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Q9ULQ1 - TPC1_HUMAN

UniProt

Q9ULQ1 - TPC1_HUMAN

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Protein

Two pore calcium channel protein 1

Gene

TPCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal and endosomal membrane.1 Publication

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. NAADP-sensitive calcium-release channel activity Source: UniProtKB
  3. voltage-gated calcium channel activity Source: GO_Central

GO - Biological processi

  1. calcium ion transport Source: GO_Central
  2. ion transmembrane transport Source: GO_Central
  3. membrane depolarization during action potential Source: GO_Central
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.1.11.25. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Two pore calcium channel protein 1
Alternative name(s):
Voltage-dependent calcium channel protein TPC1
Gene namesi
Name:TPCN1
Synonyms:KIAA1169, TPC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18182. TPCN1.

Subcellular locationi

Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication. Endosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 112112CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=S1 of repeat ISequence AnalysisAdd
BLAST
Topological domaini134 – 1341ExtracellularSequence Analysis
Transmembranei135 – 15521Helical; Name=S2 of repeat ISequence AnalysisAdd
BLAST
Topological domaini156 – 17722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=S3 of repeat ISequence AnalysisAdd
BLAST
Topological domaini199 – 2002ExtracellularSequence Analysis
Transmembranei201 – 22020Helical; Name=S4 of repeat ISequence AnalysisAdd
BLAST
Topological domaini221 – 23414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=S5 of repeat ISequence AnalysisAdd
BLAST
Topological domaini256 – 2627ExtracellularSequence Analysis
Intramembranei263 – 28624Helical; Pore-formingSequence AnalysisAdd
BLAST
Topological domaini287 – 2948ExtracellularSequence Analysis
Transmembranei295 – 31521Helical; Name=S6 of repeat ISequence AnalysisAdd
BLAST
Topological domaini316 – 444129CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei445 – 46521Helical; Name=S1 of repeat IISequence AnalysisAdd
BLAST
Topological domaini466 – 47914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei480 – 50021Helical; Name=S2 of repeat IISequence AnalysisAdd
BLAST
Topological domaini501 – 5033CytoplasmicSequence Analysis
Transmembranei504 – 52623Helical; Name=S3 of repeat IISequence AnalysisAdd
BLAST
Topological domaini527 – 5348ExtracellularSequence Analysis
Transmembranei535 – 54915Helical; Name=S4 of repeat IISequence AnalysisAdd
BLAST
Topological domaini550 – 57324CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei574 – 59421Helical; Name=S5 of repeat IISequence AnalysisAdd
BLAST
Topological domaini595 – 62935ExtracellularSequence AnalysisAdd
BLAST
Intramembranei630 – 65324Helical; Pore-formingSequence AnalysisAdd
BLAST
Topological domaini654 – 67017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei671 – 69121Helical; Name=S6 of repeat IISequence AnalysisAdd
BLAST
Topological domaini692 – 816125CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: UniProtKB
  4. plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi273 – 2731L → P: Loss of NAADP-mediated cytoplasmic calcium release. 1 Publication

Organism-specific databases

PharmGKBiPA134922711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Two pore calcium channel protein 1PRO_0000276853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi599 – 5991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi611 – 6111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi616 – 6161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9ULQ1.
PaxDbiQ9ULQ1.
PRIDEiQ9ULQ1.

PTM databases

PhosphoSiteiQ9ULQ1.

Expressioni

Tissue specificityi

Highest expression found in the heart and kidney, and lowest expression found in the spleen.1 Publication

Gene expression databases

BgeeiQ9ULQ1.
CleanExiHS_TPCN1.
ExpressionAtlasiQ9ULQ1. baseline and differential.
GenevestigatoriQ9ULQ1.

Organism-specific databases

HPAiHPA039757.

Interactioni

Subunit structurei

Dimer.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-5239895,EBI-5239895
HAX1O001652EBI-5239895,EBI-357001
TPCN2Q8NHX99EBI-5239895,EBI-5239949

Protein-protein interaction databases

BioGridi119760. 2 interactions.
IntActiQ9ULQ1. 3 interactions.
STRINGi9606.ENSP00000376350.

