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Q9ULL8

- SHRM4_HUMAN

UniProt

Q9ULL8 - SHRM4_HUMAN

Protein

Protein Shroom4

Gene

SHROOM4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II By similarity.By similarity

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. actin filament organization Source: UniProtKB
    3. brain development Source: UniProtKB
    4. cognition Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Shroom4
    Alternative name(s):
    Second homolog of apical protein
    Gene namesi
    Name:SHROOM4
    Synonyms:KIAA1202, SHAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:29215. SHROOM4.

    Subcellular locationi

    Cytoplasmcytoskeleton 2 Publications
    Note: Shows partial colocalization with the cytoplasmic pool of F-actin.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basal plasma membrane Source: UniProtKB
    3. cortical actin cytoskeleton Source: Ensembl
    4. cytoplasm Source: UniProtKB
    5. cytoplasmic side of plasma membrane Source: UniProtKB
    6. myosin II complex Source: Ensembl
    7. stress fiber Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, X-linked, syndromic, Stocco dos Santos type (SDSX) [MIM:300434]: A syndrome characterized by severe mental retardation with hyperactivity, aggressive behavior, delayed or no speech, and seizures. Additional features include congenital bilateral hip luxation, short stature, and kyphosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1089 – 10891S → L in SDSX. 1 Publication
    VAR_032258
    A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with FBXO25.
    A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;19).

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi300434. phenotype.
    Orphaneti85288. intellectual disability, X-linked, Stocco Dos Santos type.
    PharmGKBiPA147357321.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14931493Protein Shroom4PRO_0000287077Add
    BLAST

    Proteomic databases

    PaxDbiQ9ULL8.
    PRIDEiQ9ULL8.

    PTM databases

    PhosphoSiteiQ9ULL8.

    Expressioni

    Tissue specificityi

    Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and putamen. The expression is strongest in the medulla and weakest in the cerebral cortex.1 Publication

    Gene expression databases

    BgeeiQ9ULL8.
    CleanExiHS_SHROOM4.
    GenevestigatoriQ9ULL8.

    Organism-specific databases

    HPAiHPA010565.

    Interactioni

    Subunit structurei

    Interacts directly with F-actin.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000289292.

    Structurei

    Secondary structure

    1
    1493
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 146
    Beta strandi25 – 284
    Helixi29 – 313
    Beta strandi33 – 375
    Helixi45 – 495
    Beta strandi57 – 615
    Helixi71 – 788
    Beta strandi85 – 906

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EDPNMR-A6-92[»]
    ProteinModelPortaliQ9ULL8.
    SMRiQ9ULL8. Positions 8-93, 1310-1485.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ULL8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 9283PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini1213 – 1492280ASD2PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1382 – 1488107Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi871 – 93767Cys-richAdd
    BLAST
    Compositional biasi1100 – 11078Poly-Pro
    Compositional biasi1119 – 113517Gln-richAdd
    BLAST
    Compositional biasi1136 – 118146Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the shroom family.Curated
    Contains 1 ASD2 domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG80303.
    HOGENOMiHOG000060301.
    HOVERGENiHBG108490.
    InParanoidiQ9ULL8.
    OMAiKGGLEHC.
    OrthoDBiEOG7QZG8T.
    PhylomeDBiQ9ULL8.
    TreeFamiTF333370.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR014799. ASD2.
    IPR001478. PDZ.
    IPR027687. Shroom4.
    IPR027685. Shroom_fam.
    [Graphical view]
    PANTHERiPTHR15012. PTHR15012. 1 hit.
    PTHR15012:SF31. PTHR15012:SF31. 1 hit.
    PfamiPF08687. ASD2. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS51307. ASD2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULL8-1) [UniParc]FASTAAdd to Basket

