Q9ULH7 (MKL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MKL/myocardin-like protein 2

Alternative name(s):
Megakaryoblastic leukemia 2
Myocardin-related transcription factor B
Short name=MRTF-B

Gene names

Name:	MKL2
Synonyms:	KIAA1243, MRTFB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1088 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. Ref.1
Subunit structure	Interacts with MKL1 and SRF. Ref.1
Subcellular location	Nucleus By similarity.
Domain	The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity By similarity.
Post-translational modification	O-glycosylated By similarity.
Sequence similarities	Contains 3 RPEL repeats. Contains 1 SAP domain.

Ontologies

Keywords
Biological process	Differentiation Myogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Molecular function	Activator Developmental protein
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood vessel morphogenesis Inferred from electronic annotation. Source: Compara cardiac muscle tissue development Inferred from electronic annotation. Source: Compara embryonic organ development Inferred from electronic annotation. Source: Compara heart morphogenesis Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara liver development Inferred from electronic annotation. Source: Compara muscle organ development Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of striated muscle tissue development Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: UniProtKB smooth muscle cell differentiation Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred by curator Ref.1. Source: UniProtKB
Molecular_function	nucleic acid binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara transcription coactivator activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SRF	P11831	3	EBI-493007,EBI-493034

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULH7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULH7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MIDSSKKQQQGFPEILTAGDFEPLKEKECLEGSNQKSLKEV → M
     350-418: PLNDKNSNSG...SGTKPDLIER → AYHTVSEVHM...VSSIIPGINS
     419-1088: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9ULH7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     350-461: PLNDKNSNSG...VALPVTTLHN → YGGAHAILNA...VSSIIPGINS
     462-1088: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9ULH7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MIDSSKKQQQ...EGSNQKSLKE → MDHTGAIDTE...NLPPLNERKN
     689-738: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1088	1088	MKL/myocardin-like protein 2		PRO_0000126628
Regions
	Repeat	40 – 65	26	RPEL 1
	Repeat	84 – 109	26	RPEL 2
	Repeat	128 – 153	26	RPEL 3
	Domain	389 – 423	35	SAP
	Region	563 – 591	29	Required for interaction with itself and with MKL1
	Coiled coil	545 – 601	57	Potential
	Compositional bias	671 – 787	117	Gln-rich
Amino acid modifications
	Modified residue	66	1	Phosphoserine Ref.8
	Modified residue	367	1	Phosphothreonine Ref.8
	Modified residue	370	1	Phosphothreonine Ref.8
