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Protein

Zinc finger MIZ domain-containing protein 1

Gene

ZMIZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri727 – 80478SP-RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. artery morphogenesis Source: Ensembl
  2. cell aging Source: Ensembl
  3. developmental growth Source: Ensembl
  4. heart morphogenesis Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. positive regulation of fibroblast proliferation Source: Ensembl
  7. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  8. transcription, DNA-templated Source: UniProtKB-KW
  9. vasculogenesis Source: Ensembl
  10. vitellogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene namesi
Name:ZMIZ1
Synonyms:KIAA1224, RAI17, ZIMP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:16493. ZMIZ1.

Subcellular locationi

Nucleus speckle 1 Publication. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: HPA
  3. nuclear speck Source: UniProtKB-SubCell
  4. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10671067Zinc finger MIZ domain-containing protein 1PRO_0000218987Add
BLAST

Proteomic databases

MaxQBiQ9ULJ6.
PaxDbiQ9ULJ6.
PRIDEiQ9ULJ6.

PTM databases

PhosphoSiteiQ9ULJ6.

Expressioni

Tissue specificityi

Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiQ9ULJ6.
CleanExiHS_ZMIZ1.
ExpressionAtlasiQ9ULJ6. baseline and differential.
GenevestigatoriQ9ULJ6.

Organism-specific databases

HPAiHPA045144.

Interactioni

Subunit structurei

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.1 Publication

Protein-protein interaction databases

BioGridi121427. 8 interactions.
IntActiQ9ULJ6. 17 interactions.
MINTiMINT-7970305.
STRINGi9606.ENSP00000334474.

Structurei

3D structure databases

ProteinModelPortaliQ9ULJ6.
SMRiQ9ULJ6. Positions 571-825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 30526Ala-richAdd
BLAST
Compositional biasi334 – 555222Pro-richAdd
BLAST
Compositional biasi867 – 1002136Pro-richAdd
BLAST

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Sequence similaritiesi

Contains 1 SP-RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri727 – 80478SP-RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG237400.
GeneTreeiENSGT00550000074410.
HOGENOMiHOG000253014.
HOVERGENiHBG056252.
InParanoidiQ9ULJ6.
OMAiDFMHGPQ.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ9ULJ6.
TreeFamiTF316952.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE
60 70 80 90 100
QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC
110 120 130 140 150
EELGRLLLLR HQKSRQSDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS
160 170 180 190 200
VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM
210 220 230 240 250
ASGMTTSNPG LNSPQFAGQQ QQFSAKAGPA QPYIQQSMYG RPNYPGSGGF
260 270 280 290 300
GASYPGGPNA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT
310 320 330 340 350
ATVAALQETQ NKDINQYGPM GPTQAYNSQF MNQPGPRGPA SMGGSMNPAS
360 370 380 390 400
MAAGMTPSGM SGPPMGMNQP RPPGISPFGT HGQRMPQQTY PGPRPQSLPI
410 420 430 440 450
QNIKRPYPGE PNYGNQQYGP NSQFPTQPGQ YPAPNPPRPL TSPNYPGQRM
460 470 480 490 500
PSQPSSGQYP PPTVNMGQYY KPEQFNGQNN TFSGSSYSNY SQGNVNRPPR
510 520 530 540 550
PVPVANYPHS PVPGNPTPPM TPGSSIPPYL SPSQDVKPPF PPDIKPNMSA
560 570 580 590 600
LPPPPANHND ELRLTFPVRD GVVLEPFRLE HNLAVSNHVF HLRPTVHQTL
610 620 630 640 650
MWRSDLELQF KCYHHEDRQM NTNWPASVQV SVNATPLTIE RGDNKTSHKP
660 670 680 690 700
LHLKHVCQPG RNTIQITVTA CCCSHLFVLQ LVHRPSVRSV LQGLLKKRLL
710 720 730 740 750
PAEHCITKIK RNFSSVAASS GNTTLNGEDG VEQTAIKVSL KCPITFRRIQ
760 770 780 790 800
LPARGHDCKH VQCFDLESYL QLNCERGTWR CPVCNKTALL EGLEVDQYMW
810 820 830 840 850
GILNAIQHSE FEEVTIDPTC SWRPVPIKSD LHIKDDPDGI PSKRFKTMSP
860 870 880 890 900
SQMIMPNVME MIAALGPGPS PYPLPPPPGG TNSNDYSSQG NNYQGHGNFD
910 920 930 940 950
FPHGNPGGTS MNDFMHGPPQ LSHPPDMPNN MAALEKPLSH PMQETMPHAG
960 970 980 990 1000
SSDQPHPSIQ QGLHVPHPSS QSGPPLHHSG APPPPPSQPP RQPPQAAPSS
1010 1020 1030 1040 1050
HPHSDLTFNP SSALEGQAGA QGASDMPEPS LDLLPELTNP DELLSYLDPP
1060
DLPSNSNDDL LSLFENN
Length:1,067
Mass (Da):115,483
Last modified:December 7, 2004 - v3
Checksum:i6C4137488579CC74
GO
Isoform 2 (identifier: Q9ULJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-93: LDLGYRLLAVCAANRDKFTPKSA → RPPPAGPQAPEGARAGSRPVQLL

