Q9ULJ8 (NEB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurabin-1

Alternative name(s):
Neurabin-I
Neural tissue-specific F-actin-binding protein I
Protein phosphatase 1 regulatory subunit 9A

Gene names

Name:	PPP1R9A
Synonyms:	KIAA1222

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1098 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity By similarity.
Subunit structure	Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2 and p70-S6K By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cell junction › synapse › synaptosome By similarity.
Domain	Interacts with p70-S6K via its PDZ domain By similarity. The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates By similarity.
Sequence similarities	Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cell junction Cytoplasm Cytoskeleton Synapse Synaptosome
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	Actin-binding
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell neuron projection Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULJ8-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULJ8-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-918: MLKTESSGER...STDGEDSLER → MHITKLLPPK...ETLISDKKGS
     960-967: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9ULJ8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     630-630: E → ENTVAELQGMSGNCNNNNNYFLK
     919-919: K → KPSNSFYNHM...MSVVWIQETN
     960-967: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9ULJ8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     920-1028: NFTFNDDFSP...LLQLDGNKLK → PSNSFYNHMH...SQSLALSSDE

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1098

1098

Neurabin-1

PRO_0000071507

Regions

Domain

504 – 592

89

PDZ

Domain

988 – 1051

64

SAM

Region

1 – 144

144

Actin-binding

Region

425 – 502

78

Interacts with protein phosphatase 1 By similarity

Region

597 – 1090

494

Interacts with TGN38 By similarity

Coiled coil

597 – 627

31

Potential

Coiled coil

670 – 824

155

Potential

Coiled coil

1033 – 1090

58

Potential

Compositional bias

447 – 450

4

Poly-Glu

Compositional bias

829 – 833

5

Poly-Asn

Amino acid modifications

Modified residue

338

1

Phosphoserine Ref.5

Modified residue

460

1

Phosphoserine; by PKA By similarity

Modified residue

840

1

Phosphoserine Ref.7

Natural variations

Alternative sequence

1 – 918

918

MLKTE…DSLER → MHITKLLPPKGLRTSSPESD SGVPPLTPVDSNVPFSSDHI AEFQEEPLDPEMGPLSSMWG DTSLFSTSKSDHDVEESPCH HQTTNKKILREKDDAKDPKS LRASSSLAVQGGKIKRKFVD LGAPLRRNSSKGKKWKEKEK EASRFSAGSRIFRGRLENWT PKPCSTAQTSTRSPCMPFSW FNDSRKGSYSFRNLPAPTSS LQPSPETLISDKKGS in isoform 2.

VSP_011139

Alternative sequence

630

1

E → ENTVAELQGMSGNCNNNNNY FLK in isoform 3.

VSP_044469

Alternative sequence

919

1

K → KPSNSFYNHMHITKLLPPKG LRTSSPESDSGVPPLTPVDS NVPFSSDHIAEFQEEPLDPE MGPLSSMWGDTSLFSTSKSD HDVEESPCHHQTTNKKILRE KDDAKDPKSLRASSSLAVQG GKIKRKFVDLGAPLRRNSSK GKKWKEKEKEASRFSAGSRI FRGRLENWTPKPCSTAQTST RSPCMPFSWFNDSRKGSYSF RNLPAPTSSLQPSPETLISD KKGSKVENTWITKANKRNPN PSSSSIFGRHSQLMSVVWIQ ETN in isoform 3.

VSP_044470

Alternative sequence

920 – 1028

109

NFTFN…GNKLK → PSNSFYNHMHITKLLPPKGL RTSSPESDSGVPPLTPVDSN VPFSSDHIAEFQEEPLDPEM GPLSSMWGDTSLFSTSKSDH DVEESPCHHQTTNKKILREK DDAKDPKSLRASSSLAVQGG KIKRKFVDLGAPLRRNSSKG KKWKEKEKEASRFSAGSRIF RGRLENWTPKPCSTAQTSTR SPCMPFSWFNDSRKGSYSFR NLPAPTSSLQPSPETLISDK KGSKNFTFNDDFSPSSTSSA DLSGLGAEPKTPGLSQSLAL SSDE in isoform 4.

VSP_044471

Alternative sequence

960 – 967

8

Missing in isoform 2 and isoform 3.

VSP_005121

Natural variant

331

1

M → V. Ref.3
Corresponds to variant rs10230714 [ dbSNP | Ensembl ].

