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Protein

Proline-rich protein 12

Gene

PRR12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi347 – 35913A.T hook 1Add
BLAST
DNA bindingi381 – 39313A.T hook 2Add
BLAST

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 12
Gene namesi
Name:PRR12Imported
Synonyms:KIAA1205
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29217. PRR12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903328.

Polymorphism and mutation databases

BioMutaiPRR12.
DMDMi109892840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12151215Proline-rich protein 12PRO_0000243945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineCombined sources
Modified residuei256 – 2561PhosphoserineCombined sources
Modified residuei314 – 3141PhosphoserineBy similarity
Modified residuei402 – 4021N6-acetyllysineCombined sources
Modified residuei483 – 4831PhosphothreonineCombined sources
Modified residuei487 – 4871PhosphoserineCombined sources
Modified residuei560 – 5601PhosphoserineCombined sources
Modified residuei561 – 5611PhosphoserineCombined sources
Modified residuei566 – 5661PhosphoserineCombined sources
Modified residuei740 – 7401PhosphothreonineCombined sources
Modified residuei747 – 7471PhosphoserineCombined sources
Modified residuei1104 – 11041PhosphoserineCombined sources
Isoform 3 (identifier: Q9ULL5-3)
Modified residuei651 – 6511PhosphoserineCombined sourcesCurated
Modified residuei738 – 7381PhosphothreonineCombined sourcesCurated

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ULL5.
MaxQBiQ9ULL5.
PaxDbiQ9ULL5.
PRIDEiQ9ULL5.

PTM databases

iPTMnetiQ9ULL5.

Expressioni

Gene expression databases

BgeeiQ9ULL5.
CleanExiHS_PRR12.
GenevisibleiQ9ULL5. HS.

Organism-specific databases

HPAiHPA011959.

Interactioni

Protein-protein interaction databases

BioGridi121549. 9 interactions.
IntActiQ9ULL5. 6 interactions.
STRINGi9606.ENSP00000394510.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 724720Pro-richAdd
BLAST
Compositional biasi845 – 91672Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 A.T hook DNA-binding domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4805. Eukaryota.
ENOG410Y937. LUCA.
GeneTreeiENSGT00440000037417.
HOGENOMiHOG000202654.
HOVERGENiHBG082198.
InParanoidiQ9ULL5.
OMAiATSVVHY.
OrthoDBiEOG7VQJCD.
PhylomeDBiQ9ULL5.
TreeFamiTF333141.

