Q9ULL8 (SHRM4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Shroom4

Alternative name(s):
Second homolog of apical protein

Gene names

Name:	SHROOM4
Synonyms:	KIAA1202, SHAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1493 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II By similarity. Ref.6
Subunit structure	Interacts directly with F-actin By similarity.
Subcellular location	Cytoplasm › cytoskeleton. Note: Shows partial colocalization with the cytoplasmic pool of F-actin. Ref.6 Ref.8
Tissue specificity	Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and putamen. The expression is strongest in the medulla and weakest in the cerebral cortex. Ref.8
Involvement in disease	Mental retardation, X-linked, syndromic, Stocco dos Santos type (SDSX) [MIM:300434]: A syndrome characterized by severe mental retardation with hyperactivity, aggressive behavior, delayed or no speech, and seizures. Additional features include congenital bilateral hip luxation, short stature, and kyphosis. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with FBXO25. A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;19).
Sequence similarities	Belongs to the shroom family. Contains 1 ASD2 domain. Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence BAA86516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAM13070.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Disease mutation Mental retardation
Domain	Coiled coil
Ligand	Actin-binding
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament organization Inferred from sequence or structural similarity. Source: UniProtKB brain development Inferred from direct assay Ref.8. Source: UniProtKB cognition Inferred from direct assay Ref.8. Source: UniProtKB
Cellular_component	apical plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB basal plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB cortical actin cytoskeleton Inferred from electronic annotation. Source: Compara cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB internal side of plasma membrane Inferred from direct assay Ref.8. Source: UniProtKB myosin II complex Inferred from electronic annotation. Source: Compara nucleus Inferred from direct assay. Source: HPA stress fiber Inferred from electronic annotation. Source: Compara
Molecular_function	actin filament binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULL8-1)

Also known as: SHAP-B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULL8-2)

Also known as: SHAP-A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1493

1493

Protein Shroom4

PRO_0000287077

Regions

Domain

10 – 92

83

PDZ

Domain

1213 – 1492

280

ASD2

Coiled coil

1382 – 1488

107

Potential

Compositional bias

871 – 937

67

Cys-rich

Compositional bias

1100 – 1107

8

Poly-Pro

Compositional bias

1119 – 1135

17

Gln-rich

Compositional bias

1136 – 1181

46

Glu-rich

Natural variations

Alternative sequence

1 – 116

116

Missing in isoform 2.

VSP_025290

Natural variant

722

1

R → H.
Corresponds to variant rs3761506 [ dbSNP | Ensembl ].

VAR_057770

Natural variant

807

1

I → T.
Corresponds to variant rs3761505 [ dbSNP | Ensembl ].

VAR_057771

Natural variant

970

1

D → G.
Corresponds to variant rs2281571 [ dbSNP | Ensembl ].

VAR_032257

Natural variant

1089

1

S → L in SDSX. Ref.8

VAR_032258

Experimental info

Sequence conflict

1129 – 1131

3

KQQ → QQQQKQQE in BAA86516. Ref.1

Sequence conflict

1129 – 1131

3

KQQ → QQQQKQQE in AAI51241. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1493

Helix Strand Turn

Details...

