Q9ULL4 (PLXB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plexin-B3

Gene names

Name:	PLXNB3
Synonyms:	KIAA1206, PLXN6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1909 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Ref.6 Ref.8 Ref.9
Subunit structure	Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA By similarity. Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain). Ref.5 Ref.7 Ref.9
Subcellular location	Cell membrane; Single-pass type I membrane protein. Note: Colocalizes with RIT2/RIN at the plasma membrane. Ref.6 Ref.7
Tissue specificity	Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. Ref.7 Ref.8 Ref.9
Sequence similarities	Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 3 PSI domains. Contains 1 Sema domain.
Sequence caution	The sequence BAA86520.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Neurogenesis
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FSCN1	Q16658	2	EBI-311073,EBI-351076
MET	P08581	2	EBI-311073,EBI-1039152
MST1R	Q04912	2	EBI-311073,EBI-2637518

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULL4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULL4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MCHAAQETPLLHHFM → MELTPASSLTCSLLSPRLPGSFPQLRRVPPCSRPWLPK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 44	44	Potential
	Chain	45 – 1909	1865	Plexin-B3		PRO_0000024674
Regions
	Topological domain	45 – 1255	1211	Extracellular Potential
	Transmembrane	1256 – 1276	21	Helical; Potential
	Topological domain	1277 – 1909	633	Cytoplasmic Potential
	Domain	45 – 471	427	Sema
	Domain	473 – 526	54	PSI 1
	Domain	620 – 682	63	PSI 2
	Domain	787 – 833	47	PSI 3
	Domain	835 – 925	91	IPT/TIG 1
	Domain	927 – 1012	86	IPT/TIG 2
	Domain	1015 – 1145	131	IPT/TIG 3
	Domain	1159 – 1244	86	IPT/TIG 4
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	615	1	N-linked (GlcNAc...) Potential
	Glycosylation	802	1	N-linked (GlcNAc...) Potential
	Glycosylation	900	1	N-linked (GlcNAc...) Potential
	Glycosylation	957	1	N-linked (GlcNAc...) Potential
	Glycosylation	1101	1	N-linked (GlcNAc...) Potential
	Glycosylation	1218	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 107		By similarity
	Disulfide bond	132 ↔ 140		By similarity
	Disulfide bond	267 ↔ 370		By similarity
	Disulfide bond	283 ↔ 315		By similarity
	Disulfide bond	333 ↔ 357		By similarity
	Disulfide bond	474 ↔ 491		By similarity
	Disulfide bond	480 ↔ 525		By similarity
	Disulfide bond	483 ↔ 500		By similarity
	Disulfide bond	494 ↔ 506		By similarity
	Disulfide bond	562 ↔ 580		By similarity
Natural variations
	Alternative sequence	1 – 15	15	MCHAA…LHHFM → MELTPASSLTCSLLSPRLPG SFPQLRRVPPCSRPWLPK in isoform 2.		VSP_044467
	Natural variant	126	1	A → T. Corresponds to variant rs34360382 [ dbSNP | Ensembl ].		VAR_050601
	Natural variant	598	1	V → I. Ref.3 Corresponds to variant rs2266879 [ dbSNP | Ensembl ].		VAR_019681
	Natural variant	1156	1	E → D. Ref.3 Corresponds to variant rs6643791 [ dbSNP | Ensembl ].		VAR_061538
	Natural variant	1535	1	M → T. Ref.3 Corresponds to variant rs5987155 [ dbSNP | Ensembl ].		VAR_019682
	Natural variant	1651	1	E → A. Corresponds to variant rs34762690 [ dbSNP | Ensembl ].		VAR_068807
Experimental info
	Sequence conflict	149	1	A → V in BAH12182. Ref.3
	Sequence conflict	300	1	L → P in BAH12182. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 11753CD58C7AC226	FASTA	1,909	206,847
	10 20 30 40 50 60 MCHAAQETPL LHHFMAPVMA RWPPFGLCLL LLLLSPPPLP LTGAHRFSAP NTTLNHLALA 70 80 90 100 110 120 PGRGTLYVGA VNRLFQLSPE LQLEAVAVTG PVIDSPDCVP FRDPAECPQA QLTDNANQLL 130 140 150 160 170 180 LVSSRAQELV ACGQVRQGVC ETRRLGDVAE VLYQAEDPGD GQFVAANTPG VATVGLVVPL 190 200 210 220 230 240 PGRDLLLVAR GLAGKLSAGV PPLAIRQLAG SQPFSSEGLG RLVVGDFSDY NNSYVGAFAD 250 260 270 280 290 300 ARSAYFVFRR RGARAQAEYR SYVARVCLGD TNLYSYVEVP LACQGQGLIQ AAFLAPGTLL 310 320 330 340 350 360 GVFAAGPRGT QAALCAFPMV ELGASMEQAR RLCYTAGGRG PSGAEEATVE YGVTSRCVTL 370 380 390 400 410 420 PLDSPESYPC GDEHTPSPIA GRQPLEVQPL LKLGQPVSAV AALQADGHMI AFLGDTQGQL 430 440 450 460 470 480 YKVFLHGSQG QVYHSQQVGP PGSAISPDLL LDSSGSHLYV LTAHQVDRIP VAACPQFPDC 490 500 510 520 530 540 ASCLQAQDPL CGWCVLQGRC TRKGQCGRAG QLNQWLWSYE EDSHCLHIQS LLPGHHPRQE 550 560 570 580 590 600 QGQVTLSVPR LPILDADEYF HCAFGDYDSL AHVEGPHVAC VTPPQDQVPL NPPGTDHVTV 610 620 630 640 650 660 PLALMFEDVT VAATNFSFYD CSAVQALEAA APCRACVGSI WRCHWCPQSS HCVYGEHCPE 670 680 690 700 710 720 GERTIYSAQE VDIQVRGPGA CPQVEGLAGP HLVPVGWESH LALRVRNLQH FRGLPASFHC 730 740 750 760 770 780 WLELPGELRG LPATLEETAG DSGLIHCQAH QFYPSMSQRE LPVPIYVTQG EAQRLDNTHA 790 800 810 820 830 840 LYVILYDCAM GHPDCSHCQA ANRSLGCLWC ADGQPACRYG PLCPPGAVEL LCPAPSIDAV 850 860 870 880 890 900 EPLTGPPEGG LALTILGSNL GRAFADVQYA VSVASRPCNP EPSLYRTSAR IVCVTSPAPN 910 920 930 940 950 960 GTTGPVRVAI KSQPPGISSQ HFTYQDPVLL SLSPRWGPQA GGTQLTIRGQ HLQTGGNTSA 970 980 990 1000 1010 1020 FVGGQPCPIL EPVCPEAIVC RTRPQAAPGE AAVLVVFGHA QRTLLASPFR YTANPQLVAA 1030 1040 1050 1060 1070 1080 EPSASFRGGG RLIRVRGTGL