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Protein

ATPase family AAA domain-containing protein 2B

Gene

ATAD2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi441 – 448ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: GO_Central
  • lysine-acetylated histone binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119778-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 2B
Gene namesi
Name:ATAD2B
Synonyms:KIAA1240
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29230. ATAD2B.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54454.
PharmGKBiPA162377039.

Chemistry databases

ChEMBLiCHEMBL2176775.

Polymorphism and mutation databases

BioMutaiATAD2B.
DMDMi296439432.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507891 – 1458ATPase family AAA domain-containing protein 2BAdd BLAST1458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei221PhosphothreonineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1347PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULI0.
PaxDbiQ9ULI0.
PeptideAtlasiQ9ULI0.
PRIDEiQ9ULI0.

PTM databases

iPTMnetiQ9ULI0.
PhosphoSitePlusiQ9ULI0.

Expressioni

Gene expression databases

BgeeiENSG00000119778.
CleanExiHS_ATAD2B.
ExpressionAtlasiQ9ULI0. baseline and differential.
GenevisibleiQ9ULI0. HS.

Organism-specific databases

HPAiHPA034555.

Interactioni

Subunit structurei

Binds acetylated lysine residues in histone H1.4, H2A, H2B, H3 and H4 (in vitro).1 Publication

GO - Molecular functioni

  • lysine-acetylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119961. 1 interactor.
STRINGi9606.ENSP00000238789.

Chemistry databases

BindingDBiQ9ULI0.

Structurei

Secondary structure

11458
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi952 – 975Combined sources24
Helixi978 – 980Combined sources3
Turni989 – 991Combined sources3
Helixi995 – 998Combined sources4
Helixi1005 – 1013Combined sources9
Helixi1020 – 1037Combined sources18
Beta strandi1040 – 1042Combined sources3
Helixi1043 – 1066Combined sources24
Helixi1069 – 1083Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKWNMR-A958-1080[»]
3LXJX-ray2.33A/B/C/D952-1086[»]
ProteinModelPortaliQ9ULI0.
SMRiQ9ULI0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ULI0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini975 – 1045BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili943 – 974Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi257 – 262Poly-Glu6
Compositional biasi1247 – 1250Poly-Ser4

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
KOG0732. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000034119.
HOVERGENiHBG080873.
InParanoidiQ9ULI0.
OrthoDBiEOG091G0152.
PhylomeDBiQ9ULI0.
TreeFamiTF314783.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNTRKSSLR LLGSKSPGPG PGPGAGAEPG ATGGSSHFIS SRTRSSKTRA
60 70 80 90 100
ASCPAAKAGG SGGAGVTLDE ARKVEVDGSL SDSHVSPPAK RTLKQPDSVC
110 120 130 140 150
KDKSKSRSTG QREEWNLSTG QARLTSQPGA TLPNGHSGLS LRSHPLRGEK
160 170 180 190 200
KGDGDLSCIN GDMEVRKSCR SRKNRFESVN QSLLFDQLVN STAEAVLQEM
210 220 230 240 250
DNINIRQNRR SGEVERLRMW TDTEFENMDM YSRVKRRRKS LRRNSYGIQN
260 270 280 290 300
HHEVSTEGEE EESQEEDGDI EVEEAEGEEN DRPYNLRQRK TVDRYQAPPI
310 320 330 340 350
VPAHQKKREN TLFDIHRSPA RRSHIRRKKH AIHSSDTTSS DEERFERRKS
360 370 380 390 400
KSMARARNRC LPMNFRAEDL ASGILRERVK VGASLADVDP MNIDKSVRFD
410 420 430 440 450
SIGGLSHHIH ALKEMVVFPL LYPEIFEKFK IQPPRGCLFY GPPGTGKTLV
460 470 480 490 500
ARALANECSQ GDKKVAFFMR KGADCLSKWV GESERQLRLL FDQAYLMRPS
510 520 530 540 550
IIFFDEIDGL APVRSSRQDQ IHSSIVSTLL ALMDGLDNRG EIVVIGATNR
560 570 580 590 600
LDSIDPALRR PGRFDREFLF NLPDQKARKH ILQIHTRDWN PKLSDAFLGE
610 620 630 640 650
LAEKCVGYCG ADIKALCTEA ALIALRRRYP QIYASSHKLQ LDVSSIVLSA
660 670 680 690 700
QDFYHAMQNI VPASQRAVMS SGHALSPIIR PLLERSFNNI LAVLQKVFPH
710 720 730 740 750
AEISQSDKKE DIETLILEDS EDENALSIFE TNCHSGSPKK QSSSAAIHKP
760 770 780 790 800
YLHFTMSPYH QPTSYRPRLL LSGERGSGQT SHLAPALLHT LERFSVHRLD
810 820 830 840 850
LPALYSVSAK TPEESCAQIF REARRTVPSI VYMPHIGDWW EAVSETVRAT
860 870 880 890 900
FLTLLQDIPS FSPIFLLSTS ETMYSELPEE VKCIFRIQYE EVLYIQRPIE
910 920 930 940 950
EDRRKFFQEL ILNQASMAPP RRKHAALCAM EVLPLALPSP PRQLSESEKS
960 970 980 990 1000
RMEDQEENTL RELRLFLRDV TKRLATDKRF NIFSKPVDIE EVSDYLEVIK
1010 1020 1030 1040 1050
EPMDLSTVIT KIDKHNYLTA KDFLKDIDLI CSNALEYNPD KDPGDKIIRH
1060 1070 1080 1090 1100
RACTLKDTAH AIIAAELDPE FNKLCEEIKE ARIKRGLSVT SEQINPHSTG
1110 1120 1130 1140 1150
ARKTETRVEE AFRHKQRNPM DVWHNSANKC AFRVRRKSRR RSQWGKGIIK
1160 1170 1180 1190 1200
KRKVNNLKKD EEDTKFADYE NHTEDRKLLE NGEFEVSTDC HEENGEETGD
1210 1220 1230 1240 1250
LSMTNDESSC DIMDLDQGQR LNNGAGTKEN FASTEEESSN ESLLVNSSSS
1260 1270 1280 1290 1300
LNPEQTSRKE TFLKGNCLNG EASTDSFEGI PVLECQNGKL EVVSFCDSGD
1310 1320 1330 1340 1350
KCSSEQKILL EDQSKEKPET STENHGDDLE KLEALECSNN EKLEPGSDVE
1360 1370 1380 1390 1400
VKDAELDKEG ASKVKKYRKL ILEQAKTTSL ELVPEEPSEP VPPLIVDRER
1410 1420 1430 1440 1450
LKKLLDLLVD KSNNLAVDQL ERLYSLLSQC IYRHRKDYDK SQLVEEMERT

