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Q9ULJ6

- ZMIZ1_HUMAN

UniProt

Q9ULJ6 - ZMIZ1_HUMAN

Protein

Zinc finger MIZ domain-containing protein 1

Gene

ZMIZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri727 – 80478SP-RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. artery morphogenesis Source: Ensembl
    2. cell aging Source: Ensembl
    3. developmental growth Source: Ensembl
    4. heart morphogenesis Source: Ensembl
    5. in utero embryonic development Source: Ensembl
    6. positive regulation of fibroblast proliferation Source: Ensembl
    7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. transcription, DNA-templated Source: UniProtKB-KW
    9. vasculogenesis Source: Ensembl
    10. vitellogenesis Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger MIZ domain-containing protein 1
    Alternative name(s):
    PIAS-like protein Zimp10
    Retinoic acid-induced protein 17
    Gene namesi
    Name:ZMIZ1
    Synonyms:KIAA1224, RAI17, ZIMP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:16493. ZMIZ1.

    Subcellular locationi

    Nucleus speckle 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear speck Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10671067Zinc finger MIZ domain-containing protein 1PRO_0000218987Add
    BLAST

    Proteomic databases

    MaxQBiQ9ULJ6.
    PaxDbiQ9ULJ6.
    PRIDEiQ9ULJ6.

    PTM databases

    PhosphoSiteiQ9ULJ6.

    Expressioni

    Tissue specificityi

    Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ9ULJ6.
    BgeeiQ9ULJ6.
    CleanExiHS_ZMIZ1.
    GenevestigatoriQ9ULJ6.

    Organism-specific databases

    HPAiHPA045144.

    Interactioni

    Subunit structurei

    Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.1 Publication

    Protein-protein interaction databases

    BioGridi121427. 8 interactions.
    IntActiQ9ULJ6. 17 interactions.
    MINTiMINT-7970305.
    STRINGi9606.ENSP00000334474.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULJ6.
    SMRiQ9ULJ6. Positions 571-825.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi280 – 30526Ala-richAdd
    BLAST
    Compositional biasi334 – 555222Pro-richAdd
    BLAST
    Compositional biasi867 – 1002136Pro-richAdd
    BLAST

    Domaini

    The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

    Sequence similaritiesi

    Contains 1 SP-RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri727 – 80478SP-RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG237400.
    HOGENOMiHOG000253014.
    HOVERGENiHBG056252.
    InParanoidiQ9ULJ6.
    OMAiDFMHGPQ.
    OrthoDBiEOG715Q3Q.
    PhylomeDBiQ9ULJ6.
    TreeFamiTF316952.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004181. Znf_MIZ.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF02891. zf-MIZ. 1 hit.
    [Graphical view]
    PROSITEiPS51044. ZF_SP_RING. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULJ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE     50
    QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC 100
    EELGRLLLLR HQKSRQSDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS 150
    VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM 200
    ASGMTTSNPG LNSPQFAGQQ QQFSAKAGPA QPYIQQSMYG RPNYPGSGGF 250
    GASYPGGPNA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 300
    ATVAALQETQ NKDINQYGPM GPTQAYNSQF MNQPGPRGPA SMGGSMNPAS 350
    MAAGMTPSGM SGPPMGMNQP RPPGISPFGT HGQRMPQQTY PGPRPQSLPI 400
    QNIKRPYPGE PNYGNQQYGP NSQFPTQPGQ YPAPNPPRPL TSPNYPGQRM 450
    PSQPSSGQYP PPTVNMGQYY KPEQFNGQNN TFSGSSYSNY SQGNVNRPPR 500
    PVPVANYPHS PVPGNPTPPM TPGSSIPPYL SPSQDVKPPF PPDIKPNMSA 550
    LPPPPANHND ELRLTFPVRD GVVLEPFRLE HNLAVSNHVF HLRPTVHQTL 600
    MWRSDLELQF KCYHHEDRQM NTNWPASVQV SVNATPLTIE RGDNKTSHKP 650
    LHLKHVCQPG RNTIQITVTA CCCSHLFVLQ LVHRPSVRSV LQGLLKKRLL 700
    PAEHCITKIK RNFSSVAASS GNTTLNGEDG VEQTAIKVSL KCPITFRRIQ 750
    LPARGHDCKH VQCFDLESYL QLNCERGTWR CPVCNKTALL EGLEVDQYMW 800
    GILNAIQHSE FEEVTIDPTC SWRPVPIKSD LHIKDDPDGI PSKRFKTMSP 850
    SQMIMPNVME MIAALGPGPS PYPLPPPPGG TNSNDYSSQG NNYQGHGNFD 900
    FPHGNPGGTS MNDFMHGPPQ LSHPPDMPNN MAALEKPLSH PMQETMPHAG 950
    SSDQPHPSIQ QGLHVPHPSS QSGPPLHHSG APPPPPSQPP RQPPQAAPSS 1000
    HPHSDLTFNP SSALEGQAGA QGASDMPEPS LDLLPELTNP DELLSYLDPP 1050
    DLPSNSNDDL LSLFENN 1067
    Length:1,067
    Mass (Da):115,483
    Last modified:December 7, 2004 - v3
    Checksum:i6C4137488579CC74
    GO
    Isoform 2 (identifier: Q9ULJ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.
         71-93: LDLGYRLLAVCAANRDKFTPKSA → RPPPAGPQAPEGARAGSRPVQLL

    Note: Incomplete sequence. No experimental confirmation available.

    Show »
    Length:997
    Mass (Da):107,270
    Checksum:i34F34FA14347319C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti551 – 5511L → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036326

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_012185Add
    BLAST
    Alternative sequencei71 – 9323LDLGY…TPKSA → RPPPAGPQAPEGARAGSRPV QLL in isoform 2. 1 PublicationVSP_012186Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY235683 mRNA. Translation: AAP13542.1.
    AL391665 Genomic DNA. Translation: CAI40993.2.
    AB033050 mRNA. Translation: BAA86538.2.
    CCDSiCCDS7357.1. [Q9ULJ6-1]
    RefSeqiNP_065071.1. NM_020338.3. [Q9ULJ6-1]
    UniGeneiHs.193118.

    Genome annotation databases

    EnsembliENST00000334512; ENSP00000334474; ENSG00000108175. [Q9ULJ6-1]
    GeneIDi57178.
    KEGGihsa:57178.
    UCSCiuc001kaf.2. human. [Q9ULJ6-1]

    Polymorphism databases

    DMDMi56404979.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY235683 mRNA. Translation: AAP13542.1 .
    AL391665 Genomic DNA. Translation: CAI40993.2 .
    AB033050 mRNA. Translation: BAA86538.2 .
    CCDSi CCDS7357.1. [Q9ULJ6-1 ]
    RefSeqi NP_065071.1. NM_020338.3. [Q9ULJ6-1 ]
    UniGenei Hs.193118.

    3D structure databases

    ProteinModelPortali Q9ULJ6.
    SMRi Q9ULJ6. Positions 571-825.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121427. 8 interactions.
    IntActi Q9ULJ6. 17 interactions.
    MINTi MINT-7970305.
    STRINGi 9606.ENSP00000334474.

    PTM databases

    PhosphoSitei Q9ULJ6.

    Polymorphism databases

    DMDMi 56404979.

    Proteomic databases

    MaxQBi Q9ULJ6.
    PaxDbi Q9ULJ6.
    PRIDEi Q9ULJ6.

    Protocols and materials databases

    DNASUi 57178.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334512 ; ENSP00000334474 ; ENSG00000108175 . [Q9ULJ6-1 ]
    GeneIDi 57178.
    KEGGi hsa:57178.
    UCSCi uc001kaf.2. human. [Q9ULJ6-1 ]

    Organism-specific databases

    CTDi 57178.
    GeneCardsi GC10P080828.
    HGNCi HGNC:16493. ZMIZ1.
    HPAi HPA045144.
    MIMi 607159. gene.
    neXtProti NX_Q9ULJ6.
    PharmGKBi PA162409804.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237400.
    HOGENOMi HOG000253014.
    HOVERGENi HBG056252.
    InParanoidi Q9ULJ6.
    OMAi DFMHGPQ.
    OrthoDBi EOG715Q3Q.
    PhylomeDBi Q9ULJ6.
    TreeFami TF316952.

    Miscellaneous databases

    ChiTaRSi ZMIZ1. human.
    GeneWikii ZMIZ1.
    GenomeRNAii 57178.
    NextBioi 63207.
    PROi Q9ULJ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULJ6.
    Bgeei Q9ULJ6.
    CleanExi HS_ZMIZ1.
    Genevestigatori Q9ULJ6.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004181. Znf_MIZ.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF02891. zf-MIZ. 1 hit.
    [Graphical view ]
    PROSITEi PS51044. ZF_SP_RING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci."
      Sharma M., Li X., Wang Y., Zarnegar M., Huang C.-Y., Palvimo J.J., Lim B., Sun Z.
      EMBO J. 22:6101-6114(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH AR, SUMOYLATION.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-1067 (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-551.

    Entry informationi

    Entry nameiZMIZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULJ6
    Secondary accession number(s): Q5JSH9, Q7Z7E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3