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Protein

YEATS domain-containing protein 2

Gene

YEATS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

GO - Molecular functioni

  • TBP-class protein binding Source: BHF-UCL

GO - Biological processi

  • histone H3 acetylation Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163872-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
YEATS domain-containing protein 2
Gene namesi
Name:YEATS2
Synonyms:KIAA1197
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25489. YEATS2.

Subcellular locationi

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: BHF-UCL
  • mitotic spindle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55689.
OpenTargetsiENSG00000163872.
PharmGKBiPA134922615.

Polymorphism and mutation databases

BioMutaiYEATS2.
DMDMi85542165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763661 – 1422YEATS domain-containing protein 2Add BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineBy similarity1
Modified residuei157PhosphoserineCombined sources1
Modified residuei407PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei478PhosphothreonineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Cross-linki592Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei627PhosphoserineCombined sources1
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki1110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1219PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ULM3.
MaxQBiQ9ULM3.
PaxDbiQ9ULM3.
PeptideAtlasiQ9ULM3.
PRIDEiQ9ULM3.

PTM databases

iPTMnetiQ9ULM3.
PhosphoSitePlusiQ9ULM3.

Expressioni

Gene expression databases

BgeeiENSG00000163872.
CleanExiHS_YEATS2.
ExpressionAtlasiQ9ULM3. baseline and differential.
GenevisibleiQ9ULM3. HS.

Organism-specific databases

HPAiHPA045891.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.1 Publication

GO - Molecular functioni

  • TBP-class protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi120815. 40 interactors.
IntActiQ9ULM3. 8 interactors.
STRINGi9606.ENSP00000306983.

Structurei

Secondary structure

11422
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi205 – 218Combined sources14
Helixi221 – 223Combined sources3
Beta strandi232 – 239Combined sources8
Helixi247 – 249Combined sources3
Beta strandi251 – 257Combined sources7
Helixi260 – 262Combined sources3
Beta strandi267 – 270Combined sources4
Beta strandi272 – 282Combined sources11
Beta strandi286 – 295Combined sources10
Beta strandi301 – 306Combined sources6
Beta strandi314 – 330Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IQLX-ray2.10A201-332[»]
ProteinModelPortaliQ9ULM3.
SMRiQ9ULM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 317YEATSPROSITE-ProRule annotationAdd BLAST111

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili47 – 80Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi794 – 842Gly-richAdd BLAST49

Sequence similaritiesi

Contains 1 YEATS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000155538.
HOVERGENiHBG062745.
InParanoidiQ9ULM3.
OMAiPIPKIHG.
OrthoDBiEOG091G0EXM.
PhylomeDBiQ9ULM3.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 2 hits.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF
60 70 80 90 100
ALEMKNKEHE IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK
110 120 130 140 150
TCDTMVFNHP AIKKFLESPS RSSSPANQRA ETPSANHSES DSLSQHNDFL
160 170 180 190 200
SDKDNNSNMD IEERLSNNME QRPSRNTGRD TSRITGSHKT EQRNADLTDE
210 220 230 240 250
TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG SRREPSINHF
260 270 280 290 300
VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR
310 320 330 340 350
IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD
360 370 380 390 400
APPSLPLTIP APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL
410 420 430 440 450
PSSLERTPTK MTTSQKVTFC SHGNSAFQPI ASSCKIVPQS QVPNPESPGK
460 470 480 490 500
SFQPITMSCK IVSGSPISTP SPSPLPRTPT STPVHVKQGT AGSVINNPYV
510 520 530 540 550
IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK IHGSSFVTST
560 570 580 590 600
VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH
610 620 630 640 650
VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV
660 670 680 690 700
VGVPVGSALP STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA
710 720 730 740 750
IVSGGGGTIV AQPVQTLTKA QVTAAGPQKS GSQGSVMATL QLPATNLANL
760 770 780 790 800
ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG AILRATNNAN LQSGSAASGG
810 820 830 840 850
SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP GGISQHLTYT
860 870 880 890 900
SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK
910 920 930 940 950
VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG
960 970 980 990 1000
GVITTATSPA VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA
1010 1020 1030 1040 1050
TVGTCKAATP TVVSATSLVP TPNPISGKAT VSGLLKIHSS QSSPQQAVLT
1060 1070 1080 1090 1100
IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF STSKPPAILP VAAPTPVVPS
1110 1120 1130 1140 1150
SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY VIKIDHLETI
1160 1170 1180 1190 1200
QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT
1210 1220 1230 1240 1250
MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI
1260 1270 1280 1290 1300
EDVLTQIDSE PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS
1310 1320 1330 1340 1350
EPVKINIKKE QEEKQEEVKF YLPPTPGSEF IGDVTQKIGI TLQPVALHRN
1360 1370 1380 1390 1400
VYASVVEDMI LKATEQLVND ILRQALAVGY QTASHNRIPK EITVSNIHQA
1410 1420
ICNIPFLDFL TNKHMGILNE DQ
Length:1,422
Mass (Da):150,782
Last modified:January 10, 2006 - v2
Checksum:i7800718C08B634B3
GO

Sequence cautioni

The sequence BAA86511 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051494184I → V.Corresponds to variant rs16858033dbSNPEnsembl.1
Natural variantiVAR_051495530V → I.Corresponds to variant rs262993dbSNPEnsembl.1
Natural variantiVAR_051496993Q → H.Corresponds to variant rs3211095dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033023 mRNA. Translation: BAA86511.1. Different initiation.
AC068769 Genomic DNA. No translation available.
AC131160 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78316.1.
CH471052 Genomic DNA. Translation: EAW78317.1.
BC082270 mRNA. Translation: AAH82270.1.
BC150273 mRNA. Translation: AAI50274.1.
CCDSiCCDS43175.1.
RefSeqiNP_060493.3. NM_018023.4.
XP_016862298.1. XM_017006809.1.
XP_016862299.1. XM_017006810.1.
UniGeneiHs.632575.

Genome annotation databases

EnsembliENST00000305135; ENSP00000306983; ENSG00000163872.
GeneIDi55689.
KEGGihsa:55689.
UCSCiuc003fly.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033023 mRNA. Translation: BAA86511.1. Different initiation.
AC068769 Genomic DNA. No translation available.
AC131160 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78316.1.
CH471052 Genomic DNA. Translation: EAW78317.1.
BC082270 mRNA. Translation: AAH82270.1.
BC150273 mRNA. Translation: AAI50274.1.
CCDSiCCDS43175.1.
RefSeqiNP_060493.3. NM_018023.4.
XP_016862298.1. XM_017006809.1.
XP_016862299.1. XM_017006810.1.
UniGeneiHs.632575.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IQLX-ray2.10A201-332[»]
ProteinModelPortaliQ9ULM3.
SMRiQ9ULM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120815. 40 interactors.
IntActiQ9ULM3. 8 interactors.
STRINGi9606.ENSP00000306983.

PTM databases

iPTMnetiQ9ULM3.
PhosphoSitePlusiQ9ULM3.

Polymorphism and mutation databases

BioMutaiYEATS2.
DMDMi85542165.

Proteomic databases

EPDiQ9ULM3.
MaxQBiQ9ULM3.
PaxDbiQ9ULM3.
PeptideAtlasiQ9ULM3.
PRIDEiQ9ULM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305135; ENSP00000306983; ENSG00000163872.
GeneIDi55689.
KEGGihsa:55689.
UCSCiuc003fly.2. human.

Organism-specific databases

CTDi55689.
DisGeNETi55689.
GeneCardsiYEATS2.
H-InvDBHIX0119993.
HGNCiHGNC:25489. YEATS2.
HPAiHPA045891.
MIMi613373. gene.
neXtProtiNX_Q9ULM3.
OpenTargetsiENSG00000163872.
PharmGKBiPA134922615.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3149. Eukaryota.
COG5033. LUCA.
GeneTreeiENSGT00530000063543.
HOGENOMiHOG000155538.
HOVERGENiHBG062745.
InParanoidiQ9ULM3.
OMAiPIPKIHG.
OrthoDBiEOG091G0EXM.
PhylomeDBiQ9ULM3.
TreeFamiTF314586.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163872-MONOMER.
ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiYEATS2. human.
GenomeRNAii55689.
PROiQ9ULM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163872.
CleanExiHS_YEATS2.
ExpressionAtlasiQ9ULM3. baseline and differential.
GenevisibleiQ9ULM3. HS.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 2 hits.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYETS2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULM3
Secondary accession number(s): A7E2B9
, D3DNS9, Q641P6, Q9NW96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.