VHMFETFL
Length:1,458
Mass (Da):164,914
Last modified:May 18, 2010 - v3
Checksum:iCE7480D7EEBE6F9C
GO
Isoform 2 (identifier: Q9ULI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     988-992: Missing.

Show »
Length:1,453
Mass (Da):164,328
Checksum:i826AB705C4CB3A49
GO

Sequence cautioni

The sequence BAD18469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207Q → R in BAC04429 (PubMed:14702039).Curated1
Sequence conflicti291T → A in BAC04429 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055467118S → P.Corresponds to variant rs10210982dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023276988 – 992Missing in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009242 Genomic DNA. No translation available.
AC066692 Genomic DNA. No translation available.
AC079924 Genomic DNA. No translation available.
AK094821 mRNA. Translation: BAC04429.1.
AK131301 mRNA. Translation: BAD18469.1. Different initiation.
AB033066 mRNA. Translation: BAA86554.1.
CCDSiCCDS46227.1. [Q9ULI0-1]
RefSeqiNP_001229267.2. NM_001242338.2.
NP_060022.2. NM_017552.3.
UniGeneiHs.467862.
Hs.656359.

Genome annotation databases

EnsembliENST00000238789; ENSP00000238789; ENSG00000119778.
GeneIDi54454.
KEGGihsa:54454.
UCSCiuc002rek.5. human. [Q9ULI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009242 Genomic DNA. No translation available.
AC066692 Genomic DNA. No translation available.
AC079924 Genomic DNA. No translation available.
AK094821 mRNA. Translation: BAC04429.1.
AK131301 mRNA. Translation: BAD18469.1. Different initiation.
AB033066 mRNA. Translation: BAA86554.1.
CCDSiCCDS46227.1. [Q9ULI0-1]
RefSeqiNP_001229267.2. NM_001242338.2.
NP_060022.2. NM_017552.3.
UniGeneiHs.467862.
Hs.656359.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKWNMR-A958-1080[»]
3LXJX-ray2.33A/B/C/D952-1086[»]
ProteinModelPortaliQ9ULI0.
SMRiQ9ULI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119961. 1 interactor.
STRINGi9606.ENSP00000238789.

Chemistry databases

BindingDBiQ9ULI0.
ChEMBLiCHEMBL2176775.

PTM databases

iPTMnetiQ9ULI0.
PhosphoSitePlusiQ9ULI0.

Polymorphism and mutation databases

BioMutaiATAD2B.
DMDMi296439432.

Proteomic databases

EPDiQ9ULI0.
PaxDbiQ9ULI0.
PeptideAtlasiQ9ULI0.
PRIDEiQ9ULI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238789; ENSP00000238789; ENSG00000119778.
GeneIDi54454.
KEGGihsa:54454.
UCSCiuc002rek.5. human. [Q9ULI0-1]

Organism-specific databases

CTDi54454.
DisGeNETi54454.
GeneCardsiATAD2B.
HGNCiHGNC:29230. ATAD2B.
HPAiHPA034555.
MIMi615347. gene.
neXtProtiNX_Q9ULI0.
PharmGKBiPA162377039.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
KOG0732. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000034119.
HOVERGENiHBG080873.
InParanoidiQ9ULI0.
OrthoDBiEOG091G0152.
PhylomeDBiQ9ULI0.
TreeFamiTF314783.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119778-MONOMER.

Miscellaneous databases

ChiTaRSiATAD2B. human.
EvolutionaryTraceiQ9ULI0.
GenomeRNAii54454.
PROiQ9ULI0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119778.
CleanExiHS_ATAD2B.
ExpressionAtlasiQ9ULI0. baseline and differential.
GenevisibleiQ9ULI0. HS.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00382. AAA. 1 hit.
SM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS00674. AAA. 1 hit.
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATD2B_HUMAN
AccessioniPrimary (citable) accession number: Q9ULI0
Secondary accession number(s): B9ZVQ5, Q6ZNA6, Q8N9E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.