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Protein

RING finger protein 150

Gene

RNF150

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri278 – 319RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170153-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 150
Gene namesi
Name:RNF150
Synonyms:KIAA1214
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:23138. RNF150.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 208ExtracellularSequence analysisAdd BLAST174
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 438CytoplasmicSequence analysisAdd BLAST209

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57484.
OpenTargetsiENSG00000170153.
PharmGKBiPA134918555.

Polymorphism and mutation databases

BioMutaiRNF150.
DMDMi134035025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000028069735 – 438RING finger protein 150Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ULK6.
PeptideAtlasiQ9ULK6.
PRIDEiQ9ULK6.

PTM databases

iPTMnetiQ9ULK6.
PhosphoSitePlusiQ9ULK6.

Expressioni

Gene expression databases

BgeeiENSG00000170153.
CleanExiHS_RNF150.
ExpressionAtlasiQ9ULK6. baseline and differential.
GenevisibleiQ9ULK6. HS.

Organism-specific databases

HPAiHPA037987.

Interactioni

Protein-protein interaction databases

BioGridi121553. 13 interactors.
IntActiQ9ULK6. 10 interactors.
STRINGi9606.ENSP00000425840.

Structurei

3D structure databases

ProteinModelPortaliQ9ULK6.
SMRiQ9ULK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 183PAAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 64Poly-Gly4

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri278 – 319RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000231432.
HOVERGENiHBG057659.
InParanoidiQ9ULK6.
OMAiNNETITM.
OrthoDBiEOG091G08OR.
PhylomeDBiQ9ULK6.
TreeFamiTF317486.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMSLIQACC SLALSTWLLS FCFVHLLCLD FTVAEKEEWY TAFVNITYAE
60 70 80 90 100
PAPDPGAGAA GGGGAELHTE KTECGRYGEH SPKQDARGEV VMASSAHDRL
110 120 130 140 150
ACDPNTKFAA PTRGKNWIAL IPKGNCTYRD KIRNAFLQNA SAVVIFNVGS
160 170 180 190 200
NTNETITMPH AGVEDIVAIM IPEPKGKEIV SLLERNITVT MYITIGTRNL
210 220 230 240 250
QKYVSRTSVV FVSISFIVLM IISLAWLVFY YIQRFRYANA RDRNQRRLGD
260 270 280 290 300
AAKKAISKLQ IRTIKKGDKE TESDFDNCAV CIEGYKPNDV VRILPCRHLF
310 320 330 340 350
HKSCVDPWLL DHRTCPMCKM NILKALGIPP NADCMDDLPT DFEGSLGGPP
360 370 380 390 400
TNQITGASDT TVNESSVTLD PAVRTVGALQ VVQDTDPIPQ EGDVIFTTNS
410 420 430
EQEPAVSSDS DISLIMAMEV GLSDVELSTD QDCEEVKS
Length:438
Mass (Da):48,072
Last modified:March 20, 2007 - v2
Checksum:i12E495CD0793DF85
GO
Isoform 2 (identifier: Q9ULK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-245: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):43,046
Checksum:iFC3892867AD2F9E4
GO
Isoform 3 (identifier: Q9ULK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-405: QEPA → FCHT
     406-438: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):44,620
Checksum:i6368FD16A0BEAF27
GO
Isoform 4 (identifier: Q9ULK6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.
     142-161: AVVIFNVGSNTNETITMPHA → MSSHAQPLKLISPCPYSLSS

