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Protein

Kinesin-like protein KIF26A

Gene

KIF26A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi469 – 476ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF26A
Gene namesi
Name:KIF26A
Synonyms:KIAA1236
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20226. KIF26A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000066735.
PharmGKBiPA134888008.

Polymorphism and mutation databases

BioMutaiKIF26A.
DMDMi160014128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072991 – 1882Kinesin-like protein KIF26AAdd BLAST1882

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei1262PhosphoserineCombined sources1
Modified residuei1662PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULI4.
MaxQBiQ9ULI4.
PaxDbiQ9ULI4.
PeptideAtlasiQ9ULI4.
PRIDEiQ9ULI4.

PTM databases

iPTMnetiQ9ULI4.
PhosphoSitePlusiQ9ULI4.

Expressioni

Gene expression databases

BgeeiENSG00000066735.
CleanExiHS_KIF26A.
ExpressionAtlasiQ9ULI4. baseline and differential.
GenevisibleiQ9ULI4. HS.

Organism-specific databases

HPAiHPA046882.
HPA060346.

Interactioni

Subunit structurei

Interacts with GRB2 (via SH2 domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117584. 6 interactors.
IntActiQ9ULI4. 8 interactors.
STRINGi9606.ENSP00000388241.

Structurei

3D structure databases

ProteinModelPortaliQ9ULI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini371 – 725Kinesin motorPROSITE-ProRule annotationAdd BLAST355

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1784 – 1812Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00650000093360.
HOGENOMiHOG000081802.
HOVERGENiHBG108063.
InParanoidiQ9ULI4.
KOiK10404.
OMAiHMSLERC.
OrthoDBiEOG091G0097.
PhylomeDBiQ9ULI4.
TreeFamiTF105235.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRGVPLCA AQPAVAEGGP AREPPPLLEV SPRKRLPAGP DQDPCGSRPA
60 70 80 90 100
PEGAGAGPEQ GHSAGGGGWC RHCHTKLVEL KRQAWKLVSG PGTTLRDPCL
110 120 130 140 150
SALLLDKLPA PGALPACRPE AERRCDVCAT HLQQLTREAM HLLQAPASHE
160 170 180 190 200
DLDAPHGGPS LAPPSTTTSS RDTPGPAGPA GRQPGRAGPD RTKGLAWSPG
210 220 230 240 250
PSVQVSVAPA GLGGALSTVT IQAQQCLEGM WSVSRVNSFL PPACLAEAAV
260 270 280 290 300
AAVAVADTVR ECPPVAGPDG LSKAWGRGGV CTSALVTPTP GSVGGSTGPS
310 320 330 340 350
AAASFFIRAM QKLSLASKRK KPHPPPPPAT RGTSTYPTDF SGVLQLWPPP
360 370 380 390 400
APPCLLRAAS KTKDNPGSIG KVKVMLRIWP AQGAQRSAEA MSFLKVDPRK
410 420 430 440 450
KQVILYDPAA GPPGSAGPRR AATAAVPKMF AFDAVFPQDS EQAEVCSGTV
460 470 480 490 500
ADVLQSVVSG ADGCIFSFGH MSLGKSYTMI GKDSSPQSLG IVPCAISWLF
510 520 530 540 550
RLIEERRERT GTRFSVRVSA VEVCGRDQSL RDLLAEVAPG SLQDTQSPGV
560 570 580 590 600
YLREDPVCGA QLQNQSELRA PTAEKAAFYL DAALAARSTS RAGCGEDARR
610 620 630 640 650
SSHMLFTLHV YQYRMEKCGR GGMSGGRSRL HLIDLGSCEA AAGRAGEAAG
660 670 680 690 700
GPLCLSLSAL GSVILALVNG AKHVPYRDHR LTMLLRESLA TAGCRTTMIA
710 720 730 740 750
HVSDAPAQHA ETLSTVQLAA RIHRLRRKKA KYASSSSGGE SSCEEGRARR
760 770 780 790 800
PPHLRPFHPR TVALDPDRTP PCLPGDPDYS SSSEQSCDTV IYVGPGGAAL
810 820 830 840 850
SDRELTDNEG PPDFVPIIPA LSRHRPSKGP RDADHFRCST FAELQERLEC
860 870 880 890 900
MDGNEGPSGG PGGTDGAQAS PARGGRKPSP PEAASPRKAV GTPMAASTPR
910 920 930 940 950
GSSGPDTHQG TPEPCKAIVW GDQREDSSAW PELLVPEKAA VSGGRRPLPS
960 970 980 990 1000
PAPPPPQLLE ACRAPEEPGG GGTDGVARTP PVGMSGQVAG SPMLPGATCP
1010 1020 1030 1040 1050
RLAAGSRCPE RGLLTTTVTL QRPVELNGED ELVFTVVEEL SLGALAGAGR
1060 1070 1080 1090 1100
PTSLASFDSD CSLRALASGS RPVSIISSIN DEFDAYTSQA PEGGPLEGAA
1110 1120 1130 1140 1150
WAGSSHGSSI SSWLSEVSVC TADSRDPTPQ PRFSPDSLAG LDPGGPPALD
1160 1170 1180 1190 1200
GSLGDGSSGF LGPDRPDSPG PTWGPCPGEV AAVAPSRPGR EPQAGPSRWA
1210 1220 1230 1240 1250
SAAQTIHSSL PRKPRTASAT TRVGCARLGQ SPPGRGGLFE DPWLLRVGEC
1260 1270 1280 1290 1300
DTQAASAGRA PSPTLGSPRL PEAQVMLACA QRVVDGCEVA ARAARRPEAV
1310 1320 1330 1340 1350
ARIPPLRRGA TTLGVTTPAV SWGDAPTEVV ACSGSLKASP TSKKGLAPKA
1360 1370 1380 1390 1400
GFLPRPSGAA PPAPPTRKSS LEQRSSPASA PPHAVNPARV GAAAVLRGEE
1410 1420 1430 1440 1450
EPRPSSRADH SVPRATSSLK ARASKVEAAH RLAGHASLER YEGLAHSSSK
1460 1470 1480 1490 1500
GREAPGRPPR AVPKLGVPPS SPTHGPAPAC RSGAAKAVGA PKPPVGGGKG
1510 1520 1530 1540 1550
RGLVAGGSRA LGPSVKLSTA SVTGRSPGGP VAGPRAAPRA GPSVGAKAGR
1560 1570 1580 1590 1600
GTVMGTKQAL RAAHSRVHEL SASGAPGRGG SSWGSADSDS GHDSGVNVGE
1610 1620 1630 1640 1650
ERPPTGPALP SPYSKVTAPR RPQRYSSGHG SDNSSVLSGE LPPAMGRTAL
1660 1670 1680 1690 1700
FHHSGGSSGY ESLRRDSEAT GSASSAPDSM SESGAASPGA RTRSLKSPKK
1710 1720 1730 1740 1750
RATGLQRRRL IPAPLPDTTA LGRKPSLPGQ WVDLPPPLAG SLKEPFEIKV
1760 1770 1780 1790 1800
YEIDDVERLQ RPRPTPREAP TQGLACVSTR LRLAERRQQR LREVQAKHKH
1810 1820 1830 1840 1850
LCEELAETQG RLMLEPGRWL EQFEVDPELE PESAEYLAAL ERATAALEQC
1860 1870 1880
VNLCKAHVMM VTCFDISVAA SAAIPGPQEV DV
Length:1,882
Mass (Da):194,590
Last modified:October 23, 2007 - v3
Checksum:iC35E3458BCF3D147
GO

Sequence cautioni

The sequence AAH09415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1284 – 1287VDGC → ERER in AAH25353 (PubMed:15489334).Curated4
Sequence conflicti1513P → L in AAH25353 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359399 Genomic DNA. No translation available.
AB033062 mRNA. Translation: BAA86550.2.
BC009415 mRNA. Translation: AAH09415.1. Different initiation.
BC025353 mRNA. Translation: AAH25353.1.
AL117589 mRNA. Translation: CAB56009.1.
CCDSiCCDS45171.1.
PIRiT17319.
RefSeqiNP_056471.1. NM_015656.1.
UniGeneiHs.134970.

Genome annotation databases

EnsembliENST00000423312; ENSP00000388241; ENSG00000066735.
GeneIDi26153.
KEGGihsa:26153.
UCSCiuc001yos.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359399 Genomic DNA. No translation available.
AB033062 mRNA. Translation: BAA86550.2.
BC009415 mRNA. Translation: AAH09415.1. Different initiation.
BC025353 mRNA. Translation: AAH25353.1.
AL117589 mRNA. Translation: CAB56009.1.
CCDSiCCDS45171.1.
PIRiT17319.
RefSeqiNP_056471.1. NM_015656.1.
UniGeneiHs.134970.

3D structure databases

ProteinModelPortaliQ9ULI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117584. 6 interactors.
IntActiQ9ULI4. 8 interactors.
STRINGi9606.ENSP00000388241.

PTM databases

iPTMnetiQ9ULI4.
PhosphoSitePlusiQ9ULI4.

Polymorphism and mutation databases

BioMutaiKIF26A.
DMDMi160014128.

Proteomic databases

EPDiQ9ULI4.
MaxQBiQ9ULI4.
PaxDbiQ9ULI4.
PeptideAtlasiQ9ULI4.
PRIDEiQ9ULI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423312; ENSP00000388241; ENSG00000066735.
GeneIDi26153.
KEGGihsa:26153.
UCSCiuc001yos.5. human.

Organism-specific databases

CTDi26153.
GeneCardsiKIF26A.
H-InvDBHIX0012012.
HGNCiHGNC:20226. KIF26A.
HPAiHPA046882.
HPA060346.
MIMi613231. gene.
neXtProtiNX_Q9ULI4.
OpenTargetsiENSG00000066735.
PharmGKBiPA134888008.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00650000093360.
HOGENOMiHOG000081802.
HOVERGENiHBG108063.
InParanoidiQ9ULI4.
KOiK10404.
OMAiHMSLERC.
OrthoDBiEOG091G0097.
PhylomeDBiQ9ULI4.
TreeFamiTF105235.

Enzyme and pathway databases

ReactomeiR-HSA-2132295. MHC class II antigen presentation.
R-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF26A. human.
GenomeRNAii26153.
PROiQ9ULI4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000066735.
CleanExiHS_KIF26A.
ExpressionAtlasiQ9ULI4. baseline and differential.
GenevisibleiQ9ULI4. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI26A_HUMAN
AccessioniPrimary (citable) accession number: Q9ULI4
Secondary accession number(s): Q8TAZ7, Q96GK3, Q9UFL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In contrast to other kinesin-like proteins, residues required for ATPase activity are missing.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.