##gff-version 3 Q9ULQ1 UniProtKB Chain 1 816 . . . ID=PRO_0000276853;Note=Two pore channel protein 1 Q9ULQ1 UniProtKB Topological domain 1 112 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 113 133 . . . Note=Helical%3B Name%3DS1 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 134 134 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 135 155 . . . Note=Helical%3B Name%3DS2 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 156 177 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 178 198 . . . Note=Helical%3B Name%3DS3 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 199 200 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 201 220 . . . Note=Helical%3B Name%3DS4 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 221 234 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 235 255 . . . Note=Helical%3B Name%3DS5 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 256 262 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Intramembrane 263 286 . . . Note=Helical%3B Pore-forming;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 287 294 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 295 315 . . . Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 316 444 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 445 465 . . . Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 466 479 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 480 500 . . . Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 501 503 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 504 526 . . . Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 527 534 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 535 549 . . . Note=Helical%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 550 573 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 574 594 . . . Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 595 629 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Intramembrane 630 653 . . . Note=Helical%3B Pore-forming;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 654 670 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Transmembrane 671 691 . . . Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Topological domain 692 816 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Region 17 64 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULQ1 UniProtKB Region 782 816 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULQ1 UniProtKB Coiled coil 769 796 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Compositional bias 41 64 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULQ1 UniProtKB Compositional bias 791 816 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULQ1 UniProtKB Glycosylation 599 599 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Glycosylation 611 611 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Glycosylation 616 616 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULQ1 UniProtKB Alternative sequence 1 366 . . . ID=VSP_023003;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9ULQ1 UniProtKB Alternative sequence 1 1 . . . ID=VSP_041346;Note=In isoform 3. M->MESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPGYHILRATGEENM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9ULQ1 UniProtKB Alternative sequence 569 618 . . . ID=VSP_023004;Note=In isoform 2. SLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRT->RYCQPPPWPAGPGAVWQCPVGAGAEWQSGERSSTKDCNRGPDGAPRSLES;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9ULQ1 UniProtKB Alternative sequence 619 816 . . . ID=VSP_023005;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9ULQ1 UniProtKB Mutagenesis 219 223 . . . Note=Loss of voltage sensitivity. RRNLR->QQNLQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24776928;Dbxref=PMID:24776928 Q9ULQ1 UniProtKB Mutagenesis 273 273 . . . Note=Loss of NAADP-mediated cytoplasmic calcium release. L->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19620632;Dbxref=PMID:19620632 Q9ULQ1 UniProtKB Mutagenesis 539 539 . . . Note=Loss of voltage sensitivity. R->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24776928;Dbxref=PMID:24776928 Q9ULQ1 UniProtKB Mutagenesis 740 741 . . . Note=No effect on subcellular location. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20880839;Dbxref=PMID:20880839 Q9ULQ1 UniProtKB Sequence conflict 621 621 . . . Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305