteinModelPortali Q9ULR3.
SMRi Q9ULR3. Positions 248-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121530. 2 interactions.
IntActi Q9ULR3. 1 interaction.

PTM databases

PhosphoSitei Q9ULR3.

Polymorphism databases

DMDMi 147721250.

Proteomic databases

MaxQBi Q9ULR3.
PaxDbi Q9ULR3.
PRIDEi Q9ULR3.

Protocols and materials databases

DNASUi 57460.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228705 ; ENSP00000228705 ; ENSG00000111110 .
GeneIDi 57460.
KEGGi hsa:57460.
UCSCi uc001srk.3. human.

Organism-specific databases

CTDi 57460.
GeneCardsi GC12M063037.
H-InvDB HIX0018169.
HGNCi HGNC:18583. PPM1H.
HPAi CAB020694.
neXtProti NX_Q9ULR3.
PharmGKBi PA38354.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00530000063231.
HOGENOMi HOG000251606.
HOVERGENi HBG105802.
InParanoidi Q9ULR3.
KOi K17503.
OMAi ERTVYNI.
OrthoDBi EOG7F511J.
PhylomeDBi Q9ULR3.
TreeFami TF314700.

Miscellaneous databases

ChiTaRSi PPM1H. human.
GenomeRNAii 57460.
NextBioi 63648.
PROi Q9ULR3.

Gene expression databases

Bgeei Q9ULR3.
CleanExi HS_PPM1H.
Genevestigatori Q9ULR3.

Family and domain databases

Gene3Di 3.60.40.10. 4 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 4 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of Urcc2, a novel gene up-regulated in colon cancer."
    Shimokawa T., Furukawa Y., Nakamura Y.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-514.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124; SER-211; SER-221; THR-224 AND SER-422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPM1H_HUMAN
AccessioniPrimary (citable) accession number: Q9ULR3
Secondary accession number(s): B1Q2A9, B2RXG4, Q6PI86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-354 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3