Q9ULJ1 (ODF2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Outer dense fiber protein 2-like

Gene names

Name:	ODF2L
Synonyms:	KIAA1229

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	636 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ODF2 family.

Sequence caution

The sequence AAH29420.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH47368.1 differs from that shown. Reason: Erroneous termination at position 397. Translated as Glu. The sequence AK308351 differs from that shown. Reason: Frameshift at position 296. The sequence BAA86543.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	centrosome Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULJ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULJ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     454-506: Missing.
     632-636: DPETP → KAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE

Isoform 3 (identifier: Q9ULJ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     353-381: Missing.
     506-506: Q → QILKQWEEYSVLAW

Isoform 4 (identifier: Q9ULJ1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     353-381: Missing.
     632-636: DPETP → KAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE

Isoform 5 (identifier: Q9ULJ1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     353-381: Missing.
     632-636: DPETP → KAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 636	636	Outer dense fiber protein 2-like		PRO_0000308909
Regions
	Coiled coil	36 – 97	62	Potential
	Coiled coil	141 – 220	80	Potential
	Coiled coil	249 – 325	77	Potential
	Coiled coil	377 – 484	108	Potential
	Coiled coil	519 – 631	113	Potential
Natural variations
	Alternative sequence	1 – 131	131	Missing in isoform 5.		VSP_040930
	Alternative sequence	353 – 381	29	Missing in isoform 3, isoform 4 and isoform 5.		VSP_029057
	Alternative sequence	454 – 506	53	Missing in isoform 2.		VSP_029058
	Alternative sequence	506	1	Q → QILKQWEEYSVLAW in isoform 3.		VSP_029059
	Alternative sequence	632 – 636	5	DPETP → KAQHQEVCLKEVQNSLEKSE NQNESIKNYLQFLKTSYVTM FE in isoform 2, isoform 4 and isoform 5.		VSP_029060
	Natural variant	177	1	R → H. Corresponds to variant rs12032435 [ dbSNP | Ensembl ].		VAR_036882
	Natural variant	350	1	K → R. Ref.5 Corresponds to variant rs17854440 [ dbSNP | Ensembl ].		VAR_036883
Experimental info
	Sequence conflict	135	1	E → G in AAH47368. Ref.5
	Sequence conflict	203	1	L → S in AAH29420. Ref.5
	Sequence conflict	339	1	Y → H in BAA86543. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: D74FAB4F22F21581	FASTA	636	73,728
	10 20 30 40 50 60 MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV 70 80 90 100 110 120 THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR 130 140 150 160 170 180 DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ 190 200 210 220 230 240 SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV 250 260 270 280 290 300 ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV 310 320 330 340 350 360 QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKLRFPCRIT 370 380 390 400 410 420 ESKNMNILIV LDMLCYISSE KTTLAALKDE VVSVENELSE LQEVEKKQKT LIEMYKTQVQ 430 440 450 460 470 480 KLQEAAEIVK SRCENLLHKN NQITKTKNKN VEKMRGQMES HLKELERVCD SLTAAERRLH 490 500 510 520 530 540 ECQESLQCCK GKCADQEHTI RELQGQVDGN HNLLTKLSLE EENCLIQLKC ENLQQKLEQM 550 560 570 580 590 600 DAENKELEKK LANQEECLKH SNLKFKEKSA EYTALARQLE AALEEGRQKV AEEIEKMSSR 610 620 630 ESALQIKILD LETELRKKNE EQNQLVCKMN SDPETP
	Isoform 2 [UniParc]. Checksum: 08EEED881F4457B5	FASTA	620	72,053
	10 20 30 40 50 60 MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV 70 80 90 100 110 120 THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR 130 140 150 160 170 180 DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ 190 200 210 220 230 240 SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV 250 260 270 280 290 300 ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV 310 320 330 340 350 360 QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKLRFPCRIT 370 380 390 400 410 420 ESKNMNILIV LDMLCYISSE KTTLAALKDE VVSVENELSE LQEVEKKQKT LIEMYKTQVQ 430 440 450 460 470 480 KLQEAAEIVK SRCENLLHKN NQITKTKNKN VEKVDGNHNL LTKLSLEEEN CLIQLKCENL 490 500 510 520 530 540 QQKLEQMDAE NKELEKKLAN QEECLKHSNL KFKEKSAEYT ALARQLEAAL EEGRQKVAEE 550 560 570 580 590 600 IEKMSSRESA LQIKILDLET ELRKKNEEQN QLVCKMNSKA QHQEVCLKEV QNSLEKSENQ 610 620 NESIKNYLQF LKTSYVTMFE
	Isoform 3 [UniParc]. Checksum: 10437F28D20EAB06	FASTA	620	71,962
	10 20 30 40 50 60 MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV 70 80 90 100 110 120 THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR 130 140 150 160 170 180 DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ 190 200 210 220 230 240 SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV 250 260 270 280 290 300 ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV 310 320 330 340 350 360 QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKTTLAALKD 370 380 390 400 410 420 EVVSVENELS ELQEVEKKQK TLIEMYKTQV QKLQEAAEIV KSRCENLLHK NNQITKTKNK 430 440 450 460 470 480 NVEKMRGQME SHLKELERVC DSLTAAERRL HECQESLQCC KGKCADQEHT IRELQGQILK 490 500 510 520 530 540 QWEEYSVLAW VDGNHNLLTK LSLEEENCLI QLKCENLQQK LEQMDAENKE LEKKLANQEE 550 560 570 580 590 600 CLKHSNLKFK EKSAEYTALA RQLEAALEEG RQKVAEEIEK MSSRESALQI KILDLETELR 610 620 KKNEEQNQLV CKMNSDPETP
	Isoform 4 [UniParc]. Checksum: C7F94FF7790D8FF1	FASTA	644	74,765
	10 20 30 40 50 60 MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV 70 80 90 100 110 120 THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR 130 140 150 160 170 180 DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ 190 200 210 220 230 240 SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV 250 260 270 280 290 300 ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV 310 320 330 340 350 360 QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKTTLAALKD 370 380 390 400 410 420 EVVSVENELS ELQEVEKKQK TLIEMYKTQV QKLQEAAEIV KSRCENLLHK NNQITKTKNK 430 440 450 460 470 480 NVEKMRGQME SHLKELERVC DSLTAAERRL HECQESLQCC KGKCADQEHT IRELQGQVDG 490 500 510 520 530 540 NHNLLTKLSL EEENCLIQLK CENLQQKLEQ MDAENKELEK KLANQEECLK HSNLKFKEKS 550 560 570 580 590 600 AEYTALARQL EAALEEGRQK VAEEIEKMSS RESALQIKIL DLETELRKKN EEQNQLVCKM 610 620 630 640 NSKAQHQEVC LKEVQNSLEK SENQNESIKN YLQFLKTSYV TMFE
	Isoform 5 [UniParc]. Checksum: 056290F9824311AD	FASTA	513	59,803
	10 20 30 40 50 60 MLLENLTDNE SENTNLKKKV FEKEAHIQEL SCLFQSEKAN TLKANRFSQS VKVVHERLQI 70 80 90 100 110 120 QIHKREAEND KLKEYVKSLE TKIAKWNLQS RMNKNEAIVM KEASRQKTVA LKKASKVYKQ 130 140 150 160 170 180 RLDHFTGAIE KLTSQIRDQE AKLSETISAS NAWKSHYEKI VIEKTELEVQ IETMKKQIIN 190 200 210 220 230 240 LLEDLKKMED HGKNSCEEIL RKVHSIEYEN ETLNLENTKL KTTLAALKDE VVSVENELSE 250 260 270 280 290 300 LQEVEKKQKT LIEMYKTQVQ KLQEAAEIVK SRCENLLHKN NQITKTKNKN VEKMRGQMES 310 320 330 340 350 360 HLKELERVCD SLTAAERRLH ECQESLQCCK GKCADQEHTI RELQGQVDGN HNLLTKLSLE 370 380 390 400 410 420 EENCLIQLKC ENLQQKLEQM DAENKELEKK LANQEECLKH SNLKFKEKSA EYTALARQLE 430 440 450 460 470 480 AALEEGRQKV AEEIEKMSSR ESALQIKILD LETELRKKNE EQNQLVCKMN SKAQHQEVCL 490 500 510 KEVQNSLEKS ENQNESIKNY LQFLKTSYVT MFE