Structurei

3D structure databases

ProteinModelPortaliQ9ULQ1.
SMRiQ9ULQ1. Positions 198-321, 434-689.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili769 – 79628Sequence AnalysisAdd
BLAST

Domaini

Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity).By similarity

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280094.
GeneTreeiENSGT00530000063660.
HOGENOMiHOG000006773.
HOVERGENiHBG080605.
InParanoidiQ9ULQ1.
KOiK16896.
OMAiMVAFELC.
OrthoDBiEOG7W41B7.
PhylomeDBiQ9ULQ1.
TreeFamiTF328550.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028801. TPC1.
[Graphical view]
PANTHERiPTHR10037:SF201. PTHR10037:SF201. 1 hit.
PfamiPF00520. Ion_trans. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULQ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSLDDDVP LILTLDEGGS APLAPSNGLG QEELPSKNGG SYAIHDSQAP 
        60         70         80         90        100
SLSSGGESSP SSPAHNWEMN YQEAAIYLQE GENNDKFFTH PKDAKALAAY 
       110        120        130        140        150
LFAHNHLFYL MELATALLLL LLSLCEAPAV PALRLGIYVH ATLELFALMV 
       160        170        180        190        200
VVFELCMKLR WLGLHTFIRH KRTMVKTSVL VVQFVEAIVV LVRQMSHVRV 
       210        220        230        240        250
TRALRCIFLV DCRYCGGVRR NLRQIFQSLP PFMDILLLLL FFMIIFAILG 
       260        270        280        290        300
FYLFSPNPSD PYFSTLENSI VSLFVLLTTA NFPDVMMPSY SRNPWSCVFF 
       310        320        330        340        350
IVYLSIELYF IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLI 
       360        370        380        390        400
SQRRPAGISY RQFEGLMRFY KPRMSARERY LTFKALNQNN TPLLSLKDFY 
       410        420        430        440        450
DIYEVAALKW KAKKNREHWF DELPRTALLI FKGINILVKS KAFQYFMYLV 
       460        470        480        490        500
VAVNGVWILV ETFMLKGGNF FSKHVPWSYL VFLTIYGVEL FLKVAGLGPV 
       510        520        530        540        550
EYLSSGWNLF DFSVTVFAFL GLLALALNME PFYFIVVLRP LQLLRLFKLK 
       560        570        580        590        600
ERYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFC GIVFPNCCNT 
       610        620        630        640        650
STVADAYRWR NHTVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY 
       660        670        680        690        700
IIMEGVTSQT SHWSRLYFMT FYIVTMVVMT IIVAFILEAF VFRMNYSRKN 
       710        720        730        740        750
QDSEVDGGIT LEKEISKEEL VAVLELYREA RGASSDVTRL LETLSQMERY 
       760        770        780        790        800
QQHSMVFLGR RSRTKSDLSL KMYQEEIQEW YEEHAREQEQ QRQLSSSAAP 
       810 
AAQQPPGSRQ RSQTVT
Length:816
Mass (Da):94,147
Last modified:February 6, 2007 - v3
Checksum:iD6D26BFAF33E1463
GO
Isoform 2 (identifier: Q9ULQ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-366: Missing.
     569-618: SLGLTLLIFY...WRNHTVGNRT → RYCQPPPWPA...PDGAPRSLES
     619-816: Missing.

Show »
Length:252
Mass (Da):29,136
Checksum:iBDD06287A468FA93
GO
Isoform 3 (identifier: Q9ULQ1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPGYHILRATGEENM

Show »
Length:888
Mass (Da):101,796
Checksum:iD3267C511D4C6BC4
GO

Sequence cautioni

The sequence AK057414 differs from that shown. Reason: Frameshift at position 273. Curated
The sequence BAA86483.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti621 – 6211E → G in AK057414. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 366366Missing in isoform 2. 1 PublicationVSP_023003Add
BLAST
Alternative sequencei1 – 11M → MESCYIAQAGLELLGSSSSP TLTSQSAEITEDASNGGVSE QHPWPSGFERELKPETISSP GYHILRATGEENM in isoform 3. 1 PublicationVSP_041346
Alternative sequencei569 – 61850SLGLT…VGNRT → RYCQPPPWPAGPGAVWQCPV GAGAEWQSGERSSTKDCNRG PDGAPRSLES in isoform 2. 1 PublicationVSP_023004Add
BLAST
Alternative sequencei619 – 816198Missing in isoform 2. 1 PublicationVSP_023005Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083666 mRNA. Translation: AAM01199.1.
AB032995 mRNA. Translation: BAA86483.2. Different initiation.
AK057414 mRNA. No translation available.
AK075071 mRNA. Translation: BAC11385.1.
AC010178 Genomic DNA. No translation available.
AC089999 Genomic DNA. No translation available.
AC127004 Genomic DNA. No translation available.
BC136795 mRNA. Translation: AAI36796.1.
BC136796 mRNA. Translation: AAI36797.1.
BC150203 mRNA. Translation: AAI50204.1.
BC152423 mRNA. Translation: AAI52424.1.
CCDSiCCDS31908.1. [Q9ULQ1-1]
CCDS44985.1. [Q9ULQ1-3]
RefSeqiNP_001137291.1. NM_001143819.2. [Q9ULQ1-3]
NP_001288143.1. NM_001301214.1.
NP_060371.2. NM_017901.5. [Q9ULQ1-1]
UniGeneiHs.524763.

