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Q9ULK4

- MED23_HUMAN

UniProt

Q9ULK4 - MED23_HUMAN

Protein

Mediator of RNA polymerase II transcription subunit 23

Gene

MED23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (22 Feb 2003)
      Previous versions | rss
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    Functioni

    Required for transcriptional activation subsequent to the assembly of the preinitiation complex By similarity. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.By similarity3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. regulation of transcription, DNA-templated Source: MGI
    3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    4. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_12627. Generic Transcription Pathway.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 23
    Alternative name(s):
    Activator-recruited cofactor 130 kDa component
    Short name:
    ARC130
    Cofactor required for Sp1 transcriptional activation subunit 3
    Short name:
    CRSP complex subunit 3
    Mediator complex subunit 23
    Protein sur-2 homolog
    Short name:
    hSur-2
    Transcriptional coactivator CRSP130
    Vitamin D3 receptor-interacting protein complex 130 kDa component
    Short name:
    DRIP130
    Gene namesi
    Name:MED23
    Synonyms:ARC130, CRSP3, DRIP130, KIAA1216, SUR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:2372. MED23.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. mediator complex Source: Ensembl
    2. nucleoplasm Source: Reactome
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti617 – 6171P → Q in MRT18; specifically impairs the response of JUN and FOS immediate early genes to serum mitogens by altering the interaction between enhancer-bound transcription factors (TCF7L2 and ELK1 respectively) and Mediator complex. 1 Publication
    VAR_066596

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi614249. phenotype.
    Orphaneti88616. Autosomal recessive nonsyndromic intellectual disability.
    PharmGKBiPA162395499.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13681368Mediator of RNA polymerase II transcription subunit 23PRO_0000079358Add
    BLAST

    Proteomic databases

    MaxQBiQ9ULK4.
    PaxDbiQ9ULK4.
    PRIDEiQ9ULK4.

    PTM databases

    PhosphoSiteiQ9ULK4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULK4.
    BgeeiQ9ULK4.
    GenevestigatoriQ9ULK4.

    Interactioni

    Subunit structurei

    Interacts with ELK1 By similarity. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein.By similarity11 Publications

    Protein-protein interaction databases

    BioGridi114829. 47 interactions.
    DIPiDIP-31461N.
    IntActiQ9ULK4. 20 interactions.
    MINTiMINT-4719443.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULK4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Mediator complex subunit 23 family.Curated

    Phylogenomic databases

    eggNOGiNOG305557.
    HOVERGENiHBG051122.
    KOiK15166.
    OrthoDBiEOG7CCBQ5.
    PhylomeDBiQ9ULK4.
    TreeFamiTF324163.

    Family and domain databases

    InterProiIPR021629. Mediator_Med23.
    [Graphical view]
    PfamiPF11573. Med23. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q9ULK4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG     50
    LSQESHEQCI QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES 100
    LINSDTLEWE RTQLWALTFK LVRKIIGGVD YKGVRDLLKV ILEKILTIPN 150
    TVSSAVVQQL LAAREVIAYI LERNACLLPA YFAVTEIRKL YPEGKLPHWL 200
    LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS WKLDPATLRF 250
    PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL 300
    EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP 350
    HMVLSLHQKL AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD 400
    LLYPEKEYIP VPDINKPQST HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS 450
    LRLHHEFLQQ SLRNKSLQMN DYKIALLCNA YSTNSECFTL PMGALVETIY 500
    GNGIMRIPLP GTNCMASGSI TPLPMNLLDS LTVHAKMSLI HSIATRVIKL 550
    AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI 600
    LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL 650
    RLITALGSSE VQPQFTRFLS DPKTVLSAES EELNRALILT LARATHVTDF 700
    FTGSDSIQGT WCKDILQTIM SFTPHNWASH TLSCFPGPLQ AFFKQNNVPQ 750
    ESRFNLKKNV EEEYRKWKSM SNENDIITHF SMQGSPPLFL CLLWKMLLET 800
    DHINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG QQLNKCIEIL 850
    NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV 900
    SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VDPPVQIQSP 950
    YLPIYFGNVC LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR 1000
    PVTYLYNTLH YYEMHLRDRA FLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK 1050
    CAMNAREENP WVPDDTYYCR LIGRLVDTMA GKSPGPFPNC DWRFNEFPNP 1100
    AAHALHVTCV ELMALAVSGK EVGNALLNVV LKSQPLVPRE NITAWMNAIG 1150
    LIITALPEPY WIVLHDRIVS VISSPSLTSE TEWVGYPFRL FDFTACHQSY 1200
    SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPIVK TEFQLLYVYH 1250
    LVGPFLQRFQ QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH 1300
    MKYMFTGDSV KEQVEKIICN LKPALKLRLR FITHISKMEP AAVPPQAMNS 1350
    GSPAPQSNQV PVSLPVTQ 1368
    Length:1,368
    Mass (Da):156,474
    Last modified:February 22, 2003 - v2
    Checksum:i2BEE9FF5E328477D
    GO
    Isoform 2 (identifier: Q9ULK4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         292-292: Q → QTLNIAQ
         870-880: AMRSHEGNEAQ → VRINTFLSLFS
         881-1368: Missing.

