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Q9ULL8

- SHRM4_HUMAN

UniProt

Q9ULL8 - SHRM4_HUMAN

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Protein
Protein Shroom4
Gene
SHROOM4, KIAA1202, SHAP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II By similarity.1 Publication

GO - Molecular functioni

  1. actin filament binding Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. actin filament organization Source: UniProtKB
  3. brain development Source: UniProtKB
  4. cognition Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Shroom4
Alternative name(s):
Second homolog of apical protein
Gene namesi
Name:SHROOM4
Synonyms:KIAA1202, SHAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:29215. SHROOM4.

Subcellular locationi

Cytoplasmcytoskeleton
Note: Shows partial colocalization with the cytoplasmic pool of F-actin.2 Publications

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basal plasma membrane Source: UniProtKB
  3. cortical actin cytoskeleton Source: Ensembl
  4. cytoplasm Source: UniProtKB
  5. cytoplasmic side of plasma membrane Source: UniProtKB
  6. myosin II complex Source: Ensembl
  7. stress fiber Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Mental retardation, X-linked, syndromic, Stocco dos Santos type (SDSX) [MIM:300434]: A syndrome characterized by severe mental retardation with hyperactivity, aggressive behavior, delayed or no speech, and seizures. Additional features include congenital bilateral hip luxation, short stature, and kyphosis.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1089 – 10891S → L in SDSX. 1 Publication
VAR_032258
A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with FBXO25.
A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;19).

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi300434. phenotype.
Orphaneti85288. intellectual disability, X-linked, Stocco Dos Santos type.
PharmGKBiPA147357321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14931493Protein Shroom4
PRO_0000287077Add
BLAST

Proteomic databases

PaxDbiQ9ULL8.
PRIDEiQ9ULL8.

PTM databases

PhosphoSiteiQ9ULL8.

Expressioni

Tissue specificityi

Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and putamen. The expression is strongest in the medulla and weakest in the cerebral cortex.1 Publication

Gene expression databases

BgeeiQ9ULL8.
CleanExiHS_SHROOM4.
GenevestigatoriQ9ULL8.

Organism-specific databases

HPAiHPA010565.

Interactioni

Subunit structurei

Interacts directly with F-actin By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000289292.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146
Beta strandi25 – 284
Helixi29 – 313
Beta strandi33 – 375
Helixi45 – 495
Beta strandi57 – 615
Helixi71 – 788
Beta strandi85 – 906

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EDPNMR-A6-92[»]
ProteinModelPortaliQ9ULL8.
SMRiQ9ULL8. Positions 8-93, 1310-1485.

Miscellaneous databases

EvolutionaryTraceiQ9ULL8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9283PDZ
Add
BLAST
Domaini1213 – 1492280ASD2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1382 – 1488107 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi871 – 93767Cys-rich
Add
BLAST
Compositional biasi1100 – 11078Poly-Pro
Compositional biasi1119 – 113517Gln-rich
Add
BLAST
Compositional biasi1136 – 118146Glu-rich
Add
BLAST

Sequence similaritiesi

Belongs to the shroom family.
Contains 1 ASD2 domain.
Contains 1 PDZ (DHR) domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80303.
HOGENOMiHOG000060301.
HOVERGENiHBG108490.
InParanoidiQ9ULL8.
OMAiKGGLEHC.
OrthoDBiEOG7QZG8T.
PhylomeDBiQ9ULL8.
TreeFamiTF333370.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR014799. ASD2.
IPR001478. PDZ.
IPR027687. Shroom4.
IPR027685. Shroom_fam.
[Graphical view]
PANTHERiPTHR15012. PTHR15012. 1 hit.
PTHR15012:SF31. PTHR15012:SF31. 1 hit.
PfamiPF08687. ASD2. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS51307. ASD2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULL8-1) [UniParc]FASTAAdd to Basket