Genome annotation databases

EnsembliENST00000335509; ENSP00000335300; ENSG00000186815. [Q9ULQ1-1]
ENST00000541517; ENSP00000438125; ENSG00000186815. [Q9ULQ1-3]
ENST00000550785; ENSP00000448083; ENSG00000186815. [Q9ULQ1-3]
GeneIDi53373.
KEGGihsa:53373.
UCSCiuc001tuw.3. human. [Q9ULQ1-1]
uc001tux.3. human. [Q9ULQ1-3]

Polymorphism databases

DMDMi125991219.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083666 mRNA. Translation: AAM01199.1.
AB032995 mRNA. Translation: BAA86483.2. Different initiation.
AK057414 mRNA. No translation available.
AK075071 mRNA. Translation: BAC11385.1.
AC010178 Genomic DNA. No translation available.
AC089999 Genomic DNA. No translation available.
AC127004 Genomic DNA. No translation available.
BC136795 mRNA. Translation: AAI36796.1.
BC136796 mRNA. Translation: AAI36797.1.
BC150203 mRNA. Translation: AAI50204.1.
BC152423 mRNA. Translation: AAI52424.1.
CCDSiCCDS31908.1. [Q9ULQ1-1]
CCDS44985.1. [Q9ULQ1-3]
RefSeqiNP_001137291.1. NM_001143819.2. [Q9ULQ1-3]
NP_001288143.1. NM_001301214.1.
NP_060371.2. NM_017901.5. [Q9ULQ1-1]
UniGeneiHs.524763.

3D structure databases

ProteinModelPortaliQ9ULQ1.
SMRiQ9ULQ1. Positions 198-321, 434-689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119760. 2 interactions.
IntActiQ9ULQ1. 3 interactions.
STRINGi9606.ENSP00000376350.

Protein family/group databases

TCDBi1.A.1.11.25. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteiQ9ULQ1.

Polymorphism databases

DMDMi125991219.

Proteomic databases

MaxQBiQ9ULQ1.
PaxDbiQ9ULQ1.
PRIDEiQ9ULQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335509; ENSP00000335300; ENSG00000186815. [Q9ULQ1-1]
ENST00000541517; ENSP00000438125; ENSG00000186815. [Q9ULQ1-3]
ENST00000550785; ENSP00000448083; ENSG00000186815. [Q9ULQ1-3]
GeneIDi53373.
KEGGihsa:53373.
UCSCiuc001tuw.3. human. [Q9ULQ1-1]
uc001tux.3. human. [Q9ULQ1-3]

Organism-specific databases

CTDi53373.
GeneCardsiGC12P113660.
HGNCiHGNC:18182. TPCN1.
HPAiHPA039757.
MIMi609666. gene.
neXtProtiNX_Q9ULQ1.
PharmGKBiPA134922711.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG280094.
GeneTreeiENSGT00530000063660.
HOGENOMiHOG000006773.
HOVERGENiHBG080605.
InParanoidiQ9ULQ1.
KOiK16896.
OMAiMVAFELC.
OrthoDBiEOG7W41B7.
PhylomeDBiQ9ULQ1.
TreeFamiTF328550.

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSiTPCN1. human.
GeneWikiiTPCN1.
GenomeRNAii53373.
NextBioi56034.
PROiQ9ULQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULQ1.
CleanExiHS_TPCN1.
ExpressionAtlasiQ9ULQ1. baseline and differential.
GenevestigatoriQ9ULQ1.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028801. TPC1.
[Graphical view]
PANTHERiPTHR10037:SF201. PTHR10037:SF201. 1 hit.
PfamiPF00520. Ion_trans. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Placenta.
  5. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling."
    Brailoiu E., Churamani D., Cai X., Schrlau M.G., Brailoiu G.C., Gao X., Hooper R., Boulware M.J., Dun N.J., Marchant J.S., Patel S.
    J. Cell Biol. 186:201-209(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LEU-273, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Entry informationi

Entry nameiTPC1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULQ1
Secondary accession number(s): A7E258, Q86XS9, Q8NC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.