    Also known as: SHAP-B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENRPGSFQY VPVQLQGGAP WGFTLKGGLE HCEPLTVSKI EDGGKAALSQ     50
    KMRTGDELVN INGTPLYGSR QEALILIKGS FRILKLIVRR RNAPVSRPHS 100
    WHVAKLLEGC PEAATTMHFP SEAFSLSWHS GCNTSDVCVQ WCPLSRHCST 150
    EKSSSIGSME SLEQPGQATY ESHLLPIDQN MYPNQRDSAY SSFSASSNAS 200
    DCALSLRPEE PASTDCIMQG PGPTKAPSGR PNVAETSGGS RRTNGGHLTP 250
    SSQMSSRPQE GYQSGPAKAV RGPPQPPVRR DSLQASRAQL LNGEQRRASE 300
    PVVPLPQKEK LSLEPVLPAR NPNRFCCLSG HDQVTSEGHQ NCEFSQPPES 350
    SQQGSEHLLM QASTKAVGSP KACDRASSVD SNPLNEASAE LAKASFGRPP 400
    HLIGPTGHRH SAPEQLLASH LQHVHLDTRG SKGMELPPVQ DGHQWTLSPL 450
    HSSHKGKKSP CPPTGGTHDQ SSKERKTRQV DDRSLVLGHQ SQSSPPHGEA 500
    DGHPSEKGFL DPNRTSRAAS ELANQQPSAS GSLVQQATDC SSTTKAASGT 550
    EAGEEGDSEP KECSRMGGRR SGGTRGRSIQ NRRKSERFAT NLRNEIQRRK 600
    AQLQKSKGPL SQLCDTKEPV EETQEPPESP PLTASNTSLL SSCKKPPSPR 650
    DKLFNKSMML RARSSECLSQ APESHESRTG LEGRISPGQR PGQSSLGLNT 700
    WWKAPDPSSS DPEKAHAHCG VRGGHWRWSP EHNSQPLVAA AMEGPSNPGD 750
    NKELKASTAQ AGEDAILLPF ADRRKFFEES SKSLSTSHLP GLTTHSNKTF 800
    TQRPKPIDQN FQPMSSSCRE LRRHPMDQSY HSADQPYHAT DQSYHSMSPL 850
    QSETPTYSEC FASKGLENSM CCKPLHCGDF DYHRTCSYSC SVQGALVHDP 900
    CIYCSGEICP ALLKRNMMPN CYNCRCHHHQ CIRCSVCYHN PQHSALEDSS 950
    LAPGNTWKPR KLTVQEFPGD KWNPITGNRK TSQSGREMAH SKTSFSWATP 1000
    FHPCLENPAL DLSSYRAISS LDLLGDFKHA LKKSEETSVY EEGSSLASMP 1050
    HPLRSRAFSE SHISLAPQST RAWGQHRREL FSKGDETQSD LLGARKKAFP 1100
    PPRPPPPNWE KYRLFRAAQQ QKQQQQQQKQ QEEEEEEEEE EEEEEEEEEE 1150
    EAEEEEEELP PQYFSSETSG SCALNPEEVL EQPQPLSFGH LEGSRQGSQS 1200
    VPAEQESFAL HSSDFLPPIR GHLGSQPEQA QPPCYYGIGG LWRTSGQEAT 1250
    ESAKQEFQHF SPPSGAPGIP TSYSAYYNIS VAKAELLNKL KDQPEMAEIG 1300
    LGEEEVDHEL AQKKIQLIES ISRKLSVLRE AQRGLLEDIN ANSALGEEVE 1350
    ANLKAVCKSN EFEKYHLFVG DLDKVVNLLL SLSGRLARVE NALNSIDSEA 1400
    NQEKLVLIEK KQQLTGQLAD AKELKEHVDR REKLVFGMVS RYLPQDQLQD 1450
    YQHFVKMKSA LIIEQRELEE KIKLGEEQLK CLRESLLLGP SNF 1493
    Length:1,493
    Mass (Da):164,857
    Last modified:November 30, 2010 - v3
    Checksum:i40260DC12A24EAFF
    GO
    Isoform 2 (identifier: Q9ULL8-2) [UniParc]FASTAAdd to Basket

    Also known as: SHAP-A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-116: Missing.

    Show »
    Length:1,377
    Mass (Da):152,183
    Checksum:i8CDB0DC1B5552E43
    GO

    Sequence cautioni

    The sequence BAA86516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAM13070.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1129 – 11313KQQ → QQQQKQQE in BAA86516. (PubMed:10574462)Curated
    Sequence conflicti1129 – 11313KQQ → QQQQKQQE in AAI51241. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti722 – 7221R → H.
    Corresponds to variant rs3761506 [ dbSNP | Ensembl ].
    VAR_057770
    Natural varianti807 – 8071I → T.
    Corresponds to variant rs3761505 [ dbSNP | Ensembl ].
    VAR_057771
    Natural varianti970 – 9701D → G.
    Corresponds to variant rs2281571 [ dbSNP | Ensembl ].
    VAR_032257
    Natural varianti1089 – 10891S → L in SDSX. 1 Publication
    VAR_032258

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_025290Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033028 mRNA. Translation: BAA86516.1. Different initiation.
    AL121865 Genomic DNA. Translation: CAM13070.1. Sequence problems.
    AL445491 Genomic DNA. No translation available.
    AL359272 Genomic DNA. No translation available.
    BC151240 mRNA. Translation: AAI51241.1.
    AY044234 mRNA. Translation: AAK95579.1.
    CCDSiCCDS35277.1. [Q9ULL8-1]
    RefSeqiNP_065768.2. NM_020717.3. [Q9ULL8-1]
    XP_006724653.1. XM_006724590.1. [Q9ULL8-2]
    UniGeneiHs.420541.

