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Q9ULM3

- YETS2_HUMAN

UniProt

Q9ULM3 - YETS2_HUMAN

Protein

YEATS domain-containing protein 2

Gene

YEATS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
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    Functioni

    Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

    GO - Molecular functioni

    1. protein binding Source: BHF-UCL
    2. TBP-class protein binding Source: BHF-UCL

    GO - Biological processi

    1. chromatin organization Source: Reactome
    2. histone H3 acetylation Source: BHF-UCL
    3. negative regulation of transcription, DNA-templated Source: BHF-UCL
    4. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    YEATS domain-containing protein 2
    Gene namesi
    Name:YEATS2
    Synonyms:KIAA1197
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25489. YEATS2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
    2. mitotic spindle Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134922615.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14221422YEATS domain-containing protein 2PRO_0000076366Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei118 – 1181Phosphoserine1 Publication
    Modified residuei447 – 4471Phosphoserine2 Publications
    Modified residuei463 – 4631Phosphoserine1 Publication
    Modified residuei465 – 4651Phosphoserine1 Publication
    Modified residuei471 – 4711Phosphoserine1 Publication
    Modified residuei473 – 4731Phosphoserine1 Publication
    Modified residuei536 – 5361Phosphoserine2 Publications
    Modified residuei575 – 5751Phosphoserine1 Publication
    Modified residuei627 – 6271Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULM3.
    PaxDbiQ9ULM3.
    PRIDEiQ9ULM3.

    PTM databases

    PhosphoSiteiQ9ULM3.

    Expressioni

    Gene expression databases

    BgeeiQ9ULM3.
    CleanExiHS_YEATS2.
    GenevestigatoriQ9ULM3.

    Organism-specific databases

    HPAiHPA045891.

    Interactioni

    Subunit structurei

    Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.1 Publication

    Protein-protein interaction databases

    BioGridi120815. 20 interactions.
    STRINGi9606.ENSP00000306983.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULM3.
    SMRiQ9ULM3. Positions 204-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 317111YEATSPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili47 – 8034Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi794 – 84249Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 YEATS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5033.
    HOGENOMiHOG000155538.
    HOVERGENiHBG062745.
    InParanoidiQ9ULM3.
    OMAiSPIPKIH.
    OrthoDBiEOG70PBX3.
    PhylomeDBiQ9ULM3.
    TreeFamiTF314586.

    Family and domain databases

    InterProiIPR005033. YEATS.
    [Graphical view]
    PANTHERiPTHR23195. PTHR23195. 1 hit.
    PfamiPF03366. YEATS. 1 hit.
    [Graphical view]
    PROSITEiPS51037. YEATS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ULM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF     50
    ALEMKNKEHE IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK 100
    TCDTMVFNHP AIKKFLESPS RSSSPANQRA ETPSANHSES DSLSQHNDFL 150
    SDKDNNSNMD IEERLSNNME QRPSRNTGRD TSRITGSHKT EQRNADLTDE 200
    TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG SRREPSINHF 250
    VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR 300
    IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD 350
    APPSLPLTIP APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL 400
    PSSLERTPTK MTTSQKVTFC SHGNSAFQPI ASSCKIVPQS QVPNPESPGK 450
    SFQPITMSCK IVSGSPISTP SPSPLPRTPT STPVHVKQGT AGSVINNPYV 500
    IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK IHGSSFVTST 550
    VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH 600
    VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV 650
    VGVPVGSALP STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA 700
    IVSGGGGTIV AQPVQTLTKA QVTAAGPQKS GSQGSVMATL QLPATNLANL 750
    ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG AILRATNNAN LQSGSAASGG 800
    SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP GGISQHLTYT 850
    SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK 900
    VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG 950
    GVITTATSPA VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA 1000
    TVGTCKAATP TVVSATSLVP TPNPISGKAT VSGLLKIHSS QSSPQQAVLT 1050
    IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF STSKPPAILP VAAPTPVVPS 1100
    SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY VIKIDHLETI 1150
    QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT 1200
    MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI 1250
    EDVLTQIDSE PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS 1300
    EPVKINIKKE QEEKQEEVKF YLPPTPGSEF IGDVTQKIGI TLQPVALHRN 1350
    VYASVVEDMI LKATEQLVND ILRQALAVGY QTASHNRIPK EITVSNIHQA 1400
    ICNIPFLDFL TNKHMGILNE DQ 1422
    Length:1,422
    Mass (Da):150,782
    Last modified:January 10, 2006 - v2
    Checksum:i7800718C08B634B3
    GO

