Q9ULK4 (MED23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 23

Alternative name(s):
Activator-recruited cofactor 130 kDa component
Short name=ARC130
Cofactor required for Sp1 transcriptional activation subunit 3
Short name=CRSP complex subunit 3
Mediator complex subunit 23
Protein sur-2 homolog
Short name=hSur-2
Transcriptional coactivator CRSP130
Vitamin D3 receptor-interacting protein complex 130 kDa component
Short name=DRIP130

Gene names

Name:	MED23
Synonyms:	ARC130, CRSP3, DRIP130, KIAA1216, SUR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1368 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for transcriptional activation subsequent to the assembly of the preinitiation complex By similarity. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. Ref.2 Ref.12 Ref.16
Subunit structure	Interacts with ELK1 By similarity. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein. Ref.1 Ref.2 Ref.3 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16
Subcellular location	Nucleus Probable.
Involvement in disease	Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18
Sequence similarities	Belongs to the Mediator complex subunit 23 family.
Sequence caution	The sequence AAD12724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAD31729.1 differs from that shown. Reason: Frameshift at positions 945 and 950. The sequence BAA86530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Disease	Disease mutation Mental retardation
Molecular function	Activator
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.3. Source: ProtInc transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome
Cellular_component	mediator complex Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from direct assay Ref.3. Source: MGI
Molecular_function	transcription coactivator activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9ULK4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULK4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     292-292: Q → QTLNIAQ
     870-880: AMRSHEGNEAQ → VRINTFLSLFS
     881-1368: Missing.

Isoform 3 (identifier: Q9ULK4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     292-292: Q → QTLNIAQ
     1360-1368: Missing.

Isoform 4 (identifier: Q9ULK4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1360-1368: Missing.