	Modified residue	541	1	Phosphoserine Ref.10
	Modified residue	921	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 41	41	MIDSS…SLKEV → M in isoform 2.		VSP_007653
	Alternative sequence	1 – 40	40	MIDSS…KSLKE → MDHTGAIDTEDEVGPLAHLA PSPQSEAVAHEFQELSLQSS QNLPPLNERKN in isoform 4.		VSP_013355
	Alternative sequence	350 – 461	112	PLNDK…TTLHN → YGGAHAILNAGFSVVFMRNY KLPKVECCHLFVLSNDFHFF VIRAYHTVSEVHMVRVACIP FQFLSSKIGSEFLQVRNAFS QLFIQICLLLEHQNSTRCSE KSVSSIIPGINS in isoform 3.		VSP_007656
	Alternative sequence	350 – 418	69	PLNDK…DLIER → AYHTVSEVHMVRVACIPFQF LSSKIGSEFLQVRNAFSQLF IQICLLLEHQNSTRCSEKSV SSIIPGINS in isoform 2.		VSP_007654
	Alternative sequence	419 – 1088	670	Missing in isoform 2.		VSP_007655
	Alternative sequence	462 – 1088	627	Missing in isoform 3.		VSP_007657
	Alternative sequence	689 – 738	50	Missing in isoform 4.		VSP_013356
	Natural variant	390	1	D → G Found in a renal cell carcinoma sample; somatic mutation. Ref.12		VAR_064732
Experimental info
	Sequence conflict	266	1	K → R in BAC04200. Ref.2
	Sequence conflict	350	1	P → A in AAQ82435. Ref.1
	Sequence conflict	592	1	E → G in CAH18657. Ref.7
	Sequence conflict	598	1	Q → R in AAQ82435. Ref.1
	Sequence conflict	629	1	D → G in AAQ82435. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2003. Version 3. Checksum: 0CA4A52A115C0C83	FASTA	1,088	118,127
	10 20 30 40 50 60 MIDSSKKQQQ GFPEILTAGD FEPLKEKECL EGSNQKSLKE VLQLRLQQRR TREQLVDQGI 70 80 90 100 110 120 MPPLKSPAAF HEQIKSLERA RTENFLKHKI RSRPDRSELV RMHILEETFA EPSLQATQMK 130 140 150 160 170 180 LKRARLADDL NEKIAQRPGP MELVEKNILP VDSSVKEAII GVGKEDYPHT QGDFSFDEDS 190 200 210 220 230 240 SDALSPDQPA SQESQGSAAS PSEPKVSESP SPVTTNTPAQ FASVSPTVPE FLKTPPTADQ 250 260 270 280 290 300 PPPRPAAPVL PTNTVSSAKP GPALVKQSHP KNPNDKHRSK KCKDPKPRVK KLKYHQYIPP 310 320 330 340 350 360 DQKGEKNEPQ MDSNYARLLQ QQQLFLQLQI LSQQKQHYNY QTILPAPFKP LNDKNSNSGN 370 380 390 400 410 420 SALNNATPNT PRQNTSTPVR KPGPLPSSLD DLKVSELKTE LKLRGLPVSG TKPDLIERLK 430 440 450 460 470 480 PYQEVNSSGL AAGGIVAVSS SAIVTSNPEV TVALPVTTLH NTVTSSVSTL KAELPPTGTS 490 500 510 520 530 540 NATRVENVHS PLPISPSPSE QSSLSTDDTN MADTFTEIMT MMSPSQFLSS SPLRMTNNED 550 560 570 580 590 600 SLSPTSSTLS NLELDAAEKD RKLQEKEKQI EELKRKLEQE QKLVEVLKMQ LEVEKRGQQQ 610 620 630 640 650 660 RPLEAQPSAP GHSVKSDQKH GSLGSSIKDE ASLPDCSSSR QPIPVASHAV GQPVSTGGQT 670 680 690 700 710 720 LVAKKAVVIK QEVPVGQAEQ QSVVSQFYVS SQGQPPPAVV AQPQALLTTQ TAQLLLPVSI 730 740 750 760 770 780 QGSSVTSVQL PVGSLKLQTS PQAGMQTQPQ IATAAQIPTA ALASGLAPTV PQTQDTFPQH 790 800 810 820 830 840 VLSQPQQVRK VFTNSASSNT VLPYQRHPAP AVQQPFINKA SNSVLQSRNA PLPSLQNGPN 850 860 870 880 890 900 TPNKPSSPPP PQQFVVQHSL FGSPVAKTKD PPRYEEAIKQ TRSTQAPLPE ISNAHSQQMD 910 920 930 940 950 960 DLFDILIKSG EISLPIKEEP SPISKMRPVT ASITTMPVNT VVSRPPPQVQ MAPPVSLEPM 970 980 990 1000 1010 1020 GSLSASLENQ LEAFLDGTLP SANEIPPLQS SSEDREPFSL IEDLQNDLLS HSGMLDHSHS 1030 1040 1050 1060 1070 1080 PMETSETQFA AGTPCLSLDL SDSNLDNMEW LDITMPNSSS GLTPLSTTAP SMFSADFLDP QDLPLPWD