    Sequence cautioni

    The sequence BAA86511.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti184 – 1841I → V.
    Corresponds to variant rs16858033 [ dbSNP | Ensembl ].
    VAR_051494
    Natural varianti530 – 5301V → I.
    Corresponds to variant rs262993 [ dbSNP | Ensembl ].
    VAR_051495
    Natural varianti993 – 9931Q → H.
    Corresponds to variant rs3211095 [ dbSNP | Ensembl ].
    VAR_051496

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033023 mRNA. Translation: BAA86511.1. Different initiation.
    AC068769 Genomic DNA. No translation available.
    AC131160 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78316.1.
    CH471052 Genomic DNA. Translation: EAW78317.1.
    BC082270 mRNA. Translation: AAH82270.1.
    BC150273 mRNA. Translation: AAI50274.1.
    CCDSiCCDS43175.1.
    RefSeqiNP_060493.3. NM_018023.4.
    UniGeneiHs.632575.

    Genome annotation databases

    EnsembliENST00000305135; ENSP00000306983; ENSG00000163872.
    GeneIDi55689.
    KEGGihsa:55689.
    UCSCiuc003fly.2. human.

    Polymorphism databases

    DMDMi85542165.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033023 mRNA. Translation: BAA86511.1 . Different initiation.
    AC068769 Genomic DNA. No translation available.
    AC131160 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78316.1 .
    CH471052 Genomic DNA. Translation: EAW78317.1 .
    BC082270 mRNA. Translation: AAH82270.1 .
    BC150273 mRNA. Translation: AAI50274.1 .
    CCDSi CCDS43175.1.
    RefSeqi NP_060493.3. NM_018023.4.
    UniGenei Hs.632575.

    3D structure databases

    ProteinModelPortali Q9ULM3.
    SMRi Q9ULM3. Positions 204-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120815. 20 interactions.
    STRINGi 9606.ENSP00000306983.

    PTM databases

    PhosphoSitei Q9ULM3.

    Polymorphism databases

    DMDMi 85542165.

    Proteomic databases

    MaxQBi Q9ULM3.
    PaxDbi Q9ULM3.
    PRIDEi Q9ULM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305135 ; ENSP00000306983 ; ENSG00000163872 .
    GeneIDi 55689.
    KEGGi hsa:55689.
    UCSCi uc003fly.2. human.

    Organism-specific databases

    CTDi 55689.
    GeneCardsi GC03P183416.
    H-InvDB HIX0119993.
    HGNCi HGNC:25489. YEATS2.
    HPAi HPA045891.
    MIMi 613373. gene.
    neXtProti NX_Q9ULM3.
    PharmGKBi PA134922615.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5033.
    HOGENOMi HOG000155538.
    HOVERGENi HBG062745.
    InParanoidi Q9ULM3.
    OMAi SPIPKIH.
    OrthoDBi EOG70PBX3.
    PhylomeDBi Q9ULM3.
    TreeFami TF314586.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.

    Miscellaneous databases

    ChiTaRSi YEATS2. human.
    GenomeRNAii 55689.
    NextBioi 60493.
    PROi Q9ULM3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ULM3.
    CleanExi HS_YEATS2.
    Genevestigatori Q9ULM3.

    Family and domain databases

    InterProi IPR005033. YEATS.
    [Graphical view ]
    PANTHERi PTHR23195. PTHR23195. 1 hit.
    Pfami PF03366. YEATS. 1 hit.
    [Graphical view ]
    PROSITEi PS51037. YEATS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
      Guelman S., Kozuka K., Mao Y., Pham V., Solloway M.J., Wang J., Wu J., Lill J.R., Zha J.
      Mol. Cell. Biol. 29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN ATAC COMPLEX.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447; SER-463; SER-465; SER-471; SER-473; SER-575 AND SER-627, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447 AND SER-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYETS2_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULM3
    Secondary accession number(s): A7E2B9
    , D3DNS9, Q641P6, Q9NW96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3