    Genome annotation databases

    EnsembliENST00000289292; ENSP00000289292; ENSG00000158352. [Q9ULL8-1]
    ENST00000376020; ENSP00000365188; ENSG00000158352. [Q9ULL8-1]
    ENST00000460112; ENSP00000421450; ENSG00000158352. [Q9ULL8-2]
    GeneIDi57477.
    KEGGihsa:57477.
    UCSCiuc004dpe.2. human. [Q9ULL8-1]

    Polymorphism databases

    DMDMi313104187.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033028 mRNA. Translation: BAA86516.1 . Different initiation.
    AL121865 Genomic DNA. Translation: CAM13070.1 . Sequence problems.
    AL445491 Genomic DNA. No translation available.
    AL359272 Genomic DNA. No translation available.
    BC151240 mRNA. Translation: AAI51241.1 .
    AY044234 mRNA. Translation: AAK95579.1 .
    CCDSi CCDS35277.1. [Q9ULL8-1 ]
    RefSeqi NP_065768.2. NM_020717.3. [Q9ULL8-1 ]
    XP_006724653.1. XM_006724590.1. [Q9ULL8-2 ]
    UniGenei Hs.420541.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EDP NMR - A 6-92 [» ]
    ProteinModelPortali Q9ULL8.
    SMRi Q9ULL8. Positions 8-93, 1310-1485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000289292.

    PTM databases

    PhosphoSitei Q9ULL8.

    Polymorphism databases

    DMDMi 313104187.

    Proteomic databases

    PaxDbi Q9ULL8.
    PRIDEi Q9ULL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289292 ; ENSP00000289292 ; ENSG00000158352 . [Q9ULL8-1 ]
    ENST00000376020 ; ENSP00000365188 ; ENSG00000158352 . [Q9ULL8-1 ]
    ENST00000460112 ; ENSP00000421450 ; ENSG00000158352 . [Q9ULL8-2 ]
    GeneIDi 57477.
    KEGGi hsa:57477.
    UCSCi uc004dpe.2. human. [Q9ULL8-1 ]

    Organism-specific databases

    CTDi 57477.
    GeneCardsi GC0XM050351.
    HGNCi HGNC:29215. SHROOM4.
    HPAi HPA010565.
    MIMi 300434. phenotype.
    300579. gene.
    neXtProti NX_Q9ULL8.
    Orphaneti 85288. intellectual disability, X-linked, Stocco Dos Santos type.
    PharmGKBi PA147357321.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80303.
    HOGENOMi HOG000060301.
    HOVERGENi HBG108490.
    InParanoidi Q9ULL8.
    OMAi KGGLEHC.
    OrthoDBi EOG7QZG8T.
    PhylomeDBi Q9ULL8.
    TreeFami TF333370.

    Miscellaneous databases

    EvolutionaryTracei Q9ULL8.
    GenomeRNAii 57477.
    NextBioi 63723.
    PROi Q9ULL8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ULL8.
    CleanExi HS_SHROOM4.
    Genevestigatori Q9ULL8.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR014799. ASD2.
    IPR001478. PDZ.
    IPR027687. Shroom4.
    IPR027685. Shroom_fam.
    [Graphical view ]
    PANTHERi PTHR15012. PTHR15012. 1 hit.
    PTHR15012:SF31. PTHR15012:SF31. 1 hit.
    Pfami PF08687. ASD2. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS51307. ASD2. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "5'-sequence of TATA-box dependent expression forms of the human SHAP gene."
      Patzak D.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-839 (ISOFORM 2).
      Tissue: Heart.
    5. Cited for: NOMENCLATURE.
    6. "Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins."
      Dietz M.L., Bernaciak T.M., Vendetti F., Kielec J.M., Hildebrand J.D.
      J. Biol. Chem. 281:20542-20554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Solution structure of the PDZ domain from human Shroom family member 4."
      RIKEN structural genomics initiative (RSGI)
      Submitted (AUG-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 6-93.
    8. Cited for: VARIANT SDSX LEU-1089, CHROMOSOMAL TRANSLOCATION WITH FBXO25, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSHRM4_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULL8
    Secondary accession number(s): A7E2X9, D6RFW0, Q96LA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3