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Protein

Pleckstrin homology domain-containing family G member 1

Gene

PLEKHG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 1
Gene namesi
Name:PLEKHG1
Synonyms:KIAA1209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20884. PLEKHG1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134922441.

Polymorphism and mutation databases

BioMutaiPLEKHG1.
DMDMi62288848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13851385Pleckstrin homology domain-containing family G member 1PRO_0000080964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1192 – 11921PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULL1.
MaxQBiQ9ULL1.
PaxDbiQ9ULL1.
PeptideAtlasiQ9ULL1.
PRIDEiQ9ULL1.

PTM databases

iPTMnetiQ9ULL1.
PhosphoSiteiQ9ULL1.

Expressioni

Gene expression databases

BgeeiQ9ULL1.
CleanExiHS_PLEKHG1.
ExpressionAtlasiQ9ULL1. baseline and differential.
GenevisibleiQ9ULL1. HS.

Organism-specific databases

HPAiHPA027319.
HPA028270.

Interactioni

Protein-protein interaction databases

BioGridi121550. 15 interactions.
IntActiQ9ULL1. 17 interactions.
STRINGi9606.ENSP00000351318.

Structurei

3D structure databases

ProteinModelPortaliQ9ULL1.
SMRiQ9ULL1. Positions 117-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 293181DHPROSITE-ProRule annotationAdd
BLAST
Domaini317 – 416100PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3518. Eukaryota.
ENOG410XR81. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000115556.
HOVERGENiHBG053605.
InParanoidiQ9ULL1.
OMAiDYQMFVP.
OrthoDBiEOG7K9K2H.
PhylomeDBiQ9ULL1.
TreeFamiTF328565.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSDSDRPV SFGSTSSSAS SRDSHGSFGS RMTLVSNSHM GLFNQDKEVG
60 70 80 90 100
AIKLELIPAR PFSSSELQRD NPATGQQNAD EGSERPPRAQ WRVDSNGAPK
110 120 130 140 150
TIADSATSPK LLYVDRVVQE ILETERTYVQ DLKSIVEDYL DCIRDQTKLP
160 170 180 190 200
LGTEERSALF GNIQDIYHFN SELLQDLENC ENDPVAIAEC FVSKSEEFHI
210 220 230 240 250
YTQYCTNYPR SVAVLTECMR NKILAKFFRE RQETLKHSLP LGSYLLKPVQ
260 270 280 290 300
RILKYHLLLH EIENHLDKDT EGYDVVLDAI DTMQRVAWHI NDMKRKHEHA
310 320 330 340 350
VRLQEIQSLL TNWKGPDLTS YGELVLEGTF RIQRAKNERT LFLFDKLLLI
360 370 380 390 400
TKKRDDTFTY KAHILCGNLM LVEVIPKEPL SFSVFHYKNP KLQHTVQAKS
410 420 430 440 450
QQDKRLWVLH LKRLILENHA AKIPAKAKQA ILEMDAIHHP GFCYSPEGGT
460 470 480 490 500
KALFGSKEGS APYRLRRKSE PSSRSHKVLK TSETAQDIQK VSREEGSPQL
510 520 530 540 550
SSARPSPAQR NSQPSSSTMI SVLRAGGALR NIWTDHQIRQ ALFPSRRSPQ
560 570 580 590 600
ENEDDEDDYQ MFVPSFSSSD LNSTRLCEDS TSSRPCSWHM GQMESTETSS
610 620 630 640 650
SGHRIVRRAS SAGESNTCPP EIGTSDRTRE LQNSPKTEGQ EEMTPFGSSI
660 670 680 690 700
ELTIDDIDHV YDNISYEDLK LMVAKREEAE STPSKSARDS VRPKSTPELA
710 720 730 740 750
FTKRQAGHSK GSLYAQTDGT LSGGEASSQS THELQAVEEN IYDTIGLPDP
760 770 780 790 800
PSLGFKCSSL KRAKRSTFLG LEADFVCCDS LRPFVSQDSL QLSEDEAPYH
810 820 830 840 850
QATPDHGYLS LLYDSPSGNL SMPHKPVSDK LSEEVDEIWN DLENYIKKNE
860 870 880 890 900
DKARDRLLAA FPVSKDDVPD RLHAESTPEL SRDVGRSVST LSLPESQALL
910 920 930 940 950
TPVKSRAGRA SRANCPFEED LISKEGSFMS LNRLSLASEM PLMDNPYDLA
960 970 980 990 1000
NSGLSQTDPE NPDLGMEATD KTKSRVFMMA RQYSQKIKKA NQLLKVKSLE
1010 1020 1030 1040 1050
LEQPPASQHQ KSMHKDLAAI LEEKKQGGPA IGARIAEYSQ LYDQIVFRES
1060 1070 1080 1090 1100
PLKIQKDGWA SPQESSLLRS VSPSQVHHGS GDWLLHSTYS NGELADFCLP
1110 1120 1130 1140 1150
PEQDLRSRYP TFEINTKSTP RQLSAACSVP SLQTSDPLPG SVQRCSVVVS
1160 1170 1180 1190 1200
QPNKENWCQD HLYNSLGRKG ISAKSQPYHR SQSSSSVLIN KSMDSINYPS
1210 1220 1230 1240 1250
DVGKQQLLSL HRSSRCESHQ DLLPDIADSH QQGTEKLSDL TLQDSQKVVV
1260 1270 1280 1290 1300
VNRNLPLNAQ IATQNYFSNF KETDGDEDDY VEIKSEEDES ELELSHNRRR
1310 1320 1330 1340 1350
KSDSKFVDAD FSDNVCSGNT LHSLNSPRTP KKPVNSKLGL SPYLTPYNDS
1360 1370 1380
DKLNDYLWRG PSPNQQNIVQ SLREKFQCLS SSSFA
Length:1,385
Mass (Da):155,439
Last modified:February 1, 2005 - v2
Checksum:i1174A1AC7A9EB913
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti787 – 7871Q → R.
Corresponds to variant rs17080381 [ dbSNP | Ensembl ].
VAR_051988
Natural varianti1071 – 10711V → A.
Corresponds to variant rs17080410 [ dbSNP | Ensembl ].
VAR_051989
Natural varianti1321 – 13211L → S.
Corresponds to variant rs17054318 [ dbSNP | Ensembl ].
VAR_051990
Natural varianti1377 – 13771Q → P.
Corresponds to variant rs58786678 [ dbSNP | Ensembl ].
VAR_061797

