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Q9ULQ1

- TPC1_HUMAN

UniProt

Q9ULQ1 - TPC1_HUMAN

Protein

Two pore calcium channel protein 1

Gene

TPCN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal and endosomal membrane.1 Publication

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. NAADP-sensitive calcium-release channel activity Source: UniProtKB
    3. protein binding Source: IntAct
    4. voltage-gated calcium channel activity Source: RefGenome

    GO - Biological processi

    1. calcium ion transport Source: RefGenome
    2. ion transmembrane transport Source: RefGenome
    3. membrane depolarization during action potential Source: RefGenome
    4. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi1.A.1.11.25. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Two pore calcium channel protein 1
    Alternative name(s):
    Voltage-dependent calcium channel protein TPC1
    Gene namesi
    Name:TPCN1
    Synonyms:KIAA1169, TPC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18182. TPCN1.

    Subcellular locationi

    Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: UniProtKB
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi273 – 2731L → P: Loss of NAADP-mediated cytoplasmic calcium release. 1 Publication

    Organism-specific databases

    PharmGKBiPA134922711.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 816816Two pore calcium channel protein 1PRO_0000276853Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi611 – 6111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi616 – 6161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9ULQ1.
    PaxDbiQ9ULQ1.
    PRIDEiQ9ULQ1.

    PTM databases

    PhosphoSiteiQ9ULQ1.

    Expressioni

    Tissue specificityi

    Highest expression found in the heart and kidney, and lowest expression found in the spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ9ULQ1.
    BgeeiQ9ULQ1.
    CleanExiHS_TPCN1.
    GenevestigatoriQ9ULQ1.

    Organism-specific databases

    HPAiHPA039757.

    Interactioni

    Subunit structurei

    Dimer.Curated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself3EBI-5239895,EBI-5239895
    HAX1O001652EBI-5239895,EBI-357001
    TPCN2Q8NHX99EBI-5239895,EBI-5239949

    Protein-protein interaction databases

    IntActiQ9ULQ1. 3 interactions.
    STRINGi9606.ENSP00000376350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULQ1.
    SMRiQ9ULQ1. Positions 198-321, 434-689.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 112112CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini134 – 1341ExtracellularSequence Analysis
    Topological domaini156 – 17722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 2002ExtracellularSequence Analysis
    Topological domaini221 – 23414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 2627ExtracellularSequence Analysis
    Topological domaini287 – 2948ExtracellularSequence Analysis
    Topological domaini316 – 444129CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini466 – 47914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini501 – 5033CytoplasmicSequence Analysis
    Topological domaini527 – 5348ExtracellularSequence Analysis
    Topological domaini550 – 57324CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini595 – 62935ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini654 – 67017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini692 – 816125CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei263 – 28624Helical; Pore-formingSequence AnalysisAdd
    BLAST
    Intramembranei630 – 65324Helical; Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei113 – 13321Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei445 – 46521Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei504 – 52623Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei535 – 54915Helical; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei574 – 59421Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei671 – 69121Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili769 – 79628Sequence AnalysisAdd
    BLAST

    Domaini

    Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position By similarity.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280094.
    HOGENOMiHOG000006773.
    HOVERGENiHBG080605.
    InParanoidiQ9ULQ1.
    KOiK16896.
    OMAiWLGFHTF.
    OrthoDBiEOG7W41B7.
    PhylomeDBiQ9ULQ1.
    TreeFamiTF328550.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR028801. TPC1.
    [Graphical view]
    PANTHERiPTHR10037:SF201. PTHR10037:SF201. 1 hit.
    PfamiPF00520. Ion_trans. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULQ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP    50
    SLSSGGESSP SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY 100
    LFAHNHLFYL MELATALLLL LLSLCEAPAV PALRLGIYVH ATLELFALMV 150
    VVFELCMKLR WLGLHTFIRH KRTMVKTSVL VVQFVEAIVV LVRQMSHVRV 200
    TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL FFMIIFAILG 250
    FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF 300
    IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLI 350
    SQRRPAGISY RQFEGLMRFY KPRMSARERY LTFKALNQNN TPLLSLKDFY 400
    DIYEVAALKW KAKKNREHWF DELPRTALLI FKGINILVKS KAFQYFMYLV 450
    VAVNGVWILV ETFMLKGGNF FSKHVPWSYL VFLTIYGVEL FLKVAGLGPV 500
    EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP LQLLRLFKLK 550
    ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT 600
    STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY 650
    IIMEGVTSQT SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN 700
    QDSEVDGGIT LEKEISKEEL VAVLELYREA RGASSDVTRL LETLSQMERY 750
    QQHSMVFLGR RSRTKSDLSL KMYQEEIQEW YEEHAREQEQ QRQLSSSAAP 800
    AAQQPPGSRQ RSQTVT 816
    Length:816
    Mass (Da):94,147
    Last modified:February 6, 2007 - v3
    Checksum:iD6D26BFAF33E1463
    GO
    Isoform 2 (identifier: Q9ULQ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-366: Missing.
         569-618: SLGLTLLIFY...WRNHTVGNRT → RYCQPPPWPA...PDGAPRSLES
         619-816: Missing.

