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Q9ULJ3

- ZBT21_HUMAN

UniProt

Q9ULJ3 - ZBT21_HUMAN

Protein

Zinc finger and BTB domain-containing protein 21

Gene

ZBTB21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Acts as a transcription repressor.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri546 – 56924C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri575 – 59824C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri670 – 69223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri775 – 79824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri909 – 93224C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri937 – 95923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1043 – 106523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. methyl-CpG binding Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 21
    Alternative name(s):
    Zinc finger protein 295
    Gene namesi
    Name:ZBTB21
    Synonyms:KIAA1227, ZNF295
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:13083. ZBTB21.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Colocalizes with ZBTB14 in nucleus in HEK293 cells.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37659.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10661066Zinc finger and BTB domain-containing protein 21PRO_0000047515Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei381 – 3811Phosphoserine1 Publication
    Modified residuei411 – 4111Phosphoserine2 Publications
    Modified residuei422 – 4221Phosphoserine2 Publications
    Modified residuei431 – 4311Phosphothreonine3 Publications
    Modified residuei434 – 4341Phosphoserine2 Publications
    Modified residuei435 – 4351Phosphoserine2 Publications
    Modified residuei438 – 4381Phosphoserine1 Publication
    Modified residuei605 – 6051Phosphoserine2 Publications
    Modified residuei714 – 7141Phosphoserine2 Publications
    Modified residuei1003 – 10031Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULJ3.
    PaxDbiQ9ULJ3.
    PRIDEiQ9ULJ3.

    PTM databases

    PhosphoSiteiQ9ULJ3.

    Expressioni

    Tissue specificityi

    Ubiquitous in fetal and adult tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9ULJ3.
    BgeeiQ9ULJ3.
    CleanExiHS_ZNF295.
    GenevestigatoriQ9ULJ3.

    Organism-specific databases

    HPAiHPA024655.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with ZBTB14.1 Publication

    Protein-protein interaction databases

    BioGridi119066. 8 interactions.
    IntActiQ9ULJ3. 1 interaction.
    MINTiMINT-1688321.
    STRINGi9606.ENSP00000308759.

    Structurei

    Secondary structure

    1
    1066
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni725 – 7273
    Helixi734 – 74613
    Turni751 – 7533
    Beta strandi757 – 7593
    Helixi760 – 76910
    Helixi773 – 7753
    Helixi778 – 7803
    Helixi787 – 79610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WJPNMR-A713-806[»]
    ProteinModelPortaliQ9ULJ3.
    SMRiQ9ULJ3. Positions 15-114, 540-600, 664-806, 909-972, 1035-1065.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9ULJ3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 9667BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 9667Mediates homodimerizationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri546 – 56924C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri575 – 59824C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri670 – 69223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri748 – 77023C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri775 – 79824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri909 – 93224C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri937 – 95923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1043 – 106523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG303726.
    HOGENOMiHOG000237324.
    HOVERGENiHBG056929.
    InParanoidiQ9ULJ3.
    OMAiDNVLNYI.
    OrthoDBiEOG7TF789.
    PhylomeDBiQ9ULJ3.
    TreeFamiTF331184.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULJ3-1) [UniParc]FASTAAdd to Basket