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450339, AL035086 Genomic DNA. Translation: CAI12939.1.
AB033035 mRNA. Translation: BAA86523.1.
CCDSiCCDS34552.1.
RefSeqiNP_001025055.1. NM_001029884.1.
XP_005267122.1. XM_005267065.2.
XP_005267123.1. XM_005267066.1.
XP_006715584.1. XM_006715521.1.
XP_006715585.1. XM_006715522.2.
XP_011534285.1. XM_011535983.1.
UniGeneiHs.189781.

Genome annotation databases

EnsembliENST00000358517; ENSP00000351318; ENSG00000120278.
ENST00000367328; ENSP00000356297; ENSG00000120278.
GeneIDi57480.
KEGGihsa:57480.
UCSCiuc003qny.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450339, AL035086 Genomic DNA. Translation: CAI12939.1.
AB033035 mRNA. Translation: BAA86523.1.
CCDSiCCDS34552.1.
RefSeqiNP_001025055.1. NM_001029884.1.
XP_005267122.1. XM_005267065.2.
XP_005267123.1. XM_005267066.1.
XP_006715584.1. XM_006715521.1.
XP_006715585.1. XM_006715522.2.
XP_011534285.1. XM_011535983.1.
UniGeneiHs.189781.

3D structure databases

ProteinModelPortaliQ9ULL1.
SMRiQ9ULL1. Positions 117-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121550. 15 interactions.
IntActiQ9ULL1. 17 interactions.
STRINGi9606.ENSP00000351318.

PTM databases

iPTMnetiQ9ULL1.
PhosphoSiteiQ9ULL1.

Polymorphism and mutation databases

BioMutaiPLEKHG1.
DMDMi62288848.

Proteomic databases

EPDiQ9ULL1.
MaxQBiQ9ULL1.
PaxDbiQ9ULL1.
PeptideAtlasiQ9ULL1.
PRIDEiQ9ULL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358517; ENSP00000351318; ENSG00000120278.
ENST00000367328; ENSP00000356297; ENSG00000120278.
GeneIDi57480.
KEGGihsa:57480.
UCSCiuc003qny.1. human.

Organism-specific databases

CTDi57480.
GeneCardsiPLEKHG1.
H-InvDBHIX0006294.
HGNCiHGNC:20884. PLEKHG1.
HPAiHPA027319.
HPA028270.
neXtProtiNX_Q9ULL1.
PharmGKBiPA134922441.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3518. Eukaryota.
ENOG410XR81. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000115556.
HOVERGENiHBG053605.
InParanoidiQ9ULL1.
OMAiDYQMFVP.
OrthoDBiEOG7K9K2H.
PhylomeDBiQ9ULL1.
TreeFamiTF328565.

Miscellaneous databases

ChiTaRSiPLEKHG1. human.
GenomeRNAii57480.
PROiQ9ULL1.

Gene expression databases

BgeeiQ9ULL1.
CleanExiHS_PLEKHG1.
ExpressionAtlasiQ9ULL1. baseline and differential.
GenevisibleiQ9ULL1. HS.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-1385.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPKHG1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULL1
Secondary accession number(s): Q5T1F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: February 1, 2005
Last modified: July 6, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.