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Protein

Zinc finger protein 490

Gene

ZNF490

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 490
Gene namesi
Name:ZNF490
Synonyms:KIAA1198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23705. ZNF490.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990049.

Polymorphism and mutation databases

BioMutaiZNF490.
DMDMi20140911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Zinc finger protein 490PRO_0000047613Add
BLAST

Proteomic databases

MaxQBiQ9ULM2.
PaxDbiQ9ULM2.
PeptideAtlasiQ9ULM2.
PRIDEiQ9ULM2.

PTM databases

iPTMnetiQ9ULM2.
PhosphoSiteiQ9ULM2.

Expressioni

Gene expression databases

BgeeiQ9ULM2.
CleanExiHS_ZNF490.
ExpressionAtlasiQ9ULM2. baseline and differential.
GenevisibleiQ9ULM2. HS.

Organism-specific databases

HPAiHPA005576.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC136Q96JN2-23EBI-1105370,EBI-10171416
CCNDBP1O952733EBI-1105370,EBI-748961
CEP70Q8NHQ13EBI-1105370,EBI-739624
KRTAP10-7P604093EBI-1105370,EBI-10172290
LZTS2Q9BRK43EBI-1105370,EBI-741037
MDFIQ997504EBI-1105370,EBI-724076
MTUS2Q5JR594EBI-1105370,EBI-742948
NDEL1Q9GZM83EBI-1105370,EBI-928842
TRIM41Q8WV443EBI-1105370,EBI-725997
TSGA10Q9BZW73EBI-1105370,EBI-744794
ZC4H2Q9NQZ63EBI-1105370,EBI-747993

Protein-protein interaction databases

BioGridi121544. 27 interactions.
IntActiQ9ULM2. 13 interactions.
STRINGi9606.ENSP00000311521.

Structurei

3D structure databases

ProteinModelPortaliQ9ULM2.
SMRiQ9ULM2. Positions 54-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 13276KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri156 – 17823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri194 – 21623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri222 – 24423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri250 – 27223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ULM2.
KOiK09228.
OMAiCENKEDR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9ULM2.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNSSLSFQ MERPLEEQVQ SKWSSSQGRT GTGGSDVLQM QNSEHHGQSI
60 70 80 90 100
KTQTDSISLE DVAVNFTLEE WALLDPGQRN IYRDVMRATF KNLACIGEKW
110 120 130 140 150
KDQDIEDEHK NQGRNLRSPM VEALCENKED CPCGKSTSQI PDLNTNLETP
160 170 180 190 200
TGLKPCDCSV CGEVFMHQVS LNRHMRSHTE QKPNECHEYG EKPHKCKECG
210 220 230 240 250
KTFTRSSSIR THERIHTGEK PYECKECGKA FAFLFSFRNH IRIHTGETPY
260 270 280 290 300
ECKECGKAFR YLTALRRHEK NHTGEKPYKC KQCGKAFIYY QPFLTHERTH
310 320 330 340 350
TGEKPYECKQ CGKAFSCPTY LRSHEKTHTG EKPFVCRECG RAFFSHSSLR
360 370 380 390 400
KHVKTHTGVQ PYTCKKCGEA FKSSSSCEVH ERTHFGEKPY ECKQCGKAFN
410 420 430 440 450
SSSYLQLHER VHTGEKTYEC KECGKAFLYS THFRIHERTH TREKPYECKQ
460 470 480 490 500
CGRVFIYFSH LRRHERSHTG VKPCECKQCG KAFTCLNSLK VHKRIHTGER
510 520
PFQCRQCGKA FSYSKSLHVH ERTHSRQKP
Length:529
Mass (Da):61,340
Last modified:February 21, 2002 - v2
Checksum:iECBA528D4808153C
GO

Sequence cautioni

The sequence BAA86512.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033024 mRNA. Translation: BAA86512.1. Different initiation.
BC038586 mRNA. Translation: AAH38586.1.
CCDSiCCDS12272.1.
RefSeqiNP_065765.1. NM_020714.2.
UniGeneiHs.655860.

Genome annotation databases

EnsembliENST00000311437; ENSP00000311521; ENSG00000188033.
GeneIDi57474.
KEGGihsa:57474.
UCSCiuc002mtz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033024 mRNA. Translation: BAA86512.1. Different initiation.
BC038586 mRNA. Translation: AAH38586.1.
CCDSiCCDS12272.1.
RefSeqiNP_065765.1. NM_020714.2.
UniGeneiHs.655860.

3D structure databases

ProteinModelPortaliQ9ULM2.
SMRiQ9ULM2. Positions 54-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121544. 27 interactions.
IntActiQ9ULM2. 13 interactions.
STRINGi9606.ENSP00000311521.

PTM databases

iPTMnetiQ9ULM2.
PhosphoSiteiQ9ULM2.

Polymorphism and mutation databases

BioMutaiZNF490.
DMDMi20140911.

Proteomic databases

MaxQBiQ9ULM2.
PaxDbiQ9ULM2.
PeptideAtlasiQ9ULM2.
PRIDEiQ9ULM2.

Protocols and materials databases

DNASUi57474.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311437; ENSP00000311521; ENSG00000188033.
GeneIDi57474.
KEGGihsa:57474.
UCSCiuc002mtz.3. human.

Organism-specific databases

CTDi57474.
GeneCardsiZNF490.
HGNCiHGNC:23705. ZNF490.
HPAiHPA005576.
neXtProtiNX_Q9ULM2.
PharmGKBiPA134990049.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9ULM2.
KOiK09228.
OMAiCENKEDR.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9ULM2.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii57474.
PROiQ9ULM2.

Gene expression databases

BgeeiQ9ULM2.
CleanExiHS_ZNF490.
ExpressionAtlasiQ9ULM2. baseline and differential.
GenevisibleiQ9ULM2. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN490_HUMAN
AccessioniPrimary (citable) accession number: Q9ULM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: July 6, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.