Show »
Length:297
Mass (Da):32,834
Checksum:i0DB0131BFC32DBDC
GO

Sequence cautioni

The sequence BAA86528 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0238431 – 141Missing in isoform 4. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_023844142 – 161AVVIF…TMPHA → MSSHAQPLKLISPCPYSLSS in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_023845204 – 245Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_023846402 – 405QEPA → FCHT in isoform 3. 1 Publication4
Alternative sequenceiVSP_023847406 – 438Missing in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033040 mRNA. Translation: BAA86528.1. Different initiation.
AK130520 mRNA. Translation: BAC85369.1.
AC093905 Genomic DNA. No translation available.
AC096733 Genomic DNA. No translation available.
AC097475 Genomic DNA. No translation available.
BC101992 mRNA. Translation: AAI01993.1.
CCDSiCCDS34065.1. [Q9ULK6-1]
RefSeqiNP_065775.1. NM_020724.1. [Q9ULK6-1]
XP_011530450.1. XM_011532148.2. [Q9ULK6-4]
UniGeneiHs.659104.

Genome annotation databases

EnsembliENST00000306799; ENSP00000304321; ENSG00000170153. [Q9ULK6-2]
ENST00000420921; ENSP00000394581; ENSG00000170153. [Q9ULK6-4]
ENST00000507500; ENSP00000425568; ENSG00000170153. [Q9ULK6-3]
ENST00000515673; ENSP00000425840; ENSG00000170153. [Q9ULK6-1]
GeneIDi57484.
KEGGihsa:57484.
UCSCiuc003iio.2. human. [Q9ULK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033040 mRNA. Translation: BAA86528.1. Different initiation.
AK130520 mRNA. Translation: BAC85369.1.
AC093905 Genomic DNA. No translation available.
AC096733 Genomic DNA. No translation available.
AC097475 Genomic DNA. No translation available.
BC101992 mRNA. Translation: AAI01993.1.
CCDSiCCDS34065.1. [Q9ULK6-1]
RefSeqiNP_065775.1. NM_020724.1. [Q9ULK6-1]
XP_011530450.1. XM_011532148.2. [Q9ULK6-4]
UniGeneiHs.659104.

3D structure databases

ProteinModelPortaliQ9ULK6.
SMRiQ9ULK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121553. 13 interactors.
IntActiQ9ULK6. 10 interactors.
STRINGi9606.ENSP00000425840.

PTM databases

iPTMnetiQ9ULK6.
PhosphoSitePlusiQ9ULK6.

Polymorphism and mutation databases

BioMutaiRNF150.
DMDMi134035025.

Proteomic databases

PaxDbiQ9ULK6.
PeptideAtlasiQ9ULK6.
PRIDEiQ9ULK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306799; ENSP00000304321; ENSG00000170153. [Q9ULK6-2]
ENST00000420921; ENSP00000394581; ENSG00000170153. [Q9ULK6-4]
ENST00000507500; ENSP00000425568; ENSG00000170153. [Q9ULK6-3]
ENST00000515673; ENSP00000425840; ENSG00000170153. [Q9ULK6-1]
GeneIDi57484.
KEGGihsa:57484.
UCSCiuc003iio.2. human. [Q9ULK6-1]

Organism-specific databases

CTDi57484.
DisGeNETi57484.
GeneCardsiRNF150.
H-InvDBHIX0024725.
HGNCiHGNC:23138. RNF150.
HPAiHPA037987.
neXtProtiNX_Q9ULK6.
OpenTargetsiENSG00000170153.
PharmGKBiPA134918555.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00760000119057.
HOGENOMiHOG000231432.
HOVERGENiHBG057659.
InParanoidiQ9ULK6.
OMAiNNETITM.
OrthoDBiEOG091G08OR.
PhylomeDBiQ9ULK6.
TreeFamiTF317486.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170153-MONOMER.

Miscellaneous databases

GenomeRNAii57484.
PROiQ9ULK6.

Gene expression databases

BgeeiENSG00000170153.
CleanExiHS_RNF150.
ExpressionAtlasiQ9ULK6. baseline and differential.
GenevisibleiQ9ULK6. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003137. PA_domain.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02225. PA. 1 hit.
PF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN150_HUMAN
AccessioniPrimary (citable) accession number: Q9ULK6
Secondary accession number(s): Q3T1D0, Q6ZNW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.