VAR_051746

Experimental info

Sequence conflict

379

1

C → S in AAI50637. Ref.3

Sequence conflict

952

1

S → P in BAA90928. Ref.1

Isoform 3:

Sequence conflict

1039

1

R → Q in AAI50637. Ref.3

Isoform 4:

Sequence conflict

1017

1

R → Q in AAI30450. Ref.3

Sequence conflict

1057

1

S → N in AAI30450. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1098

Helix Strand Turn

Details...

Beta strand

500 – 508

9

Beta strand

516 – 524

9

Beta strand

531 – 539

9

Helix

544 – 548

5

Beta strand

556 – 560

5

Helix

570 – 579

10

Beta strand

582 – 591

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 998FD9821C422891	FASTA	1,098	123,342
	10 20 30 40 50 60 MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG SQQSRGRKYG 70 80 90 100 110 120 SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM KPKEFLEKTD GSVVKLESSV 130 140 150 160 170 180 SERISRFDTM YDGPSYSKFT ETRKMFERSV HESGQNNRYS PKKEKAGGSE PQDEWGGSKS 190 200 210 220 230 240 NRGSTDSLDS LSSRTEAVSP TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS 250 260 270 280 290 300 VTVTNLDTFG HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS 310 320 330 340 350 360 KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN LVGREAAKQQ 370 380 390 400 410 420 RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD YNVYRVRSRY NSDWGETGTE 430 440 450 460 470 480 QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE IPANRKIKFS SAPIKVFNTY SNEDYDRRND 490 500 510 520 530 540 EVDPVAASAE YELEKRVEKL ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT 550 560 570 580 590 600 EGGAAQRDGR IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA 610 620 630 640 650 660 QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS DMAIEVFELP 670 680 690 700 710 720 ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK LQAAENEKVR WELEKTQLQQ 730 740 750 760 770 780 NIEENKERML KLESYWIEAQ TLCHTVNEHL KETQSQYQAL EKKYNKAKKL IKDFQQKELD 790 800 810 820 830 840 FIKRQEAERK KIEDLEKAHL VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS 850 860 870 880 890 900 LGEVSKGDTM ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR 910 920 930 940 950 960 TRLYDSVSST DGEDSLERKN FTFNDDFSPS STSSADLSGL GAEPKTPGLS QSLALSSDES 970 980 990 1000 1010 1020 LDMIDDEILD DGQSPKHSQC QNRAVQEWSV QQVSHWLMSL NLEQYVSEFS AQNITGEQLL 1030 1040 1050 1060 1070 1080 QLDGNKLKAL GMTASQDRAV VKKKLKEMKM SLEKARKAQE KMEKQREKLR RKEQEQMQRK 1090 SKKTEKMTST TAEGAGEQ
	Isoform 2 (Short) [UniParc]. Checksum: 766E2172EC14E378	FASTA	387	43,095
	10 20 30 40 50 60 MHITKLLPPK GLRTSSPESD SGVPPLTPVD SNVPFSSDHI AEFQEEPLDP EMGPLSSMWG 70 80 90 100 110 120 DTSLFSTSKS DHDVEESPCH HQTTNKKILR EKDDAKDPKS LRASSSLAVQ GGKIKRKFVD 130 140 150 160 170 180 LGAPLRRNSS KGKKWKEKEK EASRFSAGSR IFRGRLENWT PKPCSTAQTS TRSPCMPFSW 190 200 210 220 230 240 FNDSRKGSYS FRNLPAPTSS LQPSPETLIS DKKGSKNFTF NDDFSPSSTS SADLSGLGAE 250 260 270 280 290 300 PKTPGLSQSL ALSSDEILDD GQSPKHSQCQ NRAVQEWSVQ QVSHWLMSLN LEQYVSEFSA 310 320 330 340 350 360 QNITGEQLLQ LDGNKLKALG MTASQDRAVV KKKLKEMKMS LEKARKAQEK MEKQREKLRR 370 380 KEQEQMQRKS KKTEKMTSTT AEGAGEQ
	Isoform 3 [UniParc]. Checksum: 032653B6F678A491	FASTA	1,374	154,050
	10 20 30 40 50 60 MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG SQQSRGRKYG 70 80 90 100 110 120 SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM KPKEFLEKTD GSVVKLESSV 130 140 150 160 170 180 SERISRFDTM YDGPSYSKFT ETRKMFERSV HESGQNNRYS PKKEKAGGSE PQDEWGGSKS 190 200 210 220 230 240 NRGSTDSLDS LSSRTEAVSP TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS 250 260 270 280 290 300 VTVTNLDTFG HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS 310 320 330 340 350 360 KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN LVGREAAKQQ 370 380 390 400 410 420 RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD YNVYRVRSRY NSDWGETGTE 430 440 450 460 470 480 QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE IPANRKIKFS SAPIKVFNTY SNEDYDRRND 490 500 510 520 530 540 EVDPVAASAE YELEKRVEKL ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT 550 560 570 580 590 600 EGGAAQRDGR IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA 610 620 630 640 650 660 QLISQTLEQE RRQRELLEQH YAQYDADDDE NTVAELQGMS GNCNNNNNYF LKTGEYATDE 670 680 690 700 710 720 EEDEVGPVLP GSDMAIEVFE LPENEDMFSP SELDTSKLSH KFKELQIKHA VTEAEIQKLK 730 740 750 760 770 780 TKLQAAENEK VRWELEKTQL QQNIEENKER MLKLESYWIE AQTLCHTVNE HLKETQSQYQ 790 800 810 820 830 840 ALEKKYNKAK KLIKDFQQKE LDFIKRQEAE RKKIEDLEKA HLVEVQGLQV RIRDLEAEVF 850 860 870 880 890 900 RLLKQNGTQV NNNNNIFERR TSLGEVSKGD TMENLDGKQT SCQDGLSQDL NEAVPETERL 910 920 930 940 950 960 DSKALKTRAQ LSVKNRRQRP SRTRLYDSVS STDGEDSLER KPSNSFYNHM HITKLLPPKG 970 980 990 1000 1010 1020 LRTSSPESDS GVPPLTPVDS NVPFSSDHIA EFQEEPLDPE MGPLSSMWGD TSLFSTSKSD 1030 1040 1050 1060 1070 1080 HDVEESPCHH QTTNKKILRE KDDAKDPKSL RASSSLAVQG GKIKRKFVDL GAPLRRNSSK 1090 1100 1110 1120 1130 1140 GKKWKEKEKE ASRFSAGSRI FRGRLENWTP KPCSTAQTST RSPCMPFSWF NDSRKGSYSF 1150 1160 1170 1180 1190 1200 RNLPAPTSSL QPSPETLISD KKGSKVENTW ITKANKRNPN PSSSSIFGRH SQLMSVVWIQ 1210 1220 1230 1240 1250 1260 ETNNFTFNDD FSPSSTSSAD LSGLGAEPKT PGLSQSLALS SDEILDDGQS PKHSQCQNRA 1270 1280 1290 1300 1310 1320 VQEWSVQQVS HWLMSLNLEQ YVSEFSAQNI TGEQLLQLDG NKLKALGMTA SQDRAVVKKK 1330 1340 1350 1360 1370 LKEMKMSLEK ARKAQEKMEK QREKLRRKEQ EQMQRKSKKT EKMTSTTAEG AGEQ
	Isoform 4 [UniParc]. Checksum: 297ABA81A72D3FA5	FASTA	1,253	140,302
	10 20 30 40 50 60 MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG SQQSRGRKYG 70 80 90 100 110 120 SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM KPKEFLEKTD GSVVKLESSV 130 140 150 160 170 180 SERISRFDTM YDGPSYSKFT ETRKMFERSV HESGQNNRYS PKKEKAGGSE PQDEWGGSKS 190 200 210 220 230 240 NRGSTDSLDS LSSRTEAVSP TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS 250 260 270 280 290 300 VTVTNLDTFG HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS 310 320 330 340 350 360 KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN LVGREAAKQQ 370 380 390 400 410 420 RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD YNVYRVRSRY NSDWGETGTE 430 440 450 460 470 480 QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE IPANRKIKFS SAPIKVFNTY SNEDYDRRND 490 500 510 520 530 540 EVDPVAASAE YELEKRVEKL ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT 550 560 570 580 590 600 EGGAAQRDGR IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA 610 620 630 640 650 660 QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS DMAIEVFELP 670 680 690 700 710 720 ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK LQAAENEKVR WELEKTQLQQ 730 740 750 760 770 780 NIEENKERML KLESYWIEAQ TLCHTVNEHL KETQSQYQAL EKKYNKAKKL IKDFQQKELD 790 800 810 820 830 840 FIKRQEAERK KIEDLEKAHL VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS 850 860 870 880 890 900 LGEVSKGDTM ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR 910 920 930 940 950 960 TRLYDSVSST DGEDSLERKP SNSFYNHMHI TKLLPPKGLR TSSPESDSGV PPLTPVDSNV 970 980 990 1000 1010 1020 PFSSDHIAEF QEEPLDPEMG PLSSMWGDTS LFSTSKSDHD VEESPCHHQT TNKKILREKD 1030 1040 1050 1060 1070 1080 DAKDPKSLRA SSSLAVQGGK IKRKFVDLGA PLRRNSSKGK KWKEKEKEAS RFSAGSRIFR 1090 1100 1110 1120 1130 1140 GRLENWTPKP CSTAQTSTRS PCMPFSWFND SRKGSYSFRN LPAPTSSLQP SPETLISDKK 1150 1160 1170 1180 1190 1200 GSKNFTFNDD FSPSSTSSAD LSGLGAEPKT PGLSQSLALS SDEALGMTAS QDRAVVKKKL 1210 1220 1230 1240 1250 KEMKMSLEKA RKAQEKMEKQ REKLRRKEQE QMQRKSKKTE KMTSTTAEGA GEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT VAL-331.
[4]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 357-1098 (ISOFORM 1). Tissue: Brain.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-840, MASS SPECTROMETRY.
[8]	"Solution structure of the PDZ domain of spinophilin/neurabinII protein." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 500-593.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK000075 mRNA. Translation: BAA90928.1.
AC002429 Genomic DNA. No translation available.
AC004022 Genomic DNA. Translation: AAC35294.2.
AC073886 Genomic DNA. No translation available.
AC073890 Genomic DNA. No translation available.
BC130449 mRNA. Translation: AAI30450.1.
BC150636 mRNA. Translation: AAI50637.1.
AB033048 mRNA. Translation: BAA86536.1.

IPI

IPI00008144.
IPI00215793.
IPI00896452.
IPI00927107.

RefSeq

NP_001159632.1. NM_001166160.1.
NP_001159633.1. NM_001166161.1.
NP_001159634.1. NM_001166162.1.
NP_001159635.1. NM_001166163.1.
NP_060120.2. NM_017650.2.

UniGene

Hs.21816.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WF8	NMR	-	A	500-593	[»]

ProteinModelPortal

Q9ULJ8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9ULJ8. 1 interaction.

MINT

MINT-106754.

STRING

9606.ENSP00000344524.

PTM databases

PhosphoSite

Q9ULJ8.

Polymorphism databases

DMDM

50403806.

Proteomic databases

PaxDb

Q9ULJ8.

PRIDE

Q9ULJ8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000340694; ENSP00000344524; ENSG00000158528.
ENST00000424654; ENSP00000411342; ENSG00000158528.
ENST00000433360; ENSP00000405514; ENSG00000158528.
ENST00000433881; ENSP00000398870; ENSG00000158528.
ENST00000456331; ENSP00000402893; ENSG00000158528.

GeneID

55607.

KEGG

hsa:55607.

UCSC

uc003unp.3. human.
uc003unr.3. human.

Organism-specific databases

CTD

55607.

GeneCards

GC07P094536.

HGNC

HGNC:14946. PPP1R9A.

HPA

CAB018752.
HPA017914.
HPA027726.

MIM

602468. gene.

neXtProt

NX_Q9ULJ8.

PharmGKB

PA33661.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

NOG314102.

HOGENOM

HOG000252962.

HOVERGEN

HBG005213.

InParanoid

Q9ULJ8.

OMA

SEPQDEW.

Gene expression databases

ArrayExpress

Q9ULJ8.

Bgee

Q9ULJ8.

CleanEx

HS_PPP1R9A.

Genevestigator

Q9ULJ8.

Family and domain databases

Gene3D

1.10.150.50. 1 hit.

InterPro

IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011510. SAM_2.
[Graphical view]

Pfam

PF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.
SSF47769. SAM_homology. 1 hit.

PROSITE

PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9ULJ8.

GenomeRNAi

55607.

NextBio

60161.

SOURCE

Search...

Entry information

Entry name

NEB1_HUMAN

Accession

Primary (citable) accession number: Q9ULJ8
Secondary accession number(s): A1L494 , B2RWQ1, E9PCA0, E9PCK6, E9PDX1, O76059, Q9NXT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.