Beta strand

9 – 14

6

Beta strand

25 – 28

4

Helix

29 – 31

3

Beta strand

33 – 37

5

Helix

45 – 49

5

Beta strand

57 – 61

5

Helix

71 – 78

8

Beta strand

85 – 90

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SHAP-B) [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 40260DC12A24EAFF	FASTA	1,493	164,857
	10 20 30 40 50 60 MENRPGSFQY VPVQLQGGAP WGFTLKGGLE HCEPLTVSKI EDGGKAALSQ KMRTGDELVN 70 80 90 100 110 120 INGTPLYGSR QEALILIKGS FRILKLIVRR RNAPVSRPHS WHVAKLLEGC PEAATTMHFP 130 140 150 160 170 180 SEAFSLSWHS GCNTSDVCVQ WCPLSRHCST EKSSSIGSME SLEQPGQATY ESHLLPIDQN 190 200 210 220 230 240 MYPNQRDSAY SSFSASSNAS DCALSLRPEE PASTDCIMQG PGPTKAPSGR PNVAETSGGS 250 260 270 280 290 300 RRTNGGHLTP SSQMSSRPQE GYQSGPAKAV RGPPQPPVRR DSLQASRAQL LNGEQRRASE 310 320 330 340 350 360 PVVPLPQKEK LSLEPVLPAR NPNRFCCLSG HDQVTSEGHQ NCEFSQPPES SQQGSEHLLM 370 380 390 400 410 420 QASTKAVGSP KACDRASSVD SNPLNEASAE LAKASFGRPP HLIGPTGHRH SAPEQLLASH 430 440 450 460 470 480 LQHVHLDTRG SKGMELPPVQ DGHQWTLSPL HSSHKGKKSP CPPTGGTHDQ SSKERKTRQV 490 500 510 520 530 540 DDRSLVLGHQ SQSSPPHGEA DGHPSEKGFL DPNRTSRAAS ELANQQPSAS GSLVQQATDC 550 560 570 580 590 600 SSTTKAASGT EAGEEGDSEP KECSRMGGRR SGGTRGRSIQ NRRKSERFAT NLRNEIQRRK 610 620 630 640 650 660 AQLQKSKGPL SQLCDTKEPV EETQEPPESP PLTASNTSLL SSCKKPPSPR DKLFNKSMML 670 680 690 700 710 720 RARSSECLSQ APESHESRTG LEGRISPGQR PGQSSLGLNT WWKAPDPSSS DPEKAHAHCG 730 740 750 760 770 780 VRGGHWRWSP EHNSQPLVAA AMEGPSNPGD NKELKASTAQ AGEDAILLPF ADRRKFFEES 790 800 810 820 830 840 SKSLSTSHLP GLTTHSNKTF TQRPKPIDQN FQPMSSSCRE LRRHPMDQSY HSADQPYHAT 850 860 870 880 890 900 DQSYHSMSPL QSETPTYSEC FASKGLENSM CCKPLHCGDF DYHRTCSYSC SVQGALVHDP 910 920 930 940 950 960 CIYCSGEICP ALLKRNMMPN CYNCRCHHHQ CIRCSVCYHN PQHSALEDSS LAPGNTWKPR 970 980 990 1000 1010 1020 KLTVQEFPGD KWNPITGNRK TSQSGREMAH SKTSFSWATP FHPCLENPAL DLSSYRAISS 1030 1040 1050 1060 1070 1080 LDLLGDFKHA LKKSEETSVY EEGSSLASMP HPLRSRAFSE SHISLAPQST RAWGQHRREL 1090 1100 1110 1120 1130 1140 FSKGDETQSD LLGARKKAFP PPRPPPPNWE KYRLFRAAQQ QKQQQQQQKQ QEEEEEEEEE 1150 1160 1170 1180 1190 1200 EEEEEEEEEE EAEEEEEELP PQYFSSETSG SCALNPEEVL EQPQPLSFGH LEGSRQGSQS 1210 1220 1230 1240 1250 1260 VPAEQESFAL HSSDFLPPIR GHLGSQPEQA QPPCYYGIGG LWRTSGQEAT ESAKQEFQHF 1270 1280 1290 1300 1310 1320 SPPSGAPGIP TSYSAYYNIS VAKAELLNKL KDQPEMAEIG LGEEEVDHEL AQKKIQLIES 1330 1340 1350 1360 1370 1380 ISRKLSVLRE AQRGLLEDIN ANSALGEEVE ANLKAVCKSN EFEKYHLFVG DLDKVVNLLL 1390 1400 1410 1420 1430 1440 SLSGRLARVE NALNSIDSEA NQEKLVLIEK KQQLTGQLAD AKELKEHVDR REKLVFGMVS 1450 1460 1470 1480 1490 RYLPQDQLQD YQHFVKMKSA LIIEQRELEE KIKLGEEQLK CLRESLLLGP SNF
	Isoform 2 (SHAP-A) [UniParc]. Checksum: 8CDB0DC1B5552E43	FASTA	1,377	152,183
	10 20 30 40 50 60 MHFPSEAFSL SWHSGCNTSD VCVQWCPLSR HCSTEKSSSI GSMESLEQPG QATYESHLLP 70 80 90 100 110 120 IDQNMYPNQR DSAYSSFSAS SNASDCALSL RPEEPASTDC IMQGPGPTKA PSGRPNVAET 130 140 150 160 170 180 SGGSRRTNGG HLTPSSQMSS RPQEGYQSGP AKAVRGPPQP PVRRDSLQAS RAQLLNGEQR 190 200 210 220 230 240 RASEPVVPLP QKEKLSLEPV LPARNPNRFC CLSGHDQVTS EGHQNCEFSQ PPESSQQGSE 250 260 270 280 290 300 HLLMQASTKA VGSPKACDRA SSVDSNPLNE ASAELAKASF GRPPHLIGPT GHRHSAPEQL 310 320 330 340 350 360 LASHLQHVHL DTRGSKGMEL PPVQDGHQWT LSPLHSSHKG KKSPCPPTGG THDQSSKERK 370 380 390 400 410 420 TRQVDDRSLV