    Show »
    Length:252
    Mass (Da):29,136
    Checksum:iBDD06287A468FA93
    GO
    Isoform 3 (identifier: Q9ULQ1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPGYHILRATGEENM

    Show »
    Length:888
    Mass (Da):101,796
    Checksum:iD3267C511D4C6BC4
    GO

    Sequence cautioni

    The sequence AK057414 differs from that shown. Reason: Frameshift at position 273.
    The sequence BAA86483.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti621 – 6211E → G in AK057414. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 366366Missing in isoform 2. 1 PublicationVSP_023003Add
    BLAST
    Alternative sequencei1 – 11M → MESCYIAQAGLELLGSSSSP TLTSQSAEITEDASNGGVSE QHPWPSGFERELKPETISSP GYHILRATGEENM in isoform 3. 1 PublicationVSP_041346
    Alternative sequencei569 – 61850SLGLT…VGNRT → RYCQPPPWPAGPGAVWQCPV GAGAEWQSGERSSTKDCNRG PDGAPRSLES in isoform 2. 1 PublicationVSP_023004Add
    BLAST
    Alternative sequencei619 – 816198Missing in isoform 2. 1 PublicationVSP_023005Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083666 mRNA. Translation: AAM01199.1.
    AB032995 mRNA. Translation: BAA86483.2. Different initiation.
    AK057414 mRNA. No translation available.
    AK075071 mRNA. Translation: BAC11385.1.
    AC010178 Genomic DNA. No translation available.
    AC089999 Genomic DNA. No translation available.
    AC127004 Genomic DNA. No translation available.
    BC136795 mRNA. Translation: AAI36796.1.
    BC136796 mRNA. Translation: AAI36797.1.
    BC150203 mRNA. Translation: AAI50204.1.
    BC152423 mRNA. Translation: AAI52424.1.
    CCDSiCCDS31908.1. [Q9ULQ1-1]
    CCDS44985.1. [Q9ULQ1-3]
    RefSeqiNP_001137291.1. NM_001143819.1. [Q9ULQ1-3]
    NP_060371.2. NM_017901.4. [Q9ULQ1-1]
    UniGeneiHs.524763.

    Genome annotation databases

    EnsembliENST00000335509; ENSP00000335300; ENSG00000186815. [Q9ULQ1-1]
    ENST00000541517; ENSP00000438125; ENSG00000186815. [Q9ULQ1-3]
    ENST00000550785; ENSP00000448083; ENSG00000186815. [Q9ULQ1-3]
    GeneIDi53373.
    KEGGihsa:53373.
    UCSCiuc001tuw.3. human. [Q9ULQ1-1]
    uc001tux.3. human. [Q9ULQ1-3]

    Polymorphism databases

    DMDMi125991219.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083666 mRNA. Translation: AAM01199.1 .
    AB032995 mRNA. Translation: BAA86483.2 . Different initiation.
    AK057414 mRNA. No translation available.
    AK075071 mRNA. Translation: BAC11385.1 .
    AC010178 Genomic DNA. No translation available.
    AC089999 Genomic DNA. No translation available.
    AC127004 Genomic DNA. No translation available.
    BC136795 mRNA. Translation: AAI36796.1 .
    BC136796 mRNA. Translation: AAI36797.1 .
    BC150203 mRNA. Translation: AAI50204.1 .
    BC152423 mRNA. Translation: AAI52424.1 .
    CCDSi CCDS31908.1. [Q9ULQ1-1 ]
    CCDS44985.1. [Q9ULQ1-3 ]
    RefSeqi NP_001137291.1. NM_001143819.1. [Q9ULQ1-3 ]
    NP_060371.2. NM_017901.4. [Q9ULQ1-1 ]
    UniGenei Hs.524763.

    3D structure databases

    ProteinModelPortali Q9ULQ1.
    SMRi Q9ULQ1. Positions 198-321, 434-689.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ULQ1. 3 interactions.
    STRINGi 9606.ENSP00000376350.

    Protein family/group databases

    TCDBi 1.A.1.11.25. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q9ULQ1.

    Polymorphism databases

    DMDMi 125991219.

    Proteomic databases

    MaxQBi Q9ULQ1.
    PaxDbi Q9ULQ1.
    PRIDEi Q9ULQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335509 ; ENSP00000335300 ; ENSG00000186815 . [Q9ULQ1-1 ]
    ENST00000541517 ; ENSP00000438125 ; ENSG00000186815 . [Q9ULQ1-3 ]
    ENST00000550785 ; ENSP00000448083 ; ENSG00000186815 . [Q9ULQ1-3 ]
    GeneIDi 53373.
    KEGGi hsa:53373.
    UCSCi uc001tuw.3. human. [Q9ULQ1-1 ]
    uc001tux.3. human. [Q9ULQ1-3 ]

    Organism-specific databases

    CTDi 53373.
    GeneCardsi GC12P113660.
    HGNCi HGNC:18182. TPCN1.
    HPAi HPA039757.
    MIMi 609666. gene.
    neXtProti NX_Q9ULQ1.
    PharmGKBi PA134922711.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280094.
    HOGENOMi HOG000006773.
    HOVERGENi HBG080605.
    InParanoidi Q9ULQ1.
    KOi K16896.
    OMAi WLGFHTF.
    OrthoDBi EOG7W41B7.
    PhylomeDBi Q9ULQ1.
    TreeFami TF328550.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    ChiTaRSi TPCN1. human.
    GeneWikii TPCN1.
    GenomeRNAii 53373.
    NextBioi 56034.
    PROi Q9ULQ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULQ1.
    Bgeei Q9ULQ1.
    CleanExi HS_TPCN1.
    Genevestigatori Q9ULQ1.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR028801. TPC1.
    [Graphical view ]
    PANTHERi PTHR10037:SF201. PTHR10037:SF201. 1 hit.
    Pfami PF00520. Ion_trans. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Placenta.
    5. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling."
      Brailoiu E., Churamani D., Cai X., Schrlau M.G., Brailoiu G.C., Gao X., Hooper R., Boulware M.J., Dun N.J., Marchant J.S., Patel S.
      J. Cell Biol. 186:201-209(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF LEU-273, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTPC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULQ1
    Secondary accession number(s): A7E258, Q86XS9, Q8NC20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3