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Q9ULH0 (KDIS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinase D-interacting substrate of 220 kDa
Alternative name(s):
Ankyrin repeat-rich membrane-spanning protein
Gene names
Name:KIDINS220
Synonyms:ARMS, KIAA1250
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1771 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration By similarity. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. Ref.6

Subunit structure

Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZ domains. Interacts with EPHA4 and PRKD1 By similarity. Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner By similarity. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation By similarity. Interacts (via C-terminal domain) with MAGI2 (via PDZ domain) By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential. Late endosome By similarity. Note: Localized at late endosome before or after nerve growth factor (NGF) stimulation.

Tissue specificity

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. Ref.6

Domain

The transmembrane domain mediates interaction with NTRK1 By similarity.

Post-translational modification

Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) By similarity.

Sequence similarities

Contains 12 ANK repeats.

Contains 1 KAP NTPase domain.

Sequence caution

The sequence BAA86564.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAB14728.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNeurogenesis
   Cellular componentEndosome
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Repeat
Transmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Traceable author statement. Source: Reactome

cellular response to nerve growth factor stimulus

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasmic transport

Inferred from sequence or structural similarity. Source: UniProtKB

dendrite morphogenesis

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

nerve growth factor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

positive regulation of neuron projection development

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

late endosome

Inferred from sequence or structural similarity. Source: UniProtKB

protein complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionPDZ domain binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ULH0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ULH0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     1138-1194: Missing.
Isoform 3 (identifier: Q9ULH0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: L → LQ
     1005-1030: ISKNIPTTKDVEPLLEIDGDIRNFEV → CCGADSCDRDRIGISKSVLVAMLMES
     1031-1771: Missing.
Isoform 4 (identifier: Q9ULH0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1195: Missing.
Isoform 5 (identifier: Q9ULH0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1228: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17711771Kinase D-interacting substrate of 220 kDa
PRO_0000322119

Regions

Topological domain1 – 499499Cytoplasmic Potential
Transmembrane500 – 52021Helical; Potential
Topological domain521 – 5244Extracellular Potential
Transmembrane525 – 54521Helical; Potential
Topological domain546 – 659114Cytoplasmic Potential
Transmembrane660 – 68021Helical; Potential
Topological domain681 – 6855Extracellular Potential
Transmembrane686 – 70621Helical; Potential
Topological domain707 – 17711065Cytoplasmic Potential
Repeat4 – 3330ANK 1
Repeat37 – 6630ANK 2
Repeat70 – 9930ANK 3
Repeat103 – 13230ANK 4
Repeat136 – 16530ANK 5
Repeat169 – 19830ANK 6
Repeat202 – 23130ANK 7
Repeat235 – 26430ANK 8
Repeat268 – 29730ANK 9
Repeat301 – 33030ANK 10
Repeat334 – 36330ANK 11
Repeat367 – 39630ANK 12
Domain440 – 953514KAP NTPase
Region1089 – 10924Mediates interaction with CRKL By similarity
Region1767 – 17715Mediates interaction with SNTA1 By similarity

Amino acid modifications

Modified residue9181Phosphoserine Ref.8
Modified residue13651Phosphoserine Ref.8
Modified residue15211Phosphoserine Ref.8
Modified residue15551Phosphoserine Ref.11 Ref.13
Modified residue16331Phosphoserine Ref.13

Natural variations

Alternative sequence1 – 12281228Missing in isoform 5.
VSP_031861
Alternative sequence1 – 4242Missing in isoform 2.
VSP_031862
Alternative sequence1351L → LQ in isoform 3.
VSP_031863
Alternative sequence1005 – 103026ISKNI…RNFEV → CCGADSCDRDRIGISKSVLV AMLMES in isoform 3.
VSP_031864
Alternative sequence1031 – 1771741Missing in isoform 3.
VSP_031865
Alternative sequence1138 – 119457Missing in isoform 2.
VSP_031866
Alternative sequence1177 – 119519Missing in isoform 4.
VSP_031867
Natural variant5381I → T.
Corresponds to variant rs2289229 [ dbSNP | Ensembl ].
VAR_048285
Natural variant13071R → H.
Corresponds to variant rs2304591 [ dbSNP | Ensembl ].
VAR_039399
Natural variant16081Q → H. Ref.3 Ref.4 Ref.5
Corresponds to variant rs1044280 [ dbSNP | Ensembl ].
VAR_039400