Isoform 5 (identifier: Q9ULK4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1361-1368: PVSLPVTQ → DTLT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1368	1368	Mediator of RNA polymerase II transcription subunit 23		PRO_0000079358
Natural variations
	Alternative sequence	292	1	Q → QTLNIAQ in isoform 2 and isoform 3.		VSP_004034
	Alternative sequence	870 – 880	11	AMRSHEGNEAQ → VRINTFLSLFS in isoform 2.		VSP_004036
	Alternative sequence	881 – 1368	488	Missing in isoform 2.		VSP_004037
	Alternative sequence	1360 – 1368	9	Missing in isoform 3 and isoform 4.		VSP_004035
	Alternative sequence	1361 – 1368	8	PVSLPVTQ → DTLT in isoform 5.		VSP_028380
	Natural variant	617	1	P → Q in MRT18; specifically impairs the response of JUN and FOS immediate early genes to serum mitogens by altering the interaction between enhancer-bound transcription factors (TCF7L2 and ELK1 respectively) and Mediator complex. Ref.18		VAR_066596
Experimental info
	Sequence conflict	59	1	C → W in AAH60759. Ref.8
	Sequence conflict	131	1	Y → N in AAD31729. Ref.1
	Sequence conflict	208	1	F → V in AAD30202. Ref.2
	Sequence conflict	230	1	V → E in AAD30202. Ref.2
	Sequence conflict	464	1	N → H in AAD30202. Ref.2
	Sequence conflict	488	1	F → V in AAD30202. Ref.2
	Sequence conflict	507	1	I → L in AAD30202. Ref.2
	Sequence conflict	518	1	G → A in AAD30202. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 22, 2003. Version 2. Checksum: 2BEE9FF5E328477D	FASTA	1,368	156,474
	10 20 30 40 50 60 METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG LSQESHEQCI 70 80 90 100 110 120 QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES LINSDTLEWE RTQLWALTFK 130 140 150 160 170 180 LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA 190 200 210 220 230 240 YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS 250 260 270 280 290 300 WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL 310 320 330 340 350 360 EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP HMVLSLHQKL 370 380 390 400 410 420 AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD LLYPEKEYIP VPDINKPQST 430 440 450 460 470 480 HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS LRLHHEFLQQ SLRNKSLQMN DYKIALLCNA 490 500 510 520 530 540 YSTNSECFTL PMGALVETIY GNGIMRIPLP GTNCMASGSI TPLPMNLLDS LTVHAKMSLI 550 560 570 580 590 600 HSIATRVIKL AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI 610 620 630 640 650 660 LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL RLITALGSSE 670 680 690 700 710 720 VQPQFTRFLS DPKTVLSAES EELNRALILT LARATHVTDF FTGSDSIQGT WCKDILQTIM 730 740 750 760 770 780 SFTPHNWASH TLSCFPGPLQ AFFKQNNVPQ ESRFNLKKNV EEEYRKWKSM SNENDIITHF 790 800 810 820 830 840 SMQGSPPLFL CLLWKMLLET DHINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG 850 860 870 880 890 900 QQLNKCIEIL NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV 910 920 930 940 950 960 SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VDPPVQIQSP YLPIYFGNVC 970 980 990 1000 1010 1020 LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR PVTYLYNTLH YYEMHLRDRA 1030 1040 1050 1060 1070 1080 FLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK CAMNAREENP WVPDDTYYCR LIGRLVDTMA 1090 1100 1110 1120 1130 1140 GKSPGPFPNC DWRFNEFPNP AAHALHVTCV ELMALAVSGK EVGNALLNVV LKSQPLVPRE 1150 1160 1170 1180 1190 1200 NITAWMNAIG LIITALPEPY WIVLHDRIVS VISSPSLTSE TEWVGYPFRL FDFTACHQSY 1210 1220 1230 1240 1250 1260 SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPIVK TEFQLLYVYH LVGPFLQRFQ 1270 1280 1290 1300 1310 1320 QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH MKYMFTGDSV KEQVEKIICN 1330 1340 1350 1360 LKPALKLRLR FITHISKMEP AAVPPQAMNS GSPAPQSNQV PVSLPVTQ
	Isoform 2 [UniParc]. Checksum: F1461C27AF9D7817	FASTA	886	100,834
