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Protein

Zinc finger and BTB domain-containing protein 21

Gene

ZBTB21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcription repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • methyl-CpG binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 21
Alternative name(s):
Zinc finger protein 295
Gene namesi
Name:ZBTB21
Synonyms:KIAA1227, ZNF295
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:13083. ZBTB21.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Colocalizes with ZBTB14 in nucleus in HEK293 cells.

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi49854.
OpenTargetsiENSG00000173276.
PharmGKBiPA37659.

Polymorphism and mutation databases

BioMutaiZBTB21.
DMDMi9979550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475151 – 1066Zinc finger and BTB domain-containing protein 21Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei345PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei431PhosphothreonineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei605PhosphoserineCombined sources1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei714PhosphoserineCombined sources1
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1003PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ULJ3.
PaxDbiQ9ULJ3.
PeptideAtlasiQ9ULJ3.
PRIDEiQ9ULJ3.

PTM databases

iPTMnetiQ9ULJ3.
PhosphoSitePlusiQ9ULJ3.

Expressioni

Tissue specificityi

Ubiquitous in fetal and adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000173276.
CleanExiHS_ZNF295.
ExpressionAtlasiQ9ULJ3. baseline and differential.
GenevisibleiQ9ULJ3. HS.

Organism-specific databases

HPAiHPA024655.
HPA031757.
HPA031758.

Interactioni

Subunit structurei

Homodimer. Interacts with ZBTB14.1 Publication

Protein-protein interaction databases

BioGridi119066. 24 interactors.
IntActiQ9ULJ3. 6 interactors.
MINTiMINT-1688321.
STRINGi9606.ENSP00000308759.

Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni725 – 727Combined sources3
Helixi734 – 746Combined sources13
Turni751 – 753Combined sources3
Beta strandi757 – 759Combined sources3
Helixi760 – 769Combined sources10
Helixi773 – 775Combined sources3
Helixi778 – 780Combined sources3
Helixi787 – 796Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJPNMR-A713-806[»]
ProteinModelPortaliQ9ULJ3.
SMRiQ9ULJ3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULJ3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 96BTBPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 96Mediates homodimerizationAdd BLAST67

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri546 – 569C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri575 – 598C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri670 – 692C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri748 – 770C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 798C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri909 – 932C2H2-type 6; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri937 – 959C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1043 – 1065C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000237324.
HOVERGENiHBG056929.
InParanoidiQ9ULJ3.
OMAiHQELLCS.
OrthoDBiEOG091G01Q4.
PhylomeDBiQ9ULJ3.
TreeFamiTF331184.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULJ3-1) [UniParc]FASTAAdd to basket
Also known as: ZNF295L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA
60 70 80 90 100
SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA
110 120 130 140 150
AVQELGYSLG ISFLTNIVSK TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI
160 170 180 190 200
VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI AVKANTNKPH VPKPIEPLHN
210 220 230 240 250
LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV LPSKPLQDRE
260 270 280 290 300
AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG
310 320 330 340 350
QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV
360 370 380 390 400
PVYSPSIDLK SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ
410 420 430 440 450
VLQPHRLRSF SASQSTDREG ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD
460 470 480 490 500
AATTAAASSS SVTRDLSLKT EDDQKDMSRL PAKRRFQADR RLPFKKLKVN
510 520 530 540 550
EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT RPNKKFKCKH
560 570 580 590 600
CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI
610 620 630 640 650
VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS
660 670 680 690 700
SSQAQQVIKR NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV
710 720 730 740 750
NKVAKPKEHA PLASPVENKE VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC
760 770 780 790 800
PYCSLRFFSP ELKQEHESKC EYKKLTCLEC MRTFKSSFSI WRHQVEVHNQ
810 820 830 840 850
NNMAPTENFS LPVLDHNGDV TGSSRPQSQP EPNKVNHIVT TKDDNVFSDS
860 870 880 890 900
SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA
910 920 930 940 950
GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF
960 970 980 990 1000
RLWSHFQSHM SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE
1010 1020 1030 1040 1050
PDSPTGLSEN PTPATEKLFV PQESDTLFYH APPLSAITFK RQFMCKLCHR
1060
TFKTAFSLWS HEQTHN
Length:1,066
Mass (Da):118,870
Last modified:December 1, 2000 - v2
Checksum:iE1779E26943FDAC8
GO
Isoform 2 (identifier: Q9ULJ3-2) [UniParc]FASTAAdd to basket
Also known as: ZNF295S

The sequence of this isoform differs from the canonical sequence as follows:
     535-735: Missing.