Experimental info

Sequence conflict13351T → P in CAE45935. Ref.4
Sequence conflict16131N → D in BAB14285. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: FD1F99DB88B6996D

FASTA1,771196,542
        10         20         30         40         50         60 
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN LEIVKELIKN 

        70         80         90        100        110        120 
GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR DMGGWTALMW ACYKGRTDVV 

       130        140        150        160        170        180 
ELLLSHGANP SVTGLYSVYP IIWAAGRGHA DIVHLLLQNG AKVNCSDKYG TTPLVWAARK 

       190        200        210        220        230        240 
GHLECVKHLL AMGADVDQEG ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL 

       250        260        270        280        290        300 
MIASKEGHTE IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ 

       310        320        330        340        350        360 
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV VELLLDKGAK 

       370        380        390        400        410        420 
VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP NKAGETPYNI DCSHQKSILT 

       430        440        450        460        470        480 
QIFGARHLSP TETDGDMLGY DLYSSALADI LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE 

       490        500        510        520        530        540 
DEMKTFAGQQ IEPLFQFSWL IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF 

       550        560        570        580        590        600 
IVIYFGGRRE GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT 

       610        620        630        640        650        660 
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK WKKTCCLPSF 

       670        680        690        700        710        720 
VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV GLAFVLNCRT WWQVLDSLLN 

       730        740        750        760        770        780 
SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE LMARMAKTID SFTQNQTRLV VIIDGLDACE 

       790        800        810        820        830        840 
QDKVLQMLDT VRVLFSKGPF IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL 

       850        860        870        880        890        900 
PVFLNSRGLS NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR 

       910        920        930        940        950        960 
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG RLLRANQISF 

       970        980        990       1000       1010       1020 
NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT IYERISKNIP TTKDVEPLLE 

      1030       1040       1050       1060       1070       1080 
IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC TVNLDPKLRE IIADVRAARE QISIGGLAYP 

      1090       1100       1110       1120       1130       1140 
PLPLHEGPPR APSGYSQPPS VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF 

      1150       1160       1170       1180       1190       1200 
FAPYLYTPRY YPGGSQHLIS RPSVKTSLPR DQNNGLEVIK EDAAEGLSSP TDSSRGSGPA 

      1210       1220       1230       1240       1250       1260 
PGPVVLLNSL NVDAVCEKLK QIEGLDQSML PQYCTTIKKA NINGRVLAQC NIDELKKEMN 

      1270       1280       1290       1300       1310       1320 
MNFGDWHLFR STVLEMRNAE SHVVPEDPRF LSESSSGPAP HGEPARRASH NELPHTELSS 

      1330       1340       1350       1360       1370       1380 
QTPYTLNFSF EELNTLGLDE GAPRHSNLSW QSQTRRTPSL SSLNSQDSSI EISKLTDKVQ 

      1390       1400       1410       1420       1430       1440 
AEYRDAYREY IAQMSQLEGG PGSTTISGRS SPHSTYYMGQ SSSGGSIHSN LEQEKGKDSE 

      1450       1460       1470       1480       1490       1500 
PKPDDGRKSF LMKRGDVIDY SSSGVSTNDA SPLDPITEED EKSDQSGSKL LPGKKSSERS 

      1510       1520       1530       1540       1550       1560 
SLFQTDLKLK GSGLRYQKLP SDEDESGTEE SDNTPLLKDD KDRKAEGKVE RVPKSPEHSA 

      1570       1580       1590       1600       1610       1620 
EPIRTFIKAK EYLSDALLDK KDSSDSGVRS SESSPNHSLH NEVADDSQLE KANLIELEDD 

      1630       1640       1650       1660       1670       1680 
SHSGKRGIPH SLSGLQDPII ARMSICSEDK KSPSECSLIA SSPEENWPAC QKAYNLNRTP 

      1690       1700       1710       1720       1730       1740 
STVTLNNNSA PANRANQNFD EMEGIRETSQ VILRPSSSPN PTTIQNENLK SMTHKRSQRS 

      1750       1760       1770 
SYTRLSKDPP ELHAAASSES TGFGEERESI L 

« Hide

Isoform 2 [UniParc].