Family and domain databases

InterProiIPR025451. DUF4211.
[Graphical view]
PfamiPF13926. DUF4211. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQLPGVPPG PPHPVRPPPP PPPPMPLQLE AHLRSHGLEP AAPSPRLRPE
60 70 80 90 100
ESLDPPGAMQ ELLGALEPLP PAPGDTGVGP PNSEGKDPAG AYRSPSPQGT
110 120 130 140 150
KAPRFVPLTS ICFPDSLLQD EERSFFPTME EMFGGGAADD YGKAGPPEDE
160 170 180 190 200
GDPKAGAGPP PGPPAYDPYG PYCPGRASGA GPETPGLGLD PNKPPELPST
210 220 230 240 250
VNAEPLGLIQ SGPHQAAPPP PPPPPPPPAP ASEPKGGLTS PIFCSTKPKK
260 270 280 290 300
LLKTSSFHLL RRRDPPFQTP KKLYAQEYEF EADEDKADVP ADIRLNPRRL
310 320 330 340 350
PDLVSSCRSR PALSPLGDID FCPPNPGPDG PRRRGRKPTK AKRDGPPRPR
360 370 380 390 400
GRPRIRPLEV PTTAGPASAS TPTDGAKKPR GRGRGRGRKA EEAGGTRLEP
410 420 430 440 450
LKPLKIKLSV PKAGEGLGTS SGDAISGTDH NSLDSSLTRE KIEAKIKEVE
460 470 480 490 500
EKQPEMKSGF MASFLDFLKS GKRHPPLYQA GLTPPLSPPK SVPPSVPARG
510 520 530 540 550
LQPQPPATPA VPHPPPSGAF GLGGALEAAE SEGLGLGCPS PCKRLDEELK
560 570 580 590 600
RNLETLPSFS SDEEDSVAKN RDLQESISSA ISALDDPPLA GPKDTSTPDG
610 620 630 640 650
PPLAPAAAVP GPPPLPGLPS ANSNGTPEPP LLEEKPPPTP PPAPTPQPQP
660 670 680 690 700
PPPPPPPQPA LPSPPPLVAP TPSSPPPPPL PPPPPPAMPS PPPPPPPAAA
710 720 730 740 750
PLAAPPEEPA APSPEDPELP DTRPLHLAKK QETAAVCGET DEEAGESGGE
760 770 780 790 800
GIFRERDEFV IRAEDIPSLK LALQTGREPP PIWRVQKALL QKFTPEIKDG
810 820 830 840 850
QRQFCATSNY LGYFGDAKNR YQRLYVKFLE NVNKKDYVRV CARKPWHRPP
860 870 880 890 900
VPVRRSGQAK NPVSAGGSSA PPPKAPAPPP KPETPEKTTS EKPPEQTPET
910 920 930 940 950
AMPEPPAPEK PSLLRPVEKE KEKEKVTRGE RPLRGERATS GRQTRPERSL
960 970 980 990 1000
ATGQPATSRL PKARPTKVKA EPPPKKRKKW LKEAGGNATA GGGPPGSSSD
1010 1020 1030 1040 1050
SESSPGAPSE DERAVPGRLL KTRAMREMYR SYVEMLVSTA LDPDMIQALE
1060 1070 1080 1090 1100
DTHDELYLPP MRKIDGLLNE HKKKVLKRLS LSPALQDALH TFPQLQVEQS
1110 1120 1130 1140 1150
GEGSPEEGAV RLRPAGEPYN RKTLSKLKRS VVRAQEFKVE LEKSGYYTLY
1160 1170 1180 1190 1200
HSLHHYKYHT FLRCRDQTLA IEGGAEDLGQ EEVVQQCMRN QPWLEQLFDS
1210
FSDLLAQAQA HSRCG
Length:1,215
Mass (Da):129,991
Last modified:June 27, 2006 - v2
Checksum:i197FC768E1139688
GO
Isoform 2 (identifier: Q9ULL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1125: Missing.

Note: No experimental confirmation available.
Show »
Length:1,143
Mass (Da):121,917
Checksum:i2C44FCFD15CD813E
GO
Isoform 3 (identifier: Q9ULL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEQLPGVPPGPPHPVR → MDRNYPSAGF...TRDGAPQPPP

Note: No experimental confirmation available. Prediction based on ortholog sequences.Combined sourcesCurated
Show »
Length:2,036
Mass (Da):211,044
Checksum:i11D30279770ECFF0
GO

Sequence cautioni

The sequence BAA86519.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Isoform 3 : The sequence BF805116 differs from that shown. Reason: Frameshift at position 10. Combined sourcesCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616MEQLP…PHPVR → MDRNYPSAGFGDPLGAGAGW SYERSAKASLVYGSSRTSHP ETDILHRQAYAAPHPLQSYA TNHHPAGLSGLFDTGLHHAG SAGPDASVMNLISALESRGP QPGPSASSLLSQFRSPSWQT AMHTPGPTELFISGALPGSS TFPSSSALSAYQHPASFGSR PFPVPSSLSLQDPPFSPPAN GLLSPHDVLHLKPSQAPTVP SSLGFERLAGGGVLGPAGLG PAQTPPYRPGPPDPPPPPRH LPTQFNLLASSSAAAAAAEQ SSPQLYNFSGAAPGPPPPER ALPRQDTVIKHYQRPASAQP PPPPPPAHALQHYLSCGGSY PSMGHRANLACSPLGGGEPS PGAGEPSKAGPSGATAGASG RATGPEAAGGGGAGGGGGGY RPIIQSPGYKTGKGGYGAAA GGATRPPPPRSTATPKCQSL GGPAAAYATGKASGAGGAGG QAYSPGQPQGLLGPQAYGQG FGGGQAQDLSKAPSYSGGPP QPPSGPPPPGLATCQSYSPD QLQGQLYGVQGEPYPGPAAH SQGLPTASPSLSYSTGHSPA LSGHGGGWGPSSLGGGGEAS PSHIIRPLQSPPATGRPPGV GSPGAPGKYLSSVLASAPFL APPGAGSYAAGAGGYKGKGD GSELLAGPGGPPAERTEDEE FLIQHLLQAPSPPRTSGADG LVGEDGAADASKGLGGSGGA GGPPGTPYELAKEDPQRYHL QSVIRTSASLDEGATAALEL GLGRLKEKKKGPERGGETPE GLATSVVHYGAGAKELGAFL QKSPPPPPPTAQSTQPTPHG LLLEAGGPDLPLVLPPPPPQ LLPSVLSHAPSPSPSASKVG VHLLEPATRDGAPQPPP in isoform 3. CuratedVSP_040929Add
BLAST
Alternative sequencei1054 – 112572Missing in isoform 2. 1 PublicationVSP_019503Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033031 mRNA. Translation: BAA86519.1. Different initiation.
AC010619 Genomic DNA. No translation available.
AC011495 Genomic DNA. No translation available.
BF805116 mRNA. No translation available.
BC034003 mRNA. Translation: AAH34003.1.
CCDSiCCDS46143.1. [Q9ULL5-3]
RefSeqiNP_065770.1. NM_020719.1. [Q9ULL5-3]
UniGeneiHs.590971.

Genome annotation databases

EnsembliENST00000418929; ENSP00000394510; ENSG00000126464. [Q9ULL5-3]
ENST00000615927; ENSP00000478000; ENSG00000126464. [Q9ULL5-1]
GeneIDi57479.
KEGGihsa:57479.
UCSCiuc002poo.5. human. [Q9ULL5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033031 mRNA. Translation: BAA86519.1. Different initiation.
AC010619 Genomic DNA. No translation available.
AC011495 Genomic DNA. No translation available.
BF805116 mRNA. No translation available.
BC034003 mRNA. Translation: AAH34003.1.
CCDSiCCDS46143.1. [Q9ULL5-3]
RefSeqiNP_065770.1. NM_020719.1. [Q9ULL5-3]
UniGeneiHs.590971.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121549. 9 interactions.
IntActiQ9ULL5. 6 interactions.
STRINGi9606.ENSP00000394510.

PTM databases

iPTMnetiQ9ULL5.

Polymorphism and mutation databases

BioMutaiPRR12.
DMDMi109892840.

Proteomic databases

EPDiQ9ULL5.
MaxQBiQ9ULL5.
PaxDbiQ9ULL5.
PRIDEiQ9ULL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418929; ENSP00000394510; ENSG00000126464. [Q9ULL5-3]
ENST00000615927; ENSP00000478000; ENSG00000126464. [Q9ULL5-1]
GeneIDi57479.
KEGGihsa:57479.
UCSCiuc002poo.5. human. [Q9ULL5-1]

Organism-specific databases

CTDi57479.
GeneCardsiPRR12.
H-InvDBHIX0015335.
HGNCiHGNC:29217. PRR12.
HPAiHPA011959.
MIMi616633. gene.
neXtProtiNX_Q9ULL5.
PharmGKBiPA134903328.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4805. Eukaryota.
ENOG410Y937. LUCA.
GeneTreeiENSGT00440000037417.
HOGENOMiHOG000202654.
HOVERGENiHBG082198.
InParanoidiQ9ULL5.
OMAiATSVVHY.
OrthoDBiEOG7VQJCD.
PhylomeDBiQ9ULL5.
TreeFamiTF333141.

Miscellaneous databases

ChiTaRSiPRR12. human.
GenomeRNAii57479.
PROiQ9ULL5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULL5.
CleanExiHS_PRR12.
GenevisibleiQ9ULL5. HS.

Family and domain databases

InterProiIPR025451. DUF4211.
[Graphical view]
PfamiPF13926. DUF4211. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 544-1215 (ISOFORM 2).
    Tissue: Pancreas.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487; THR-740 AND SER-747, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND SER-1104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256; THR-483; SER-487; SER-560; SER-561; THR-740 AND SER-747, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560 AND SER-561, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44; THR-483; SER-487; SER-560; SER-561; SER-566 AND SER-1104, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651 AND THR-738 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-560; SER-561 AND SER-566, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-651 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPRR12_HUMAN
AccessioniPrimary (citable) accession number: Q9ULL5
Secondary accession number(s): E9PB06, Q8N4J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.