##gff-version 3 Q9ULM3 UniProtKB Chain 1 1422 . . . ID=PRO_0000076366;Note=YEATS domain-containing protein 2 Q9ULM3 UniProtKB Domain 200 345 . . . Note=YEATS;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00376 Q9ULM3 UniProtKB Region 117 198 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Region 259 261 . . . Note=Histone H3K27cr binding;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27103431,ECO:0007744|PDB:5IQL;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Region 282 284 . . . Note=Histone H3K27cr binding;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:27103431,ECO:0007744|PDB:5IQL;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Region 465 486 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Region 513 540 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Region 794 842 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Coiled coil 47 80 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9ULM3 UniProtKB Compositional bias 117 152 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Compositional bias 153 169 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Compositional bias 182 198 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Compositional bias 828 842 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9ULM3 UniProtKB Modified residue 118 118 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:18669648;Dbxref=PMID:18669648 Q9ULM3 UniProtKB Modified residue 120 120 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q3TUF7 Q9ULM3 UniProtKB Modified residue 157 157 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9ULM3 UniProtKB Modified residue 407 407 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9ULM3 UniProtKB Modified residue 447 447 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:21406692,PMID:23186163 Q9ULM3 UniProtKB Modified residue 463 463 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q9ULM3 UniProtKB Modified residue 465 465 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q9ULM3 UniProtKB Modified residue 471 471 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:20068231;Dbxref=PMID:20068231 Q9ULM3 UniProtKB Modified residue 473 473 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q9ULM3 UniProtKB Modified residue 478 478 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9ULM3 UniProtKB Modified residue 536 536 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:21406692,PMID:23186163 Q9ULM3 UniProtKB Modified residue 575 575 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q9ULM3 UniProtKB Modified residue 627 627 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163 Q9ULM3 UniProtKB Modified residue 1219 1219 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9ULM3 UniProtKB Cross-link 9 9 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 113 113 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 189 189 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 370 370 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 487 487 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 552 552 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 592 592 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733 Q9ULM3 UniProtKB Cross-link 649 649 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 773 773 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 923 923 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 1110 1110 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:25114211;Dbxref=PMID:25114211 Q9ULM3 UniProtKB Cross-link 1110 1110 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:25772364,ECO:0007744|PubMed:28112733;Dbxref=PMID:25772364,PMID:28112733 Q9ULM3 UniProtKB Cross-link 1130 1130 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 1222 1222 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Cross-link 1285 1285 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9ULM3 UniProtKB Natural variant 184 184 . . . ID=VAR_051494;Note=I->V;Dbxref=dbSNP:rs16858033 Q9ULM3 UniProtKB Natural variant 530 530 . . . ID=VAR_051495;Note=V->I;Dbxref=dbSNP:rs262993 Q9ULM3 UniProtKB Natural variant 993 993 . . . ID=VAR_051496;Note=Q->H;Dbxref=dbSNP:rs3211095 Q9ULM3 UniProtKB Mutagenesis 259 259 . . . Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 261 261 . . . Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 262 262 . . . Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 282 282 . . . Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 283 283 . . . Note=Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 284 284 . . . Note=Abolished binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 285 285 . . . Note=Strongly reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Mutagenesis 313 313 . . . Note=Reduced binding to histone H3 crotonylated at 'Lys-27' (H3K27cr). Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27103431;Dbxref=PMID:27103431 Q9ULM3 UniProtKB Beta strand 208 218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Helix 221 223 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 232 239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Turn 248 250 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 251 257 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Helix 260 262 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 267 270 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 272 283 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 286 294 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 300 306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 314 316 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE Q9ULM3 UniProtKB Beta strand 318 327 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7EIE