DVVQRPLLSV WLEADAEVQA SRAQPQDPQP RRSCGAPAAD 1090 1100 1110 1120 1130 1140 PQACIQLGGG LLQCSTVCSV NSSSLLLCRS PAVPDRAHPQ RVFFTLDNVQ VDFASASGGQ 1150 1160 1170 1180 1190 1200 GFLYQPNPRL APLSREGPAR PYRLKPGHVL DVEGEGLNLG ISKEEVRVHI GRGECLVKTL 1210 1220 1230 1240 1250 1260 TRTHLYCEPP AHAPQPANGS GLPQFVVQMG NVQLALGPVQ YEAEPPLSAF PVEAQAGVGM 1270 1280 1290 1300 1310 1320 GAAVLIAAVL LLTLMYRHKS KQALRDYQKV LVQLESLETG VGDQCRKEFT DLMTEMTDLS 1330 1340 1350 1360 1370 1380 SDLEGSGIPF LDYRTYAERA FFPGHGGCPL QPKPEGPGED GHCATVRQGL TQLSNLLNSK 1390 1400 1410 1420 1430 1440 LFLLTLIHTL EEQPSFSQRD RCHVASLLSL ALHGKLEYLT DIMRTLLGDL AAHYVHRNPK 1450 1460 1470 1480 1490 1500 LMLRRTETMV EKLLTNWLSI CLYAFLREVA GEPLYMLFRA IQYQVDKGPV DAVTGKAKRT 1510 1520 1530 1540 1550 1560 LNDSRLLRED VEFQPLTLMV LVGPGAGGAA GSSEMQRVPA RVLDTDTITQ VKEKVLDQVY 1570 1580 1590 1600 1610 1620 KGTPFSQRPS VHALDLEWRS GLAGHLTLSD EDLTSVTQNH WKRLNTLQHY KVPDGATVGL 1630 1640 1650 1660 1670 1680 VPQLHRGSTI SQSLAQRCPL GENIPTLEDG EEGGVCLWHL VKATEEPEGA KVRCSSLRER 1690 1700 1710 1720 1730 1740 EPARAKAIPE IYLTRLLSMK GTLQKFVDDT FQAILSVNRP IPIAVKYLFD LLDELAEKHG 1750 1760 1770 1780 1790 1800 IEDPGTLHIW KTNSLLLRFW VNALKNPQLI FDVRVSDNVD AILAVIAQTF IDSCTTSEHK 1810 1820 1830 1840 1850 1860 VGRDSPVNKL LYAREIPRYK QMVERYYADI RQSSPASYQE MNSALAELSG NYTSAPHCLE 1870 1880 1890 1900 ALQELYNHIH RYYDQIISAL EEDPVGQKLQ LACRLQQVAA LVENKVTDL
	Isoform 2 [UniParc]. Checksum: BA26AFFF478B979B	FASTA	1,932	209,301
	10 20 30 40 50 60 MELTPASSLT CSLLSPRLPG SFPQLRRVPP CSRPWLPKAP VMARWPPFGL CLLLLLLSPP 70 80 90 100 110 120 PLPLTGAHRF SAPNTTLNHL ALAPGRGTLY VGAVNRLFQL SPELQLEAVA VTGPVIDSPD 130 140 150 160 170 180 CVPFRDPAEC PQAQLTDNAN QLLLVSSRAQ ELVACGQVRQ GVCETRRLGD VAEVLYQAED 190 200 210 220 230 240 PGDGQFVAAN TPGVATVGLV VPLPGRDLLL VARGLAGKLS AGVPPLAIRQ LAGSQPFSSE 250 260 270 280 290 300 GLGRLVVGDF SDYNNSYVGA FADARSAYFV FRRRGARAQA EYRSYVARVC LGDTNLYSYV 310 320 330 340 350 360 EVPLACQGQG LIQAAFLAPG TLLGVFAAGP RGTQAALCAF PMVELGASME QARRLCYTAG 370 380 390 400 410 420 GRGPSGAEEA TVEYGVTSRC VTLPLDSPES YPCGDEHTPS PIAGRQPLEV QPLLKLGQPV 430 440 450 460 470 480 SAVAALQADG HMIAFLGDTQ GQLYKVFLHG SQGQVYHSQQ VGPPGSAISP DLLLDSSGSH 490 500 510 520 530 540 LYVLTAHQVD RIPVAACPQF PDCASCLQAQ DPLCGWCVLQ GRCTRKGQCG RAGQLNQWLW 550 560 570 580 590 600 SYEEDSHCLH IQSLLPGHHP RQEQGQVTLS VPRLPILDAD EYFHCAFGDY DSLAHVEGPH 610 620 630 640 650 660 VACVTPPQDQ VPLNPPGTDH VTVPLALMFE DVTVAATNFS FYDCSAVQAL EAAAPCRACV 670 680 690 700 710 720 GSIWRCHWCP QSSHCVYGEH CPEGERTIYS AQEVDIQVRG