Show »
Length:865
Mass (Da):95,807
Checksum:i722AB5BE41C99614
GO

Sequence cautioni

The sequence BAA86541 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti961S → P in AAH63290 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052807185N → S.Corresponds to variant rs871545dbSNPEnsembl.1
Natural variantiVAR_052808218K → Q.Corresponds to variant rs871546dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041349535 – 735Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041014 mRNA. Translation: BAD74063.1.
AB041015 mRNA. Translation: BAD74064.1.
AB033053 mRNA. Translation: BAA86541.1. Different initiation.
AP001745 Genomic DNA. Translation: BAA95529.1.
CH471079 Genomic DNA. Translation: EAX09579.1.
CH471079 Genomic DNA. Translation: EAX09580.1.
CH471079 Genomic DNA. Translation: EAX09581.1.
BC063290 mRNA. Translation: AAH63290.1.
CCDSiCCDS13678.1. [Q9ULJ3-1]
CCDS42934.1. [Q9ULJ3-2]
RefSeqiNP_001091872.1. NM_001098402.1. [Q9ULJ3-1]
NP_001091873.1. NM_001098403.1. [Q9ULJ3-2]
NP_001307658.1. NM_001320729.1. [Q9ULJ3-2]
NP_001307660.1. NM_001320731.1. [Q9ULJ3-1]
NP_065778.3. NM_020727.4. [Q9ULJ3-1]
XP_005261178.1. XM_005261121.3. [Q9ULJ3-1]
XP_011527890.1. XM_011529588.2. [Q9ULJ3-1]
XP_011527892.1. XM_011529590.2. [Q9ULJ3-1]
XP_016883849.1. XM_017028360.1. [Q9ULJ3-1]
XP_016883850.1. XM_017028361.1. [Q9ULJ3-1]
UniGeneiHs.434947.
Hs.618406.

Genome annotation databases

EnsembliENST00000310826; ENSP00000308759; ENSG00000173276. [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276. [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276. [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276. [Q9ULJ3-1]
GeneIDi49854.
KEGGihsa:49854.
UCSCiuc002yzy.5. human. [Q9ULJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041014 mRNA. Translation: BAD74063.1.
AB041015 mRNA. Translation: BAD74064.1.
AB033053 mRNA. Translation: BAA86541.1. Different initiation.
AP001745 Genomic DNA. Translation: BAA95529.1.
CH471079 Genomic DNA. Translation: EAX09579.1.
CH471079 Genomic DNA. Translation: EAX09580.1.
CH471079 Genomic DNA. Translation: EAX09581.1.
BC063290 mRNA. Translation: AAH63290.1.
CCDSiCCDS13678.1. [Q9ULJ3-1]
CCDS42934.1. [Q9ULJ3-2]
RefSeqiNP_001091872.1. NM_001098402.1. [Q9ULJ3-1]
NP_001091873.1. NM_001098403.1. [Q9ULJ3-2]
NP_001307658.1. NM_001320729.1. [Q9ULJ3-2]
NP_001307660.1. NM_001320731.1. [Q9ULJ3-1]
NP_065778.3. NM_020727.4. [Q9ULJ3-1]
XP_005261178.1. XM_005261121.3. [Q9ULJ3-1]
XP_011527890.1. XM_011529588.2. [Q9ULJ3-1]
XP_011527892.1. XM_011529590.2. [Q9ULJ3-1]
XP_016883849.1. XM_017028360.1. [Q9ULJ3-1]
XP_016883850.1. XM_017028361.1. [Q9ULJ3-1]
UniGeneiHs.434947.
Hs.618406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJPNMR-A713-806[»]
ProteinModelPortaliQ9ULJ3.
SMRiQ9ULJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119066. 24 interactors.
IntActiQ9ULJ3. 6 interactors.
MINTiMINT-1688321.
STRINGi9606.ENSP00000308759.

PTM databases

iPTMnetiQ9ULJ3.
PhosphoSitePlusiQ9ULJ3.

Polymorphism and mutation databases

BioMutaiZBTB21.
DMDMi9979550.

Proteomic databases

EPDiQ9ULJ3.
PaxDbiQ9ULJ3.
PeptideAtlasiQ9ULJ3.
PRIDEiQ9ULJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310826; ENSP00000308759; ENSG00000173276. [Q9ULJ3-1]
ENST00000398499; ENSP00000381512; ENSG00000173276. [Q9ULJ3-1]
ENST00000398505; ENSP00000381517; ENSG00000173276. [Q9ULJ3-2]
ENST00000398511; ENSP00000381523; ENSG00000173276. [Q9ULJ3-1]
GeneIDi49854.
KEGGihsa:49854.
UCSCiuc002yzy.5. human. [Q9ULJ3-1]

Organism-specific databases

CTDi49854.
DisGeNETi49854.
GeneCardsiZBTB21.
HGNCiHGNC:13083. ZBTB21.
HPAiHPA024655.
HPA031757.
HPA031758.
MIMi616485. gene.
neXtProtiNX_Q9ULJ3.
OpenTargetsiENSG00000173276.
PharmGKBiPA37659.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00810000125416.
HOGENOMiHOG000237324.
HOVERGENiHBG056929.
InParanoidiQ9ULJ3.
OMAiHQELLCS.
OrthoDBiEOG091G01Q4.
PhylomeDBiQ9ULJ3.
TreeFamiTF331184.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173276-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9ULJ3.
GeneWikiiZNF295.
GenomeRNAii49854.
PROiQ9ULJ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173276.
CleanExiHS_ZNF295.
ExpressionAtlasiQ9ULJ3. baseline and differential.
GenevisibleiQ9ULJ3. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT21_HUMAN
AccessioniPrimary (citable) accession number: Q9ULJ3
Secondary accession number(s): Q5R2W1, Q5R2W2, Q6P4R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.