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Protein

Neurabin-1

Gene

PPP1R9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurabin-1
Alternative name(s):
Neurabin-I
Neural tissue-specific F-actin-binding protein I
Protein phosphatase 1 regulatory subunit 9A
Gene namesi
Name:PPP1R9A
Synonyms:KIAA1222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14946. PPP1R9A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33661.

Polymorphism and mutation databases

BioMutaiPPP1R9A.
DMDMi50403806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10981098Neurabin-1PRO_0000071507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei192 – 1921PhosphoserineBy similarity
Modified residuei312 – 3121PhosphothreonineBy similarity
Modified residuei338 – 3381PhosphoserineCombined sources
Modified residuei371 – 3711PhosphoserineBy similarity
Modified residuei460 – 4601Phosphoserine; by PKABy similarity
Modified residuei840 – 8401PhosphoserineCombined sources
Modified residuei915 – 9151PhosphoserineBy similarity
Modified residuei928 – 9281PhosphoserineBy similarity
Modified residuei956 – 9561PhosphoserineBy similarity
Modified residuei957 – 9571PhosphoserineBy similarity
Modified residuei960 – 9601PhosphoserineBy similarity
Modified residuei974 – 9741PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULJ8.
MaxQBiQ9ULJ8.
PaxDbiQ9ULJ8.
PRIDEiQ9ULJ8.

PTM databases

iPTMnetiQ9ULJ8.
PhosphoSiteiQ9ULJ8.

Expressioni

Gene expression databases

BgeeiQ9ULJ8.
CleanExiHS_PPP1R9A.
ExpressionAtlasiQ9ULJ8. baseline and differential.
GenevisibleiQ9ULJ8. HS.

Organism-specific databases

HPAiCAB018752.
HPA017914.
HPA027726.

Interactioni

Subunit structurei

Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2 and p70-S6K (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RGS2P412203EBI-2515561,EBI-712388

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120747. 32 interactions.
IntActiQ9ULJ8. 17 interactions.
MINTiMINT-106754.
STRINGi9606.ENSP00000405514.

Structurei

Secondary structure

1
1098
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi500 – 5089Combined sources
Beta strandi516 – 5249Combined sources
Beta strandi531 – 5399Combined sources
Helixi544 – 5485Combined sources
Beta strandi556 – 5605Combined sources
Helixi570 – 57910Combined sources
Beta strandi582 – 59110Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WF8NMR-A500-593[»]
ProteinModelPortaliQ9ULJ8.
SMRiQ9ULJ8. Positions 435-593, 985-1055.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULJ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini504 – 59289PDZPROSITE-ProRule annotationAdd
BLAST
Domaini988 – 105164SAMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 144144Actin-bindingAdd
BLAST
Regioni425 – 50278Interacts with protein phosphatase 1By similarityAdd
BLAST
Regioni597 – 1090494Interacts with TGN38By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili597 – 62731Sequence analysisAdd
BLAST
Coiled coili670 – 824155Sequence analysisAdd
BLAST
Coiled coili1033 – 109058Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi447 – 4504Poly-Glu
Compositional biasi829 – 8335Poly-Asn

Domaini

Interacts with p70-S6K via its PDZ domain.By similarity
The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.By similarity

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1945. Eukaryota.
ENOG410Y7F2. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000252962.
HOVERGENiHBG005213.
InParanoidiQ9ULJ8.
KOiK17551.
OMAiSPKHSQC.
OrthoDBiEOG7XM2WV.
PhylomeDBiQ9ULJ8.
TreeFamiTF105540.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR029994. Neurabin-1.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR16154:SF22. PTHR16154:SF22. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULJ8-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG
60 70 80 90 100
SQQSRGRKYG SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM
110 120 130 140 150
KPKEFLEKTD GSVVKLESSV SERISRFDTM YDGPSYSKFT ETRKMFERSV
160 170 180 190 200
HESGQNNRYS PKKEKAGGSE PQDEWGGSKS NRGSTDSLDS LSSRTEAVSP
210 220 230 240 250
TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS VTVTNLDTFG
260 270 280 290 300
HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS
310 320 330 340 350
KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN
360 370 380 390 400
LVGREAAKQQ RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD
410 420 430 440 450
YNVYRVRSRY NSDWGETGTE QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE
460 470 480 490 500
IPANRKIKFS SAPIKVFNTY SNEDYDRRND EVDPVAASAE YELEKRVEKL
510 520 530 540 550
ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT EGGAAQRDGR
560 570 580 590 600
IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA
610 620 630 640 650
QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS
660 670 680 690 700
DMAIEVFELP ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK
710 720 730 740 750
LQAAENEKVR WELEKTQLQQ NIEENKERML KLESYWIEAQ TLCHTVNEHL
760 770 780 790 800
KETQSQYQAL EKKYNKAKKL IKDFQQKELD FIKRQEAERK KIEDLEKAHL
810 820 830 840 850
VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS LGEVSKGDTM
860 870 880 890 900
ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR
910 920 930 940 950
TRLYDSVSST DGEDSLERKN FTFNDDFSPS STSSADLSGL GAEPKTPGLS
960 970 980 990 1000
QSLALSSDES LDMIDDEILD DGQSPKHSQC QNRAVQEWSV QQVSHWLMSL
1010 1020 1030 1040 1050
NLEQYVSEFS AQNITGEQLL QLDGNKLKAL GMTASQDRAV VKKKLKEMKM
1060 1070 1080 1090
SLEKARKAQE KMEKQREKLR RKEQEQMQRK SKKTEKMTST TAEGAGEQ
Length:1,098
Mass (Da):123,342
Last modified:July 19, 2004 - v2
Checksum:i998FD9821C422891
GO
Isoform 2 (identifier: Q9ULJ8-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-918: MLKTESSGER...STDGEDSLER → MHITKLLPPK...ETLISDKKGS
     960-967: Missing.

Note: No experimental confirmation available.
Show »
Length:387
Mass (Da):43,095
Checksum:i766E2172EC14E378
GO
Isoform 3 (identifier: Q9ULJ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     630-630: E → ENTVAELQGMSGNCNNNNNYFLK
     919-919: K → KPSNSFYNHM...MSVVWIQETN
     960-967: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,374
Mass (Da):154,050
Checksum:i032653B6F678A491
GO
Isoform 4 (identifier: Q9ULJ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     920-1028: NFTFNDDFSP...LLQLDGNKLK → PSNSFYNHMH...SQSLALSSDE

Note: No experimental confirmation available.Curated
Show »
Length:1,253
Mass (Da):140,302
Checksum:i297ABA81A72D3FA5
GO
Isoform 5 (identifier: Q9ULJ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     919-919: K → KGLRTSSPES...TLISDKKGSK
     960-967: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,296
Mass (Da):145,176
Checksum:iE757C7C0B46A2EC8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti379 – 3791C → S in AAI50637 (PubMed:15489334).Curated
Sequence conflicti952 – 9521S → P in BAA90928 (PubMed:14702039).Curated
Isoform 4 (identifier: Q9ULJ8-4)
Sequence conflicti1017 – 10171R → Q in AAI30450 (PubMed:15489334).Curated
Sequence conflicti1057 – 10571S → N in AAI30450 (PubMed:15489334).Curated
Isoform 3 (identifier: Q9ULJ8-3)
Sequence conflicti1039 – 10391R → Q in AAI50637 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti331 – 3311M → V.1 Publication
Corresponds to variant rs10230714 [ dbSNP | Ensembl ].
VAR_051746

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 918918MLKTE…DSLER → MHITKLLPPKGLRTSSPESD SGVPPLTPVDSNVPFSSDHI AEFQEEPLDPEMGPLSSMWG DTSLFSTSKSDHDVEESPCH HQTTNKKILREKDDAKDPKS LRASSSLAVQGGKIKRKFVD LGAPLRRNSSKGKKWKEKEK EASRFSAGSRIFRGRLENWT PKPCSTAQTSTRSPCMPFSW FNDSRKGSYSFRNLPAPTSS LQPSPETLISDKKGS in isoform 2. 1 PublicationVSP_011139Add
BLAST
Alternative sequencei630 – 6301E → ENTVAELQGMSGNCNNNNNY FLK in isoform 3. 1 PublicationVSP_044469
Alternative sequencei919 – 9191K → KPSNSFYNHMHITKLLPPKG LRTSSPESDSGVPPLTPVDS NVPFSSDHIAEFQEEPLDPE MGPLSSMWGDTSLFSTSKSD HDVEESPCHHQTTNKKILRE KDDAKDPKSLRASSSLAVQG GKIKRKFVDLGAPLRRNSSK GKKWKEKEKEASRFSAGSRI FRGRLENWTPKPCSTAQTST RSPCMPFSWFNDSRKGSYSF RNLPAPTSSLQPSPETLISD KKGSKVENTWITKANKRNPN PSSSSIFGRHSQLMSVVWIQ ETN in isoform 3. 1 PublicationVSP_044470
Alternative sequencei919 – 9191K → KGLRTSSPESDSGVPPLTPV DSNVPFSSDHIAEFQEEPLD PEMGPLSSMWGDTSLFSTSK SDHDVEESPCHHQTTNKKIL REKDDAKDPKSLRASSSLAV QGGKIKRKFVDLGAPLRRNS SKGKKWKEKEKEASRFSAGS RIFRGRLENWTPKPCSTAQT STRSPCMPFSWFNDSRKGSY SFRNLPAPTSSLQPSPETLI SDKKGSK in isoform 5. CuratedVSP_053808
Alternative sequencei920 – 1028109NFTFN…GNKLK → PSNSFYNHMHITKLLPPKGL RTSSPESDSGVPPLTPVDSN VPFSSDHIAEFQEEPLDPEM GPLSSMWGDTSLFSTSKSDH DVEESPCHHQTTNKKILREK DDAKDPKSLRASSSLAVQGG KIKRKFVDLGAPLRRNSSKG KKWKEKEKEASRFSAGSRIF RGRLENWTPKPCSTAQTSTR SPCMPFSWFNDSRKGSYSFR NLPAPTSSLQPSPETLISDK KGSKNFTFNDDFSPSSTSSA DLSGLGAEPKTPGLSQSLAL SSDE in isoform 4. 1 PublicationVSP_044471Add
BLAST
Alternative sequencei960 – 9678Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsVSP_005121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000075 mRNA. Translation: BAA90928.1.
AC002429 Genomic DNA. No translation available.
AC004022 Genomic DNA. Translation: AAC35294.2.
AC073886 Genomic DNA. No translation available.
AC073890 Genomic DNA. No translation available.
BC130449 mRNA. Translation: AAI30450.1.
BC150636 mRNA. Translation: AAI50637.1.
AB033048 mRNA. Translation: BAA86536.1.
CCDSiCCDS34683.1. [Q9ULJ8-1]
CCDS55127.1. [Q9ULJ8-3]
CCDS55128.1. [Q9ULJ8-4]
CCDS55129.1. [Q9ULJ8-5]
RefSeqiNP_001159632.1. NM_001166160.1. [Q9ULJ8-3]
NP_001159633.1. NM_001166161.1. [Q9ULJ8-5]
NP_001159634.1. NM_001166162.1. [Q9ULJ8-4]
NP_001159635.1. NM_001166163.1.
NP_060120.2. NM_017650.2. [Q9ULJ8-1]
XP_011514693.1. XM_011516391.1. [Q9ULJ8-5]
UniGeneiHs.21816.

Genome annotation databases

EnsembliENST00000289495; ENSP00000289495; ENSG00000158528. [Q9ULJ8-5]
ENST00000340694; ENSP00000344524; ENSG00000158528. [Q9ULJ8-1]
ENST00000424654; ENSP00000411342; ENSG00000158528. [Q9ULJ8-4]
ENST00000433360; ENSP00000405514; ENSG00000158528. [Q9ULJ8-3]
ENST00000433881; ENSP00000398870; ENSG00000158528. [Q9ULJ8-1]
ENST00000456331; ENSP00000402893; ENSG00000158528. [Q9ULJ8-4]
GeneIDi55607.
KEGGihsa:55607.
UCSCiuc003unp.5. human. [Q9ULJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000075 mRNA. Translation: BAA90928.1.
AC002429 Genomic DNA. No translation available.
AC004022 Genomic DNA. Translation: AAC35294.2.
AC073886 Genomic DNA. No translation available.
AC073890 Genomic DNA. No translation available.
BC130449 mRNA. Translation: AAI30450.1.
BC150636 mRNA. Translation: AAI50637.1.
AB033048 mRNA. Translation: BAA86536.1.
CCDSiCCDS34683.1. [Q9ULJ8-1]
CCDS55127.1. [Q9ULJ8-3]
CCDS55128.1. [Q9ULJ8-4]
CCDS55129.1. [Q9ULJ8-5]
RefSeqiNP_001159632.1. NM_001166160.1. [Q9ULJ8-3]
NP_001159633.1. NM_001166161.1. [Q9ULJ8-5]
NP_001159634.1. NM_001166162.1. [Q9ULJ8-4]
NP_001159635.1. NM_001166163.1.
NP_060120.2. NM_017650.2. [Q9ULJ8-1]
XP_011514693.1. XM_011516391.1. [Q9ULJ8-5]
UniGeneiHs.21816.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WF8NMR-A500-593[»]
ProteinModelPortaliQ9ULJ8.
SMRiQ9ULJ8. Positions 435-593, 985-1055.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120747. 32 interactions.
IntActiQ9ULJ8. 17 interactions.
MINTiMINT-106754.
STRINGi9606.ENSP00000405514.

PTM databases

iPTMnetiQ9ULJ8.
PhosphoSiteiQ9ULJ8.

Polymorphism and mutation databases

BioMutaiPPP1R9A.
DMDMi50403806.

Proteomic databases

EPDiQ9ULJ8.
MaxQBiQ9ULJ8.
PaxDbiQ9ULJ8.
PRIDEiQ9ULJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289495; ENSP00000289495; ENSG00000158528. [Q9ULJ8-5]
ENST00000340694; ENSP00000344524; ENSG00000158528. [Q9ULJ8-1]
ENST00000424654; ENSP00000411342; ENSG00000158528. [Q9ULJ8-4]
ENST00000433360; ENSP00000405514; ENSG00000158528. [Q9ULJ8-3]
ENST00000433881; ENSP00000398870; ENSG00000158528. [Q9ULJ8-1]
ENST00000456331; ENSP00000402893; ENSG00000158528. [Q9ULJ8-4]
GeneIDi55607.
KEGGihsa:55607.
UCSCiuc003unp.5. human. [Q9ULJ8-1]

Organism-specific databases

CTDi55607.
GeneCardsiPPP1R9A.
HGNCiHGNC:14946. PPP1R9A.
HPAiCAB018752.
HPA017914.
HPA027726.
MIMi602468. gene.
neXtProtiNX_Q9ULJ8.
PharmGKBiPA33661.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1945. Eukaryota.
ENOG410Y7F2. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000252962.
HOVERGENiHBG005213.
InParanoidiQ9ULJ8.
KOiK17551.
OMAiSPKHSQC.
OrthoDBiEOG7XM2WV.
PhylomeDBiQ9ULJ8.
TreeFamiTF105540.

Miscellaneous databases

ChiTaRSiPPP1R9A. human.
EvolutionaryTraceiQ9ULJ8.
GeneWikiiPPP1R9A.
GenomeRNAii55607.
NextBioi60161.
PROiQ9ULJ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULJ8.
CleanExiHS_PPP1R9A.
ExpressionAtlasiQ9ULJ8. baseline and differential.
GenevisibleiQ9ULJ8. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR029994. Neurabin-1.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR16154:SF22. PTHR16154:SF22. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT VAL-331.
  4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 357-1098 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-840, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Solution structure of the PDZ domain of spinophilin/neurabinII protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 500-593.

Entry informationi

Entry nameiNEB1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ8
Secondary accession number(s): A1L494
, B2RWQ1, E9PCA0, E9PCK6, E9PDX1, F8W7J9, O76059, Q9NXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 19, 2004
Last modified: April 13, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.