    Show »
    Length:886
    Mass (Da):100,834
    Checksum:iF1461C27AF9D7817
    GO
    Isoform 3 (identifier: Q9ULK4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         292-292: Q → QTLNIAQ
         1360-1368: Missing.

    Show »
    Length:1,365
    Mass (Da):156,194
    Checksum:i8F401B9FF90878C3
    GO
    Isoform 4 (identifier: Q9ULK4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1360-1368: Missing.

    Show »
    Length:1,359
    Mass (Da):155,553
    Checksum:iE6EB563FEBC111DE
    GO
    Isoform 5 (identifier: Q9ULK4-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1361-1368: PVSLPVTQ → DTLT

    Show »
    Length:1,364
    Mass (Da):156,082
    Checksum:i55BAD400A566EB56
    GO
    Isoform 6 (identifier: Q9ULK4-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         457-475: FLQQSLRNKSLQMNDYKIA → SAFANCFQITCMGDLTHTP
         476-1368: Missing.

    Show »
    Length:475
    Mass (Da):54,314
    Checksum:i3621AC3036B0F0B5
    GO

    Sequence cautioni

    The sequence AAD31729.1 differs from that shown. Reason: Frameshift at positions 945 and 950.
    The sequence AAD12724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAA86530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591C → W in AAH60759. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311Y → N in AAD31729. (PubMed:10235266)Curated
    Sequence conflicti208 – 2081F → V in AAD30202. (PubMed:10353252)Curated
    Sequence conflicti230 – 2301V → E in AAD30202. (PubMed:10353252)Curated
    Sequence conflicti464 – 4641N → H in AAD30202. (PubMed:10353252)Curated
    Sequence conflicti488 – 4881F → V in AAD30202. (PubMed:10353252)Curated
    Sequence conflicti507 – 5071I → L in AAD30202. (PubMed:10353252)Curated
    Sequence conflicti518 – 5181G → A in AAD30202. (PubMed:10353252)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti617 – 6171P → Q in MRT18; specifically impairs the response of JUN and FOS immediate early genes to serum mitogens by altering the interaction between enhancer-bound transcription factors (TCF7L2 and ELK1 respectively) and Mediator complex. 1 Publication
    VAR_066596

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei292 – 2921Q → QTLNIAQ in isoform 2 and isoform 3. 2 PublicationsVSP_004034
    Alternative sequencei457 – 47519FLQQS…DYKIA → SAFANCFQITCMGDLTHTP in isoform 6. 1 PublicationVSP_047860Add
    BLAST
    Alternative sequencei476 – 1368893Missing in isoform 6. 1 PublicationVSP_047861Add
    BLAST
    Alternative sequencei870 – 88011AMRSHEGNEAQ → VRINTFLSLFS in isoform 2. 1 PublicationVSP_004036Add
    BLAST
    Alternative sequencei881 – 1368488Missing in isoform 2. 1 PublicationVSP_004037Add
    BLAST
    Alternative sequencei1360 – 13689Missing in isoform 3 and isoform 4. 2 PublicationsVSP_004035
    Alternative sequencei1361 – 13688PVSLPVTQ → DTLT in isoform 5. 1 PublicationVSP_028380

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105332 mRNA. Translation: AAD31729.1. Frameshift.
    AF135022 mRNA. Translation: AAD30202.1.
    AF104255 mRNA. Translation: AAD12724.1. Different initiation.
    EU392526 mRNA. Translation: ACB88854.1.
    AB033042 mRNA. Translation: BAA86530.1. Different initiation.
    AL136776 mRNA. Translation: CAB66710.1.
    AL121575 Genomic DNA. Translation: CAB92072.1.
    AL121575 Genomic DNA. Translation: CAB92073.1.
    AL121575 Genomic DNA. Translation: CAI23319.1.
    AL121575 Genomic DNA. Translation: CAI23320.1.
    CH471051 Genomic DNA. Translation: EAW48052.1.
    BC060759 mRNA. Translation: AAH60759.1.
    CCDSiCCDS5146.1. [Q9ULK4-3]
    CCDS5147.1. [Q9ULK4-1]
    CCDS59039.1. [Q9ULK4-5]
    RefSeqiNP_001257450.1. NM_001270521.1. [Q9ULK4-4]
    NP_001257451.1. NM_001270522.1. [Q9ULK4-5]
    NP_004821.2. NM_004830.3. [Q9ULK4-1]
    NP_057063.2. NM_015979.3. [Q9ULK4-3]
    UniGeneiHs.29679.

    Genome annotation databases

    EnsembliENST00000354577; ENSP00000346588; ENSG00000112282. [Q9ULK4-3]
    ENST00000368053; ENSP00000357032; ENSG00000112282. [Q9ULK4-2]
    ENST00000368060; ENSP00000357039; ENSG00000112282. [Q9ULK4-5]
    ENST00000368068; ENSP00000357047; ENSG00000112282. [Q9ULK4-1]
    ENST00000539158; ENSP00000445072; ENSG00000112282. [Q9ULK4-6]
    GeneIDi9439.
    KEGGihsa:9439.
    UCSCiuc003qcq.4. human. [Q9ULK4-3]
    uc003qcs.2. human. [Q9ULK4-1]
    uc003qct.2. human. [Q9ULK4-2]
    uc031spr.1. human. [Q9ULK4-5]

    Polymorphism databases

    DMDMi28558074.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105332 mRNA. Translation: AAD31729.1 . Frameshift.
    AF135022 mRNA. Translation: AAD30202.1 .
    AF104255 mRNA. Translation: AAD12724.1 . Different initiation.
    EU392526 mRNA. Translation: ACB88854.1 .
    AB033042 mRNA. Translation: BAA86530.1 . Different initiation.
    AL136776 mRNA. Translation: CAB66710.1 .
    AL121575 Genomic DNA. Translation: CAB92072.1 .
    AL121575 Genomic DNA. Translation: CAB92073.1 .
    AL121575 Genomic DNA. Translation: CAI23319.1 .
    AL121575 Genomic DNA. Translation: CAI23320.1 .
    CH471051 Genomic DNA. Translation: EAW48052.1 .
    BC060759 mRNA. Translation: AAH60759.1 .
    CCDSi CCDS5146.1. [Q9ULK4-3 ]
    CCDS5147.1. [Q9ULK4-1 ]
    CCDS59039.1. [Q9ULK4-5 ]
    RefSeqi NP_001257450.1. NM_001270521.1. [Q9ULK4-4 ]
    NP_001257451.1. NM_001270522.1. [Q9ULK4-5 ]
    NP_004821.2. NM_004830.3. [Q9ULK4-1 ]
    NP_057063.2. NM_015979.3. [Q9ULK4-3 ]
    UniGenei Hs.29679.

    3D structure databases

    ProteinModelPortali Q9ULK4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114829. 47 interactions.
    DIPi DIP-31461N.
    IntActi Q9ULK4. 20 interactions.
    MINTi MINT-4719443.

    Chemistry

    BindingDBi Q9ULK4.
    ChEMBLi CHEMBL4146.

    PTM databases

    PhosphoSitei Q9ULK4.

    Polymorphism databases

    DMDMi 28558074.

    Proteomic databases

    MaxQBi Q9ULK4.
    PaxDbi Q9ULK4.
    PRIDEi Q9ULK4.

