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Q9ULM3

- YETS2_HUMAN

UniProt

Q9ULM3 - YETS2_HUMAN

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Protein

YEATS domain-containing protein 2

Gene

YEATS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

GO - Molecular functioni

  1. TBP-class protein binding Source: BHF-UCL

GO - Biological processi

  1. chromatin organization Source: Reactome
  2. histone H3 acetylation Source: BHF-UCL
  3. negative regulation of transcription, DNA-templated Source: BHF-UCL
  4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_172610. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 2
Gene namesi
Name:YEATS2
Synonyms:KIAA1197
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:25489. YEATS2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  2. mitotic spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14221422YEATS domain-containing protein 2PRO_0000076366Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181Phosphoserine1 Publication
Modified residuei447 – 4471Phosphoserine2 Publications
Modified residuei463 – 4631Phosphoserine1 Publication
Modified residuei465 – 4651Phosphoserine1 Publication
Modified residuei471 – 4711Phosphoserine1 Publication
Modified residuei473 – 4731Phosphoserine1 Publication
Modified residuei536 – 5361Phosphoserine2 Publications
Modified residuei575 – 5751Phosphoserine1 Publication
Modified residuei627 – 6271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ULM3.
PaxDbiQ9ULM3.
PRIDEiQ9ULM3.

PTM databases

PhosphoSiteiQ9ULM3.

Expressioni

Gene expression databases

BgeeiQ9ULM3.
CleanExiHS_YEATS2.
GenevestigatoriQ9ULM3.

Organism-specific databases

HPAiHPA045891.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.1 Publication

Protein-protein interaction databases

BioGridi120815. 27 interactions.
STRINGi9606.ENSP00000306983.

Structurei

3D structure databases

ProteinModelPortaliQ9ULM3.
SMRiQ9ULM3. Positions 204-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 317111YEATSPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 8034Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi794 – 84249Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 YEATS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5033.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000155538.
HOVERGENiHBG062745.
InParanoidiQ9ULM3.
OMAiSPIPKIH.
OrthoDBiEOG70PBX3.
PhylomeDBiQ9ULM3.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF
60 70 80 90 100
ALEMKNKEHE IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK
110 120 130 140 150
TCDTMVFNHP AIKKFLESPS RSSSPANQRA ETPSANHSES DSLSQHNDFL
160 170 180 190 200
SDKDNNSNMD IEERLSNNME QRPSRNTGRD TSRITGSHKT EQRNADLTDE
210 220 230 240 250
TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG SRREPSINHF
260 270 280 290 300
VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR
310 320 330 340 350
IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD
360 370 380 390 400
APPSLPLTIP APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL
410 420 430 440 450
PSSLERTPTK MTTSQKVTFC SHGNSAFQPI ASSCKIVPQS QVPNPESPGK
460 470 480 490 500
SFQPITMSCK IVSGSPISTP SPSPLPRTPT STPVHVKQGT AGSVINNPYV
510 520 530 540 550
IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK IHGSSFVTST
560 570 580 590 600
VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH
610 620 630 640 650
VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV
660 670 680 690 700
VGVPVGSALP STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA
710 720 730 740 750
IVSGGGGTIV AQPVQTLTKA QVTAAGPQKS GSQGSVMATL QLPATNLANL
760 770 780 790 800
ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG AILRATNNAN LQSGSAASGG
810 820 830 840 850
SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP GGISQHLTYT
860 870 880 890 900
SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK
910 920 930 940 950
VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG
960 970 980 990 1000
GVITTATSPA VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA
1010 1020 1030 1040 1050
TVGTCKAATP TVVSATSLVP TPNPISGKAT VSGLLKIHSS QSSPQQAVLT
1060 1070 1080 1090 1100
IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF STSKPPAILP VAAPTPVVPS
1110 1120 1130 1140 1150
SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY VIKIDHLETI
1160 1170 1180 1190 1200
QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT
1210 1220 1230 1240 1250
MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI
1260 1270 1280 1290 1300
EDVLTQIDSE PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS
1310 1320 1330 1340 1350
EPVKINIKKE QEEKQEEVKF YLPPTPGSEF IGDVTQKIGI TLQPVALHRN
1360 1370 1380 1390 1400
VYASVVEDMI LKATEQLVND ILRQALAVGY QTASHNRIPK EITVSNIHQA
1410 1420
ICNIPFLDFL TNKHMGILNE DQ
Length:1,422
Mass (Da):150,782
Last modified:January 10, 2006 - v2
Checksum:i7800718C08B634B3
GO