PGACPQVEGL AGPHLVPVGW 730 740 750 760 770 780 ESHLALRVRN LQHFRGLPAS FHCWLELPGE LRGLPATLEE TAGDSGLIHC QAHQFYPSMS 790 800 810 820 830 840 QRELPVPIYV TQGEAQRLDN THALYVILYD CAMGHPDCSH CQAANRSLGC LWCADGQPAC 850 860 870 880 890 900 RYGPLCPPGA VELLCPAPSI DAVEPLTGPP EGGLALTILG SNLGRAFADV QYAVSVASRP 910 920 930 940 950 960 CNPEPSLYRT SARIVCVTSP APNGTTGPVR VAIKSQPPGI SSQHFTYQDP VLLSLSPRWG 970 980 990 1000 1010 1020 PQAGGTQLTI RGQHLQTGGN TSAFVGGQPC PILEPVCPEA IVCRTRPQAA PGEAAVLVVF 1030 1040 1050 1060 1070 1080 GHAQRTLLAS PFRYTANPQL VAAEPSASFR GGGRLIRVRG TGLDVVQRPL LSVWLEADAE 1090 1100 1110 1120 1130 1140 VQASRAQPQD PQPRRSCGAP AADPQACIQL GGGLLQCSTV CSVNSSSLLL CRSPAVPDRA 1150 1160 1170 1180 1190 1200 HPQRVFFTLD NVQVDFASAS GGQGFLYQPN PRLAPLSREG PARPYRLKPG HVLDVEGEGL 1210 1220 1230 1240 1250 1260 NLGISKEEVR VHIGRGECLV KTLTRTHLYC EPPAHAPQPA NGSGLPQFVV QMGNVQLALG 1270 1280 1290 1300 1310 1320 PVQYEAEPPL SAFPVEAQAG VGMGAAVLIA AVLLLTLMYR HKSKQALRDY QKVLVQLESL 1330 1340 1350 1360 1370 1380 ETGVGDQCRK EFTDLMTEMT DLSSDLEGSG IPFLDYRTYA ERAFFPGHGG CPLQPKPEGP 1390 1400 1410 1420 1430 1440 GEDGHCATVR QGLTQLSNLL NSKLFLLTLI HTLEEQPSFS QRDRCHVASL LSLALHGKLE 1450 1460 1470 1480 1490 1500 YLTDIMRTLL GDLAAHYVHR NPKLMLRRTE TMVEKLLTNW LSICLYAFLR EVAGEPLYML 1510 1520 1530 1540 1550 1560 FRAIQYQVDK GPVDAVTGKA KRTLNDSRLL REDVEFQPLT LMVLVGPGAG GAAGSSEMQR 1570 1580 1590 1600 1610 1620 VPARVLDTDT ITQVKEKVLD QVYKGTPFSQ RPSVHALDLE WRSGLAGHLT LSDEDLTSVT 1630 1640 1650 1660 1670 1680 QNHWKRLNTL QHYKVPDGAT VGLVPQLHRG STISQSLAQR CPLGENIPTL EDGEEGGVCL 1690 1700 1710 1720 1730 1740 WHLVKATEEP EGAKVRCSSL REREPARAKA IPEIYLTRLL SMKGTLQKFV DDTFQAILSV 1750 1760 1770 1780 1790 1800 NRPIPIAVKY LFDLLDELAE KHGIEDPGTL HIWKTNSLLL RFWVNALKNP QLIFDVRVSD 1810 1820 1830 1840 1850 1860 NVDAILAVIA QTFIDSCTTS EHKVGRDSPV NKLLYAREIP RYKQMVERYY ADIRQSSPAS 1870 1880 1890 1900 1910 1920 YQEMNSALAE LSGNYTSAPH CLEALQELYN HIHRYYDQII SALEEDPVGQ KLQLACRLQQ 1930 VAALVENKVT DL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the new human plexin family member, plexin related protein." Veske A., Michelson P., Finckh U., Gal A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ILE-598; ASP-1156 AND THR-1535. Tissue: Hippocampus.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Interplay between scatter factor receptors and B plexins controls invasive growth." Conrotto P., Corso S., Gamberini S., Comoglio P.M., Giordano S. Oncogene 23:5131-5137(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MET AND MST1R.
