Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ULK4 (MED23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mediator of RNA polymerase II transcription subunit 23
Alternative name(s):
Activator-recruited cofactor 130 kDa component
Short name=ARC130
Cofactor required for Sp1 transcriptional activation subunit 3
Short name=CRSP complex subunit 3
Mediator complex subunit 23
Protein sur-2 homolog
Short name=hSur-2
Transcriptional coactivator CRSP130
Vitamin D3 receptor-interacting protein complex 130 kDa component
Short name=DRIP130
Gene names
Name:MED23
Synonyms:ARC130, CRSP3, DRIP130, KIAA1216, SUR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1368 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for transcriptional activation subsequent to the assembly of the preinitiation complex By similarity. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. Ref.2 Ref.13 Ref.17

Subunit structure

Interacts with ELK1 By similarity. Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein. Ref.1 Ref.2 Ref.3 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17

Subcellular location

Nucleus Probable.

Involvement in disease

Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20

Sequence similarities

Belongs to the Mediator complex subunit 23 family.

Sequence caution

The sequence AAD12724.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAD31729.1 differs from that shown. Reason: Frameshift at positions 945 and 950.

The sequence BAA86530.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9ULK4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ULK4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     292-292: Q → QTLNIAQ
     870-880: AMRSHEGNEAQ → VRINTFLSLFS
     881-1368: Missing.
Isoform 3 (identifier: Q9ULK4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     292-292: Q → QTLNIAQ
     1360-1368: Missing.
Isoform 4 (identifier: Q9ULK4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1360-1368: Missing.
Isoform 5 (identifier: Q9ULK4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1361-1368: PVSLPVTQ → DTLT
Isoform 6 (identifier: Q9ULK4-6)

The sequence of this isoform differs from the canonical sequence as follows:
     457-475: FLQQSLRNKSLQMNDYKIA → SAFANCFQITCMGDLTHTP
     476-1368: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13681368Mediator of RNA polymerase II transcription subunit 23
PRO_0000079358

Natural variations

Alternative sequence2921Q → QTLNIAQ in isoform 2 and isoform 3.
VSP_004034
Alternative sequence457 – 47519FLQQS…DYKIA → SAFANCFQITCMGDLTHTP in isoform 6.
VSP_047860
Alternative sequence476 – 1368893Missing in isoform 6.
VSP_047861
Alternative sequence870 – 88011AMRSHEGNEAQ → VRINTFLSLFS in isoform 2.
VSP_004036
Alternative sequence881 – 1368488Missing in isoform 2.
VSP_004037
Alternative sequence1360 – 13689Missing in isoform 3 and isoform 4.
VSP_004035
Alternative sequence1361 – 13688PVSLPVTQ → DTLT in isoform 5.
VSP_028380
Natural variant6171P → Q in MRT18; specifically impairs the response of JUN and FOS immediate early genes to serum mitogens by altering the interaction between enhancer-bound transcription factors (TCF7L2 and ELK1 respectively) and Mediator complex. Ref.20
VAR_066596

Experimental info

Sequence conflict591C → W in AAH60759. Ref.9
Sequence conflict1311Y → N in AAD31729. Ref.1
Sequence conflict2081F → V in AAD30202. Ref.2
Sequence conflict2301V → E in AAD30202. Ref.2
Sequence conflict4641N → H in AAD30202. Ref.2
Sequence conflict4881F → V in AAD30202. Ref.2
Sequence conflict5071I → L in AAD30202. Ref.2
Sequence conflict5181G → A in AAD30202. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 22, 2003. Version 2.
Checksum: 2BEE9FF5E328477D

FASTA1,368156,474
        10         20         30         40         50         60 
METQLQSIFE EVVKTEVIEE AFPGMFMDTP EDEKTKLISC LGAFRQFWGG LSQESHEQCI 

        70         80         90        100        110        120 
QWIVKFIHGQ HSPKRISFLY DCLAMAVETG LLPPRLVCES LINSDTLEWE RTQLWALTFK 

       130        140        150        160        170        180 
LVRKIIGGVD YKGVRDLLKV ILEKILTIPN TVSSAVVQQL LAAREVIAYI LERNACLLPA 

       190        200        210        220        230        240 
YFAVTEIRKL YPEGKLPHWL LGNLVSDFVD TFRPTARINS ICGRCSLLPV VNNSGAICNS 

       250        260        270        280        290        300 
WKLDPATLRF PLKGLLPYDK DLFEPQTALL RYVLEQPYSR DMVCNMLGLN KQHKQRCPVL 

       310        320        330        340        350        360 
EDQLVDLVVY AMERSETEEK FDDGGTSQLL WQHLSSQLIF FVLFQFASFP HMVLSLHQKL 

       370        380        390        400        410        420 
AGRGLIKGRD HLMWVLLQFI SGSIQKNALA DFLPVMKLFD LLYPEKEYIP VPDINKPQST 