References

[1]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Placenta.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-350. Tissue: Brain, Pituitary and Prostate.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-402 (ISOFORM 5). Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033055 mRNA. Translation: BAA86543.1. Different initiation. CR591511 mRNA. No translation available. AL136382, AC119749 Genomic DNA. Translation: CAI23513.1. AL136382, AC119749 Genomic DNA. Translation: CAI23514.1. CH471097 Genomic DNA. Translation: EAW73190.1. CH471097 Genomic DNA. Translation: EAW73192.1. BC029420 mRNA. Translation: AAH29420.1. Sequence problems. BC047368 mRNA. Translation: AAH47368.1. Sequence problems. BC091490 mRNA. Translation: AAH91490.1. AK308351 mRNA. No translation available.
IPI	IPI00008135. IPI00478622. IPI00556188. IPI00737794. IPI00984018.
RefSeq	NP_001007023.2. NM_001007022.2. NP_001171694.1. NM_001184765.1. NP_001171695.1. NM_001184766.1. NP_065780.2. NM_020729.2.
UniGene	Hs.149360.
3D structure databases
ProteinModelPortal	Q9ULJ1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULJ1. 25 interactions.
PTM databases
PhosphoSite	Q9ULJ1.
Polymorphism databases
DMDM	160013283.
Proteomic databases
PRIDE	Q9ULJ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359242; ENSP00000359600; ENSG00000122417. ENST00000449149; ENSP00000394525; ENSG00000122417.
GeneID	57489.
KEGG	hsa:57489.
NMPDR	fig|9606.3.peg.1443.
UCSC	uc001dll.1. human. uc001dlm.1. human. uc001dlp.1. human.
Organism-specific databases
CTD	57489.
GeneCards	GC01M086808.
HGNC	HGNC:29225. ODF2L.
HPA	HPA028020. HPA028095. HPA028333.
neXtProt	NX_Q9ULJ1.
PharmGKB	PA142671232.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063497.
HOVERGEN	HBG054948.
OMA	QIRDQEA.
OrthoDB	EOG4F4S9Q.
Gene expression databases
ArrayExpress	Q9ULJ1.
Bgee	Q9ULJ1.
CleanEx	HS_ODF2L.
Genevestigator	Q9ULJ1.
Family and domain databases
ProtoNet	Search...
Other
NextBio	63772.

Entry information

Entry name

ODF2L_HUMAN

Accession

Primary (citable) accession number: Q9ULJ1
Secondary accession number(s): A8MU56 , Q05C40, Q5BJG5, Q5TBX3, Q5TBX4, Q86X31

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.