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Protein

Striatin-interacting protein 2

Gene

STRIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

GO - Biological processi

  • cell migration Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Striatin-interacting protein 2
Alternative name(s):
Protein FAM40B
Gene namesi
Name:STRIP2
Synonyms:FAM40B, KIAA1170
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22209. STRIP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923427.

Polymorphism and mutation databases

BioMutaiSTRIP2.
DMDMi71151881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Striatin-interacting protein 2PRO_0000187022Add
BLAST

Proteomic databases

MaxQBiQ9ULQ0.
PaxDbiQ9ULQ0.
PRIDEiQ9ULQ0.

PTM databases

PhosphoSiteiQ9ULQ0.

Expressioni

Gene expression databases

BgeeiQ9ULQ0.
CleanExiHS_FAM40B.
GenevisibleiQ9ULQ0. HS.

Organism-specific databases

HPAiHPA019657.

Interactioni

Subunit structurei

Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.By similarity1 Publication

Protein-protein interaction databases

BioGridi121534. 14 interactions.
IntActiQ9ULQ0. 15 interactions.
MINTiMINT-3082270.
STRINGi9606.ENSP00000249344.

Structurei

3D structure databases

ProteinModelPortaliQ9ULQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi577 – 5826Poly-Leu

Sequence similaritiesi

Belongs to the STRIP family.Curated

Phylogenomic databases

eggNOGiNOG247682.
GeneTreeiENSGT00400000022095.
HOGENOMiHOG000252963.
HOVERGENiHBG081506.
InParanoidiQ9ULQ0.
OrthoDBiEOG7W1536.
PhylomeDBiQ9ULQ0.
TreeFamiTF314205.

Family and domain databases

InterProiIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamiPF11882. DUF3402. 1 hit.
PF07923. N1221. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDPAAPGTG GPPANGNGNG GGKGKQAAPK GREAFRSQRR ESEGSVDCPT
60 70 80 90 100
LEFEYGDADG HAAELSELYS YTENLEFTNN RRCFEEDFKT QVQGKEWLEL
110 120 130 140 150
EEDAQKAYIM GLLDRLEVVS RERRLKVARA VLYLAQGTFG ECDSEVDVLH
160 170 180 190 200
WSRYNCFLLY QMGTFSTFLE LLHMEIDNSQ ACSSALRKPA VSIADSTELR
210 220 230 240 250
VLLSVMYLMV ENIRLERETD PCGWRTARET FRTELSFSMH NEEPFALLLF
260 270 280 290 300
SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQTL KVQKRAELGL
310 320 330 340 350
PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG RRGSRRQLLT
360 370 380 390 400
KQDSLDIYNE RDLFKTEEPA TEEEEESAGD GERTLDGELD LLEQDPLVPP
410 420 430 440 450
PPSQAPLSAE RVAFPKGLPW APKVRQKDIE HFLEMSRNKF IGFTLGQDTD
460 470 480 490 500
TLVGLPRPIH ESVKTLKQHK YISIADVQIK NEEELEKCPM SLGEEVVPET
510 520 530 540 550
PCEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI LADVLPEEMP
560 570 580 590 600
ITVLQSMKLG IDVNRHKEII VKSISTLLLL LLKHFKLNHI YQFEYVSQHL
610 620 630 640 650
VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL PELTTESLEA
660 670 680 690 700
GDNSQFCWRN LFSCINLLRL LNKLTKWKHS RTMMLVVFKS APILKRALKV
710 720 730 740 750
KQAMLQLYVL KLLKLQTKYL GRQWRKSNMK TMSAIYQKVR HRMNDDWAYG
760 770 780 790 800
NDIDARPWDF QAEECTLRAN IEAFNSRRYD RPQDSEFSPV DNCLQSVLGQ
810 820 830
RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH
Length:834
Mass (Da):95,360
Last modified:July 19, 2005 - v2
Checksum:i3DAF1DA8FD6E4C4D
GO
Isoform 2 (identifier: Q9ULQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     752-758: DIDARPW → GESSQSS
     759-834: Missing.

Show »
Length:758
Mass (Da):86,018
Checksum:iC70233AEEB0C6690
GO

Sequence cautioni

The sequence BAA86484.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti383 – 3831R → Q.
Corresponds to variant rs2242030 [ dbSNP | Ensembl ].
VAR_049021

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei752 – 7587DIDARPW → GESSQSS in isoform 2. 1 PublicationVSP_014867
Alternative sequencei759 – 83476Missing in isoform 2. 1 PublicationVSP_014868Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032996 mRNA. Translation: BAA86484.1. Different initiation.
AC009244 Genomic DNA. No translation available.
BC019064 mRNA. Translation: AAH19064.1.
CCDSiCCDS34752.1. [Q9ULQ0-1]
CCDS47709.1. [Q9ULQ0-2]
RefSeqiNP_001127808.1. NM_001134336.1. [Q9ULQ0-2]
NP_065755.1. NM_020704.2. [Q9ULQ0-1]
UniGeneiHs.489988.

Genome annotation databases

EnsembliENST00000249344; ENSP00000249344; ENSG00000128578.
ENST00000435494; ENSP00000392393; ENSG00000128578. [Q9ULQ0-2]
GeneIDi57464.
KEGGihsa:57464.
UCSCiuc003vow.3. human. [Q9ULQ0-2]
uc011koy.2. human. [Q9ULQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032996 mRNA. Translation: BAA86484.1. Different initiation.
AC009244 Genomic DNA. No translation available.
BC019064 mRNA. Translation: AAH19064.1.
CCDSiCCDS34752.1. [Q9ULQ0-1]
CCDS47709.1. [Q9ULQ0-2]
RefSeqiNP_001127808.1. NM_001134336.1. [Q9ULQ0-2]
NP_065755.1. NM_020704.2. [Q9ULQ0-1]
UniGeneiHs.489988.

3D structure databases

ProteinModelPortaliQ9ULQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121534. 14 interactions.
IntActiQ9ULQ0. 15 interactions.
MINTiMINT-3082270.
STRINGi9606.ENSP00000249344.

PTM databases

PhosphoSiteiQ9ULQ0.

Polymorphism and mutation databases

BioMutaiSTRIP2.
DMDMi71151881.

Proteomic databases

MaxQBiQ9ULQ0.
PaxDbiQ9ULQ0.
PRIDEiQ9ULQ0.

Protocols and materials databases

DNASUi57464.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249344; ENSP00000249344; ENSG00000128578.
ENST00000435494; ENSP00000392393; ENSG00000128578. [Q9ULQ0-2]
GeneIDi57464.
KEGGihsa:57464.
UCSCiuc003vow.3. human. [Q9ULQ0-2]
uc011koy.2. human. [Q9ULQ0-1]

Organism-specific databases

CTDi57464.
GeneCardsiGC07P129074.
H-InvDBHIX0007066.
HGNCiHGNC:22209. STRIP2.
HPAiHPA019657.
neXtProtiNX_Q9ULQ0.
PharmGKBiPA134923427.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG247682.
GeneTreeiENSGT00400000022095.
HOGENOMiHOG000252963.
HOVERGENiHBG081506.
InParanoidiQ9ULQ0.
OrthoDBiEOG7W1536.
PhylomeDBiQ9ULQ0.
TreeFamiTF314205.

Miscellaneous databases

GenomeRNAii57464.
NextBioi63670.
PROiQ9ULQ0.

Gene expression databases

BgeeiQ9ULQ0.
CleanExiHS_FAM40B.
GenevisibleiQ9ULQ0. HS.

Family and domain databases

InterProiIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamiPF11882. DUF3402. 1 hit.
PF07923. N1221. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  4. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
    Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G., Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I., Aebersold R., Raught B., Gingras A.C.
    Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTTNBP2NL.
  5. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
    Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
    BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSTRP2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULQ0
Secondary accession number(s): Q8WUZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 22, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.