Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ULQ0

- STRP2_HUMAN

UniProt

Q9ULQ0 - STRP2_HUMAN

Protein

Striatin-interacting protein 2

Gene

STRIP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

    GO - Biological processi

    1. cell migration Source: UniProtKB
    2. cytoskeleton organization Source: UniProtKB
    3. regulation of cell shape Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Striatin-interacting protein 2
    Alternative name(s):
    Protein FAM40B
    Gene namesi
    Name:STRIP2
    Synonyms:FAM40B, KIAA1170
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:22209. STRIP2.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Enriched in lamellipodia.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134923427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Striatin-interacting protein 2PRO_0000187022Add
    BLAST

    Proteomic databases

    MaxQBiQ9ULQ0.
    PaxDbiQ9ULQ0.
    PRIDEiQ9ULQ0.

    PTM databases

    PhosphoSiteiQ9ULQ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULQ0.
    BgeeiQ9ULQ0.
    CleanExiHS_FAM40B.
    GenevestigatoriQ9ULQ0.

    Organism-specific databases

    HPAiHPA019657.

    Interactioni

    Subunit structurei

    Component of striatin-interacting phosphatase and kinase (STRIPAK) complex By similarity. Interacts with CTTNBP2NL.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi121534. 14 interactions.
    IntActiQ9ULQ0. 15 interactions.
    MINTiMINT-3082270.
    STRINGi9606.ENSP00000249344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi577 – 5826Poly-Leu

    Sequence similaritiesi

    Belongs to the STRIP family.Curated

    Phylogenomic databases

    eggNOGiNOG247682.
    HOGENOMiHOG000252963.
    HOVERGENiHBG081506.
    InParanoidiQ9ULQ0.
    OMAiMYLLVEN.
    OrthoDBiEOG7W1536.
    PhylomeDBiQ9ULQ0.
    TreeFamiTF314205.

    Family and domain databases

    InterProiIPR021819. DUF3402.
    IPR012486. N1221.
    [Graphical view]
    PfamiPF11882. DUF3402. 1 hit.
    PF07923. N1221. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULQ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDPAAPGTG GPPANGNGNG GGKGKQAAPK GREAFRSQRR ESEGSVDCPT    50
    LEFEYGDADG HAAELSELYS YTENLEFTNN RRCFEEDFKT QVQGKEWLEL 100
    EEDAQKAYIM GLLDRLEVVS RERRLKVARA VLYLAQGTFG ECDSEVDVLH 150
    WSRYNCFLLY QMGTFSTFLE LLHMEIDNSQ ACSSALRKPA VSIADSTELR 200
    VLLSVMYLMV ENIRLERETD PCGWRTARET FRTELSFSMH NEEPFALLLF 250
    SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQTL KVQKRAELGL 300
    PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG RRGSRRQLLT 350
    KQDSLDIYNE RDLFKTEEPA TEEEEESAGD GERTLDGELD LLEQDPLVPP 400
    PPSQAPLSAE RVAFPKGLPW APKVRQKDIE HFLEMSRNKF IGFTLGQDTD 450
    TLVGLPRPIH ESVKTLKQHK YISIADVQIK NEEELEKCPM SLGEEVVPET 500
    PCEILYQGML YSLPQYMIAL LKILLAAAPT SKAKTDSINI LADVLPEEMP 550
    ITVLQSMKLG IDVNRHKEII VKSISTLLLL LLKHFKLNHI YQFEYVSQHL 600
    VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL PELTTESLEA 650
    GDNSQFCWRN LFSCINLLRL LNKLTKWKHS RTMMLVVFKS APILKRALKV 700
    KQAMLQLYVL KLLKLQTKYL GRQWRKSNMK TMSAIYQKVR HRMNDDWAYG 750
    NDIDARPWDF QAEECTLRAN IEAFNSRRYD RPQDSEFSPV DNCLQSVLGQ 800
    RLDLPEDFHY SYELWLEREV FSQPICWEEL LQNH 834
    Length:834
    Mass (Da):95,360
    Last modified:July 19, 2005 - v2
    Checksum:i3DAF1DA8FD6E4C4D
    GO
    Isoform 2 (identifier: Q9ULQ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         752-758: DIDARPW → GESSQSS
         759-834: Missing.