	10 20 30 40 50 60 METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG LSQESHEQCI 70 80 90 100 110 120 QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES LINSDTLEWE RTQLWALTFK 130 140 150 160 170 180 LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA 190 200 210 220 230 240 YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS 250 260 270 280 290 300 WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQTLNIAQHK 310 320 330 340 350 360 QRCPVLEDQL VDLVVYAMER SETEEKFDDG GTSQLLWQHL SSQLIFFVLF QFASFPHMVL 370 380 390 400 410 420 SLHQKLAGRG LIKGRDHLMW VLLQFISGSI QKNALADFLP VMKLFDLLYP EKEYIPVPDI 430 440 450 460 470 480 NKPQSTHAFA MTCIWIHLNR KAQNDNSKLQ IPIPHSLRLH HEFLQQSLRN KSLQMNDYKI 490 500 510 520 530 540 ALLCNAYSTN SECFTLPMGA LVETIYGNGI MRIPLPGTNC MASGSITPLP MNLLDSLTVH 550 560 570 580 590 600 AKMSLIHSIA TRVIKLAHAK SSVALAPALV ETYSRLLVYM EIESLGIKGF ISQLLPTVFK 610 620 630 640 650 660 SHAWGILHTL LEMFSYRMHH IQPHYRVQLL SHLHTLAAVA QTNQNQLHLC VESTALRLIT 670 680 690 700 710 720 ALGSSEVQPQ FTRFLSDPKT VLSAESEELN RALILTLARA THVTDFFTGS DSIQGTWCKD 730 740 750 760 770 780 ILQTIMSFTP HNWASHTLSC FPGPLQAFFK QNNVPQESRF NLKKNVEEEY RKWKSMSNEN 790 800 810 820 830 840 DIITHFSMQG SPPLFLCLLW KMLLETDHIN QIGYRVLERI GARALVAHVR TFADFLVYEF 850 860 870 880 STSAGGQQLN KCIEILNDMV WKYNIVTLDR LILCLVRINT FLSLFS
	Isoform 3 [UniParc]. Checksum: 8F401B9FF90878C3	FASTA	1,365	156,194
	10 20 30 40 50 60 METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG LSQESHEQCI 70 80 90 100 110 120 QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES LINSDTLEWE RTQLWALTFK 130 140 150 160 170 180 LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA 190 200 210 220 230 240 YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS 250 260 270 280 290 300 WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQTLNIAQHK 310 320 330 340 350 360 QRCPVLEDQL VDLVVYAMER SETEEKFDDG GTSQLLWQHL SSQLIFFVLF QFASFPHMVL 370 380 390 400 410 420 SLHQKLAGRG LIKGRDHLMW VLLQFISGSI QKNALADFLP VMKLFDLLYP EKEYIPVPDI 430 440 450 460 470 480 NKPQSTHAFA MTCIWIHLNR KAQNDNSKLQ IPIPHSLRLH HEFLQQSLRN KSLQMNDYKI 490 500 510 520 530 540 ALLCNAYSTN SECFTLPMGA LVETIYGNGI MRIPLPGTNC MASGSITPLP MNLLDSLTVH 550 560 570 580 590 600 AKMSLIHSIA TRVIKLAHAK SSVALAPALV ETYSRLLVYM EIESLGIKGF ISQLLPTVFK 610 620 630 640 650 660 SHAWGILHTL LEMFSYRMHH IQPHYRVQLL SHLHTLAAVA QTNQNQLHLC VESTALRLIT 670 680 690 700 710 720 ALGSSEVQPQ FTRFLSDPKT VLSAESEELN RALILTLARA THVTDFFTGS DSIQGTWCKD 730 740 750 760 770 780 ILQTIMSFTP HNWASHTLSC FPGPLQAFFK QNNVPQESRF NLKKNVEEEY RKWKSMSNEN 790 800 810 820 830 840 DIITHFSMQG SPPLFLCLLW KMLLETDHIN QIGYRVLERI GARALVAHVR TFADFLVYEF 850 860 870 880 890 900 STSAGGQQLN KCIEILNDMV WKYNIVTLDR LILCLAMRSH EGNEAQVCYF IIQLLLLKPN 910 920 930 940 950 960 DFRNRVSDFV KENSPEHWLQ NDWHTKHMNY HKKYPEKLYF EGLAEQVDPP VQIQSPYLPI 970 980 990 1000 1010 1020 YFGNVCLRFL PVFDIVIHRF LELLPVSKSL ETLLDHLGGL YKFHDRPVTY LYNTLHYYEM 1030 1040 1050 1060 1070 1080 HLRDRAFLKR KLVHAIIGSL KDNRPQGWCL SDTYLKCAMN AREENPWVPD DTYYCRLIGR 1090 1100 1110 1120 1130 1140 LVDTMAGKSP GPFPNCDWRF NEFPNPAAHA LHVTCVELMA LAVSGKEVGN ALLNVVLKSQ 1150 1160 1170 1180 1190 1200 PLVPRENITA WMNAIGLIIT ALPEPYWIVL HDRIVSVISS PSLTSETEWV GYPFRLFDFT 1210 1220 1230 1240 1250 1260 ACHQSYSEMS CSYTLALAHA VWHHSSIGQL SLIPKFLTEV LLPIVKTEFQ LLYVYHLVGP 1270 1280 1290 1300 1310 1320 FLQRFQQERT RCMIEIGVAF YDMLLNVDQC STHLNYMDPI CDFLYHMKYM FTGDSVKEQV 1330 1340 1350 1360 EKIICNLKPA LKLRLRFITH ISKMEPAAVP PQAMNSGSPA PQSNQ
	Isoform 4 [UniParc]. Checksum: E6EB563FEBC111DE	FASTA	1,359	155,553
	10 20 30 40 50 60 METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG LSQESHEQCI 70 80 90 100 110 120 QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES LINSDTLEWE RTQLWALTFK 130 140 150 160 170 180 LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA 190 200 210 220 230 240 YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS 250 260 270 280 290 300 WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL 310 320 330 340 350 360 EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP HMVLSLHQKL 370 380 390 400 410 420 AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD LLYPEKEYIP VPDINKPQST 430 440 450 460 470 480 HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS LRLHHEFLQQ SLRNKSLQMN DYKIALLCNA 490 500 510 520 530 540 YSTNSECFTL PMGALVETIY GNGIMRIPLP GTNCMASGSI TPLPMNLLDS LTVHAKMSLI 550 560 570 580 590 600 HSIATRVIKL AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI 610 620 630 640 650 660 LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL RLITALGSSE 670 680 690 700 710 720 VQPQFTRFLS DPKTVLSAES EELNRALILT LARATHVTDF FTGSDSIQGT WCKDILQTIM 730 740 750 760 770 780 SFTPHNWASH TLSCFPGPLQ AFFKQNNVPQ ESRFNLKKNV EEEYRKWKSM