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Q9ULK0

- GRID1_HUMAN

UniProt

Q9ULK0 - GRID1_HUMAN

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Protein
Glutamate receptor ionotropic, delta-1
Gene
GRID1, KIAA1220
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. ionotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. ion transmembrane transport Source: RefGenome
  2. ionotropic glutamate receptor signaling pathway Source: RefGenome
  3. social behavior Source: UniProt
  4. synaptic transmission, glutamatergic Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-1
Short name:
GluD1
Short name:
GluR delta-1 subunit
Gene namesi
Name:GRID1
Synonyms:KIAA1220
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:4575. GRID1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 562542Extracellular Reviewed prediction
Add
BLAST
Transmembranei563 – 58321Helical; Reviewed prediction
Add
BLAST
Topological domaini584 – 63754Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei638 – 65821Helical; Reviewed prediction
Add
BLAST
Topological domaini659 – 830172Extracellular Reviewed prediction
Add
BLAST
Transmembranei831 – 85121Helical; Reviewed prediction
Add
BLAST
Topological domaini852 – 1009158Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. extracellular vesicular exosome Source: UniProt
  4. ionotropic glutamate receptor complex Source: RefGenome
  5. postsynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 1009989Glutamate receptor ionotropic, delta-1
PRO_0000011561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi422 – 4221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9ULK0.
PaxDbiQ9ULK0.
PRIDEiQ9ULK0.

PTM databases

PhosphoSiteiQ9ULK0.

Expressioni

Gene expression databases

ArrayExpressiQ9ULK0.
BgeeiQ9ULK0.
CleanExiHS_GRID1.
GenevestigatoriQ9ULK0.

Interactioni

Subunit structurei

Interacts with CBLN1, and more weakly with CBLN2 By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000385395.

Structurei

3D structure databases

ProteinModelPortaliQ9ULK0.
SMRiQ9ULK0. Positions 24-853.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276334.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiQ9ULK0.
KOiK05206.
OMAiMGRCDLT.
OrthoDBiEOG7KQ20V.
PhylomeDBiQ9ULK0.
TreeFamiTF352434.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULK0-1 [UniParc]FASTAAdd to Basket

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MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL     50
NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN 100
ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN 150
DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN 200
ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS 250
KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR 300
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN 350
CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT 400
YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV 450
MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS 500
WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE 550
KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS 600
ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA 650
NLAAFLTVSR MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE 700
QDSTFAELWR TISKNGGADN CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA 750
LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL 800
KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI GLLLACLVAA 850
LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL 900
SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN 950
LPLPLSSSAT MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA 1000
LDTSHGTSI 1009
Length:1,009
Mass (Da):112,131
Last modified:November 14, 2003 - v2
Checksum:i201DA12ECC8E1F1A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti529 – 5291V → I.
Corresponds to variant rs2306265 [ dbSNP | Ensembl ].
VAR_022011

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127168 mRNA. Translation: BAG54447.1.
CH471142 Genomic DNA. Translation: EAW80340.1.
BC039263 mRNA. Translation: AAH39263.1.
AB033046 mRNA. Translation: BAA86534.1.
CCDSiCCDS31236.1.
RefSeqiNP_060021.1. NM_017551.2.
UniGeneiHs.530653.

Genome annotation databases

EnsembliENST00000327946; ENSP00000330148; ENSG00000182771.
GeneIDi2894.
KEGGihsa:2894.
UCSCiuc001kdl.1. human.

Polymorphism databases

DMDMi38372397.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127168 mRNA. Translation: BAG54447.1 .
CH471142 Genomic DNA. Translation: EAW80340.1 .
BC039263 mRNA. Translation: AAH39263.1 .
AB033046 mRNA. Translation: BAA86534.1 .
CCDSi CCDS31236.1.
RefSeqi NP_060021.1. NM_017551.2.
UniGenei Hs.530653.

3D structure databases

ProteinModelPortali Q9ULK0.
SMRi Q9ULK0. Positions 24-853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000385395.

Chemistry

BindingDBi Q9ULK0.
DrugBanki DB00142. L-Glutamic Acid.
GuidetoPHARMACOLOGYi 448.

PTM databases

PhosphoSitei Q9ULK0.

Polymorphism databases

DMDMi 38372397.

Proteomic databases

MaxQBi Q9ULK0.
PaxDbi Q9ULK0.
PRIDEi Q9ULK0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327946 ; ENSP00000330148 ; ENSG00000182771 .
GeneIDi 2894.
KEGGi hsa:2894.
UCSCi uc001kdl.1. human.

Organism-specific databases

CTDi 2894.
GeneCardsi GC10M087349.
HGNCi HGNC:4575. GRID1.
MIMi 610659. gene.
neXtProti NX_Q9ULK0.
PharmGKBi PA28970.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276334.
HOGENOMi HOG000264260.
HOVERGENi HBG051840.
InParanoidi Q9ULK0.
KOi K05206.
OMAi MGRCDLT.
OrthoDBi EOG7KQ20V.
PhylomeDBi Q9ULK0.
TreeFami TF352434.

Miscellaneous databases

GeneWikii GRID1.
GenomeRNAii 2894.
NextBioi 11451.
PROi Q9ULK0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ULK0.
Bgeei Q9ULK0.
CleanExi HS_GRID1.
Genevestigatori Q9ULK0.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Caudate nucleus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-609.
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1009.
    Tissue: Brain.

Entry informationi

Entry nameiGRID1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULK0
Secondary accession number(s): B3KXD5, Q8IXT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 14, 2003
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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