    Show »
    Length:758
    Mass (Da):86,018
    Checksum:iC70233AEEB0C6690
    GO

    Sequence cautioni

    The sequence BAA86484.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti383 – 3831R → Q.
    Corresponds to variant rs2242030 [ dbSNP | Ensembl ].
    VAR_049021

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei752 – 7587DIDARPW → GESSQSS in isoform 2. 1 PublicationVSP_014867
    Alternative sequencei759 – 83476Missing in isoform 2. 1 PublicationVSP_014868Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032996 mRNA. Translation: BAA86484.1. Different initiation.
    AC009244 Genomic DNA. No translation available.
    BC019064 mRNA. Translation: AAH19064.1.
    CCDSiCCDS34752.1. [Q9ULQ0-1]
    CCDS47709.1. [Q9ULQ0-2]
    RefSeqiNP_001127808.1. NM_001134336.1. [Q9ULQ0-2]
    NP_065755.1. NM_020704.2. [Q9ULQ0-1]
    UniGeneiHs.489988.

    Genome annotation databases

    EnsembliENST00000249344; ENSP00000249344; ENSG00000128578. [Q9ULQ0-1]
    ENST00000435494; ENSP00000392393; ENSG00000128578. [Q9ULQ0-2]
    GeneIDi57464.
    KEGGihsa:57464.
    UCSCiuc003vow.3. human. [Q9ULQ0-2]
    uc011koy.2. human. [Q9ULQ0-1]

    Polymorphism databases

    DMDMi71151881.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032996 mRNA. Translation: BAA86484.1 . Different initiation.
    AC009244 Genomic DNA. No translation available.
    BC019064 mRNA. Translation: AAH19064.1 .
    CCDSi CCDS34752.1. [Q9ULQ0-1 ]
    CCDS47709.1. [Q9ULQ0-2 ]
    RefSeqi NP_001127808.1. NM_001134336.1. [Q9ULQ0-2 ]
    NP_065755.1. NM_020704.2. [Q9ULQ0-1 ]
    UniGenei Hs.489988.

    3D structure databases

    ProteinModelPortali Q9ULQ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121534. 14 interactions.
    IntActi Q9ULQ0. 15 interactions.
    MINTi MINT-3082270.
    STRINGi 9606.ENSP00000249344.

    PTM databases

    PhosphoSitei Q9ULQ0.

    Polymorphism databases

    DMDMi 71151881.

    Proteomic databases

    MaxQBi Q9ULQ0.
    PaxDbi Q9ULQ0.
    PRIDEi Q9ULQ0.

    Protocols and materials databases

    DNASUi 57464.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249344 ; ENSP00000249344 ; ENSG00000128578 . [Q9ULQ0-1 ]
    ENST00000435494 ; ENSP00000392393 ; ENSG00000128578 . [Q9ULQ0-2 ]
    GeneIDi 57464.
    KEGGi hsa:57464.
    UCSCi uc003vow.3. human. [Q9ULQ0-2 ]
    uc011koy.2. human. [Q9ULQ0-1 ]

    Organism-specific databases

    CTDi 57464.
    GeneCardsi GC07P129074.
    H-InvDB HIX0007066.
    HGNCi HGNC:22209. STRIP2.
    HPAi HPA019657.
    neXtProti NX_Q9ULQ0.
    PharmGKBi PA134923427.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247682.
    HOGENOMi HOG000252963.
    HOVERGENi HBG081506.
    InParanoidi Q9ULQ0.
    OMAi MYLLVEN.
    OrthoDBi EOG7W1536.
    PhylomeDBi Q9ULQ0.
    TreeFami TF314205.

    Miscellaneous databases

    GenomeRNAii 57464.
    NextBioi 63670.
    PROi Q9ULQ0.

    Gene expression databases

    ArrayExpressi Q9ULQ0.
    Bgeei Q9ULQ0.
    CleanExi HS_FAM40B.
    Genevestigatori Q9ULQ0.

    Family and domain databases

    InterProi IPR021819. DUF3402.
    IPR012486. N1221.
    [Graphical view ]
    Pfami PF11882. DUF3402. 1 hit.
    PF07923. N1221. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    4. "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein."
      Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G., Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I., Aebersold R., Raught B., Gingras A.C.
      Mol. Cell. Proteomics 8:157-171(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTTNBP2NL.
    5. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
      Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
      BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSTRP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULQ0
    Secondary accession number(s): Q8WUZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3