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Protein

Zinc finger protein 490

Gene

ZNF490

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 490
Gene namesi
Name:ZNF490
Synonyms:KIAA1198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188033.9
HGNCiHGNC:23705 ZNF490
neXtProtiNX_Q9ULM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188033
PharmGKBiPA134990049

Polymorphism and mutation databases

BioMutaiZNF490
DMDMi20140911

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476131 – 529Zinc finger protein 490Add BLAST529

Proteomic databases

MaxQBiQ9ULM2
PaxDbiQ9ULM2
PeptideAtlasiQ9ULM2
PRIDEiQ9ULM2

PTM databases

iPTMnetiQ9ULM2
PhosphoSitePlusiQ9ULM2

Expressioni

Gene expression databases

BgeeiENSG00000188033
CleanExiHS_ZNF490
ExpressionAtlasiQ9ULM2 baseline and differential
GenevisibleiQ9ULM2 HS

Organism-specific databases

HPAiHPA005576

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121544, 28 interactors
IntActiQ9ULM2, 25 interactors
MINTiQ9ULM2
STRINGi9606.ENSP00000311521

Structurei

3D structure databases

ProteinModelPortaliQ9ULM2
SMRiQ9ULM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 132KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri156 – 178C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9ULM2
KOiK09228
OMAiCENKEDR
OrthoDBiEOG091G02KC
PhylomeDBiQ9ULM2
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q9ULM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNSSLSFQ MERPLEEQVQ SKWSSSQGRT GTGGSDVLQM QNSEHHGQSI
60 70 80 90 100
KTQTDSISLE DVAVNFTLEE WALLDPGQRN IYRDVMRATF KNLACIGEKW
110 120 130 140 150
KDQDIEDEHK NQGRNLRSPM VEALCENKED CPCGKSTSQI PDLNTNLETP
160 170 180 190 200
TGLKPCDCSV CGEVFMHQVS LNRHMRSHTE QKPNECHEYG EKPHKCKECG
210 220 230 240 250
KTFTRSSSIR THERIHTGEK PYECKECGKA FAFLFSFRNH IRIHTGETPY
260 270 280 290 300
ECKECGKAFR YLTALRRHEK NHTGEKPYKC KQCGKAFIYY QPFLTHERTH
310 320 330 340 350
TGEKPYECKQ CGKAFSCPTY LRSHEKTHTG EKPFVCRECG RAFFSHSSLR
360 370 380 390 400
KHVKTHTGVQ PYTCKKCGEA FKSSSSCEVH ERTHFGEKPY ECKQCGKAFN
410 420 430 440 450
SSSYLQLHER VHTGEKTYEC KECGKAFLYS THFRIHERTH TREKPYECKQ
460 470 480 490 500
CGRVFIYFSH LRRHERSHTG VKPCECKQCG KAFTCLNSLK VHKRIHTGER
510 520
PFQCRQCGKA FSYSKSLHVH ERTHSRQKP
Length:529
Mass (Da):61,340
Last modified:February 21, 2002 - v2
Checksum:iECBA528D4808153C
GO

Sequence cautioni

The sequence BAA86512 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033024 mRNA Translation: BAA86512.1 Different initiation.
BC038586 mRNA Translation: AAH38586.1
CCDSiCCDS12272.1
RefSeqiNP_065765.1, NM_020714.2
UniGeneiHs.655860

Genome annotation databases

EnsembliENST00000311437; ENSP00000311521; ENSG00000188033
GeneIDi57474
KEGGihsa:57474
UCSCiuc002mtz.3 human

Similar proteinsi

Entry informationi

Entry nameiZN490_HUMAN
AccessioniPrimary (citable) accession number: Q9ULM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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