Also known as: SHAP-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MENRPGSFQY VPVQLQGGAP WGFTLKGGLE HCEPLTVSKI EDGGKAALSQ     50
KMRTGDELVN INGTPLYGSR QEALILIKGS FRILKLIVRR RNAPVSRPHS 100
WHVAKLLEGC PEAATTMHFP SEAFSLSWHS GCNTSDVCVQ WCPLSRHCST 150
EKSSSIGSME SLEQPGQATY ESHLLPIDQN MYPNQRDSAY SSFSASSNAS 200
DCALSLRPEE PASTDCIMQG PGPTKAPSGR PNVAETSGGS RRTNGGHLTP 250
SSQMSSRPQE GYQSGPAKAV RGPPQPPVRR DSLQASRAQL LNGEQRRASE 300
PVVPLPQKEK LSLEPVLPAR NPNRFCCLSG HDQVTSEGHQ NCEFSQPPES 350
SQQGSEHLLM QASTKAVGSP KACDRASSVD SNPLNEASAE LAKASFGRPP 400
HLIGPTGHRH SAPEQLLASH LQHVHLDTRG SKGMELPPVQ DGHQWTLSPL 450
HSSHKGKKSP CPPTGGTHDQ SSKERKTRQV DDRSLVLGHQ SQSSPPHGEA 500
DGHPSEKGFL DPNRTSRAAS ELANQQPSAS GSLVQQATDC SSTTKAASGT 550
EAGEEGDSEP KECSRMGGRR SGGTRGRSIQ NRRKSERFAT NLRNEIQRRK 600
AQLQKSKGPL SQLCDTKEPV EETQEPPESP PLTASNTSLL SSCKKPPSPR 650
DKLFNKSMML RARSSECLSQ APESHESRTG LEGRISPGQR PGQSSLGLNT 700
WWKAPDPSSS DPEKAHAHCG VRGGHWRWSP EHNSQPLVAA AMEGPSNPGD 750
NKELKASTAQ AGEDAILLPF ADRRKFFEES SKSLSTSHLP GLTTHSNKTF 800
TQRPKPIDQN FQPMSSSCRE LRRHPMDQSY HSADQPYHAT DQSYHSMSPL 850
QSETPTYSEC FASKGLENSM CCKPLHCGDF DYHRTCSYSC SVQGALVHDP 900
CIYCSGEICP ALLKRNMMPN CYNCRCHHHQ CIRCSVCYHN PQHSALEDSS 950
LAPGNTWKPR KLTVQEFPGD KWNPITGNRK TSQSGREMAH SKTSFSWATP 1000
FHPCLENPAL DLSSYRAISS LDLLGDFKHA LKKSEETSVY EEGSSLASMP 1050
HPLRSRAFSE SHISLAPQST RAWGQHRREL FSKGDETQSD LLGARKKAFP 1100
PPRPPPPNWE KYRLFRAAQQ QKQQQQQQKQ QEEEEEEEEE EEEEEEEEEE 1150
EAEEEEEELP PQYFSSETSG SCALNPEEVL EQPQPLSFGH LEGSRQGSQS 1200
VPAEQESFAL HSSDFLPPIR GHLGSQPEQA QPPCYYGIGG LWRTSGQEAT 1250
ESAKQEFQHF SPPSGAPGIP TSYSAYYNIS VAKAELLNKL KDQPEMAEIG 1300
LGEEEVDHEL AQKKIQLIES ISRKLSVLRE AQRGLLEDIN ANSALGEEVE 1350
ANLKAVCKSN EFEKYHLFVG DLDKVVNLLL SLSGRLARVE NALNSIDSEA 1400
NQEKLVLIEK KQQLTGQLAD AKELKEHVDR REKLVFGMVS RYLPQDQLQD 1450
YQHFVKMKSA LIIEQRELEE KIKLGEEQLK CLRESLLLGP SNF 1493
Length:1,493
Mass (Da):164,857
Last modified:November 30, 2010 - v3
Checksum:i40260DC12A24EAFF
GO
Isoform 2 (identifier: Q9ULL8-2) [UniParc]FASTAAdd to Basket

Also known as: SHAP-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:1,377
Mass (Da):152,183
Checksum:i8CDB0DC1B5552E43
GO

Sequence cautioni

The sequence BAA86516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAM13070.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti722 – 7221R → H.
Corresponds to variant rs3761506 [ dbSNP | Ensembl ].
VAR_057770
Natural varianti807 – 8071I → T.
Corresponds to variant rs3761505 [ dbSNP | Ensembl ].
VAR_057771
Natural varianti970 – 9701D → G.
Corresponds to variant rs2281571 [ dbSNP | Ensembl ].
VAR_032257
Natural varianti1089 – 10891S → L in SDSX. 1 Publication
VAR_032258

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 2.
VSP_025290Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1129 – 11313KQQ → QQQQKQQE in BAA86516. 1 Publication
Sequence conflicti1129 – 11313KQQ → QQQQKQQE in AAI51241. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033028 mRNA. Translation: BAA86516.1. Different initiation.
AL121865 Genomic DNA. Translation: CAM13070.1. Sequence problems.
AL445491 Genomic DNA. No translation available.
AL359272 Genomic DNA. No translation available.
BC151240 mRNA. Translation: AAI51241.1.
AY044234 mRNA. Translation: AAK95579.1.
CCDSiCCDS35277.1. [Q9ULL8-1]
RefSeqiNP_065768.2. NM_020717.3. [Q9ULL8-1]
XP_006724653.1. XM_006724590.1. [Q9ULL8-2]
UniGeneiHs.420541.