	Isoform 2 [UniParc]. Checksum: 265D363A09230333	FASTA	378	42,496
	10 20 30 40 50 60 MLQLRLQQRR TREQLVDQGI MPPLKSPAAF HEQIKSLERA RTENFLKHKI RSRPDRSELV 70 80 90 100 110 120 RMHILEETFA EPSLQATQMK LKRARLADDL NEKIAQRPGP MELVEKNILP VDSSVKEAII 130 140 150 160 170 180 GVGKEDYPHT QGDFSFDEDS SDALSPDQPA SQESQGSAAS PSEPKVSESP SPVTTNTPAQ 190 200 210 220 230 240 FASVSPTVPE FLKTPPTADQ PPPRPAAPVL PTNTVSSAKP GPALVKQSHP KNPNDKHRSK 250 260 270 280 290 300 KCKDPKPRVK KLKYHQYIPP DQKGEKNEPQ MDSNYARLLQ QQQLFLQLQI LSQQKQHYNY 310 320 330 340 350 360 QTILPAPFKA YHTVSEVHMV RVACIPFQFL SSKIGSEFLQ VRNAFSQLFI QICLLLEHQN 370 STRCSEKSVS SIIPGINS
	Isoform 3 [UniParc]. Checksum: 94540BFA3F4213AB	FASTA	461	51,902
	10 20 30 40 50 60 MIDSSKKQQQ GFPEILTAGD FEPLKEKECL EGSNQKSLKE VLQLRLQQRR TREQLVDQGI 70 80 90 100 110 120 MPPLKSPAAF HEQIKSLERA RTENFLKHKI RSRPDRSELV RMHILEETFA EPSLQATQMK 130 140 150 160 170 180 LKRARLADDL NEKIAQRPGP MELVEKNILP VDSSVKEAII GVGKEDYPHT QGDFSFDEDS 190 200 210 220 230 240 SDALSPDQPA SQESQGSAAS PSEPKVSESP SPVTTNTPAQ FASVSPTVPE FLKTPPTADQ 250 260 270 280 290 300 PPPRPAAPVL PTNTVSSAKP GPALVKQSHP KNPNDKHRSK KCKDPKPRVK KLKYHQYIPP 310 320 330 340 350 360 DQKGEKNEPQ MDSNYARLLQ QQQLFLQLQI LSQQKQHYNY QTILPAPFKY GGAHAILNAG 370 380 390 400 410 420 FSVVFMRNYK LPKVECCHLF VLSNDFHFFV IRAYHTVSEV HMVRVACIPF QFLSSKIGSE 430 440 450 460 FLQVRNAFSQ LFIQICLLLE HQNSTRCSEK SVSSIIPGIN S
	Isoform 4 [UniParc]. Checksum: E8DC053F48F8AA4F	FASTA	1,049	114,119
	10 20 30 40 50 60 MDHTGAIDTE DEVGPLAHLA PSPQSEAVAH EFQELSLQSS QNLPPLNERK NVLQLRLQQR 70 80 90 100 110 120 RTREQLVDQG IMPPLKSPAA FHEQIKSLER ARTENFLKHK IRSRPDRSEL VRMHILEETF 130 140 150 160 170 180 AEPSLQATQM KLKRARLADD LNEKIAQRPG PMELVEKNIL PVDSSVKEAI IGVGKEDYPH 190 200 210 220 230 240 TQGDFSFDED SSDALSPDQP ASQESQGSAA SPSEPKVSES PSPVTTNTPA QFASVSPTVP 250 260 270 280 290 300 EFLKTPPTAD QPPPRPAAPV LPTNTVSSAK PGPALVKQSH PKNPNDKHRS KKCKDPKPRV 310 320 330 340 350 360 KKLKYHQYIP PDQKGEKNEP QMDSNYARLL QQQQLFLQLQ ILSQQKQHYN YQTILPAPFK 370 380 390 400 410 420 PLNDKNSNSG NSALNNATPN TPRQNTSTPV RKPGPLPSSL DDLKVSELKT ELKLRGLPVS 430 440 450 460 470 480 GTKPDLIERL KPYQEVNSSG LAAGGIVAVS SSAIVTSNPE VTVALPVTTL HNTVTSSVST 490 500 510 520 530 540 LKAELPPTGT SNATRVENVH SPLPISPSPS EQSSLSTDDT NMADTFTEIM TMMSPSQFLS 550 560 570 580 590 600 SSPLRMTNNE DSLSPTSSTL SNLELDAAEK DRKLQEKEKQ IEELKRKLEQ EQKLVEVLKM 610 620 630 640 650 660 QLEVEKRGQQ QRPLEAQPSA PGHSVKSDQK HGSLGSSIKD EASLPDCSSS RQPIPVASHA 670 680 690 700 710 720 VGQPVSTGGQ TLVAKKAVVI KQEVPVGQAE QQSVVSQFYT SPQAGMQTQP QIATAAQIPT 730 740 750 760 770 780 AALASGLAPT VPQTQDTFPQ HVLSQPQQVR KVFTNSASSN TVLPYQRHPA PAVQQPFINK 790 800 810 820 830 840 ASNSVLQSRN APLPSLQNGP NTPNKPSSPP PPQQFVVQHS LFGSPVAKTK DPPRYEEAIK 850 860 870 880 890 900 QTRSTQAPLP EISNAHSQQM DDLFDILIKS GEISLPIKEE PSPISKMRPV TASITTMPVN 910 920 930 940 950 960 TVVSRPPPQV QMAPPVSLEP MGSLSASLEN QLEAFLDGTL PSANEIPPLQ SSSEDREPFS 970 980 990 1000 1010 1020 LIEDLQNDLL SHSGMLDHSH SPMETSETQF AAGTPCLSLD LSDSNLDNME WLDITMPNSS 1030 1040 SGLTPLSTTA PSMFSADFLD PQDLPLPWD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation." Selvaraj A., Prywes R. J. Biol. Chem. 278:41977-41987(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH MKL1 AND SRF. Tissue: Cervix carcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Thymus.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Medulla oblongata.