Note: Incomplete sequence. No experimental confirmation available.

Show »
Length:997
Mass (Da):107,270
Checksum:i34F34FA14347319C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti551 – 5511L → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036326

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7070Missing in isoform 2. 1 PublicationVSP_012185Add
BLAST
Alternative sequencei71 – 9323LDLGY…TPKSA → RPPPAGPQAPEGARAGSRPV QLL in isoform 2. 1 PublicationVSP_012186Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY235683 mRNA. Translation: AAP13542.1.
AL391665 Genomic DNA. Translation: CAI40993.2.
AB033050 mRNA. Translation: BAA86538.2.
CCDSiCCDS7357.1. [Q9ULJ6-1]
RefSeqiNP_065071.1. NM_020338.3. [Q9ULJ6-1]
UniGeneiHs.193118.

Genome annotation databases

EnsembliENST00000334512; ENSP00000334474; ENSG00000108175. [Q9ULJ6-1]
GeneIDi57178.
KEGGihsa:57178.
UCSCiuc001kaf.2. human. [Q9ULJ6-1]

Polymorphism databases

DMDMi56404979.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY235683 mRNA. Translation: AAP13542.1.
AL391665 Genomic DNA. Translation: CAI40993.2.
AB033050 mRNA. Translation: BAA86538.2.
CCDSiCCDS7357.1. [Q9ULJ6-1]
RefSeqiNP_065071.1. NM_020338.3. [Q9ULJ6-1]
UniGeneiHs.193118.

3D structure databases

ProteinModelPortaliQ9ULJ6.
SMRiQ9ULJ6. Positions 571-825.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121427. 8 interactions.
IntActiQ9ULJ6. 17 interactions.
MINTiMINT-7970305.
STRINGi9606.ENSP00000334474.

PTM databases

PhosphoSiteiQ9ULJ6.

Polymorphism databases

DMDMi56404979.

Proteomic databases

MaxQBiQ9ULJ6.
PaxDbiQ9ULJ6.
PRIDEiQ9ULJ6.

Protocols and materials databases

DNASUi57178.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334512; ENSP00000334474; ENSG00000108175. [Q9ULJ6-1]
GeneIDi57178.
KEGGihsa:57178.
UCSCiuc001kaf.2. human. [Q9ULJ6-1]

Organism-specific databases

CTDi57178.
GeneCardsiGC10P080828.
HGNCiHGNC:16493. ZMIZ1.
HPAiHPA045144.
MIMi607159. gene.
neXtProtiNX_Q9ULJ6.
PharmGKBiPA162409804.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237400.
GeneTreeiENSGT00550000074410.
HOGENOMiHOG000253014.
HOVERGENiHBG056252.
InParanoidiQ9ULJ6.
OMAiDFMHGPQ.
OrthoDBiEOG715Q3Q.
PhylomeDBiQ9ULJ6.
TreeFamiTF316952.

Miscellaneous databases

ChiTaRSiZMIZ1. human.
GeneWikiiZMIZ1.
GenomeRNAii57178.
NextBioi63207.
PROiQ9ULJ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULJ6.
CleanExiHS_ZMIZ1.
ExpressionAtlasiQ9ULJ6. baseline and differential.
GenevestigatoriQ9ULJ6.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEiPS51044. ZF_SP_RING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci."
    Sharma M., Li X., Wang Y., Zarnegar M., Huang C.-Y., Palvimo J.J., Lim B., Sun Z.
    EMBO J. 22:6101-6114(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH AR, SUMOYLATION.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-1067 (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-551.

Entry informationi

Entry nameiZMIZ1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ6
Secondary accession number(s): Q5JSH9, Q7Z7E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: February 4, 2015
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.