Q9ULP0 (NDRG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein NDRG4

Alternative name(s):
Brain development-related molecule 1
N-myc downstream-regulated gene 4 protein
Vascular smooth muscle cell-associated protein 8
Short name=SMAP-8

Gene names

Name:	NDRG4
Synonyms:	BDM1, KIAA1180

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress By similarity. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Ref.3
Subcellular location	Cytoplasm › cytosol Ref.3 Ref.10.
Tissue specificity	Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. Ref.1 Ref.3 Ref.10
Developmental stage	Expressed in a cell cycle-specific manner in glioblastoma multiple cells. Low levels in G2/M cells increase with progression through G1 phase and entry and progression through S phase. Ref.10
Post-translational modification	Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment. Ref.3
Sequence similarities	Belongs to the NDRG family.
Sequence caution	The sequence BAA86494.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Non-traceable author statement Ref.1PubMed 11978393. Source: UniProtKB cell growth Non-traceable author statement Ref.1. Source: UniProtKB response to stress Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Non-traceable author statement Ref.1. Source: UniProtKB cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULP0-1)

Also known as: NDRG4-BVar;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULP0-2)

Also known as: NDRG4-B;

The sequence of this isoform differs from the canonical sequence as follows:
     289-302: IAYLKDRRLSGGAV → M

Isoform 3 (identifier: Q9ULP0-3)

Also known as: NDRG4-H;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MPECWDG → MAGLQELRFPEEKPLLRGQDATELESSDAFLLAADTDWK
     289-302: IAYLKDRRLSGGAV → M

Isoform 4 (identifier: Q9ULP0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     291-303: Missing.

Isoform 5 (identifier: Q9ULP0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: H → RKCSPASVSPPLPPISQSD
     289-302: IAYLKDRRLSGGAV → M

Isoform 6 (identifier: Q9ULP0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MPECWDG → MKVLGHRLELLTGLLLHDVTMAGLQELRFPEEKPLLRGQDATELESSDAFLLAADTDWK
     289-302: IAYLKDRRLSGGAV → M

Isoform 7 (identifier: Q9ULP0-7)

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: G → GVGEGNAGAVKLAGLGDPRWSPGHLLSPGHQ
     289-302: IAYLKDRRLSGGAV → M

Note: No experimental confirmation available.

Isoform 8 (identifier: Q9ULP0-8)

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: G → GRSQERRLPRVSSTVSPLQ
     289-302: IAYLKDRRLSGGAV → M

