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Q9ULJ6

- ZMIZ1_HUMAN

UniProt

Q9ULJ6 - ZMIZ1_HUMAN

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Protein

Zinc finger MIZ domain-containing protein 1

Gene
ZMIZ1, KIAA1224, RAI17, ZIMP10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri727 – 80478SP-RING-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. artery morphogenesis Source: Ensembl
  2. cell aging Source: Ensembl
  3. developmental growth Source: Ensembl
  4. heart morphogenesis Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. positive regulation of fibroblast proliferation Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
  9. vasculogenesis Source: Ensembl
  10. vitellogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene namesi
Name:ZMIZ1
Synonyms:KIAA1224, RAI17, ZIMP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:16493. ZMIZ1.

Subcellular locationi

Nucleus speckle. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear speck Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10671067Zinc finger MIZ domain-containing protein 1PRO_0000218987Add
BLAST

Proteomic databases

MaxQBiQ9ULJ6.
PaxDbiQ9ULJ6.
PRIDEiQ9ULJ6.

PTM databases

PhosphoSiteiQ9ULJ6.

Expressioni

Tissue specificityi

Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.1 Publication

Gene expression databases

ArrayExpressiQ9ULJ6.
BgeeiQ9ULJ6.
CleanExiHS_ZMIZ1.
GenevestigatoriQ9ULJ6.

Organism-specific databases

HPAiHPA045144.

Interactioni

Subunit structurei

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.1 Publication

Protein-protein interaction databases

BioGridi121427. 8 interactions.
IntActiQ9ULJ6. 17 interactions.
MINTiMINT-7970305.
STRINGi9606.ENSP00000334474.

Structurei

3D structure databases

ProteinModelPortaliQ9ULJ6.
SMRiQ9ULJ6. Positions 571-825.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 30526Ala-richAdd
BLAST
Compositional biasi334 – 555222Pro-richAdd
BLAST
Compositional biasi867 – 1002136Pro-richAdd
BLAST

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG237400.
HOGENOMiHOG000253014.
HOVERGENiHBG056252.
InParanoidiQ9ULJ6.
OMAiDFMHGPQ.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ9ULJ6.
TreeFamiTF316952.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULJ6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE     50
QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC 100
EELGRLLLLR HQKSRQSDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS 150
VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM 200
ASGMTTSNPG LNSPQFAGQQ QQFSAKAGPA QPYIQQSMYG RPNYPGSGGF 250
GASYPGGPNA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 300
ATVAALQETQ NKDINQYGPM GPTQAYNSQF MNQPGPRGPA SMGGSMNPAS 350
MAAGMTPSGM SGPPMGMNQP RPPGISPFGT HGQRMPQQTY PGPRPQSLPI 400
QNIKRPYPGE PNYGNQQYGP NSQFPTQPGQ YPAPNPPRPL TSPNYPGQRM 450
PSQPSSGQYP PPTVNMGQYY KPEQFNGQNN TFSGSSYSNY SQGNVNRPPR 500
PVPVANYPHS PVPGNPTPPM TPGSSIPPYL SPSQDVKPPF PPDIKPNMSA 550
LPPPPANHND ELRLTFPVRD GVVLEPFRLE HNLAVSNHVF HLRPTVHQTL 600
MWRSDLELQF KCYHHEDRQM NTNWPASVQV SVNATPLTIE RGDNKTSHKP 650
LHLKHVCQPG RNTIQITVTA CCCSHLFVLQ LVHRPSVRSV LQGLLKKRLL 700
PAEHCITKIK RNFSSVAASS GNTTLNGEDG VEQTAIKVSL KCPITFRRIQ 750
LPARGHDCKH VQCFDLESYL QLNCERGTWR CPVCNKTALL EGLEVDQYMW 800
GILNAIQHSE FEEVTIDPTC SWRPVPIKSD LHIKDDPDGI PSKRFKTMSP 850
SQMIMPNVME MIAALGPGPS PYPLPPPPGG TNSNDYSSQG NNYQGHGNFD 900
FPHGNPGGTS MNDFMHGPPQ LSHPPDMPNN MAALEKPLSH PMQETMPHAG 950
SSDQPHPSIQ QGLHVPHPSS QSGPPLHHSG APPPPPSQPP RQPPQAAPSS 1000
HPHSDLTFNP SSALEGQAGA QGASDMPEPS LDLLPELTNP DELLSYLDPP 1050
DLPSNSNDDL LSLFENN 1067
Length:1,067
Mass (Da):115,483
Last modified:December 7, 2004 - v3
Checksum:i6C4137488579CC74
GO
Isoform 2 (identifier: Q9ULJ6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-93: LDLGYRLLAVCAANRDKFTPKSA → RPPPAGPQAPEGARAGSRPVQLL

Note: Incomplete sequence. No experimental confirmation available.