[6]	"Plexin-B3 is a functional receptor for semaphorin 5A." Artigiani S., Conrotto P., Fazzari P., Gilestro G.F., Barberis D., Giordano S., Comoglio P.M., Tamagnone L. EMBO Rep. 5:710-714(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]	"Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin." Hartwig C., Veske A., Krejcova S., Rosenberger G., Finckh U. BMC Neurosci. 6:53-53(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[8]	"Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase." Li X., Lee A.Y. J. Biol. Chem. 285:32436-32445(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[9]	"Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton." Li X., Law J.W., Lee A.Y. Oncogene 31:595-610(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FSCN1, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF149019 mRNA. Translation: AAG01376.1. AB033032 mRNA. Translation: BAA86520.1. Different initiation. AK295762 mRNA. Translation: BAH12182.1. U52111 Genomic DNA. No translation available.
IPI	IPI00155729. IPI00943863.
RefSeq	NP_001156729.1. NM_001163257.1. NP_005384.2. NM_005393.2.
UniGene	Hs.632833.
3D structure databases
ProteinModelPortal	Q9ULL4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULL4. 10 interactions.
MINT	MINT-2822157.
STRING	9606.ENSP00000355378.
PTM databases
PhosphoSite	Q9ULL4.
Polymorphism databases
DMDM	51701857.
Proteomic databases
PaxDb	Q9ULL4.
PRIDE	Q9ULL4.
Protocols and materials databases
DNASU	5365.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361971; ENSP00000355378; ENSG00000198753. ENST00000538966; ENSP00000442736; ENSG00000198753. ENST00000593339; ENSP00000472730; ENSG00000268591. ENST00000596875; ENSP00000472712; ENSG00000268591.
GeneID	5365.
KEGG	hsa:5365.
UCSC	uc004fii.2. human.
Organism-specific databases
CTD	5365.
GeneCards	GC0XP153029.
H-InvDB	HIX0093726.
HGNC	HGNC:9105. PLXNB3.
HPA	HPA000230.
MIM	300214. gene.
neXtProt	NX_Q9ULL4.
PharmGKB	PA33431.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254546.
HOVERGEN	HBG053404.
InParanoid	Q9ULL4.
KO	K06821.
OMA	WRCHWCP.
OrthoDB	EOG49GKFP.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	Q9ULL4.
Bgee	Q9ULL4.
CleanEx	HS_PLXNB3.
Genevestigator	Q9ULL4.
GermOnline	ENSG00000198753. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 2.60.40.10. 5 hits.
InterPro	IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002909. IPT_TIG_rcpt. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR013548. Plexin_cytoplasmic_RasGAP_dom. IPR002165. Plexin_repeat. IPR008936. Rho_GTPase_activation_prot. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Pfam	PF08337. Plexin_cytopl. 1 hit. PF01437. PSI. 1 hit. PF01403. Sema. 1 hit. PF01833. TIG. 3 hits. [Graphical view]
SMART	SM00429. IPT. 3 hits. SM00423. PSI. 3 hits. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 4 hits. SSF103575. Plexin-like_fold. 1 hit. SSF48350. Rho_GAP. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PLXNB3. human.
GenomeRNAi	5365.
NextBio	20796.
SOURCE	Search...

Entry information

Entry name

PLXB3_HUMAN

Accession

Primary (citable) accession number: Q9ULL4
Secondary accession number(s): B7Z3E6, F5H773, Q9HDA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.