LGHQSQSSPP HGEADGHPSE KGFLDPNRTS RAASELANQQ PSASGSLVQQ 430 440 450 460 470 480 ATDCSSTTKA ASGTEAGEEG DSEPKECSRM GGRRSGGTRG RSIQNRRKSE RFATNLRNEI 490 500 510 520 530 540 QRRKAQLQKS KGPLSQLCDT KEPVEETQEP PESPPLTASN TSLLSSCKKP PSPRDKLFNK 550 560 570 580 590 600 SMMLRARSSE CLSQAPESHE SRTGLEGRIS PGQRPGQSSL GLNTWWKAPD PSSSDPEKAH 610 620 630 640 650 660 AHCGVRGGHW RWSPEHNSQP LVAAAMEGPS NPGDNKELKA STAQAGEDAI LLPFADRRKF 670 680 690 700 710 720 FEESSKSLST SHLPGLTTHS NKTFTQRPKP IDQNFQPMSS SCRELRRHPM DQSYHSADQP 730 740 750 760 770 780 YHATDQSYHS MSPLQSETPT YSECFASKGL ENSMCCKPLH CGDFDYHRTC SYSCSVQGAL 790 800 810 820 830 840 VHDPCIYCSG EICPALLKRN MMPNCYNCRC HHHQCIRCSV CYHNPQHSAL EDSSLAPGNT 850 860 870 880 890 900 WKPRKLTVQE FPGDKWNPIT GNRKTSQSGR EMAHSKTSFS WATPFHPCLE NPALDLSSYR 910 920 930 940 950 960 AISSLDLLGD FKHALKKSEE TSVYEEGSSL ASMPHPLRSR AFSESHISLA PQSTRAWGQH 970 980 990 1000 1010 1020 RRELFSKGDE TQSDLLGARK KAFPPPRPPP PNWEKYRLFR AAQQQKQQQQ QQKQQEEEEE 1030 1040 1050 1060 1070 1080 EEEEEEEEEE EEEEEAEEEE EELPPQYFSS ETSGSCALNP EEVLEQPQPL SFGHLEGSRQ 1090 1100 1110 1120 1130 1140 GSQSVPAEQE SFALHSSDFL PPIRGHLGSQ PEQAQPPCYY GIGGLWRTSG QEATESAKQE 1150 1160 1170 1180 1190 1200 FQHFSPPSGA PGIPTSYSAY YNISVAKAEL LNKLKDQPEM AEIGLGEEEV DHELAQKKIQ 1210 1220 1230 1240 1250 1260 LIESISRKLS VLREAQRGLL EDINANSALG EEVEANLKAV CKSNEFEKYH LFVGDLDKVV 1270 1280 1290 1300 1310 1320 NLLLSLSGRL ARVENALNSI DSEANQEKLV LIEKKQQLTG QLADAKELKE HVDRREKLVF 1330 1340 1350 1360 1370 GMVSRYLPQD QLQDYQHFVK MKSALIIEQR ELEEKIKLGE EQLKCLRESL LLGPSNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"5'-sequence of TATA-box dependent expression forms of the human SHAP gene." Patzak D. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-839 (ISOFORM 2). Tissue: Heart.
[5]	"A new standard nomenclature for proteins related to Apx and Shroom." Hagens O., Ballabio A., Kalscheuer V., Kraehenbuhl J.-P., Schiaffino M.V., Smith P., Staub O., Hildebrand J.D., Wallingford J.B. BMC Cell Biol. 7:18-18(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[6]	"Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins." Dietz M.L., Bernaciak T.M., Vendetti F., Kielec J.M., Hildebrand J.D. J. Biol. Chem. 281:20542-20554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]	"Solution structure of the PDZ domain from human Shroom family member 4." RIKEN structural genomics initiative (RSGI) Submitted (AUG-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 6-93.
[8]	"Disruptions of the novel KIAA1202 gene are associated with X-linked mental retardation." Hagens O., Dubos A., Abidi F., Barbi G., Van Zutven L., Hoeltzenbein M., Tommerup N., Moraine C., Fryns J.-P., Chelly J., van Bokhoven H., Gecz J., Dollfus H., Ropers H.-H., Schwartz C.E., de Cassia Stocco Dos Santos R., Kalscheuer V., Hanauer A. Hum. Genet. 118:578-590(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SDSX LEU-1089, CHROMOSOMAL TRANSLOCATION WITH FBXO25, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB033028 mRNA. Translation: BAA86516.1. Different initiation.
AL121865 Genomic DNA. Translation: CAM13070.1. Sequence problems.
AL445491 Genomic DNA. No translation available.
AL359272 Genomic DNA. No translation available.
BC151240 mRNA. Translation: AAI51241.1.
AY044234 mRNA. Translation: AAK95579.1.