SNENDIITHF 790 800 810 820 830 840 SMQGSPPLFL CLLWKMLLET DHINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG 850 860 870 880 890 900 QQLNKCIEIL NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV 910 920 930 940 950 960 SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VDPPVQIQSP YLPIYFGNVC 970 980 990 1000 1010 1020 LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR PVTYLYNTLH YYEMHLRDRA 1030 1040 1050 1060 1070 1080 FLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK CAMNAREENP WVPDDTYYCR LIGRLVDTMA 1090 1100 1110 1120 1130 1140 GKSPGPFPNC DWRFNEFPNP AAHALHVTCV ELMALAVSGK EVGNALLNVV LKSQPLVPRE 1150 1160 1170 1180 1190 1200 NITAWMNAIG LIITALPEPY WIVLHDRIVS VISSPSLTSE TEWVGYPFRL FDFTACHQSY 1210 1220 1230 1240 1250 1260 SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPIVK TEFQLLYVYH LVGPFLQRFQ 1270 1280 1290 1300 1310 1320 QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH MKYMFTGDSV KEQVEKIICN 1330 1340 1350 LKPALKLRLR FITHISKMEP AAVPPQAMNS GSPAPQSNQ
	Isoform 5 [UniParc]. Checksum: 55BAD400A566EB56	FASTA	1,364	156,082
	10 20 30 40 50 60 METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG LSQESHEQCI 70 80 90 100 110 120 QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES LINSDTLEWE RTQLWALTFK 130 140 150 160 170 180 LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA 190 200 210 220 230 240 YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS 250 260 270 280 290 300 WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL 310 320 330 340 350 360 EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP HMVLSLHQKL 370 380 390 400 410 420 AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD LLYPEKEYIP VPDINKPQST 430 440 450 460 470 480 HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS LRLHHEFLQQ SLRNKSLQMN DYKIALLCNA 490 500 510 520 530 540 YSTNSECFTL PMGALVETIY GNGIMRIPLP GTNCMASGSI TPLPMNLLDS LTVHAKMSLI 550 560 570 580 590 600 HSIATRVIKL AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI 610 620 630 640 650 660 LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL RLITALGSSE 670 680 690 700 710 720 VQPQFTRFLS DPKTVLSAES EELNRALILT LARATHVTDF FTGSDSIQGT WCKDILQTIM 730 740 750 760 770 780 SFTPHNWASH TLSCFPGPLQ AFFKQNNVPQ ESRFNLKKNV EEEYRKWKSM SNENDIITHF 790 800 810 820 830 840 SMQGSPPLFL CLLWKMLLET DHINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG 850 860 870 880 890 900 QQLNKCIEIL NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV 910 920 930 940 950 960 SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VDPPVQIQSP YLPIYFGNVC 970 980 990 1000 1010 1020 LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR PVTYLYNTLH YYEMHLRDRA 1030 1040 1050 1060 1070 1080 FLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK CAMNAREENP WVPDDTYYCR LIGRLVDTMA 1090 1100 1110 1120 1130 1140 GKSPGPFPNC DWRFNEFPNP AAHALHVTCV ELMALAVSGK EVGNALLNVV LKSQPLVPRE 1150 1160 1170 1180 1190 1200 NITAWMNAIG LIITALPEPY WIVLHDRIVS VISSPSLTSE TEWVGYPFRL FDFTACHQSY 1210 1220 1230 1240 1250 1260 SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPIVK TEFQLLYVYH LVGPFLQRFQ 1270 1280 1290 1300 1310 1320 QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH MKYMFTGDSV KEQVEKIICN 1330 1340 1350 1360 LKPALKLRLR FITHISKMEP AAVPPQAMNS GSPAPQSNQV DTLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex." Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M., Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P. Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 254-280; 1317-1326 AND 1331-1337, IDENTIFICATION IN ARC COMPLEX. Tissue: Cervix carcinoma.
[2]	"Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein." Boyer T.G., Martin M.E.D., Lees E., Ricciardi R.P., Berk A.J. Nature 399:276-279(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH E1A AND CDK8.
[3]	"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1." Ryu S., Zhou S., Ladurner A.G., Tjian R. Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION IN THE CRSP COMPLEX.
[4]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Placenta.
[9]	"Composite co-activator ARC mediates chromatin-directed transcriptional activation." Naeaer A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W.B., Tjian R. Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE ARC COMPLEX, PROTEIN SEQUENCE OF 465-473 AND 1302-1311.