Checksum: 103CE2C56521F5A8
Show »

FASTA1,672185,546
Isoform 3 [UniParc].

Checksum: D9E866461C13A2F5
Show »

FASTA1,031115,312
Isoform 4 [UniParc].

Checksum: C8FBB42BE1147C90
Show »

FASTA1,752194,569
Isoform 5 [UniParc].

Checksum: B4A46C01CC4C1F37
Show »

FASTA54359,967

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1636-1771 (ISOFORM 1), VARIANT HIS-1608.
Tissue: Thyroid.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1089-1771 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1526-1771 (ISOFORM 1), VARIANT HIS-1608.
Tissue: Esophageal carcinoma and Testis.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1478-1771, VARIANT HIS-1608.
[6]"ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma."
Liao Y.-H., Hsu S.-M., Huang P.-H.
Cancer Res. 67:11547-11556(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918; SER-1365 AND SER-1521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555 AND SER-1633, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033076 mRNA. Translation: BAA86564.2. Different initiation.
AK022873 mRNA. Translation: BAB14285.1.
AK023926 mRNA. Translation: BAB14728.1. Different initiation.
AL133620 mRNA. Translation: CAB63746.1.
AL137553 mRNA. Translation: CAB70807.1.
BX640878 mRNA. Translation: CAE45935.1.
BC094714 mRNA. Translation: AAH94714.1.
BC130610 mRNA. Translation: AAI30611.1.
CCDSCCDS42650.1. [Q9ULH0-1]
PIRT43458.
RefSeqNP_065789.1. NM_020738.2. [Q9ULH0-1]
UniGeneHs.9873.

3D structure databases

ProteinModelPortalQ9ULH0.
SMRQ9ULH0. Positions 5-422.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121565. 4 interactions.
IntActQ9ULH0. 7 interactions.
MINTMINT-1390552.
STRING9606.ENSP00000256707.

PTM databases

PhosphoSiteQ9ULH0.

Polymorphism databases

DMDM172044825.

Proteomic databases

MaxQBQ9ULH0.
PaxDbQ9ULH0.
PRIDEQ9ULH0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256707; ENSP00000256707; ENSG00000134313. [Q9ULH0-1]
ENST00000319688; ENSP00000319947; ENSG00000134313. [Q9ULH0-3]
ENST00000418530; ENSP00000414923; ENSG00000134313. [Q9ULH0-2]
ENST00000427284; ENSP00000411849; ENSG00000134313. [Q9ULH0-4]
ENST00000473731; ENSP00000418974; ENSG00000134313. [Q9ULH0-4]
GeneID57498.
KEGGhsa:57498.
UCSCuc002qzc.2. human. [Q9ULH0-1]
uc002qzd.2. human. [Q9ULH0-2]

Organism-specific databases

CTD57498.
GeneCardsGC02M008865.
HGNCHGNC:29508. KIDINS220.
HPAHPA014790.
neXtProtNX_Q9ULH0.
PharmGKBPA164721911.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
InParanoidQ9ULH0.
KOK12460.
OMAFKTEDTQ.
PhylomeDBQ9ULH0.
TreeFamTF344032.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkQ9ULH0.

Gene expression databases

ArrayExpressQ9ULH0.
BgeeQ9ULH0.
GenevestigatorQ9ULH0.

Family and domain databases

Gene3D1.25.40.20. 4 hits.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011646. KAP_NTPase.
IPR013761. SAM/pointed.
[Graphical view]
PfamPF00023. Ank. 3 hits.
PF12796. Ank_2. 3 hits.
PF07693. KAP_NTPase. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 11 hits.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKIDINS220. human.
GeneWikiKIDINS220.
GenomeRNAi57498.
NextBio63816.
PROQ9ULH0.

Entry information

Entry nameKDIS_HUMAN
AccessionPrimary (citable) accession number: Q9ULH0
Secondary accession number(s): A1L4N4 expand/collapse secondary AC list , Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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