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Protein NDRG4		PRO_0000159579
Regions
	Compositional bias	253 – 256	4	Poly-Thr
Amino acid modifications
	Modified residue	298	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 7	7	MPECWDG → MAGLQELRFPEEKPLLRGQD ATELESSDAFLLAADTDWK in isoform 3.		VSP_003421
	Alternative sequence	1 – 7	7	MPECWDG → MKVLGHRLELLTGLLLHDVT MAGLQELRFPEEKPLLRGQD ATELESSDAFLLAADTDWK in isoform 6.		VSP_022956
	Alternative sequence	7	1	G → GVGEGNAGAVKLAGLGDPRW SPGHLLSPGHQ in isoform 7.		VSP_045830
	Alternative sequence	7	1	G → GRSQERRLPRVSSTVSPLQ in isoform 8.		VSP_046326
	Alternative sequence	43	1	H → RKCSPASVSPPLPPISQSD in isoform 5.		VSP_022957
	Alternative sequence	289 – 302	14	IAYLK…SGGAV → M in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8.		VSP_003422
	Alternative sequence	291 – 303	13	Missing in isoform 4.		VSP_003423
Experimental info
	Sequence conflict	10	1	D → N in BAG61777. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (NDRG4-BVar) [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 4CFAFC7C820013B6	FASTA	352	38,459
	10 20 30 40 50 60 MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT 70 80 90 100 110 120 KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL 130 140 150 160 170 180 AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE 190 200 210 220 230 240 LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE 250 260 270 280 290 300 DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYIA YLKDRRLSGG 310 320 330 340 350 AVPSASMTRL ARSRTASLTS ASSVDGSRPQ ACTHSESSEG LGQVNHTMEV SC
	Isoform 2 (NDRG4-B) [UniParc]. Checksum: E5721D653F9CF056	FASTA	339	37,089
	10 20 30 40 50 60 MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT 70 80 90 100 110 120 KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL 130 140 150 160 170 180 AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE 190 200 210 220 230 240 LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE 250 260 270 280 290 300 DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYMP SASMTRLARS 310 320 330 RTASLTSASS VDGSRPQACT HSESSEGLGQ VNHTMEVSC
	Isoform 3 (NDRG4-H) [UniParc]. Checksum: F7E4FA067E0DD752	FASTA	371	40,645
	10 20 30 40 50 60 MAGLQELRFP EEKPLLRGQD ATELESSDAF LLAADTDWKE HDIETPYGLL HVVIRGSPKG 70 80 90 100 110 120 NRPAILTYHD VGLNHKLCFN TFFNFEDMQE ITKHFVVCHV DAPGQQVGAS QFPQGYQFPS 130 140 150 160 170 180 MEQLAAMLPS VVQHFGFKYV IGIGVGAGAY VLAKFALIFP DLVEGLVLVN IDPNGKGWID 190 200 210 220 230 240 WAATKLSGLT STLPDTVLSH LFSQEELVNN TELVQSYRQQ IGNVVNQANL QLFWNMYNSR 250 260 270 280 290 300 RDLDINRPGT VPNAKTLRCP VMLVVGDNAP AEDGVVECNS KLDPTTTTFL KMADSGGLPQ 310 320 330 340 350 360 VTQPGKLTEA FKYFLQGMGY MPSASMTRLA RSRTASLTSA SSVDGSRPQA CTHSESSEGL 370 GQVNHTMEVS C
	Isoform 4 [UniParc]. Checksum: E56FB113F95D3056	FASTA	339	37,045
	10 20 30 40 50 60 MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT 70 80 90 100 110 120 KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL 130 140 150 160 170 180 AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE 190 200 210 220 230 240 LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE 250 260 270 280 290 300 DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYIA SASMTRLARS 310 320 330 RTASLTSASS VDGSRPQACT HSESSEGLGQ VNHTMEVSC
	Isoform 5 [UniParc]. Checksum: 80425B23A100DEEB	FASTA	357	38,900