Genome annotation databases

EnsembliENST00000289292; ENSP00000289292; ENSG00000158352. [Q9ULL8-1]
ENST00000376020; ENSP00000365188; ENSG00000158352. [Q9ULL8-1]
ENST00000460112; ENSP00000421450; ENSG00000158352. [Q9ULL8-2]
ENST00000596464; ENSP00000472785; ENSG00000268668. [Q9ULL8-2]
ENST00000600171; ENSP00000472407; ENSG00000268668. [Q9ULL8-1]
ENST00000601085; ENSP00000468998; ENSG00000268668. [Q9ULL8-1]
GeneIDi57477.
KEGGihsa:57477.
UCSCiuc004dpe.2. human. [Q9ULL8-1]

Polymorphism databases

DMDMi313104187.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033028 mRNA. Translation: BAA86516.1 . Different initiation.
AL121865 Genomic DNA. Translation: CAM13070.1 . Sequence problems.
AL445491 Genomic DNA. No translation available.
AL359272 Genomic DNA. No translation available.
BC151240 mRNA. Translation: AAI51241.1 .
AY044234 mRNA. Translation: AAK95579.1 .
CCDSi CCDS35277.1. [Q9ULL8-1 ]
RefSeqi NP_065768.2. NM_020717.3. [Q9ULL8-1 ]
XP_006724653.1. XM_006724590.1. [Q9ULL8-2 ]
UniGenei Hs.420541.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EDP NMR - A 6-92 [» ]
ProteinModelPortali Q9ULL8.
SMRi Q9ULL8. Positions 8-93, 1310-1485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000289292.

PTM databases

PhosphoSitei Q9ULL8.

Polymorphism databases

DMDMi 313104187.

Proteomic databases

PaxDbi Q9ULL8.
PRIDEi Q9ULL8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000289292 ; ENSP00000289292 ; ENSG00000158352 . [Q9ULL8-1 ]
ENST00000376020 ; ENSP00000365188 ; ENSG00000158352 . [Q9ULL8-1 ]
ENST00000460112 ; ENSP00000421450 ; ENSG00000158352 . [Q9ULL8-2 ]
ENST00000596464 ; ENSP00000472785 ; ENSG00000268668 . [Q9ULL8-2 ]
ENST00000600171 ; ENSP00000472407 ; ENSG00000268668 . [Q9ULL8-1 ]
ENST00000601085 ; ENSP00000468998 ; ENSG00000268668 . [Q9ULL8-1 ]
GeneIDi 57477.
KEGGi hsa:57477.
UCSCi uc004dpe.2. human. [Q9ULL8-1 ]

Organism-specific databases

CTDi 57477.
GeneCardsi GC0XM050351.
HGNCi HGNC:29215. SHROOM4.
HPAi HPA010565.
MIMi 300434. phenotype.
300579. gene.
neXtProti NX_Q9ULL8.
Orphaneti 85288. intellectual disability, X-linked, Stocco Dos Santos type.
PharmGKBi PA147357321.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80303.
HOGENOMi HOG000060301.
HOVERGENi HBG108490.
InParanoidi Q9ULL8.
OMAi KGGLEHC.
OrthoDBi EOG7QZG8T.
PhylomeDBi Q9ULL8.
TreeFami TF333370.

Miscellaneous databases

EvolutionaryTracei Q9ULL8.
GenomeRNAii 57477.
NextBioi 63723.
PROi Q9ULL8.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULL8.
CleanExi HS_SHROOM4.
Genevestigatori Q9ULL8.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR014799. ASD2.
IPR001478. PDZ.
IPR027687. Shroom4.
IPR027685. Shroom_fam.
[Graphical view ]
PANTHERi PTHR15012. PTHR15012. 1 hit.
PTHR15012:SF31. PTHR15012:SF31. 1 hit.
Pfami PF08687. ASD2. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS51307. ASD2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "5'-sequence of TATA-box dependent expression forms of the human SHAP gene."
    Patzak D.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-839 (ISOFORM 2).
    Tissue: Heart.
  5. Cited for: NOMENCLATURE.
  6. "Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins."
    Dietz M.L., Bernaciak T.M., Vendetti F., Kielec J.M., Hildebrand J.D.
    J. Biol. Chem. 281:20542-20554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Solution structure of the PDZ domain from human Shroom family member 4."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 6-93.
  8. Cited for: VARIANT SDSX LEU-1089, CHROMOSOMAL TRANSLOCATION WITH FBXO25, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSHRM4_HUMAN
AccessioniPrimary (citable) accession number: Q9ULL8
Secondary accession number(s): A7E2X9, D6RFW0, Q96LA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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