    Protocols and materials databases

    DNASUi 9439.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354577 ; ENSP00000346588 ; ENSG00000112282 . [Q9ULK4-3 ]
    ENST00000368053 ; ENSP00000357032 ; ENSG00000112282 . [Q9ULK4-2 ]
    ENST00000368060 ; ENSP00000357039 ; ENSG00000112282 . [Q9ULK4-5 ]
    ENST00000368068 ; ENSP00000357047 ; ENSG00000112282 . [Q9ULK4-1 ]
    ENST00000539158 ; ENSP00000445072 ; ENSG00000112282 . [Q9ULK4-6 ]
    GeneIDi 9439.
    KEGGi hsa:9439.
    UCSCi uc003qcq.4. human. [Q9ULK4-3 ]
    uc003qcs.2. human. [Q9ULK4-1 ]
    uc003qct.2. human. [Q9ULK4-2 ]
    uc031spr.1. human. [Q9ULK4-5 ]

    Organism-specific databases

    CTDi 9439.
    GeneCardsi GC06M131895.
    HGNCi HGNC:2372. MED23.
    MIMi 605042. gene.
    614249. phenotype.
    neXtProti NX_Q9ULK4.
    Orphaneti 88616. Autosomal recessive nonsyndromic intellectual disability.
    PharmGKBi PA162395499.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG305557.
    HOVERGENi HBG051122.
    KOi K15166.
    OrthoDBi EOG7CCBQ5.
    PhylomeDBi Q9ULK4.
    TreeFami TF324163.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_12627. Generic Transcription Pathway.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Miscellaneous databases

    ChiTaRSi MED23. human.
    GeneWikii CRSP3.
    GenomeRNAii 9439.
    NextBioi 35344.
    PROi Q9ULK4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULK4.
    Bgeei Q9ULK4.
    Genevestigatori Q9ULK4.

    Family and domain databases

    InterProi IPR021629. Mediator_Med23.
    [Graphical view ]
    Pfami PF11573. Med23. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
      Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M., Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P.
      Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 254-280; 1317-1326 AND 1331-1337, IDENTIFICATION IN ARC COMPLEX.
      Tissue: Cervix carcinoma.
    2. "Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein."
      Boyer T.G., Martin M.E.D., Lees E., Ricciardi R.P., Berk A.J.
      Nature 399:276-279(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH E1A AND CDK8.
    3. "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
      Ryu S., Zhou S., Ladurner A.G., Tjian R.
      Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION IN THE CRSP COMPLEX.
    4. "Alternative splicing as a prevalent mechanism in regulating mammalian mediator tail subcomplex activity."
      Kivil A., Kazantseva A., Vinkel K.J.M., Sadam H., Neuman T., Palm K.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    5. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    7. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta.
    10. "Composite co-activator ARC mediates chromatin-directed transcriptional activation."
      Naeaer A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W.B., Tjian R.
      Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE ARC COMPLEX, PROTEIN SEQUENCE OF 465-473 AND 1302-1311.
    11. "TFIIH is negatively regulated by cdk8-containing mediator complexes."
      Akoulitchev S., Chuikov S., Reinberg D.
      Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MED6.
    12. "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
      Kang Y.K., Guermah M., Yuan C.-X., Roeder R.G.
      Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
    13. "Ras induces mediator complex exchange on C/EBP beta."
      Mo X., Kowenz-Leutz E., Xu H., Leutz A.
      Mol. Cell 13:241-250(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CEBPB.
    14. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
      Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
    15. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G.
      Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MED1 AND MED10, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
    16. "Mediator modulates Gli3-dependent Sonic hedgehog signaling."
      Zhou H., Kim S., Ishii S., Boyer T.G.
      Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDK8; CTNNB1 AND GLI3.
    17. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
      Baek H.J., Kang Y.K., Roeder R.G.
      J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MED1 AND MED10.
    18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "MED23 mutation links intellectual disability to dysregulation of immediate early gene expression."
      Hashimoto S., Boissel S., Zarhrate M., Rio M., Munnich A., Egly J.M., Colleaux L.
      Science 333:1161-1163(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MRT18 GLN-617, CHARACTERIZATION OF VARIANT MRT18 GLN-617.

    Entry informationi

    Entry nameiMED23_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULK4
    Secondary accession number(s): B9TX55
    , O95403, Q5JWT3, Q5JWT4, Q6P9H6, Q9H0J2, Q9NTT9, Q9NTU0, Q9Y5P7, Q9Y667
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: February 22, 2003
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3