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Protein

Zinc finger MIZ domain-containing protein 1

Gene

ZMIZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri727 – 804SP-RING-typePROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene namesi
Name:ZMIZ1
Synonyms:KIAA1224, RAI17, ZIMP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16493. ZMIZ1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57178.
OpenTargetsiENSG00000108175.
PharmGKBiPA162409804.

Polymorphism and mutation databases

BioMutaiZMIZ1.
DMDMi56404979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189871 – 1067Zinc finger MIZ domain-containing protein 1Add BLAST1067

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki834Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki843Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9ULJ6.
PaxDbiQ9ULJ6.
PeptideAtlasiQ9ULJ6.
PRIDEiQ9ULJ6.

PTM databases

iPTMnetiQ9ULJ6.
PhosphoSitePlusiQ9ULJ6.

Expressioni

Tissue specificityi

Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000108175.
CleanExiHS_ZMIZ1.
ExpressionAtlasiQ9ULJ6. baseline and differential.
GenevisibleiQ9ULJ6. HS.

Organism-specific databases

HPAiHPA045144.

Interactioni

Subunit structurei

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR. Interacts with NOTCH1 and RBPJ (PubMed:14609956, PubMed:26522984). Interacts with SMARCA4 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi121427. 22 interactors.
IntActiQ9ULJ6. 17 interactors.
MINTiMINT-7970305.
STRINGi9606.ENSP00000334474.

Structurei

Secondary structure

11067
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Helixi8 – 21Combined sources14
Helixi25 – 39Combined sources15
Helixi42 – 44Combined sources3
Helixi47 – 63Combined sources17
Helixi71 – 83Combined sources13
Helixi84 – 87Combined sources4
Helixi90 – 110Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AIZX-ray1.70A1-118[»]
ProteinModelPortaliQ9ULJ6.
SMRiQ9ULJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 120Sufficient for transactivation activity; sufficient for interaction with NOTCH11 PublicationAdd BLAST120
Regioni837 – 1067Transactivation domain1 PublicationAdd BLAST231

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 305Ala-richAdd BLAST26
Compositional biasi334 – 555Pro-richAdd BLAST222
Compositional biasi867 – 1002Pro-richAdd BLAST136

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri727 – 804SP-RING-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2169. Eukaryota.
ENOG410XQ2E. LUCA.
GeneTreeiENSGT00550000074410.
HOGENOMiHOG000253014.
HOVERGENiHBG056252.
InParanoidiQ9ULJ6.
OMAiDFMHGPQ.
OrthoDBiEOG091G01NY.
PhylomeDBiQ9ULJ6.
TreeFamiTF316952.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF02891. zf-MIZ. 1 hit.
PROSITEiView protein in PROSITE
PS51044. ZF_SP_RING. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE
60 70 80 90 100
QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC
110 120 130 140 150
EELGRLLLLR HQKSRQSDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS
160 170 180 190 200
VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM
210 220 230 240 250
ASGMTTSNPG LNSPQFAGQQ QQFSAKAGPA QPYIQQSMYG RPNYPGSGGF
260 270 280 290 300
GASYPGGPNA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT
310 320 330 340 350
ATVAALQETQ NKDINQYGPM GPTQAYNSQF MNQPGPRGPA SMGGSMNPAS
360 370 380 390 400
MAAGMTPSGM SGPPMGMNQP RPPGISPFGT HGQRMPQQTY PGPRPQSLPI
410 420 430 440 450
QNIKRPYPGE PNYGNQQYGP NSQFPTQPGQ YPAPNPPRPL TSPNYPGQRM
460 470 480 490 500
PSQPSSGQYP PPTVNMGQYY KPEQFNGQNN TFSGSSYSNY SQGNVNRPPR
510 520 530 540 550
PVPVANYPHS PVPGNPTPPM TPGSSIPPYL SPSQDVKPPF PPDIKPNMSA
560 570 580 590 600
LPPPPANHND ELRLTFPVRD GVVLEPFRLE HNLAVSNHVF HLRPTVHQTL
610 620 630 640 650
MWRSDLELQF KCYHHEDRQM NTNWPASVQV SVNATPLTIE RGDNKTSHKP
660 670 680 690 700
LHLKHVCQPG RNTIQITVTA CCCSHLFVLQ LVHRPSVRSV LQGLLKKRLL
710 720 730 740 750
PAEHCITKIK RNFSSVAASS GNTTLNGEDG VEQTAIKVSL KCPITFRRIQ
760 770 780 790 800
LPARGHDCKH VQCFDLESYL QLNCERGTWR CPVCNKTALL EGLEVDQYMW
810 820 830 840 850
GILNAIQHSE FEEVTIDPTC SWRPVPIKSD LHIKDDPDGI PSKRFKTMSP
860 870 880 890 900
SQMIMPNVME MIAALGPGPS PYPLPPPPGG TNSNDYSSQG NNYQGHGNFD
910 920 930 940 950
FPHGNPGGTS MNDFMHGPPQ LSHPPDMPNN MAALEKPLSH PMQETMPHAG
960 970 980 990 1000
SSDQPHPSIQ QGLHVPHPSS QSGPPLHHSG APPPPPSQPP RQPPQAAPSS
1010 1020 1030 1040 1050
HPHSDLTFNP SSALEGQAGA QGASDMPEPS LDLLPELTNP DELLSYLDPP
1060
DLPSNSNDDL LSLFENN
Length:1,067
Mass (Da):115,483
Last modified:December 7, 2004 - v3
Checksum:i6C4137488579CC74
GO
Isoform 2 (identifier: Q9ULJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-93: LDLGYRLLAVCAANRDKFTPKSA → RPPPAGPQAPEGARAGSRPVQLL

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:997
Mass (Da):107,270
Checksum:i34F34FA14347319C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036326551L → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0121851 – 70Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_01218671 – 93LDLGY…TPKSA → RPPPAGPQAPEGARAGSRPV QLL in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY235683 mRNA. Translation: AAP13542.1.
AL391665 Genomic DNA. Translation: CAI40993.2.
AB033050 mRNA. Translation: BAA86538.2.
CCDSiCCDS7357.1. [Q9ULJ6-1]
RefSeqiNP_065071.1. NM_020338.3. [Q9ULJ6-1]
UniGeneiHs.193118.

Genome annotation databases

EnsembliENST00000334512; ENSP00000334474; ENSG00000108175. [Q9ULJ6-1]
GeneIDi57178.
KEGGihsa:57178.
UCSCiuc001kaf.3. human. [Q9ULJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZMIZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ6
Secondary accession number(s): Q5JSH9, Q7Z7E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: August 30, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references