IPI

IPI00008176.
IPI00845416.

RefSeq

NP_065768.2. NM_020717.3.

UniGene

Hs.420541.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EDP	NMR	-	A	6-92	[»]

ProteinModelPortal

Q9ULL8.

SMR

Q9ULL8. Positions 8-93, 1310-1485.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000289292.

PTM databases

PhosphoSite

Q9ULL8.

Polymorphism databases

DMDM

147733019.

Proteomic databases

PaxDb

Q9ULL8.

PRIDE

Q9ULL8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000289292; ENSP00000289292; ENSG00000158352.
ENST00000376020; ENSP00000365188; ENSG00000158352.
ENST00000460112; ENSP00000421450; ENSG00000158352.
ENST00000596464; ENSP00000472785; ENSG00000268668.
ENST00000600171; ENSP00000472407; ENSG00000268668.
ENST00000601085; ENSP00000468998; ENSG00000268668.

GeneID

57477.

KEGG

hsa:57477.

UCSC

uc004dpe.2. human.

Organism-specific databases

CTD

57477.

GeneCards

GC0XM050351.

HGNC

HGNC:29215. SHROOM4.

HPA

HPA010565.

MIM

300434. phenotype.
300579. gene.

neXtProt

NX_Q9ULL8.

Orphanet

85288. Intellectual deficit, X-linked, Stocco Dos Santos type.

PharmGKB

PA147357321.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG80303.

HOGENOM

HOG000060301.

HOVERGEN

HBG108490.

InParanoid

Q9ULL8.

OMA

SQSGREM.

OrthoDB

EOG4TTGH0.

Gene expression databases

Bgee

Q9ULL8.

CleanEx

HS_SHROOM4.

Genevestigator

Q9ULL8.

Family and domain databases

InterPro

IPR014799. ASD2.
IPR001478. PDZ.
[Graphical view]

Pfam

PF08687. ASD2. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.

PROSITE

PS51307. ASD2. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9ULL8.

GenomeRNAi

57477.

NextBio

63723.

SOURCE

Search...

Entry information

Entry name

SHRM4_HUMAN

Accession

Primary (citable) accession number: Q9ULL8
Secondary accession number(s): A7E2X9, D6RFW0, Q96LA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.