	10 20 30 40 50 60 MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNRKCSPASV SPPLPPISQS 70 80 90 100 110 120 DKLCFNTFFN FEDMQEITKH FVVCHVDAPG QQVGASQFPQ GYQFPSMEQL AAMLPSVVQH 130 140 150 160 170 180 FGFKYVIGIG VGAGAYVLAK FALIFPDLVE GLVLVNIDPN GKGWIDWAAT KLSGLTSTLP 190 200 210 220 230 240 DTVLSHLFSQ EELVNNTELV QSYRQQIGNV VNQANLQLFW NMYNSRRDLD INRPGTVPNA 250 260 270 280 290 300 KTLRCPVMLV VGDNAPAEDG VVECNSKLDP TTTTFLKMAD SGGLPQVTQP GKLTEAFKYF 310 320 330 340 350 LQGMGYMPSA SMTRLARSRT ASLTSASSVD GSRPQACTHS ESSEGLGQVN HTMEVSC
	Isoform 6 [UniParc]. Checksum: 2072323C9172C2E3	FASTA	391	42,886
	10 20 30 40 50 60 MKVLGHRLEL LTGLLLHDVT MAGLQELRFP EEKPLLRGQD ATELESSDAF LLAADTDWKE 70 80 90 100 110 120 HDIETPYGLL HVVIRGSPKG NRPAILTYHD VGLNHKLCFN TFFNFEDMQE ITKHFVVCHV 130 140 150 160 170 180 DAPGQQVGAS QFPQGYQFPS MEQLAAMLPS VVQHFGFKYV IGIGVGAGAY VLAKFALIFP 190 200 210 220 230 240 DLVEGLVLVN IDPNGKGWID WAATKLSGLT STLPDTVLSH LFSQEELVNN TELVQSYRQQ 250 260 270 280 290 300 IGNVVNQANL QLFWNMYNSR RDLDINRPGT VPNAKTLRCP VMLVVGDNAP AEDGVVECNS 310 320 330 340 350 360 KLDPTTTTFL KMADSGGLPQ VTQPGKLTEA FKYFLQGMGY MPSASMTRLA RSRTASLTSA 370 380 390 SSVDGSRPQA CTHSESSEGL GQVNHTMEVS C
	Isoform 7 [UniParc]. Checksum: 7DD24F9D2E46FDAE	FASTA	369	40,049
	10 20 30 40 50 60 MPECWDGVGE GNAGAVKLAG LGDPRWSPGH LLSPGHQEHD IETPYGLLHV VIRGSPKGNR 70 80 90 100 110 120 PAILTYHDVG LNHKLCFNTF FNFEDMQEIT KHFVVCHVDA PGQQVGASQF PQGYQFPSME 130 140 150 160 170 180 QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL AKFALIFPDL VEGLVLVNID PNGKGWIDWA 190 200 210 220 230 240 ATKLSGLTST LPDTVLSHLF SQEELVNNTE LVQSYRQQIG NVVNQANLQL FWNMYNSRRD 250 260 270 280 290 300 LDINRPGTVP NAKTLRCPVM LVVGDNAPAE DGVVECNSKL DPTTTTFLKM ADSGGLPQVT 310 320 330 340 350 360 QPGKLTEAFK YFLQGMGYMP SASMTRLARS RTASLTSASS VDGSRPQACT HSESSEGLGQ VNHTMEVSC
	Isoform 8 [UniParc]. Checksum: 2CA4F68CC3298268	FASTA	357	39,168
	10 20 30 40 50 60 MPECWDGRSQ ERRLPRVSST VSPLQEHDIE TPYGLLHVVI RGSPKGNRPA ILTYHDVGLN 70 80 90 100 110 120 HKLCFNTFFN FEDMQEITKH FVVCHVDAPG QQVGASQFPQ GYQFPSMEQL AAMLPSVVQH 130 140 150 160 170 180 FGFKYVIGIG VGAGAYVLAK FALIFPDLVE GLVLVNIDPN GKGWIDWAAT KLSGLTSTLP 190 200 210 220 230 240 DTVLSHLFSQ EELVNNTELV QSYRQQIGNV VNQANLQLFW NMYNSRRDLD INRPGTVPNA 250 260 270 280 290 300 KTLRCPVMLV VGDNAPAEDG VVECNSKLDP TTTTFLKMAD SGGLPQVTQP GKLTEAFKYF 310 320 330 340 350 LQGMGYMPSA SMTRLARSRT ASLTSASSVD GSRPQACTHS ESSEGLGQVN HTMEVSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart." Zhou R.-H., Kokame K., Tsukamoto Y., Yutani C., Kato H., Miyata T. Genomics 73:86-97(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[2]	"Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family." Qu X., Zhai Y., Wei H., Zhang C., Xing G., Yu Y., He F. Mol. Cell. Biochem. 229:35-44(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Spleen.
[3]	"A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells." Nishimoto S., Tawara J., Toyoda H., Kitamura K., Komurasaki T. Eur. J. Biochem. 270:2521-2531(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY. Tissue: Heart.
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 5; 6; 7 AND 8). Tissue: Brain, Cerebellum, Hippocampus and Thalamus.
[6]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.
[8]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 80-352 (ISOFORM 1). Tissue: Brain.
