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Protein

Leucine-rich repeat and fibronectin type-III domain-containing protein 2

Gene

LRFN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8849932 Synaptic adhesion-like molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and fibronectin type-III domain-containing protein 2
Alternative name(s):
Synaptic adhesion-like molecule 1
Gene namesi
Name:LRFN2
Synonyms:KIAA1246, SALM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000156564.8
HGNCiHGNC:21226 LRFN2
MIMi612808 gene
neXtProtiNX_Q9ULH4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 534ExtracellularSequence analysisAdd BLAST514
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Topological domaini556 – 789CytoplasmicSequence analysisAdd BLAST234

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi787 – 789Missing : Loss of DLG1-, DLG3- and DLG4-binding. 1 Publication3

Organism-specific databases

DisGeNETi57497
OpenTargetsiENSG00000156564
PharmGKBiPA134913285

Polymorphism and mutation databases

BioMutaiLRFN2
DMDMi62286951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001483821 – 789Leucine-rich repeat and fibronectin type-III domain-containing protein 2Add BLAST769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 359PROSITE-ProRule annotation
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ULH4
PeptideAtlasiQ9ULH4
PRIDEiQ9ULH4

PTM databases

iPTMnetiQ9ULH4
PhosphoSitePlusiQ9ULH4

Expressioni

Gene expression databases

BgeeiENSG00000156564
CleanExiHS_LRFN2
GenevisibleiQ9ULH4 HS

Organism-specific databases

HPAiHPA013653
HPA076660

Interactioni

Subunit structurei

Forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5. Can form homomeric complexes, but not across cell junctions. Directly interacts with 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4.By similarity1 Publication

Protein-protein interaction databases

BioGridi121564, 6 interactors
STRINGi9606.ENSP00000345985

Structurei

3D structure databases

ProteinModelPortaliQ9ULH4
SMRiQ9ULH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 52LRRNTAdd BLAST32
Repeati53 – 74LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 122LRR 3Add BLAST22
Repeati125 – 146LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Domaini242 – 288LRRCTAdd BLAST47
Domaini289 – 375Ig-likeAdd BLAST87
Domaini421 – 518Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST98

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi786 – 789PDZ-binding4

Domaini

The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding.By similarity

Sequence similaritiesi

Belongs to the LRFN family.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000237343
HOVERGENiHBG052352
InParanoidiQ9ULH4
KOiK16355
OMAiATNIVGC
OrthoDBiEOG091G02SI
PhylomeDBiQ9ULH4
TreeFamiTF350185

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 6 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLLGGLLA FGMAFAVVDA CPKYCVCQNL SESLGTLCPS KGLLFVPPDI
60 70 80 90 100
DRRTVELRLG GNFIIHISRQ DFANMTGLVD LTLSRNTISH IQPFSFLDLE
110 120 130 140 150
SLRSLHLDSN RLPSLGEDTL RGLVNLQHLI VNNNQLGGIA DEAFEDFLLT
160 170 180 190 200
LEDLDLSYNN LHGLPWDSVR RMVNLHQLSL DHNLLDHIAE GTFADLQKLA
210 220 230 240 250
RLDLTSNRLQ KLPPDPIFAR SQASALTATP FAPPLSFSFG GNPLHCNCEL
260 270 280 290 300
LWLRRLERDD DLETCGSPGG LKGRYFWHVR EEEFVCEPPL ITQHTHKLLV
310 320 330 340 350
LEGQAATLKC KAIGDPSPLI HWVAPDDRLV GNSSRTAVYD NGTLDIFITT
360 370 380 390 400
SQDSGAFTCI AANAAGEATA MVEVSIVQLP HLSNSTSRTA PPKSRLSDIT
410 420 430 440 450
GSSKTSRGGG GSGGGEPPKS PPERAVLVSE VTTTSALVKW SVSKSAPRVK
460 470 480 490 500
MYQLQYNCSD DEVLIYRMIP ASNKAFVVNN LVSGTGYDLC VLAMWDDTAT
510 520 530 540 550
TLTATNIVGC AQFFTKADYP QCQSMHSQIL GGTMILVIGG IIVATLLVFI
560 570 580 590 600
VILMVRYKVC NHEAPSKMAA AVSNVYSQTN GAQPPPPSSA PAGAPPQGPP
610 620 630 640 650
KVVVRNELLD FTASLARASD SSSSSSLGSG EAAGLGRAPW RIPPSAPRPK
660 670 680 690 700
PSLDRLMGAF ASLDLKSQRK EELLDSRTPA GRGAGTSARG HHSDREPLLG
710 720 730 740 750
PPAARARSLL PLPLEGKAKR SHSFDMGDFA AAAAGGVVPG GYSPPRKVSN
760 770 780
IWTKRSLSVN GMLLPFEESD LVGARGTFGS SEWVMESTV
Length:789
Mass (Da):84,731
Last modified:March 29, 2005 - v2
Checksum:i3D1D298909267F38
GO

Sequence cautioni

The sequence BAA86560 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049894770D → N. Corresponds to variant dbSNP:rs3734559Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033072 mRNA Translation: BAA86560.1 Different initiation.
AK291474 mRNA Translation: BAF84163.1
AL591063 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04006.1
BC142616 mRNA Translation: AAI42617.1
CCDSiCCDS34443.1
RefSeqiNP_065788.1, NM_020737.2
XP_011513063.1, XM_011514761.2
XP_011513064.1, XM_011514762.2
XP_016866599.1, XM_017011110.1
UniGeneiHs.250015

Genome annotation databases

EnsembliENST00000338305; ENSP00000345985; ENSG00000156564
GeneIDi57497
KEGGihsa:57497
UCSCiuc003oph.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRFN2_HUMAN
AccessioniPrimary (citable) accession number: Q9ULH4
Secondary accession number(s): A5PKU3, Q5SYP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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