Show »
Length:997
Mass (Da):107,270
Checksum:i34F34FA14347319C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti551 – 5511L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036326

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. VSP_012185Add
BLAST
Alternative sequencei71 – 9323LDLGY…TPKSA → RPPPAGPQAPEGARAGSRPV QLL in isoform 2. VSP_012186Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY235683 mRNA. Translation: AAP13542.1.
AL391665 Genomic DNA. Translation: CAI40993.2.
AB033050 mRNA. Translation: BAA86538.2.
CCDSiCCDS7357.1. [Q9ULJ6-1]
RefSeqiNP_065071.1. NM_020338.3. [Q9ULJ6-1]
UniGeneiHs.193118.

Genome annotation databases

EnsembliENST00000334512; ENSP00000334474; ENSG00000108175. [Q9ULJ6-1]
GeneIDi57178.
KEGGihsa:57178.
UCSCiuc001kaf.2. human. [Q9ULJ6-1]

Polymorphism databases

DMDMi56404979.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY235683 mRNA. Translation: AAP13542.1 .
AL391665 Genomic DNA. Translation: CAI40993.2 .
AB033050 mRNA. Translation: BAA86538.2 .
CCDSi CCDS7357.1. [Q9ULJ6-1 ]
RefSeqi NP_065071.1. NM_020338.3. [Q9ULJ6-1 ]
UniGenei Hs.193118.

3D structure databases

ProteinModelPortali Q9ULJ6.
SMRi Q9ULJ6. Positions 571-825.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121427. 8 interactions.
IntActi Q9ULJ6. 17 interactions.
MINTi MINT-7970305.
STRINGi 9606.ENSP00000334474.

PTM databases

PhosphoSitei Q9ULJ6.

Polymorphism databases

DMDMi 56404979.

Proteomic databases

MaxQBi Q9ULJ6.
PaxDbi Q9ULJ6.
PRIDEi Q9ULJ6.

Protocols and materials databases

DNASUi 57178.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334512 ; ENSP00000334474 ; ENSG00000108175 . [Q9ULJ6-1 ]
GeneIDi 57178.
KEGGi hsa:57178.
UCSCi uc001kaf.2. human. [Q9ULJ6-1 ]

Organism-specific databases

CTDi 57178.
GeneCardsi GC10P080828.
HGNCi HGNC:16493. ZMIZ1.
HPAi HPA045144.
MIMi 607159. gene.
neXtProti NX_Q9ULJ6.
PharmGKBi PA162409804.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237400.
HOGENOMi HOG000253014.
HOVERGENi HBG056252.
InParanoidi Q9ULJ6.
OMAi DFMHGPQ.
OrthoDBi EOG715Q3Q.
PhylomeDBi Q9ULJ6.
TreeFami TF316952.

Miscellaneous databases

ChiTaRSi ZMIZ1. human.
GeneWikii ZMIZ1.
GenomeRNAii 57178.
NextBioi 63207.
PROi Q9ULJ6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ULJ6.
Bgeei Q9ULJ6.
CleanExi HS_ZMIZ1.
Genevestigatori Q9ULJ6.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02891. zf-MIZ. 1 hit.
[Graphical view ]
PROSITEi PS51044. ZF_SP_RING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci."
    Sharma M., Li X., Wang Y., Zarnegar M., Huang C.-Y., Palvimo J.J., Lim B., Sun Z.
    EMBO J. 22:6101-6114(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH AR, SUMOYLATION.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-1067 (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-551.

Entry informationi

Entry nameiZMIZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ6
Secondary accession number(s): Q5JSH9, Q7Z7E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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