       430        440        450        460        470        480 
HAFAMTCIWI HLNRKAQNDN SKLQIPIPHS LRLHHEFLQQ SLRNKSLQMN DYKIALLCNA 

       490        500        510        520        530        540 
YSTNSECFTL PMGALVETIY GNGIMRIPLP GTNCMASGSI TPLPMNLLDS LTVHAKMSLI 

       550        560        570        580        590        600 
HSIATRVIKL AHAKSSVALA PALVETYSRL LVYMEIESLG IKGFISQLLP TVFKSHAWGI 

       610        620        630        640        650        660 
LHTLLEMFSY RMHHIQPHYR VQLLSHLHTL AAVAQTNQNQ LHLCVESTAL RLITALGSSE 

       670        680        690        700        710        720 
VQPQFTRFLS DPKTVLSAES EELNRALILT LARATHVTDF FTGSDSIQGT WCKDILQTIM 

       730        740        750        760        770        780 
SFTPHNWASH TLSCFPGPLQ AFFKQNNVPQ ESRFNLKKNV EEEYRKWKSM SNENDIITHF 

       790        800        810        820        830        840 
SMQGSPPLFL CLLWKMLLET DHINQIGYRV LERIGARALV AHVRTFADFL VYEFSTSAGG 

       850        860        870        880        890        900 
QQLNKCIEIL NDMVWKYNIV TLDRLILCLA MRSHEGNEAQ VCYFIIQLLL LKPNDFRNRV 

       910        920        930        940        950        960 
SDFVKENSPE HWLQNDWHTK HMNYHKKYPE KLYFEGLAEQ VDPPVQIQSP YLPIYFGNVC 

       970        980        990       1000       1010       1020 
LRFLPVFDIV IHRFLELLPV SKSLETLLDH LGGLYKFHDR PVTYLYNTLH YYEMHLRDRA 

      1030       1040       1050       1060       1070       1080 
FLKRKLVHAI IGSLKDNRPQ GWCLSDTYLK CAMNAREENP WVPDDTYYCR LIGRLVDTMA 

      1090       1100       1110       1120       1130       1140 
GKSPGPFPNC DWRFNEFPNP AAHALHVTCV ELMALAVSGK EVGNALLNVV LKSQPLVPRE 

      1150       1160       1170       1180       1190       1200 
NITAWMNAIG LIITALPEPY WIVLHDRIVS VISSPSLTSE TEWVGYPFRL FDFTACHQSY 

      1210       1220       1230       1240       1250       1260 
SEMSCSYTLA LAHAVWHHSS IGQLSLIPKF LTEVLLPIVK TEFQLLYVYH LVGPFLQRFQ 

      1270       1280       1290       1300       1310       1320 
QERTRCMIEI GVAFYDMLLN VDQCSTHLNY MDPICDFLYH MKYMFTGDSV KEQVEKIICN 

      1330       1340       1350       1360 
LKPALKLRLR FITHISKMEP AAVPPQAMNS GSPAPQSNQV PVSLPVTQ 

« Hide

Isoform 2 [UniParc].

Checksum: F1461C27AF9D7817
Show »

FASTA886100,834
Isoform 3 [UniParc].

Checksum: 8F401B9FF90878C3
Show »

FASTA1,365156,194
Isoform 4 [UniParc].

Checksum: E6EB563FEBC111DE
Show »

FASTA1,359155,553
Isoform 5 [UniParc].

Checksum: 55BAD400A566EB56
Show »

FASTA1,364156,082
Isoform 6 [UniParc].

Checksum: 3621AC3036B0F0B5
Show »

