Q9ULK5 (VANG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 73.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Vang-like protein 2 Alternative name(s): Loop-tail protein 1 homolog Strabismus 1 Van Gogh-like protein 2 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 521 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process By similarity. |
| Subunit structure | Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 By similarity. |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Belongs to the Vang family. |
| Sequence caution | The sequence BAA86529.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Developmental protein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | apical protein localization Inferred from sequence or structural similarity. Source: UniProtKB heart loopingInferred from sequence or structural similarity. Source: UniProtKB nonmotile primary cilium assemblyInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | apical plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 521 | 521 | Vang-like protein 2 | PRO_0000186195 | |||||
Regions | |||||||||
| Topological domain | 1 – 108 | 108 | Cytoplasmic Potential | ||||||
| Transmembrane | 109 – 129 | 21 | Helical; Name=1; Potential | ||||||
| Topological domain | 130 – 147 | 18 | Extracellular Potential | ||||||
| Transmembrane | 148 – 168 | 21 | Helical; Name=2; Potential | ||||||
| Topological domain | 169 – 178 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 179 – 199 | 21 | Helical; Name=3; Potential | ||||||
| Topological domain | 200 – 217 | 18 | Extracellular Potential | ||||||
| Transmembrane | 218 – 238 | 21 | Helical; Name=4; Potential | ||||||
| Topological domain | 239 – 521 | 283 | Cytoplasmic Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [2] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB033041 mRNA. Translation: BAA86529.1. Different initiation. AL445230 Genomic DNA. Translation: CAI15015.1. CH471121 Genomic DNA. Translation: EAW52718.1. BC103920 mRNA. No translation available. |
| IPI | IPI00029449. |
| RefSeq | NP_065068.1. NM_020335.2. |
| UniGene | Hs.99477. |
3D structure databases | |
| ProteinModelPortal | Q9ULK5. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9ULK5. |
PTM databases | |
| PhosphoSite | Q9ULK5. |
Polymorphism databases | |
| DMDM | 38258849. |
Proteomic databases | |
| PRIDE | Q9ULK5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000368061; ENSP00000357040; ENSG00000162738. |
| GeneID | 57216. |
| KEGG | hsa:57216. |
| UCSC | uc001fwb.1. human. |
Organism-specific databases | |
| CTD | 57216. |
| GeneCards | GC01P160370. |
| HGNC | HGNC:15511. VANGL2. |
| HPA | HPA027043. |
| MIM | 600533. gene. |
| neXtProt | NX_Q9ULK5. |
| PharmGKB | PA37970. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG18863. |
| GeneTree | ENSGT00390000012496. |
| HOGENOM | HBG716583. |
| HOVERGEN | HBG058215. |
| InParanoid | Q9ULK5. |
| OMA | DMTPKAF. |
| OrthoDB | EOG4FJ88V. |
| PhylomeDB | Q9ULK5. |
Gene expression databases | |
| ArrayExpress | Q9ULK5. |
| Bgee | Q9ULK5. |
| CleanEx | HS_VANGL2. |
| Genevestigator | Q9ULK5. |
| GermOnline | ENSG00000162738. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR009539. Strabismus. [Graphical view] |
| KO | K04510. |
| PANTHER | PTHR20886. Strabismus. 1 hit. |
| Pfam | PF06638. Strabismus. 1 hit. [Graphical view] |
| PIRSF | PIRSF007991. Strabismus. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 63337. |
| SOURCE | Search... |
Entry information
| Entry name | VANG2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9ULK5 Secondary accession number(s): D3DVE9, Q5T212 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with