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Q9ULQ0 (STRP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Striatin-interacting protein 2
Alternative name(s):
Protein FAM40B
Gene names
Name:STRIP2
Synonyms:FAM40B, KIAA1170
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Ref.5

Subunit structure

Component of striatin-interacting phosphatase and kinase (STRIPAK) complex By similarity. Interacts with CTTNBP2NL. Ref.4

Subcellular location

Cytoplasm. Note: Enriched in lamellipodia. Ref.5

Sequence similarities

Belongs to the STRIP family.

Sequence caution

The sequence BAA86484.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell migration

Inferred from mutant phenotype Ref.5. Source: UniProtKB

cytoskeleton organization

Inferred from mutant phenotype Ref.5. Source: UniProtKB

regulation of cell shape

Inferred from mutant phenotype Ref.5. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from direct assay Ref.5. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ULQ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ULQ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     752-758: DIDARPW → GESSQSS
     759-834: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Striatin-interacting protein 2
PRO_0000187022

Regions

Compositional bias577 – 5826Poly-Leu

Natural variations

Alternative sequence752 – 7587DIDARPW → GESSQSS in isoform 2.
VSP_014867
Alternative sequence759 – 83476Missing in isoform 2.
VSP_014868
Natural variant3831R → Q.
Corresponds to variant rs2242030 [ dbSNP | Ensembl ].
VAR_049021

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: 3DAF1DA8FD6E4C4D

FASTA83495,360
        10         20         30         40         50         60 
MEDPAAPGTG GPPANGNGNG GGKGKQAAPK GREAFRSQRR ESEGSVDCPT LEFEYGDADG 

        70         80         90        100        110        120 
HAAELSELYS YTENLEFTNN RRCFEEDFKT QVQGKEWLEL EEDAQKAYIM GLLDRLEVVS 

       130        140        150        160        170        180 
RERRLKVARA VLYLAQGTFG ECDSEVDVLH WSRYNCFLLY QMGTFSTFLE LLHMEIDNSQ 

       190        200        210        220        230        240 
ACSSALRKPA VSIADSTELR VLLSVMYLMV ENIRLERETD PCGWRTARET FRTELSFSMH 

       250        260        270        280        290        300 
NEEPFALLLF SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQTL KVQKRAELGL 

       310        320        330        340        350        360 
PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG RRGSRRQLLT KQDSLDIYNE 

       370        380        390        400        410        420 
RDLFKTEEPA TEEEEESAGD GERTLDGELD LLEQDPLVPP PPSQAPLSAE RVAFPKGLPW 

       430        440        450        460        470        480 
APKVRQKDIE HFLEMSRNKF IGFTLGQDTD TLVGLPRPIH ESVKTLKQHK YISIADVQIK 

       490        500        510        520        530        540 
NEEELEKCPM SLGEEVVPET PCEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI 

       550        560        570        580        590        600 
LADVLPEEMP ITVLQSMKLG IDVNRHKEII VKSISTLLLL LLKHFKLNHI YQFEYVSQHL 

       610        620        630        640        650        660 
VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL PELTTESLEA GDNSQFCWRN 

       670        680        690        700        710        720 
LFSCINLLRL LNKLTKWKHS RTMMLVVFKS APILKRALKV KQAMLQLYVL KLLKLQTKYL 

       730        740        750        760        770        780 
GRQWRKSNMK TMSAIYQKVR HRMNDDWAYG NDIDARPWDF QAEECTLRAN IEAFNSRRYD 

       790        800        810        820        830 
RPQDSEFSPV DNCLQSVLGQ RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH 

« Hide

Isoform 2 [UniParc].

Checksum: C70233AEEB0C6690
Show »

FASTA75886,018

References

« Hide 'large scale' references
[1]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney.
[4]"A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G., Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I., Aebersold R., Raught B., Gingras A.C.
Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CTTNBP2NL.
[5]"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032996 mRNA. Translation: BAA86484.1. Different initiation.
AC009244 Genomic DNA. No translation available.
BC019064 mRNA. Translation: AAH19064.1.
CCDSCCDS34752.1. [Q9ULQ0-1]
CCDS47709.1. [Q9ULQ0-2]
RefSeqNP_001127808.1. NM_001134336.1. [Q9ULQ0-2]
NP_065755.1. NM_020704.2. [Q9ULQ0-1]
UniGeneHs.489988.

3D structure databases

ProteinModelPortalQ9ULQ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121534. 14 interactions.
IntActQ9ULQ0. 15 interactions.
MINTMINT-3082270.
STRING9606.ENSP00000249344.

PTM databases

PhosphoSiteQ9ULQ0.

Polymorphism databases

DMDM71151881.

Proteomic databases

MaxQBQ9ULQ0.
PaxDbQ9ULQ0.
PRIDEQ9ULQ0.

Protocols and materials databases

DNASU57464.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249344; ENSP00000249344; ENSG00000128578. [Q9ULQ0-1]
ENST00000435494; ENSP00000392393; ENSG00000128578. [Q9ULQ0-2]
GeneID57464.
KEGGhsa:57464.
UCSCuc003vow.3. human. [Q9ULQ0-2]
uc011koy.2. human. [Q9ULQ0-1]

Organism-specific databases

CTD57464.
GeneCardsGC07P129074.
H-InvDBHIX0007066.
HGNCHGNC:22209. STRIP2.
HPAHPA019657.
neXtProtNX_Q9ULQ0.
PharmGKBPA134923427.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247682.
HOGENOMHOG000252963.
HOVERGENHBG081506.
InParanoidQ9ULQ0.
OMAMYLLVEN.
OrthoDBEOG7W1536.
PhylomeDBQ9ULQ0.
TreeFamTF314205.

Gene expression databases

ArrayExpressQ9ULQ0.
BgeeQ9ULQ0.
CleanExHS_FAM40B.
GenevestigatorQ9ULQ0.

Family and domain databases

InterProIPR021819. DUF3402.
IPR012486. N1221.
[Graphical view]
PfamPF11882. DUF3402. 1 hit.
PF07923. N1221. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57464.
NextBio63670.
PROQ9ULQ0.

Entry information

Entry nameSTRP2_HUMAN
AccessionPrimary (citable) accession number: Q9ULQ0
Secondary accession number(s): Q8WUZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM