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Protein

Neurabin-1

Gene

PPP1R9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurabin-1
Alternative name(s):
Neurabin-I
Neural tissue-specific F-actin-binding protein I
Protein phosphatase 1 regulatory subunit 9A
Gene namesi
Name:PPP1R9A
Synonyms:KIAA1222
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14946. PPP1R9A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi55607.
OpenTargetsiENSG00000158528.
PharmGKBiPA33661.

Polymorphism and mutation databases

BioMutaiPPP1R9A.
DMDMi50403806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715071 – 1098Neurabin-1Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei192PhosphoserineBy similarity1
Modified residuei312PhosphothreonineBy similarity1
Modified residuei338PhosphoserineCombined sources1
Modified residuei371PhosphoserineBy similarity1
Modified residuei460Phosphoserine; by PKABy similarity1
Modified residuei840PhosphoserineCombined sources1
Modified residuei915PhosphoserineBy similarity1
Modified residuei928PhosphoserineBy similarity1
Modified residuei956PhosphoserineBy similarity1
Modified residuei957PhosphoserineBy similarity1
Modified residuei960PhosphoserineBy similarity1
Modified residuei974PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULJ8.
PaxDbiQ9ULJ8.
PeptideAtlasiQ9ULJ8.
PRIDEiQ9ULJ8.

PTM databases

iPTMnetiQ9ULJ8.
PhosphoSitePlusiQ9ULJ8.

Expressioni

Gene expression databases

BgeeiENSG00000158528.
CleanExiHS_PPP1R9A.
ExpressionAtlasiQ9ULJ8. baseline and differential.
GenevisibleiQ9ULJ8. HS.

Organism-specific databases

HPAiCAB018752.
HPA017914.
HPA027726.

Interactioni

Subunit structurei

Possibly exists as a homodimer, homotrimer or a homotetramer. Interacts with F-actin, protein phosphatase 1 (PP1), neurabin-2 and p70-S6K (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RGS2P412203EBI-2515561,EBI-712388

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120747. 32 interactors.
IntActiQ9ULJ8. 17 interactors.
MINTiMINT-106754.
STRINGi9606.ENSP00000405514.

Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi500 – 508Combined sources9
Beta strandi516 – 524Combined sources9
Beta strandi531 – 539Combined sources9
Helixi544 – 548Combined sources5
Beta strandi556 – 560Combined sources5
Helixi570 – 579Combined sources10
Beta strandi582 – 591Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF8NMR-A500-593[»]
ProteinModelPortaliQ9ULJ8.
SMRiQ9ULJ8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULJ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini504 – 592PDZPROSITE-ProRule annotationAdd BLAST89
Domaini988 – 1051SAMPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 144Actin-bindingAdd BLAST144
Regioni425 – 502Interaction with protein phosphatase 1By similarityAdd BLAST78
Regioni597 – 1090Interaction with TGN38By similarityAdd BLAST494

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili597 – 627Sequence analysisAdd BLAST31
Coiled coili670 – 824Sequence analysisAdd BLAST155
Coiled coili1033 – 1090Sequence analysisAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi447 – 450Poly-Glu4
Compositional biasi829 – 833Poly-Asn5

Domaini

Interacts with p70-S6K via its PDZ domain.By similarity
The PP1 binding region is natively unstructured, upon PP1 binding, it acquires structure, blocks a substrate-binding site, and restricts PP1 phosphatase specificity to a subset of substrates.By similarity

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1945. Eukaryota.
ENOG410Y7F2. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000252962.
HOVERGENiHBG005213.
InParanoidiQ9ULJ8.
KOiK17551.
OMAiSPKHSQC.
OrthoDBiEOG091G0NSU.
PhylomeDBiQ9ULJ8.
TreeFamiTF105540.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR029994. Neurabin-1.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR16154:SF22. PTHR16154:SF22. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULJ8-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG
60 70 80 90 100
SQQSRGRKYG SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM
110 120 130 140 150
KPKEFLEKTD GSVVKLESSV SERISRFDTM YDGPSYSKFT ETRKMFERSV
160 170 180 190 200
HESGQNNRYS PKKEKAGGSE PQDEWGGSKS NRGSTDSLDS LSSRTEAVSP
210 220 230 240 250
TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS VTVTNLDTFG
260 270 280 290 300
HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS
310 320 330 340 350
KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN
360 370 380 390 400
LVGREAAKQQ RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD
410 420 430 440 450
YNVYRVRSRY NSDWGETGTE QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE
460 470 480 490 500
IPANRKIKFS SAPIKVFNTY SNEDYDRRND EVDPVAASAE YELEKRVEKL
510 520 530 540 550
ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT EGGAAQRDGR
560 570 580 590 600
IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA
610 620 630 640 650
QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS
660 670 680 690 700
DMAIEVFELP ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK
710 720 730 740 750
LQAAENEKVR WELEKTQLQQ NIEENKERML KLESYWIEAQ TLCHTVNEHL
760 770 780 790 800
KETQSQYQAL EKKYNKAKKL IKDFQQKELD FIKRQEAERK KIEDLEKAHL
810 820 830 840 850
VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS LGEVSKGDTM
860 870 880 890 900
ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR
910 920 930 940 950
TRLYDSVSST DGEDSLERKN FTFNDDFSPS STSSADLSGL GAEPKTPGLS
960 970 980 990 1000
QSLALSSDES LDMIDDEILD DGQSPKHSQC QNRAVQEWSV QQVSHWLMSL
1010 1020 1030 1040 1050
NLEQYVSEFS AQNITGEQLL QLDGNKLKAL GMTASQDRAV VKKKLKEMKM
1060 1070 1080 1090
SLEKARKAQE KMEKQREKLR RKEQEQMQRK SKKTEKMTST TAEGAGEQ
Length:1,098
Mass (Da):123,342
Last modified:July 19, 2004 - v2
Checksum:i998FD9821C422891
GO
Isoform 2 (identifier: Q9ULJ8-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-918: MLKTESSGER...STDGEDSLER → MHITKLLPPK...ETLISDKKGS
     960-967: Missing.

Note: No experimental confirmation available.
Show »
Length:387
Mass (Da):43,095
Checksum:i766E2172EC14E378
GO
Isoform 3 (identifier: Q9ULJ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     630-630: E → ENTVAELQGMSGNCNNNNNYFLK
     919-919: K → KPSNSFYNHM...MSVVWIQETN
     960-967: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,374
Mass (Da):154,050
Checksum:i032653B6F678A491
GO
Isoform 4 (identifier: Q9ULJ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     920-1028: NFTFNDDFSP...LLQLDGNKLK → PSNSFYNHMH...SQSLALSSDE

Note: No experimental confirmation available.Curated
Show »
Length:1,253
Mass (Da):140,302
Checksum:i297ABA81A72D3FA5
GO
Isoform 5 (identifier: Q9ULJ8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     919-919: K → KGLRTSSPES...TLISDKKGSK
     960-967: Missing.

Note: Gene prediction based on EST data.
Show »
Length:1,296
Mass (Da):145,176
Checksum:iE757C7C0B46A2EC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379C → S in AAI50637 (PubMed:15489334).Curated1
Sequence conflicti952S → P in BAA90928 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q9ULJ8-4)
Sequence conflicti1017R → Q in AAI30450 (PubMed:15489334).Curated1
Sequence conflicti1057S → N in AAI30450 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q9ULJ8-3)
Sequence conflicti1039R → Q in AAI50637 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051746331M → V.1 PublicationCorresponds to variant rs10230714dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0111391 – 918MLKTE…DSLER → MHITKLLPPKGLRTSSPESD SGVPPLTPVDSNVPFSSDHI AEFQEEPLDPEMGPLSSMWG DTSLFSTSKSDHDVEESPCH HQTTNKKILREKDDAKDPKS LRASSSLAVQGGKIKRKFVD LGAPLRRNSSKGKKWKEKEK EASRFSAGSRIFRGRLENWT PKPCSTAQTSTRSPCMPFSW FNDSRKGSYSFRNLPAPTSS LQPSPETLISDKKGS in isoform 2. 1 PublicationAdd BLAST918
Alternative sequenceiVSP_044469630E → ENTVAELQGMSGNCNNNNNY FLK in isoform 3. 1 Publication1
Alternative sequenceiVSP_044470919K → KPSNSFYNHMHITKLLPPKG LRTSSPESDSGVPPLTPVDS NVPFSSDHIAEFQEEPLDPE MGPLSSMWGDTSLFSTSKSD HDVEESPCHHQTTNKKILRE KDDAKDPKSLRASSSLAVQG GKIKRKFVDLGAPLRRNSSK GKKWKEKEKEASRFSAGSRI FRGRLENWTPKPCSTAQTST RSPCMPFSWFNDSRKGSYSF RNLPAPTSSLQPSPETLISD KKGSKVENTWITKANKRNPN PSSSSIFGRHSQLMSVVWIQ ETN in isoform 3. 1 Publication1
Alternative sequenceiVSP_053808919K → KGLRTSSPESDSGVPPLTPV DSNVPFSSDHIAEFQEEPLD PEMGPLSSMWGDTSLFSTSK SDHDVEESPCHHQTTNKKIL REKDDAKDPKSLRASSSLAV QGGKIKRKFVDLGAPLRRNS SKGKKWKEKEKEASRFSAGS RIFRGRLENWTPKPCSTAQT STRSPCMPFSWFNDSRKGSY SFRNLPAPTSSLQPSPETLI SDKKGSK in isoform 5. Curated1
Alternative sequenceiVSP_044471920 – 1028NFTFN…GNKLK → PSNSFYNHMHITKLLPPKGL RTSSPESDSGVPPLTPVDSN VPFSSDHIAEFQEEPLDPEM GPLSSMWGDTSLFSTSKSDH DVEESPCHHQTTNKKILREK DDAKDPKSLRASSSLAVQGG KIKRKFVDLGAPLRRNSSKG KKWKEKEKEASRFSAGSRIF RGRLENWTPKPCSTAQTSTR SPCMPFSWFNDSRKGSYSFR NLPAPTSSLQPSPETLISDK KGSKNFTFNDDFSPSSTSSA DLSGLGAEPKTPGLSQSLAL SSDE in isoform 4. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_005121960 – 967Missing in isoform 2, isoform 3 and isoform 5. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000075 mRNA. Translation: BAA90928.1.
AC002429 Genomic DNA. No translation available.
AC004022 Genomic DNA. Translation: AAC35294.2.
AC073886 Genomic DNA. No translation available.
AC073890 Genomic DNA. No translation available.
BC130449 mRNA. Translation: AAI30450.1.
BC150636 mRNA. Translation: AAI50637.1.
AB033048 mRNA. Translation: BAA86536.1.
CCDSiCCDS34683.1. [Q9ULJ8-1]
CCDS55127.1. [Q9ULJ8-3]
CCDS55128.1. [Q9ULJ8-4]
CCDS55129.1. [Q9ULJ8-5]
RefSeqiNP_001159632.1. NM_001166160.1. [Q9ULJ8-3]
NP_001159633.1. NM_001166161.1. [Q9ULJ8-5]
NP_001159634.1. NM_001166162.1. [Q9ULJ8-4]
NP_001159635.1. NM_001166163.1.
NP_060120.2. NM_017650.2. [Q9ULJ8-1]
XP_016867892.1. XM_017012403.1. [Q9ULJ8-5]
XP_016867894.1. XM_017012405.1. [Q9ULJ8-1]
XP_016867895.1. XM_017012406.1. [Q9ULJ8-1]
UniGeneiHs.21816.

Genome annotation databases

EnsembliENST00000289495; ENSP00000289495; ENSG00000158528. [Q9ULJ8-5]
ENST00000340694; ENSP00000344524; ENSG00000158528. [Q9ULJ8-1]
ENST00000424654; ENSP00000411342; ENSG00000158528. [Q9ULJ8-4]
ENST00000433360; ENSP00000405514; ENSG00000158528. [Q9ULJ8-3]
ENST00000433881; ENSP00000398870; ENSG00000158528. [Q9ULJ8-1]
ENST00000456331; ENSP00000402893; ENSG00000158528. [Q9ULJ8-4]
GeneIDi55607.
KEGGihsa:55607.
UCSCiuc003unp.5. human. [Q9ULJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000075 mRNA. Translation: BAA90928.1.
AC002429 Genomic DNA. No translation available.
AC004022 Genomic DNA. Translation: AAC35294.2.
AC073886 Genomic DNA. No translation available.
AC073890 Genomic DNA. No translation available.
BC130449 mRNA. Translation: AAI30450.1.
BC150636 mRNA. Translation: AAI50637.1.
AB033048 mRNA. Translation: BAA86536.1.
CCDSiCCDS34683.1. [Q9ULJ8-1]
CCDS55127.1. [Q9ULJ8-3]
CCDS55128.1. [Q9ULJ8-4]
CCDS55129.1. [Q9ULJ8-5]
RefSeqiNP_001159632.1. NM_001166160.1. [Q9ULJ8-3]
NP_001159633.1. NM_001166161.1. [Q9ULJ8-5]
NP_001159634.1. NM_001166162.1. [Q9ULJ8-4]
NP_001159635.1. NM_001166163.1.
NP_060120.2. NM_017650.2. [Q9ULJ8-1]
XP_016867892.1. XM_017012403.1. [Q9ULJ8-5]
XP_016867894.1. XM_017012405.1. [Q9ULJ8-1]
XP_016867895.1. XM_017012406.1. [Q9ULJ8-1]
UniGeneiHs.21816.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WF8NMR-A500-593[»]
ProteinModelPortaliQ9ULJ8.
SMRiQ9ULJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120747. 32 interactors.
IntActiQ9ULJ8. 17 interactors.
MINTiMINT-106754.
STRINGi9606.ENSP00000405514.

PTM databases

iPTMnetiQ9ULJ8.
PhosphoSitePlusiQ9ULJ8.

Polymorphism and mutation databases

BioMutaiPPP1R9A.
DMDMi50403806.

Proteomic databases

EPDiQ9ULJ8.
PaxDbiQ9ULJ8.
PeptideAtlasiQ9ULJ8.
PRIDEiQ9ULJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289495; ENSP00000289495; ENSG00000158528. [Q9ULJ8-5]
ENST00000340694; ENSP00000344524; ENSG00000158528. [Q9ULJ8-1]
ENST00000424654; ENSP00000411342; ENSG00000158528. [Q9ULJ8-4]
ENST00000433360; ENSP00000405514; ENSG00000158528. [Q9ULJ8-3]
ENST00000433881; ENSP00000398870; ENSG00000158528. [Q9ULJ8-1]
ENST00000456331; ENSP00000402893; ENSG00000158528. [Q9ULJ8-4]
GeneIDi55607.
KEGGihsa:55607.
UCSCiuc003unp.5. human. [Q9ULJ8-1]

Organism-specific databases

CTDi55607.
DisGeNETi55607.
GeneCardsiPPP1R9A.
HGNCiHGNC:14946. PPP1R9A.
HPAiCAB018752.
HPA017914.
HPA027726.
MIMi602468. gene.
neXtProtiNX_Q9ULJ8.
OpenTargetsiENSG00000158528.
PharmGKBiPA33661.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1945. Eukaryota.
ENOG410Y7F2. LUCA.
GeneTreeiENSGT00390000010033.
HOGENOMiHOG000252962.
HOVERGENiHBG005213.
InParanoidiQ9ULJ8.
KOiK17551.
OMAiSPKHSQC.
OrthoDBiEOG091G0NSU.
PhylomeDBiQ9ULJ8.
TreeFamiTF105540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158528-MONOMER.

Miscellaneous databases

ChiTaRSiPPP1R9A. human.
EvolutionaryTraceiQ9ULJ8.
GeneWikiiPPP1R9A.
GenomeRNAii55607.
PROiQ9ULJ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158528.
CleanExiHS_PPP1R9A.
ExpressionAtlasiQ9ULJ8. baseline and differential.
GenevisibleiQ9ULJ8. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR029994. Neurabin-1.
IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PANTHERiPTHR16154:SF22. PTHR16154:SF22. 1 hit.
PfamiPF00595. PDZ. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEB1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ8
Secondary accession number(s): A1L494
, B2RWQ1, E9PCA0, E9PCK6, E9PDX1, F8W7J9, O76059, Q9NXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.