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Protein

Glutamate receptor ionotropic, delta-1

Gene

GRID1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73Essential for dimerizationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-1
Short name:
GluD1
Short name:
GluR delta-1 subunit
Gene namesi
Name:GRID1
Synonyms:KIAA1220
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000182771.17
HGNCiHGNC:4575 GRID1
MIMi610659 gene
neXtProtiNX_Q9ULK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 562ExtracellularSequence analysisAdd BLAST542
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 830ExtracellularSequence analysisAdd BLAST172
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1009CytoplasmicSequence analysisAdd BLAST158

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2894
OpenTargetsiENSG00000182771
PharmGKBiPA28970

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid

Polymorphism and mutation databases

BioMutaiGRID1
DMDMi38372397

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001156121 – 1009Glutamate receptor ionotropic, delta-1Add BLAST989

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 351By similarity
Disulfide bondi96 ↔ 128By similarity
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 306By similarity
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ULK0
PeptideAtlasiQ9ULK0
PRIDEiQ9ULK0

PTM databases

iPTMnetiQ9ULK0
PhosphoSitePlusiQ9ULK0

Expressioni

Gene expression databases

BgeeiENSG00000182771
CleanExiHS_GRID1
ExpressionAtlasiQ9ULK0 baseline and differential
GenevisibleiQ9ULK0 HS

Interactioni

Subunit structurei

Dimer. Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2.By similarity

Protein-protein interaction databases

BioGridi1091517 interactors.
STRINGi9606.ENSP00000330148

Structurei

3D structure databases

ProteinModelPortaliQ9ULK0
SMRiQ9ULK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 436Interaction with CBLN1By similarityAdd BLAST416

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1052 Eukaryota
ENOG410XQQV LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000264260
HOVERGENiHBG051840
InParanoidiQ9ULK0
KOiK05206
OMAiMGRCDLT
OrthoDBiEOG091G010L
PhylomeDBiQ9ULK0
TreeFamiTF352434

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL
60 70 80 90 100
NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN
110 120 130 140 150
ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN
160 170 180 190 200
DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN
210 220 230 240 250
ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS
260 270 280 290 300
KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR
310 320 330 340 350
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN
360 370 380 390 400
CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT
410 420 430 440 450
YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV
460 470 480 490 500
MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS
510 520 530 540 550
WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE
560 570 580 590 600
KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS
610 620 630 640 650
ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA
660 670 680 690 700
NLAAFLTVSR MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE
710 720 730 740 750
QDSTFAELWR TISKNGGADN CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA
760 770 780 790 800
LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL
810 820 830 840 850
KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI GLLLACLVAA
860 870 880 890 900
LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL
910 920 930 940 950
SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN
960 970 980 990 1000
LPLPLSSSAT MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA

LDTSHGTSI
Length:1,009
Mass (Da):112,131
Last modified:November 14, 2003 - v2
Checksum:i201DA12ECC8E1F1A
GO
Isoform 2 (identifier: Q9ULK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-429: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):63,658
Checksum:iADBB08EE1E1790DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022011529V → I. Corresponds to variant dbSNP:rs2306265Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0570191 – 429Missing in isoform 2. 1 PublicationAdd BLAST429

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127168 mRNA Translation: BAG54447.1
AK302192 mRNA Translation: BAH13646.1
AC022028 Genomic DNA No translation available.
AC073162 Genomic DNA No translation available.
AC079955 Genomic DNA No translation available.
AL451059 Genomic DNA No translation available.
AL596135 Genomic DNA No translation available.
AL683834 Genomic DNA No translation available.
AL732479 Genomic DNA No translation available.
AL844892 Genomic DNA No translation available.
CH471142 Genomic DNA Translation: EAW80340.1
BC039263 mRNA Translation: AAH39263.1
AB033046 mRNA Translation: BAA86534.1
CCDSiCCDS31236.1 [Q9ULK0-1]
RefSeqiNP_060021.1, NM_017551.2 [Q9ULK0-1]
UniGeneiHs.530653

Genome annotation databases

EnsembliENST00000327946; ENSP00000330148; ENSG00000182771 [Q9ULK0-1]
GeneIDi2894
KEGGihsa:2894
UCSCiuc001kdl.2 human [Q9ULK0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGRID1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULK0
Secondary accession number(s): B3KXD5, B7Z7L0, Q8IXT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: March 28, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome