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Q9ULK0

- GRID1_HUMAN

UniProt

Q9ULK0 - GRID1_HUMAN

Protein

Glutamate receptor ionotropic, delta-1

Gene

GRID1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (14 Nov 2003)
      Previous versions | rss
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    Functioni

    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: RefGenome
    2. ionotropic glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. ionotropic glutamate receptor signaling pathway Source: RefGenome
    2. ion transmembrane transport Source: RefGenome
    3. social behavior Source: UniProt
    4. synaptic transmission, glutamatergic Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, delta-1
    Short name:
    GluD1
    Short name:
    GluR delta-1 subunit
    Gene namesi
    Name:GRID1
    Synonyms:KIAA1220
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:4575. GRID1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. extracellular vesicular exosome Source: UniProt
    4. ionotropic glutamate receptor complex Source: RefGenome
    5. postsynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28970.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 1009989Glutamate receptor ionotropic, delta-1PRO_0000011561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9ULK0.
    PaxDbiQ9ULK0.
    PRIDEiQ9ULK0.

    PTM databases

    PhosphoSiteiQ9ULK0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULK0.
    BgeeiQ9ULK0.
    CleanExiHS_GRID1.
    GenevestigatoriQ9ULK0.

    Interactioni

    Subunit structurei

    Interacts with CBLN1, and more weakly with CBLN2.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000385395.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULK0.
    SMRiQ9ULK0. Positions 24-853.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 562542ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini584 – 63754CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini659 – 830172ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini852 – 1009158CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei563 – 58321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei638 – 65821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei831 – 85121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276334.
    HOGENOMiHOG000264260.
    HOVERGENiHBG051840.
    InParanoidiQ9ULK0.
    KOiK05206.
    OMAiMGRCDLT.
    OrthoDBiEOG7KQ20V.
    PhylomeDBiQ9ULK0.
    TreeFamiTF352434.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ULK0-1 [UniParc]FASTAAdd to Basket

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    MEALTLWLLP WICQCVSVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL     50
    NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN 100
    ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN 150
    DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN 200
    ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS 250
    KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCTRNNHR 300
    ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN 350
    CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT 400
    YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV 450
    MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS 500
    WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE 550
    KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR AQSAAQPRPS 600
    ASATLHSAIW IVYGAFVQQG GESSVNSMAM RIVMGSWWLF TLIVCSSYTA 650
    NLAAFLTVSR MDNPIRTFQD LSKQVEMSYG TVRDSAVYEY FRAKGTNPLE 700
    QDSTFAELWR TISKNGGADN CVSSPSEGIR KAKKGNYAFL WDVAVVEYAA 750
    LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL 800
    KQKWWPHMGR CDLTSHASAQ ADGKSLKLHS FAGVFCILAI GLLLACLVAA 850
    LELWWNSNRC HQETPKEDKE VNLEQVHRRM NSLMDEDIAH KQISPASIEL 900
    SALEMGGLAP TQTLEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN 950
    LPLPLSSSAT MPSMQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA 1000
    LDTSHGTSI 1009
    Length:1,009
    Mass (Da):112,131
    Last modified:November 14, 2003 - v2
    Checksum:i201DA12ECC8E1F1A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti529 – 5291V → I.
    Corresponds to variant rs2306265 [ dbSNP | Ensembl ].
    VAR_022011

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127168 mRNA. Translation: BAG54447.1.
    CH471142 Genomic DNA. Translation: EAW80340.1.
    BC039263 mRNA. Translation: AAH39263.1.
    AB033046 mRNA. Translation: BAA86534.1.
    CCDSiCCDS31236.1.
    RefSeqiNP_060021.1. NM_017551.2.
    UniGeneiHs.530653.

    Genome annotation databases

    EnsembliENST00000327946; ENSP00000330148; ENSG00000182771.
    GeneIDi2894.
    KEGGihsa:2894.
    UCSCiuc001kdl.1. human.

    Polymorphism databases

    DMDMi38372397.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127168 mRNA. Translation: BAG54447.1 .
    CH471142 Genomic DNA. Translation: EAW80340.1 .
    BC039263 mRNA. Translation: AAH39263.1 .
    AB033046 mRNA. Translation: BAA86534.1 .
    CCDSi CCDS31236.1.
    RefSeqi NP_060021.1. NM_017551.2.
    UniGenei Hs.530653.

    3D structure databases

    ProteinModelPortali Q9ULK0.
    SMRi Q9ULK0. Positions 24-853.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000385395.

    Chemistry

    BindingDBi Q9ULK0.
    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 448.

    PTM databases

    PhosphoSitei Q9ULK0.

    Polymorphism databases

    DMDMi 38372397.

    Proteomic databases

    MaxQBi Q9ULK0.
    PaxDbi Q9ULK0.
    PRIDEi Q9ULK0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327946 ; ENSP00000330148 ; ENSG00000182771 .
    GeneIDi 2894.
    KEGGi hsa:2894.
    UCSCi uc001kdl.1. human.

    Organism-specific databases

    CTDi 2894.
    GeneCardsi GC10M087349.
    HGNCi HGNC:4575. GRID1.
    MIMi 610659. gene.
    neXtProti NX_Q9ULK0.
    PharmGKBi PA28970.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276334.
    HOGENOMi HOG000264260.
    HOVERGENi HBG051840.
    InParanoidi Q9ULK0.
    KOi K05206.
    OMAi MGRCDLT.
    OrthoDBi EOG7KQ20V.
    PhylomeDBi Q9ULK0.
    TreeFami TF352434.

    Miscellaneous databases

    GeneWikii GRID1.
    GenomeRNAii 2894.
    NextBioi 11451.
    PROi Q9ULK0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULK0.
    Bgeei Q9ULK0.
    CleanExi HS_GRID1.
    Genevestigatori Q9ULK0.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Caudate nucleus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-609.
      Tissue: Brain.
    4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-1009.
      Tissue: Brain.

    Entry informationi

    Entry nameiGRID1_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULK0
    Secondary accession number(s): B3KXD5, Q8IXT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: November 14, 2003
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3