    Also known as: ZNF295L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA     50
    SSEYFQSLFT NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA 100
    AVQELGYSLG ISFLTNIVSK TPQAPFPTCP NRKKVFVEDD ENSSQKRSVI 150
    VCQSRNEAQG KTVSQNQPDV SHTSRPSPSI AVKANTNKPH VPKPIEPLHN 200
    LSLTEKSWPK DSSVVYAKSL EHSGSLDDPN RISLVKRNAV LPSKPLQDRE 250
    AMDDKPGVSG QLPKGKALEL ALKRPRPPVL SVCSSSETPY LLKETNKGNG 300
    QGEDRNLLYY SKLGLVIPSS GSGSGNQSID RSGPLVKSLL RRSLSMDSQV 350
    PVYSPSIDLK SSQGSSSVSS DAPGNVLCAL SQKSSLKDCS EKTALDDRPQ 400
    VLQPHRLRSF SASQSTDREG ASPVTEVRIK TEPSSPLSDP SDIIRVTVGD 450
    AATTAAASSS SVTRDLSLKT EDDQKDMSRL PAKRRFQADR RLPFKKLKVN 500
    EHGSPVSEDN FEEGSSPTLL DADFPDSDLN KDEFGELEGT RPNKKFKCKH 550
    CLKIFRSTAG LHRHVNMYHN PEKPYACDIC HKRFHTNFKV WTHCQTQHGI 600
    VKNPSPASSS HAVLDEKFQR KLIDIVRERE IKKALIIKLR RGKPGFQGQS 650
    SSQAQQVIKR NLRSRAKGAY ICTYCGKAYR FLSQFKQHIK MHPGEKPLGV 700
    NKVAKPKEHA PLASPVENKE VYQCRLCNAK LSSLLEQGSH ERLCRNAAVC 750
    PYCSLRFFSP ELKQEHESKC EYKKLTCLEC MRTFKSSFSI WRHQVEVHNQ 800
    NNMAPTENFS LPVLDHNGDV TGSSRPQSQP EPNKVNHIVT TKDDNVFSDS 850
    SEQVNFDSED SSCLPEDLSL SKQLKIQVKE EPVEEAEEEA PEASTAPKEA 900
    GPSKEASLWP CEKCGKMFTV HKQLERHQEL LCSVKPFICH VCNKAFRTNF 950
    RLWSHFQSHM SQASEESAHK ESEVCPVPTN SPSPPPLPPP PPLPKIQPLE 1000
    PDSPTGLSEN PTPATEKLFV PQESDTLFYH APPLSAITFK RQFMCKLCHR 1050
    TFKTAFSLWS HEQTHN 1066
    Length:1,066
    Mass (Da):118,870
    Last modified:December 1, 2000 - v2
    Checksum:iE1779E26943FDAC8
    GO
    Isoform 2 (identifier: Q9ULJ3-2) [UniParc]FASTAAdd to Basket

    Also known as: ZNF295S

    The sequence of this isoform differs from the canonical sequence as follows:
         535-735: Missing.

    Show »
    Length:865
    Mass (Da):95,807
    Checksum:i722AB5BE41C99614
    GO

    Sequence cautioni

    The sequence BAA86541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti961 – 9611S → P in AAH63290. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti185 – 1851N → S.
    Corresponds to variant rs871545 [ dbSNP | Ensembl ].
    VAR_052807
    Natural varianti218 – 2181K → Q.
    Corresponds to variant rs871546 [ dbSNP | Ensembl ].
    VAR_052808

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei535 – 735201Missing in isoform 2. 1 PublicationVSP_041349Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041014 mRNA. Translation: BAD74063.1.
    AB041015 mRNA. Translation: BAD74064.1.
    AB033053 mRNA. Translation: BAA86541.1. Different initiation.
    AP001745 Genomic DNA. Translation: BAA95529.1.
    CH471079 Genomic DNA. Translation: EAX09579.1.
    CH471079 Genomic DNA. Translation: EAX09580.1.
    CH471079 Genomic DNA. Translation: EAX09581.1.
    BC063290 mRNA. Translation: AAH63290.1.
    CCDSiCCDS13678.1. [Q9ULJ3-1]
    CCDS42934.1. [Q9ULJ3-2]
    RefSeqiNP_001091872.1. NM_001098402.1. [Q9ULJ3-1]
    NP_001091873.1. NM_001098403.1. [Q9ULJ3-2]
    NP_065778.3. NM_020727.4. [Q9ULJ3-1]
    XP_005261178.1. XM_005261121.1. [Q9ULJ3-1]
    XP_005261180.1. XM_005261123.1. [Q9ULJ3-2]
    UniGeneiHs.434947.
    Hs.618406.

