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Protein

Proline-rich protein 12

Gene

PRR12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi347 – 359A.T hook 1Add BLAST13
DNA bindingi381 – 393A.T hook 2Add BLAST13

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126464-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 12
Gene namesi
Name:PRR12Imported
Synonyms:KIAA1205
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29217. PRR12.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126464.
PharmGKBiPA134903328.

Polymorphism and mutation databases

BioMutaiPRR12.
DMDMi109892840.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439451 – 1215Proline-rich protein 12Add BLAST1215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei314PhosphoserineBy similarity1
Modified residuei402N6-acetyllysineCombined sources1
Modified residuei483PhosphothreonineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei561PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei740PhosphothreonineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei884PhosphothreonineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Isoform 3 (identifier: Q9ULL5-3)
Modified residuei651PhosphoserineCombined sourcesCurated1
Modified residuei738PhosphothreonineCombined sourcesCurated1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ULL5.
PaxDbiQ9ULL5.
PeptideAtlasiQ9ULL5.
PRIDEiQ9ULL5.

PTM databases

iPTMnetiQ9ULL5.
PhosphoSitePlusiQ9ULL5.

Expressioni

Gene expression databases

BgeeiENSG00000126464.
CleanExiHS_PRR12.
GenevisibleiQ9ULL5. HS.

Organism-specific databases

HPAiHPA011959.

Interactioni

Protein-protein interaction databases

BioGridi121549. 9 interactors.
IntActiQ9ULL5. 6 interactors.
STRINGi9606.ENSP00000394510.

Structurei

3D structure databases

ProteinModelPortaliQ9ULL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 724Pro-richAdd BLAST720
Compositional biasi845 – 916Pro-richAdd BLAST72

Sequence similaritiesi

Contains 2 A.T hook DNA-binding domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4805. Eukaryota.
ENOG410Y937. LUCA.
GeneTreeiENSGT00440000037417.
HOGENOMiHOG000202654.
HOVERGENiHBG082198.
InParanoidiQ9ULL5.
OMAiATSVVHY.
OrthoDBiEOG091G00P7.
PhylomeDBiQ9ULL5.
TreeFamiTF333141.

Family and domain databases

InterProiIPR025451. DUF4211.
[Graphical view]
PfamiPF13926. DUF4211. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULL5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQLPGVPPG PPHPVRPPPP PPPPMPLQLE AHLRSHGLEP AAPSPRLRPE
60 70 80 90 100
ESLDPPGAMQ ELLGALEPLP PAPGDTGVGP PNSEGKDPAG AYRSPSPQGT
110 120 130 140 150
KAPRFVPLTS ICFPDSLLQD EERSFFPTME EMFGGGAADD YGKAGPPEDE
160 170 180 190 200
GDPKAGAGPP PGPPAYDPYG PYCPGRASGA GPETPGLGLD PNKPPELPST
210 220 230 240 250
VNAEPLGLIQ SGPHQAAPPP PPPPPPPPAP ASEPKGGLTS PIFCSTKPKK
260 270 280 290 300
LLKTSSFHLL RRRDPPFQTP KKLYAQEYEF EADEDKADVP ADIRLNPRRL
310 320 330 340 350
PDLVSSCRSR PALSPLGDID FCPPNPGPDG PRRRGRKPTK AKRDGPPRPR
360 370 380 390 400
GRPRIRPLEV PTTAGPASAS TPTDGAKKPR GRGRGRGRKA EEAGGTRLEP
410 420 430 440 450
LKPLKIKLSV PKAGEGLGTS SGDAISGTDH NSLDSSLTRE KIEAKIKEVE
460 470 480 490 500
EKQPEMKSGF MASFLDFLKS GKRHPPLYQA GLTPPLSPPK SVPPSVPARG
510 520 530 540 550
LQPQPPATPA VPHPPPSGAF GLGGALEAAE SEGLGLGCPS PCKRLDEELK
560 570 580 590 600
RNLETLPSFS SDEEDSVAKN RDLQESISSA ISALDDPPLA GPKDTSTPDG
610 620 630 640 650
PPLAPAAAVP GPPPLPGLPS ANSNGTPEPP LLEEKPPPTP PPAPTPQPQP
660 670 680 690 700
PPPPPPPQPA LPSPPPLVAP TPSSPPPPPL PPPPPPAMPS PPPPPPPAAA
710 720 730 740 750
PLAAPPEEPA APSPEDPELP DTRPLHLAKK QETAAVCGET DEEAGESGGE
760 770 780 790 800
GIFRERDEFV IRAEDIPSLK LALQTGREPP PIWRVQKALL QKFTPEIKDG
810 820 830 840 850
QRQFCATSNY LGYFGDAKNR YQRLYVKFLE NVNKKDYVRV CARKPWHRPP
860 870 880 890 900
VPVRRSGQAK NPVSAGGSSA PPPKAPAPPP KPETPEKTTS EKPPEQTPET
910 920 930 940 950
AMPEPPAPEK PSLLRPVEKE KEKEKVTRGE RPLRGERATS GRQTRPERSL
960 970 980 990 1000
ATGQPATSRL PKARPTKVKA EPPPKKRKKW LKEAGGNATA GGGPPGSSSD
1010 1020 1030 1040 1050
SESSPGAPSE DERAVPGRLL KTRAMREMYR SYVEMLVSTA LDPDMIQALE
1060 1070 1080 1090 1100
DTHDELYLPP MRKIDGLLNE HKKKVLKRLS LSPALQDALH TFPQLQVEQS
1110 1120 1130 1140 1150
GEGSPEEGAV RLRPAGEPYN RKTLSKLKRS VVRAQEFKVE LEKSGYYTLY
1160 1170 1180 1190 1200
HSLHHYKYHT FLRCRDQTLA IEGGAEDLGQ EEVVQQCMRN QPWLEQLFDS
1210
FSDLLAQAQA HSRCG
Length:1,215
Mass (Da):129,991
Last modified:June 27, 2006 - v2
Checksum:i197FC768E1139688
GO
Isoform 2 (identifier: Q9ULL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1125: Missing.

Note: No experimental confirmation available.
Show »
Length:1,143
Mass (Da):121,917
Checksum:i2C44FCFD15CD813E
GO
Isoform 3 (identifier: Q9ULL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEQLPGVPPGPPHPVR → MDRNYPSAGF...TRDGAPQPPP

Note: No experimental confirmation available. Prediction based on ortholog sequences.Combined sourcesCurated
Show »
Length:2,036
Mass (Da):211,044
Checksum:i11D30279770ECFF0
GO

Sequence cautioni

The sequence BAA86519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Isoform 3 : The sequence BF805116 differs from that shown. Reason: Frameshift at position 10.Combined sourcesCurated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0409291 – 16MEQLP…PHPVR → MDRNYPSAGFGDPLGAGAGW SYERSAKASLVYGSSRTSHP ETDILHRQAYAAPHPLQSYA TNHHPAGLSGLFDTGLHHAG SAGPDASVMNLISALESRGP QPGPSASSLLSQFRSPSWQT AMHTPGPTELFISGALPGSS TFPSSSALSAYQHPASFGSR PFPVPSSLSLQDPPFSPPAN GLLSPHDVLHLKPSQAPTVP SSLGFERLAGGGVLGPAGLG PAQTPPYRPGPPDPPPPPRH LPTQFNLLASSSAAAAAAEQ SSPQLYNFSGAAPGPPPPER ALPRQDTVIKHYQRPASAQP PPPPPPAHALQHYLSCGGSY PSMGHRANLACSPLGGGEPS PGAGEPSKAGPSGATAGASG RATGPEAAGGGGAGGGGGGY RPIIQSPGYKTGKGGYGAAA GGATRPPPPRSTATPKCQSL GGPAAAYATGKASGAGGAGG QAYSPGQPQGLLGPQAYGQG FGGGQAQDLSKAPSYSGGPP QPPSGPPPPGLATCQSYSPD QLQGQLYGVQGEPYPGPAAH SQGLPTASPSLSYSTGHSPA LSGHGGGWGPSSLGGGGEAS PSHIIRPLQSPPATGRPPGV GSPGAPGKYLSSVLASAPFL APPGAGSYAAGAGGYKGKGD GSELLAGPGGPPAERTEDEE FLIQHLLQAPSPPRTSGADG LVGEDGAADASKGLGGSGGA GGPPGTPYELAKEDPQRYHL QSVIRTSASLDEGATAALEL GLGRLKEKKKGPERGGETPE GLATSVVHYGAGAKELGAFL QKSPPPPPPTAQSTQPTPHG LLLEAGGPDLPLVLPPPPPQ LLPSVLSHAPSPSPSASKVG VHLLEPATRDGAPQPPP in isoform 3. CuratedAdd BLAST16
Alternative sequenceiVSP_0195031054 – 1125Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033031 mRNA. Translation: BAA86519.1. Different initiation.
AC010619 Genomic DNA. No translation available.
AC011495 Genomic DNA. No translation available.
BF805116 mRNA. No translation available.
BC034003 mRNA. Translation: AAH34003.1.
CCDSiCCDS46143.1. [Q9ULL5-3]
RefSeqiNP_065770.1. NM_020719.2. [Q9ULL5-3]
UniGeneiHs.590971.

