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Q9ULJ6 (ZMIZ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene names
Name:ZMIZ1
Synonyms:KIAA1224, RAI17, ZIMP10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1067 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.

Subunit structure

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR. Ref.1

Subcellular location

Nucleus speckle. Cytoplasm Ref.1.

Tissue specificity

Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes. Ref.1

Domain

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.

Sequence similarities

Contains 1 SP-RING-type zinc finger.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ULJ6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ULJ6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     71-93: LDLGYRLLAVCAANRDKFTPKSA → RPPPAGPQAPEGARAGSRPVQLL
Note: Incomplete sequence. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10671067Zinc finger MIZ domain-containing protein 1
PRO_0000218987

Regions

Zinc finger727 – 80478SP-RING-type
Compositional bias280 – 30526Ala-rich
Compositional bias334 – 555222Pro-rich
Compositional bias867 – 1002136Pro-rich

Natural variations

Alternative sequence1 – 7070Missing in isoform 2.
VSP_012185
Alternative sequence71 – 9323LDLGY…TPKSA → RPPPAGPQAPEGARAGSRPV QLL in isoform 2.
VSP_012186
Natural variant5511L → V in a breast cancer sample; somatic mutation. Ref.4
VAR_036326

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 7, 2004. Version 3.
Checksum: 6C4137488579CC74

FASTA1,067115,483
        10         20         30         40         50         60 
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE QSLMGCLTVV 

        70         80         90        100        110        120 
SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC EELGRLLLLR HQKSRQSDPP 

       130        140        150        160        170        180 
GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ 

       190        200        210        220        230        240 
VLGNPMANAN NPMNPGGNPM ASGMTTSNPG LNSPQFAGQQ QQFSAKAGPA QPYIQQSMYG 

       250        260        270        280        290        300 
RPNYPGSGGF GASYPGGPNA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT 

       310        320        330        340        350        360 
ATVAALQETQ NKDINQYGPM GPTQAYNSQF MNQPGPRGPA SMGGSMNPAS MAAGMTPSGM 

       370        380        390        400        410        420 
SGPPMGMNQP RPPGISPFGT HGQRMPQQTY PGPRPQSLPI QNIKRPYPGE PNYGNQQYGP 

       430        440        450        460        470        480 
NSQFPTQPGQ YPAPNPPRPL TSPNYPGQRM PSQPSSGQYP PPTVNMGQYY KPEQFNGQNN 

       490        500        510        520        530        540 
TFSGSSYSNY SQGNVNRPPR PVPVANYPHS PVPGNPTPPM TPGSSIPPYL SPSQDVKPPF 

       550        560        570        580        590        600 
PPDIKPNMSA LPPPPANHND ELRLTFPVRD GVVLEPFRLE HNLAVSNHVF HLRPTVHQTL 

       610        620        630        640        650        660 
MWRSDLELQF KCYHHEDRQM NTNWPASVQV SVNATPLTIE RGDNKTSHKP LHLKHVCQPG 

       670        680        690        700        710        720 
RNTIQITVTA CCCSHLFVLQ LVHRPSVRSV LQGLLKKRLL PAEHCITKIK RNFSSVAASS 

       730        740        750        760        770        780 
GNTTLNGEDG VEQTAIKVSL KCPITFRRIQ LPARGHDCKH VQCFDLESYL QLNCERGTWR 

       790        800        810        820        830        840 
CPVCNKTALL EGLEVDQYMW GILNAIQHSE FEEVTIDPTC SWRPVPIKSD LHIKDDPDGI 

       850        860        870        880        890        900 
PSKRFKTMSP SQMIMPNVME MIAALGPGPS PYPLPPPPGG TNSNDYSSQG NNYQGHGNFD 

       910        920        930        940        950        960 
FPHGNPGGTS MNDFMHGPPQ LSHPPDMPNN MAALEKPLSH PMQETMPHAG SSDQPHPSIQ 

       970        980        990       1000       1010       1020 
QGLHVPHPSS QSGPPLHHSG APPPPPSQPP RQPPQAAPSS HPHSDLTFNP SSALEGQAGA 

      1030       1040       1050       1060 
QGASDMPEPS LDLLPELTNP DELLSYLDPP DLPSNSNDDL LSLFENN 

« Hide

Isoform 2 [UniParc].

Checksum: 34F34FA14347319C
Show »

FASTA997107,270

References

« Hide 'large scale' references
[1]"hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci."
Sharma M., Li X., Wang Y., Zarnegar M., Huang C.-Y., Palvimo J.J., Lim B., Sun Z.
EMBO J. 22:6101-6114(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH AR, SUMOYLATION.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-1067 (ISOFORM 2).
Tissue: Brain.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-551.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY235683 mRNA. Translation: AAP13542.1.
AL391665 Genomic DNA. Translation: CAI40993.2.
AB033050 mRNA. Translation: BAA86538.2.
CCDSCCDS7357.1. [Q9ULJ6-1]
RefSeqNP_065071.1. NM_020338.3. [Q9ULJ6-1]
UniGeneHs.193118.

3D structure databases

ProteinModelPortalQ9ULJ6.
SMRQ9ULJ6. Positions 571-825.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121427. 8 interactions.
IntActQ9ULJ6. 17 interactions.
MINTMINT-7970305.
STRING9606.ENSP00000334474.

PTM databases

PhosphoSiteQ9ULJ6.

Polymorphism databases

DMDM56404979.

Proteomic databases

MaxQBQ9ULJ6.
PaxDbQ9ULJ6.
PRIDEQ9ULJ6.

Protocols and materials databases

DNASU57178.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334512; ENSP00000334474; ENSG00000108175. [Q9ULJ6-1]
GeneID57178.
KEGGhsa:57178.
UCSCuc001kaf.2. human. [Q9ULJ6-1]

Organism-specific databases

CTD57178.
GeneCardsGC10P080828.
HGNCHGNC:16493. ZMIZ1.
HPAHPA045144.
MIM607159. gene.
neXtProtNX_Q9ULJ6.
PharmGKBPA162409804.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237400.
HOGENOMHOG000253014.
HOVERGENHBG056252.
InParanoidQ9ULJ6.
OMADFMHGPQ.
OrthoDBEOG715Q3Q.
PhylomeDBQ9ULJ6.
TreeFamTF316952.

Gene expression databases

ArrayExpressQ9ULJ6.
BgeeQ9ULJ6.
CleanExHS_ZMIZ1.
GenevestigatorQ9ULJ6.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR004181. Znf_MIZ.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF02891. zf-MIZ. 1 hit.
[Graphical view]
PROSITEPS51044. ZF_SP_RING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZMIZ1. human.
GeneWikiZMIZ1.
GenomeRNAi57178.
NextBio63207.
PROQ9ULJ6.
SOURCESearch...

Entry information

Entry nameZMIZ1_HUMAN
AccessionPrimary (citable) accession number: Q9ULJ6
Secondary accession number(s): Q5JSH9, Q7Z7E6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM