Q9ULM3 (YETS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
YEATS domain-containing protein 2

Gene names

Name:	YEATS2
Synonyms:	KIAA1197

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1422 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Ref.10
Subunit structure	Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.
Subcellular location	Nucleus Probable.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.11
Sequence similarities	Contains 1 YEATS domain.
Sequence caution	The sequence BAA86511.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histone H3 acetylation Inferred from direct assay. Source: BHF-UCL negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: BHF-UCL
Cellular component	Ada2/Gcn5/Ada3 transcription activator complex Inferred from direct assay. Source: BHF-UCL
Molecular function	TBP-class protein binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1422	1422	YEATS domain-containing protein 2		PRO_0000076366
Regions
	Domain	207 – 317	111	YEATS
	Coiled coil	47 – 80	34	Potential
	Compositional bias	794 – 842	49	Gly-rich
Amino acid modifications
	Modified residue	118	1	Phosphoserine Ref.5 Ref.8
	Modified residue	144	1	Phosphoserine Ref.6
	Modified residue	447	1	Phosphoserine Ref.5 Ref.9
	Modified residue	463	1	Phosphoserine Ref.9
	Modified residue	465	1	Phosphoserine Ref.5 Ref.9
	Modified residue	473	1	Phosphoserine Ref.9
	Modified residue	519	1	Phosphoserine Ref.5 Ref.9
	Modified residue	521	1	Phosphothreonine Ref.9
	Modified residue	536	1	Phosphoserine Ref.9 Ref.11
	Modified residue	765	1	Phosphoserine Ref.7
Natural variations
	Natural variant	184	1	I → V. Corresponds to variant rs16858033 [ dbSNP | Ensembl ].		VAR_051494
	Natural variant	530	1	V → I. Corresponds to variant rs262993 [ dbSNP | Ensembl ].		VAR_051495
	Natural variant	993	1	Q → H. Corresponds to variant rs3211095 [ dbSNP | Ensembl ].		VAR_051496

Sequences

	Sequence		Length	Mass (Da)
	Q9ULM3 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: 7800718C08B634B3	FASTA	1,422	150,782
	10 20 30 40 50 60 MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF ALEMKNKEHE 70 80 90 100 110 120 IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK TCDTMVFNHP AIKKFLESPS 130 140 150 160 170 180 RSSSPANQRA ETPSANHSES DSLSQHNDFL SDKDNNSNMD IEERLSNNME QRPSRNTGRD 190 200 210 220 230 240 TSRITGSHKT EQRNADLTDE TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG 250 260 270 280 290 300 SRREPSINHF VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR 310 320 330 340 350 360 IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD APPSLPLTIP 370 380 390 400 410 420 APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL PSSLERTPTK MTTSQKVTFC 430 440 450 460 470 480 SHGNSAFQPI ASSCKIVPQS QVPNPESPGK SFQPITMSCK IVSGSPISTP SPSPLPRTPT 490 500 510 520 530 540 STPVHVKQGT AGSVINNPYV IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK 550 560 570 580 590 600 IHGSSFVTST VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH 610 620 630 640 650 660 VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV VGVPVGSALP 670 680 690 700 710 720 STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA IVSGGGGTIV AQPVQTLTKA 730 740 750 760 770 780 QVTAAGPQKS GSQGSVMATL QLPATNLANL ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG 790 800 810 820 830 840 AILRATNNAN LQSGSAASGG SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP 850 860 870 880 890 900 GGISQHLTYT SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK 910 920 930 940 950 960 VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG GVITTATSPA 970 980 990 1000 1010 1020 VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA TVGTCKAATP TVVSATSLVP 1030 1040 1050 1060 1070 1080 TPNPISGKAT VSGLLKIHSS QSSPQQAVLT IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF 1090 1100 1110 1120 1130 1140 STSKPPAILP VAAPTPVVPS SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY 1150 1160 1170 1180 1190 1200 VIKIDHLETI QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT 1210 1220 1230 1240 1250 1260 MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI EDVLTQIDSE 1270 1280 1290 1300 1310 1320 PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS EPVKINIKKE QEEKQEEVKF 1330 1340 1350 1360 1370 1380 YLPPTPGSEF IGDVTQKIGI TLQPVALHRN VYASVVEDMI LKATEQLVND ILRQALAVGY 1390 1400 1410 1420 QTASHNRIPK EITVSNIHQA ICNIPFLDFL TNKHMGILNE DQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-447; SER-465 AND SER-519, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-765, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447; SER-463; SER-465; SER-473; SER-519; THR-521 AND SER-536, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"The double-histone-acetyltransferase complex ATAC is essential for mammalian development." Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J. Mol. Cell. Biol. 29:1176-1188(2009) [PubMed: 19103755] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN ATAC COMPLEX.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033023 mRNA. Translation: BAA86511.1. Different initiation. AC068769 Genomic DNA. No translation available. AC131160 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78316.1. CH471052 Genomic DNA. Translation: EAW78317.1. BC082270 mRNA. Translation: AAH82270.1. BC150273 mRNA. Translation: AAI50274.1.
IPI	IPI00008200.
RefSeq	NP_060493.3. NM_018023.4.
UniGene	Hs.632575.
3D structure databases
ProteinModelPortal	Q9ULM3.
SMR	Q9ULM3. Positions 205-311.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ULM3.
PTM databases
PhosphoSite	Q9ULM3.
Polymorphism databases
DMDM	85542165.
Proteomic databases
PRIDE	Q9ULM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305135; ENSP00000306983; ENSG00000163872. ENST00000421660; ENSP00000408249; ENSG00000163872.
GeneID	55689.
KEGG	hsa:55689.
UCSC	uc003fly.1. human.
Organism-specific databases
CTD	55689.
GeneCards	GC03P183416.
H-InvDB	HIX0003901.
HGNC	HGNC:25489. YEATS2.
HPA	HPA045891.
MIM	613373. gene.
neXtProt	NX_Q9ULM3.
PharmGKB	PA134922615.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14669.
GeneTree	ENSGT00530000063543.
HOGENOM	HBG713990.
HOVERGEN	HBG062745.
InParanoid	Q9ULM3.
OMA	PQGAILR.
OrthoDB	EOG4QZ7K2.
PhylomeDB	Q9ULM3.
Gene expression databases
ArrayExpress	Q9ULM3.
Bgee	Q9ULM3.
CleanEx	HS_YEATS2.
Genevestigator	Q9ULM3.
GermOnline	ENSG00000163872. Homo sapiens.
Family and domain databases
InterPro	IPR005033. YEATS. [Graphical view]
PANTHER	PTHR23195. YEATS. 1 hit.
Pfam	PF03366. YEATS. 1 hit. [Graphical view]
PROSITE	PS51037. YEATS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	60493.
SOURCE	Search...

Entry information

Entry name

YETS2_HUMAN

Accession

Primary (citable) accession number: Q9ULM3
Secondary accession number(s): A7E2B9 , D3DNS9, Q641P6, Q9NW96

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	January 10, 2006
Last modified:	January 25, 2012
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.