Genome annotation databases

EnsembliENST00000418929; ENSP00000394510; ENSG00000126464. [Q9ULL5-3]
ENST00000615927; ENSP00000478000; ENSG00000126464. [Q9ULL5-1]
GeneIDi57479.
KEGGihsa:57479.
UCSCiuc002poo.5. human. [Q9ULL5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033031 mRNA. Translation: BAA86519.1. Different initiation.
AC010619 Genomic DNA. No translation available.
AC011495 Genomic DNA. No translation available.
BF805116 mRNA. No translation available.
BC034003 mRNA. Translation: AAH34003.1.
CCDSiCCDS46143.1. [Q9ULL5-3]
RefSeqiNP_065770.1. NM_020719.2. [Q9ULL5-3]
UniGeneiHs.590971.

3D structure databases

ProteinModelPortaliQ9ULL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121549. 9 interactors.
IntActiQ9ULL5. 6 interactors.
STRINGi9606.ENSP00000394510.

PTM databases

iPTMnetiQ9ULL5.
PhosphoSitePlusiQ9ULL5.

Polymorphism and mutation databases

BioMutaiPRR12.
DMDMi109892840.

Proteomic databases

EPDiQ9ULL5.
PaxDbiQ9ULL5.
PeptideAtlasiQ9ULL5.
PRIDEiQ9ULL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418929; ENSP00000394510; ENSG00000126464. [Q9ULL5-3]
ENST00000615927; ENSP00000478000; ENSG00000126464. [Q9ULL5-1]
GeneIDi57479.
KEGGihsa:57479.
UCSCiuc002poo.5. human. [Q9ULL5-1]

Organism-specific databases

CTDi57479.
GeneCardsiPRR12.
H-InvDBHIX0015335.
HGNCiHGNC:29217. PRR12.
HPAiHPA011959.
MIMi616633. gene.
neXtProtiNX_Q9ULL5.
OpenTargetsiENSG00000126464.
PharmGKBiPA134903328.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4805. Eukaryota.
ENOG410Y937. LUCA.
GeneTreeiENSGT00440000037417.
HOGENOMiHOG000202654.
HOVERGENiHBG082198.
InParanoidiQ9ULL5.
OMAiATSVVHY.
OrthoDBiEOG091G00P7.
PhylomeDBiQ9ULL5.
TreeFamiTF333141.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126464-MONOMER.

Miscellaneous databases

ChiTaRSiPRR12. human.
GenomeRNAii57479.
PROiQ9ULL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126464.
CleanExiHS_PRR12.
GenevisibleiQ9ULL5. HS.

Family and domain databases

InterProiIPR025451. DUF4211.
[Graphical view]
PfamiPF13926. DUF4211. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRR12_HUMAN
AccessioniPrimary (citable) accession number: Q9ULL5
Secondary accession number(s): E9PB06, Q8N4J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.