Sequence cautioni

The sequence BAA86511.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti184 – 1841I → V.
Corresponds to variant rs16858033 [ dbSNP | Ensembl ].
VAR_051494
Natural varianti530 – 5301V → I.
Corresponds to variant rs262993 [ dbSNP | Ensembl ].
VAR_051495
Natural varianti993 – 9931Q → H.
Corresponds to variant rs3211095 [ dbSNP | Ensembl ].
VAR_051496

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033023 mRNA. Translation: BAA86511.1. Different initiation.
AC068769 Genomic DNA. No translation available.
AC131160 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78316.1.
CH471052 Genomic DNA. Translation: EAW78317.1.
BC082270 mRNA. Translation: AAH82270.1.
BC150273 mRNA. Translation: AAI50274.1.
CCDSiCCDS43175.1.
RefSeqiNP_060493.3. NM_018023.4.
UniGeneiHs.632575.

Genome annotation databases

EnsembliENST00000305135; ENSP00000306983; ENSG00000163872.
GeneIDi55689.
KEGGihsa:55689.
UCSCiuc003fly.2. human.

Polymorphism databases

DMDMi85542165.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033023 mRNA. Translation: BAA86511.1 . Different initiation.
AC068769 Genomic DNA. No translation available.
AC131160 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78316.1 .
CH471052 Genomic DNA. Translation: EAW78317.1 .
BC082270 mRNA. Translation: AAH82270.1 .
BC150273 mRNA. Translation: AAI50274.1 .
CCDSi CCDS43175.1.
RefSeqi NP_060493.3. NM_018023.4.
UniGenei Hs.632575.

3D structure databases

ProteinModelPortali Q9ULM3.
SMRi Q9ULM3. Positions 204-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120815. 27 interactions.
STRINGi 9606.ENSP00000306983.

PTM databases

PhosphoSitei Q9ULM3.

Polymorphism databases

DMDMi 85542165.

Proteomic databases

MaxQBi Q9ULM3.
PaxDbi Q9ULM3.
PRIDEi Q9ULM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305135 ; ENSP00000306983 ; ENSG00000163872 .
GeneIDi 55689.
KEGGi hsa:55689.
UCSCi uc003fly.2. human.

Organism-specific databases

CTDi 55689.
GeneCardsi GC03P183416.
H-InvDB HIX0119993.
HGNCi HGNC:25489. YEATS2.
HPAi HPA045891.
MIMi 613373. gene.
neXtProti NX_Q9ULM3.
PharmGKBi PA134922615.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5033.
GeneTreei ENSGT00530000063543.
HOGENOMi HOG000155538.
HOVERGENi HBG062745.
InParanoidi Q9ULM3.
OMAi SPIPKIH.
OrthoDBi EOG70PBX3.
PhylomeDBi Q9ULM3.
TreeFami TF314586.

Enzyme and pathway databases

Reactomei REACT_172610. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi YEATS2. human.
GenomeRNAii 55689.
NextBioi 60493.
PROi Q9ULM3.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULM3.
CleanExi HS_YEATS2.
Genevestigatori Q9ULM3.

Family and domain databases

InterProi IPR005033. YEATS.
[Graphical view ]
PANTHERi PTHR23195. PTHR23195. 1 hit.
Pfami PF03366. YEATS. 1 hit.
[Graphical view ]
PROSITEi PS51037. YEATS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
    Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J.
    Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN ATAC COMPLEX.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447; SER-463; SER-465; SER-471; SER-473; SER-575 AND SER-627, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447 AND SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYETS2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULM3
Secondary accession number(s): A7E2B9
, D3DNS9, Q641P6, Q9NW96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3