    Genome annotation databases

    EnsembliENST00000310826; ENSP00000308759; ENSG00000173276. [Q9ULJ3-1]
    ENST00000398499; ENSP00000381512; ENSG00000173276. [Q9ULJ3-1]
    ENST00000398505; ENSP00000381517; ENSG00000173276. [Q9ULJ3-2]
    ENST00000398511; ENSP00000381523; ENSG00000173276. [Q9ULJ3-1]
    GeneIDi49854.
    KEGGihsa:49854.
    UCSCiuc002yzy.4. human. [Q9ULJ3-1]
    uc002yzz.4. human. [Q9ULJ3-2]

    Polymorphism databases

    DMDMi9979550.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041014 mRNA. Translation: BAD74063.1 .
    AB041015 mRNA. Translation: BAD74064.1 .
    AB033053 mRNA. Translation: BAA86541.1 . Different initiation.
    AP001745 Genomic DNA. Translation: BAA95529.1 .
    CH471079 Genomic DNA. Translation: EAX09579.1 .
    CH471079 Genomic DNA. Translation: EAX09580.1 .
    CH471079 Genomic DNA. Translation: EAX09581.1 .
    BC063290 mRNA. Translation: AAH63290.1 .
    CCDSi CCDS13678.1. [Q9ULJ3-1 ]
    CCDS42934.1. [Q9ULJ3-2 ]
    RefSeqi NP_001091872.1. NM_001098402.1. [Q9ULJ3-1 ]
    NP_001091873.1. NM_001098403.1. [Q9ULJ3-2 ]
    NP_065778.3. NM_020727.4. [Q9ULJ3-1 ]
    XP_005261178.1. XM_005261121.1. [Q9ULJ3-1 ]
    XP_005261180.1. XM_005261123.1. [Q9ULJ3-2 ]
    UniGenei Hs.434947.
    Hs.618406.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WJP NMR - A 713-806 [» ]
    ProteinModelPortali Q9ULJ3.
    SMRi Q9ULJ3. Positions 15-114, 540-600, 664-806, 909-972, 1035-1065.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119066. 8 interactions.
    IntActi Q9ULJ3. 1 interaction.
    MINTi MINT-1688321.
    STRINGi 9606.ENSP00000308759.

    PTM databases

    PhosphoSitei Q9ULJ3.

    Polymorphism databases

    DMDMi 9979550.

    Proteomic databases

    MaxQBi Q9ULJ3.
    PaxDbi Q9ULJ3.
    PRIDEi Q9ULJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310826 ; ENSP00000308759 ; ENSG00000173276 . [Q9ULJ3-1 ]
    ENST00000398499 ; ENSP00000381512 ; ENSG00000173276 . [Q9ULJ3-1 ]
    ENST00000398505 ; ENSP00000381517 ; ENSG00000173276 . [Q9ULJ3-2 ]
    ENST00000398511 ; ENSP00000381523 ; ENSG00000173276 . [Q9ULJ3-1 ]
    GeneIDi 49854.
    KEGGi hsa:49854.
    UCSCi uc002yzy.4. human. [Q9ULJ3-1 ]
    uc002yzz.4. human. [Q9ULJ3-2 ]

    Organism-specific databases

    CTDi 49854.
    GeneCardsi GC21M043409.
    HGNCi HGNC:13083. ZBTB21.
    HPAi HPA024655.
    neXtProti NX_Q9ULJ3.
    PharmGKBi PA37659.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303726.
    HOGENOMi HOG000237324.
    HOVERGENi HBG056929.
    InParanoidi Q9ULJ3.
    OMAi DNVLNYI.
    OrthoDBi EOG7TF789.
    PhylomeDBi Q9ULJ3.
    TreeFami TF331184.

    Miscellaneous databases

    EvolutionaryTracei Q9ULJ3.
    GeneWikii ZNF295.
    GenomeRNAii 49854.
    NextBioi 53012.
    PROi Q9ULJ3.

    Gene expression databases

    ArrayExpressi Q9ULJ3.
    Bgeei Q9ULJ3.
    CleanExi HS_ZNF295.
    Genevestigatori Q9ULJ3.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161."
      Wang J., Kudoh J., Takayanagi A., Shimizu N.
      Biochem. Biophys. Res. Commun. 327:615-627(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INTERACTION WITH ZBTB14, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Fetal kidney and Testis.
    2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-714, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381 AND SER-422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411; SER-422; THR-431; SER-434; SER-435; SER-438; SER-605 AND SER-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411; THR-431; SER-435 AND SER-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-605 AND SER-714, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-431 AND SER-434, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Solution structure of ZF-C2H2 domains from human zinc finger protein 295."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 713-806.

    Entry informationi

    Entry nameiZBT21_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULJ3
    Secondary accession number(s): Q5R2W1, Q5R2W2, Q6P4R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3