FASTA47554,314

References

« Hide 'large scale' references
[1]"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M., Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P.
Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 254-280; 1317-1326 AND 1331-1337, IDENTIFICATION IN ARC COMPLEX.
Tissue: Cervix carcinoma.
[2]"Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein."
Boyer T.G., Martin M.E.D., Lees E., Ricciardi R.P., Berk A.J.
Nature 399:276-279(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), FUNCTION, INTERACTION WITH E1A AND CDK8.
[3]"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
Ryu S., Zhou S., Ladurner A.G., Tjian R.
Nature 397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), IDENTIFICATION IN THE CRSP COMPLEX.
[4]"Alternative splicing as a prevalent mechanism in regulating mammalian mediator tail subcomplex activity."
Kivil A., Kazantseva A., Vinkel K.J.M., Sadam H., Neuman T., Palm K.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[5]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
[7]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Placenta.
[10]"Composite co-activator ARC mediates chromatin-directed transcriptional activation."
Naeaer A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W.B., Tjian R.
Nature 398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE ARC COMPLEX, PROTEIN SEQUENCE OF 465-473 AND 1302-1311.
[11]"TFIIH is negatively regulated by cdk8-containing mediator complexes."
Akoulitchev S., Chuikov S., Reinberg D.
Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MED6.
[12]"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
Kang Y.K., Guermah M., Yuan C.-X., Roeder R.G.
Proc. Natl. Acad. Sci. U.S.A. 99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
[13]"Ras induces mediator complex exchange on C/EBP beta."
Mo X., Kowenz-Leutz E., Xu H., Leutz A.
Mol. Cell 13:241-250(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CEBPB.
[14]"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
[15]"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G.
Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MED1 AND MED10, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
[16]"Mediator modulates Gli3-dependent Sonic hedgehog signaling."
Zhou H., Kim S., Ishii S., Boyer T.G.
Mol. Cell. Biol. 26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CDK8; CTNNB1 AND GLI3.
[17]"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
Baek H.J., Kang Y.K., Roeder R.G.
J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MED1 AND MED10.
[18]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"MED23 mutation links intellectual disability to dysregulation of immediate early gene expression."
Hashimoto S., Boissel S., Zarhrate M., Rio M., Munnich A., Egly J.M., Colleaux L.
Science 333:1161-1163(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MRT18 GLN-617, CHARACTERIZATION OF VARIANT MRT18 GLN-617.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF105332 mRNA. Translation: AAD31729.1. Frameshift.
AF135022 mRNA. Translation: AAD30202.1.
AF104255 mRNA. Translation: AAD12724.1. Different initiation.
EU392526 mRNA. Translation: ACB88854.1.
AB033042 mRNA. Translation: BAA86530.1. Different initiation.
AL136776 mRNA. Translation: CAB66710.1.
AL121575 Genomic DNA. Translation: CAB92072.1.
AL121575 Genomic DNA. Translation: CAB92073.1.
AL121575 Genomic DNA. Translation: CAI23319.1.
AL121575 Genomic DNA. Translation: CAI23320.1.
CH471051 Genomic DNA. Translation: EAW48052.1.
BC060759 mRNA. Translation: AAH60759.1.
CCDSCCDS5146.1. [Q9ULK4-3]
CCDS5147.1. [Q9ULK4-1]
CCDS59039.1. [Q9ULK4-5]
RefSeqNP_001257450.1. NM_001270521.1. [Q9ULK4-4]
NP_001257451.1. NM_001270522.1. [Q9ULK4-5]
NP_004821.2. NM_004830.3. [Q9ULK4-1]
NP_057063.2. NM_015979.3. [Q9ULK4-3]
UniGeneHs.29679.

3D structure databases

ProteinModelPortalQ9ULK4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114829. 47 interactions.
DIPDIP-31461N.
IntActQ9ULK4. 19 interactions.
MINTMINT-4719443.

Chemistry

BindingDBQ9ULK4.
ChEMBLCHEMBL4146.

PTM databases

PhosphoSiteQ9ULK4.

Polymorphism databases

DMDM28558074.

Proteomic databases

MaxQBQ9ULK4.
PaxDbQ9ULK4.
PRIDEQ9ULK4.

Protocols and materials databases

DNASU9439.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354577; ENSP00000346588; ENSG00000112282. [Q9ULK4-3]
ENST00000368053; ENSP00000357032; ENSG00000112282. [Q9ULK4-2]
ENST00000368060; ENSP00000357039; ENSG00000112282. [Q9ULK4-5]
ENST00000368068; ENSP00000357047; ENSG00000112282. [Q9ULK4-1]
ENST00000539158; ENSP00000445072; ENSG00000112282. [Q9ULK4-6]
GeneID9439.
KEGGhsa:9439.
UCSCuc003qcq.4. human. [Q9ULK4-3]
uc003qcs.2. human. [Q9ULK4-1]
uc003qct.2. human. [Q9ULK4-2]
uc031spr.1. human. [Q9ULK4-5]

Organism-specific databases

CTD9439.
GeneCardsGC06M131895.
HGNCHGNC:2372. MED23.
MIM605042. gene.
614249. phenotype.
neXtProtNX_Q9ULK4.
Orphanet88616. Autosomal recessive nonsyndromic intellectual disability.
PharmGKBPA162395499.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG305557.
HOVERGENHBG051122.
KOK15166.
OrthoDBEOG7CCBQ5.
PhylomeDBQ9ULK4.
TreeFamTF324163.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9ULK4.
BgeeQ9ULK4.
GenevestigatorQ9ULK4.

Family and domain databases

InterProIPR021629. Mediator_Med23.
[Graphical view]
PfamPF11573. Med23. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMED23. human.
GeneWikiCRSP3.
GenomeRNAi9439.
NextBio35344.
PROQ9ULK4.
SOURCESearch...

Entry information

Entry nameMED23_HUMAN
AccessionPrimary (citable) accession number: Q9ULK4
Secondary accession number(s): B9TX55 expand/collapse secondary AC list , O95403, Q5JWT3, Q5JWT4, Q6P9H6, Q9H0J2, Q9NTT9, Q9NTU0, Q9Y5P7, Q9Y667
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: February 22, 2003
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM