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Q9ULK0

- GRID1_HUMAN

UniProt

Q9ULK0 - GRID1_HUMAN

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Protein

Glutamate receptor ionotropic, delta-1

Gene

GRID1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. ionotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. ionotropic glutamate receptor signaling pathway Source: RefGenome
  2. ion transmembrane transport Source: RefGenome
  3. social behavior Source: UniProt
  4. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-1
Short name:
GluD1
Short name:
GluR delta-1 subunit
Gene namesi
Name:GRID1
Synonyms:KIAA1220
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:4575. GRID1.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. extracellular vesicular exosome Source: UniProt
  4. ionotropic glutamate receptor complex Source: RefGenome
  5. postsynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 1009989Glutamate receptor ionotropic, delta-1PRO_0000011561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9ULK0.
PaxDbiQ9ULK0.
PRIDEiQ9ULK0.

PTM databases

PhosphoSiteiQ9ULK0.

Expressioni

Gene expression databases

BgeeiQ9ULK0.
CleanExiHS_GRID1.
ExpressionAtlasiQ9ULK0. baseline.
GenevestigatoriQ9ULK0.

Interactioni

Subunit structurei

Interacts with CBLN1, and more weakly with CBLN2.By similarity

Protein-protein interaction databases

BioGridi109151. 1 interaction.
STRINGi9606.ENSP00000385395.

Structurei

3D structure databases

ProteinModelPortaliQ9ULK0.
SMRiQ9ULK0. Positions 24-853.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 562542ExtracellularSequence AnalysisAdd
BLAST
Topological domaini584 – 63754CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini659 – 830172ExtracellularSequence AnalysisAdd
BLAST
Topological domaini852 – 1009158CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei563 – 58321HelicalSequence AnalysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence AnalysisAdd
BLAST
Transmembranei831 – 85121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276334.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiQ9ULK0.
KOiK05206.
OMAiMGRCDLT.
OrthoDBiEOG7KQ20V.
PhylomeDBiQ9ULK0.
TreeFamiTF352434.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULK0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL
60 70 80 90 100
NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN
110 120 130 140 150
ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN
160 170 180 190 200
DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN
210 220 230 240 250
ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS
260 270 280 290 300
KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR
310 320 330 340 350
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN
360 370 380 390 400
CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT
410 420 430 440 450
YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV
460 470 480 490 500
MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS
510 520 530 540 550
WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE
560 570 580 590 600
KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS
610 620 630 640 650
ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA
660 670 680 690 700
NLAAFLTVSR MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE
710 720 730 740 750
QDSTFAELWR TISKNGGADN CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA
760 770 780 790 800
LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL
810 820 830 840 850
KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI GLLLACLVAA
860 870 880 890 900
LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL
910 920 930 940 950
SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN
960 970 980 990 1000
LPLPLSSSAT MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA

LDTSHGTSI
Length:1,009
Mass (Da):112,131
Last modified:November 14, 2003 - v2
Checksum:i201DA12ECC8E1F1A
GO
Isoform 2 (identifier: Q9ULK0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-429: Missing.

Note: No experimental confirmation available

Show »
Length:580
Mass (Da):63,658
Checksum:iADBB08EE1E1790DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti529 – 5291V → I.
Corresponds to variant rs2306265 [ dbSNP | Ensembl ].
VAR_022011

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 429429Missing in isoform 2. 1 PublicationVSP_057019Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127168 mRNA. Translation: BAG54447.1.
AK302192 mRNA. Translation: BAH13646.1.
AC022028 Genomic DNA. No translation available.
AC073162 Genomic DNA. No translation available.
AC079955 Genomic DNA. No translation available.
AL451059 Genomic DNA. No translation available.
AL596135 Genomic DNA. No translation available.
AL683834 Genomic DNA. No translation available.
AL732479 Genomic DNA. No translation available.
AL844892 Genomic DNA. No translation available.
CH471142 Genomic DNA. Translation: EAW80340.1.
BC039263 mRNA. Translation: AAH39263.1.
AB033046 mRNA. Translation: BAA86534.1.
CCDSiCCDS31236.1.
RefSeqiNP_060021.1. NM_017551.2.
UniGeneiHs.530653.

Genome annotation databases

EnsembliENST00000327946; ENSP00000330148; ENSG00000182771.
GeneIDi2894.
KEGGihsa:2894.
UCSCiuc001kdl.1. human.

Polymorphism databases

DMDMi38372397.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127168 mRNA. Translation: BAG54447.1 .
AK302192 mRNA. Translation: BAH13646.1 .
AC022028 Genomic DNA. No translation available.
AC073162 Genomic DNA. No translation available.
AC079955 Genomic DNA. No translation available.
AL451059 Genomic DNA. No translation available.
AL596135 Genomic DNA. No translation available.
AL683834 Genomic DNA. No translation available.
AL732479 Genomic DNA. No translation available.
AL844892 Genomic DNA. No translation available.
CH471142 Genomic DNA. Translation: EAW80340.1 .
BC039263 mRNA. Translation: AAH39263.1 .
AB033046 mRNA. Translation: BAA86534.1 .
CCDSi CCDS31236.1.
RefSeqi NP_060021.1. NM_017551.2.
UniGenei Hs.530653.

3D structure databases

ProteinModelPortali Q9ULK0.
SMRi Q9ULK0. Positions 24-853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109151. 1 interaction.
STRINGi 9606.ENSP00000385395.

Chemistry

BindingDBi Q9ULK0.
GuidetoPHARMACOLOGYi 448.

PTM databases

PhosphoSitei Q9ULK0.

Polymorphism databases

DMDMi 38372397.

Proteomic databases

MaxQBi Q9ULK0.
PaxDbi Q9ULK0.
PRIDEi Q9ULK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327946 ; ENSP00000330148 ; ENSG00000182771 .
GeneIDi 2894.
KEGGi hsa:2894.
UCSCi uc001kdl.1. human.

Organism-specific databases

CTDi 2894.
GeneCardsi GC10M087349.
HGNCi HGNC:4575. GRID1.
MIMi 610659. gene.
neXtProti NX_Q9ULK0.
PharmGKBi PA28970.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276334.
GeneTreei ENSGT00760000118920.
HOGENOMi HOG000264260.
HOVERGENi HBG051840.
InParanoidi Q9ULK0.
KOi K05206.
OMAi MGRCDLT.
OrthoDBi EOG7KQ20V.
PhylomeDBi Q9ULK0.
TreeFami TF352434.

Miscellaneous databases

GeneWikii GRID1.
GenomeRNAii 2894.
NextBioi 11451.
PROi Q9ULK0.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULK0.
CleanExi HS_GRID1.
ExpressionAtlasi Q9ULK0. baseline.
Genevestigatori Q9ULK0.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Caudate nucleus and Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-609 (ISOFORM 1).
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1009 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiGRID1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULK0
Secondary accession number(s): B3KXD5, B7Z7L0, Q8IXT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3