[10]	"TFIIH is negatively regulated by cdk8-containing mediator complexes." Akoulitchev S., Chuikov S., Reinberg D. Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MED6.
[11]	"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro." Kang Y.K., Guermah M., Yuan C.-X., Roeder R.G. Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
[12]	"Ras induces mediator complex exchange on C/EBP beta." Mo X., Kowenz-Leutz E., Xu H., Leutz A. Mol. Cell 13:241-250(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CEBPB.
[13]	"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C. Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
[14]	"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription." Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G. Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MED1 AND MED10, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
[15]	"Mediator modulates Gli3-dependent Sonic hedgehog signaling." Zhou H., Kim S., Ishii S., Boyer T.G. Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CDK8; CTNNB1 AND GLI3.
[16]	"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly." Baek H.J., Kang Y.K., Roeder R.G. J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MED1 AND MED10.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]	"MED23 mutation links intellectual disability to dysregulation of immediate early gene expression." Hashimoto S., Boissel S., Zarhrate M., Rio M., Munnich A., Egly J.M., Colleaux L. Science 333:1161-1163(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MRT18 GLN-617, CHARACTERIZATION OF VARIANT MRT18 GLN-617.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF105332 mRNA. Translation: AAD31729.1. Frameshift. AF135022 mRNA. Translation: AAD30202.1. AF104255 mRNA. Translation: AAD12724.1. Different initiation. AB033042 mRNA. Translation: BAA86530.1. Different initiation. AL136776 mRNA. Translation: CAB66710.1. AL121575 Genomic DNA. Translation: CAB92072.1. AL121575 Genomic DNA. Translation: CAB92073.1. AL121575 Genomic DNA. Translation: CAI23319.1. AL121575 Genomic DNA. Translation: CAI23320.1. CH471051 Genomic DNA. Translation: EAW48052.1. BC060759 mRNA. Translation: AAH60759.1.
IPI	IPI00413272. IPI00472333. IPI00646226. IPI00844220. IPI00867654.
RefSeq	NP_001257450.1. NM_001270521.1. NP_001257451.1. NM_001270522.1. NP_004821.2. NM_004830.3. NP_057063.2. NM_015979.3.
UniGene	Hs.29679.
3D structure databases
ProteinModelPortal	Q9ULK4.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31461N.
IntAct	Q9ULK4. 16 interactions.
MINT	MINT-4719443.
PTM databases
PhosphoSite	Q9ULK4.
Polymorphism databases
DMDM	28558074.
Proteomic databases
PaxDb	Q9ULK4.
PRIDE	Q9ULK4.
Protocols and materials databases
DNASU	9439.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354577; ENSP00000346588; ENSG00000112282. ENST00000368053; ENSP00000357032; ENSG00000112282. ENST00000368060; ENSP00000357039; ENSG00000112282. ENST00000368068; ENSP00000357047; ENSG00000112282.
GeneID	9439.
KEGG	hsa:9439.
UCSC	uc003qcq.3. human. uc003qcs.1. human. uc003qct.1. human.
Organism-specific databases
CTD	9439.
GeneCards	GC06M131895.
HGNC	HGNC:2372. MED23.
MIM	605042. gene. 614249. phenotype.
neXtProt	NX_Q9ULK4.
Orphanet	88616. Autosomal recessive nonsyndromic intellectual deficit.
PharmGKB	PA162395499.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG305557.
HOVERGEN	HBG051122.
KO	K15166.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9ULK4.
Bgee	Q9ULK4.
Genevestigator	Q9ULK4.
GermOnline	ENSG00000112282. Homo sapiens.
Family and domain databases
InterPro	IPR021629. Mediator_Med23. [Graphical view]
Pfam	PF11573. Med23. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9ULK4.
ChEMBL	CHEMBL4146.
ChiTaRS	MED23. human.
GenomeRNAi	9439.
NextBio	35344.
SOURCE	Search...

Entry information

Entry name

MED23_HUMAN

Accession

Primary (citable) accession number: Q9ULK4
Secondary accession number(s): O95403 , Q5JWT3, Q5JWT4, Q6P9H6, Q9H0J2, Q9NTT9, Q9NTU0, Q9Y5P7, Q9Y667

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 22, 2003
Last sequence update:	February 22, 2003
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.