[9]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[10]	"NDRG4 is required for cell cycle progression and survival in glioblastoma cells." Schilling S.H., Hjelmeland A.B., Radiloff D.R., Liu I.M., Wakeman T.P., Fielhauer J.R., Foster E.H., Lathia J.D., Rich J.N., Wang X.F., Datto M.B. J. Biol. Chem. 284:25160-25169(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB044947 Genomic DNA. Translation: BAB20071.1. AB044947 Genomic DNA. Translation: BAB20072.1. AB044947 Genomic DNA. Translation: BAB20073.1. AB044944 mRNA. Translation: BAB20068.1. AB044945 mRNA. Translation: BAB20069.1. AB044946 mRNA. Translation: BAB20070.1. AF308608 mRNA. Translation: AAL08806.1. AB021172 mRNA. Translation: BAB20288.1. AL136584 mRNA. Translation: CAB66519.1. AK055038 mRNA. Translation: BAG51454.1. AK126574 mRNA. Translation: BAC86600.1. AK131248 mRNA. Translation: BAD18428.1. AK296415 mRNA. Translation: BAG59078.1. AK299949 mRNA. Translation: BAG61777.1. AC009118 Genomic DNA. No translation available. BC011795 mRNA. Translation: AAH11795.1. AB033006 mRNA. Translation: BAA86494.2. Different initiation.
IPI	IPI00008269. IPI00217784. IPI00418960. IPI00644702. IPI00745722. IPI00910928.
RefSeq	NP_001123959.1. NM_001130487.1. NP_001229762.1. NM_001242833.1. NP_001229763.1. NM_001242834.1. NP_001229764.1. NM_001242835.1. NP_001229765.1. NM_001242836.1. NP_065198.1. NM_020465.3. NP_075061.1. NM_022910.3.
UniGene	Hs.322430.
3D structure databases
ProteinModelPortal	Q9ULP0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000377823.
Protein family/group databases
MEROPS	S33.986.
PTM databases
PhosphoSite	Q9ULP0.
Polymorphism databases
DMDM	20141614.
Proteomic databases
PaxDb	Q9ULP0.
PRIDE	Q9ULP0.
Protocols and materials databases
DNASU	65009.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258187; ENSP00000258187; ENSG00000103034. ENST00000356752; ENSP00000349193; ENSG00000103034. ENST00000394279; ENSP00000377820; ENSG00000103034. ENST00000394282; ENSP00000377823; ENSG00000103034. ENST00000563799; ENSP00000458113; ENSG00000103034. ENST00000566192; ENSP00000454410; ENSG00000103034. ENST00000568640; ENSP00000456338; ENSG00000103034. ENST00000570248; ENSP00000457659; ENSG00000103034.
GeneID	65009.
KEGG	hsa:65009.
UCSC	uc002enk.3. human. uc002enm.3. human. uc002eno.3. human. uc002enp.3. human. uc010cdk.3. human.
Organism-specific databases
CTD	65009.
GeneCards	GC16P058497.
HGNC	HGNC:14466. NDRG4.
HPA	HPA015313. HPA017587.
MIM	614463. gene.
neXtProt	NX_Q9ULP0.
PharmGKB	PA31485.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG294160.
HOVERGEN	HBG052591.
Gene expression databases
ArrayExpress	Q9ULP0.
Bgee	Q9ULP0.
CleanEx	HS_NDRG4.
Genevestigator	Q9ULP0.
GermOnline	ENSG00000103034. Homo sapiens.
Family and domain databases
InterPro	IPR004142. Ndr. [Graphical view]
PANTHER	PTHR11034. PTHR11034. 1 hit.
Pfam	PF03096. Ndr. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	65009.
NextBio	67196.
SOURCE	Search...

Entry information

Entry name

NDRG4_HUMAN

Accession

Primary (citable) accession number: Q9ULP0
Secondary accession number(s): B3KNU2 , B4DK66, B4DSW5, H7C600, Q6ZNE7, Q6ZTI7, Q96PL9, Q9GZM1, Q9GZN3, Q9GZX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 23, 2002
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.