[5]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-1088 (ISOFORM 1). Tissue: Brain.
[6]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 415-1088 (ISOFORM 1). Tissue: Amygdala.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; THR-367; THR-370 AND SER-921, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A. Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLY-390.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY374297 mRNA. Translation: AAQ82435.1. AK093577 mRNA. Translation: BAC04200.1. AC130650 Genomic DNA. No translation available. BC047761 mRNA. Translation: AAH47761.1. AB033069 mRNA. Translation: BAA86557.2. CR749797 mRNA. Translation: CAH18657.1.
IPI	IPI00329152. IPI00335641. IPI00335643. IPI00418489.
RefSeq	NP_054767.3. NM_014048.3.
UniGene	Hs.49143.
3D structure databases
ProteinModelPortal	Q9ULH7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULH7. 2 interactions.
MINT	MINT-1190534.
STRING	9606.ENSP00000339086.
PTM databases
PhosphoSite	Q9ULH7.
Polymorphism databases
DMDM	32363203.
Proteomic databases
PaxDb	Q9ULH7.
PRIDE	Q9ULH7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318282; ENSP00000339086; ENSG00000186260. ENST00000341243; ENSP00000345841; ENSG00000186260. ENST00000573051; ENSP00000460589; ENSG00000186260. ENST00000574045; ENSP00000459205; ENSG00000186260.
GeneID	57496.
KEGG	hsa:57496.
UCSC	uc002dcg.3. human. uc002dch.3. human. uc010uzb.2. human.
Organism-specific databases
CTD	57496.
GeneCards	GC16P014072.
H-InvDB	HIX0012829.
HGNC	HGNC:29819. MKL2.
HPA	HPA011286.
MIM	609463. gene.
neXtProt	NX_Q9ULH7.
PharmGKB	PA134981329.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG82832.
HOVERGEN	HBG036493.
InParanoid	Q9ULH7.
OMA	KQTRSAQ.
Gene expression databases
ArrayExpress	Q9ULH7.
Bgee	Q9ULH7.
CleanEx	HS_MKL2.
Genevestigator	Q9ULH7.
GermOnline	ENSG00000186260. Homo sapiens.
Family and domain databases
Gene3D	1.10.720.30. 1 hit.
InterPro	IPR004018. RPEL_repeat. IPR003034. SAP_dom. [Graphical view]
Pfam	PF02755. RPEL. 3 hits. PF02037. SAP. 1 hit. [Graphical view]
SMART	SM00707. RPEL. 3 hits. SM00513. SAP. 1 hit. [Graphical view]
PROSITE	PS51073. RPEL. 3 hits. PS50800. SAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MKL2. human.
GenomeRNAi	57496.
NextBio	63808.
PMAP-CutDB	Q9ULH7.
SOURCE	Search...

Entry information

Entry name

MKL2_HUMAN

Accession

Primary (citable) accession number: Q9ULH7
Secondary accession number(s): A6ND53 , Q68CT1, Q6UB16, Q86WW2, Q8N226

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2003
Last sequence update:	June 27, 2003
Last modified:	May 1, 2013
This is version 108 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.