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Q9ULH0

- KDIS_HUMAN

UniProt

Q9ULH0 - KDIS_HUMAN

Protein

Kinase D-interacting substrate of 220 kDa

Gene

KIDINS220

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration By similarity. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.By similarity1 Publication

    GO - Molecular functioni

    1. PDZ domain binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKK activity Source: Reactome
    2. cellular response to nerve growth factor stimulus Source: UniProtKB
    3. cytoplasmic transport Source: UniProtKB
    4. dendrite morphogenesis Source: Ensembl
    5. in utero embryonic development Source: Ensembl
    6. nerve growth factor signaling pathway Source: UniProtKB
    7. neurotrophin TRK receptor signaling pathway Source: Reactome
    8. positive regulation of neuron projection development Source: UniProtKB

    Keywords - Biological processi

    Neurogenesis

    Enzyme and pathway databases

    ReactomeiREACT_12002. ARMS-mediated activation.
    SignaLinkiQ9ULH0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinase D-interacting substrate of 220 kDa
    Alternative name(s):
    Ankyrin repeat-rich membrane-spanning protein
    Gene namesi
    Name:KIDINS220
    Synonyms:ARMS, KIAA1250
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:29508. KIDINS220.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Late endosome By similarity
    Note: Localized at late endosome before or after nerve growth factor (NGF) stimulation.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: UniProtKB
    4. membrane Source: UniProtKB
    5. protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164721911.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17711771Kinase D-interacting substrate of 220 kDaPRO_0000322119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei918 – 9181Phosphoserine1 Publication
    Modified residuei1365 – 13651Phosphoserine1 Publication
    Modified residuei1521 – 15211Phosphoserine1 Publication
    Modified residuei1555 – 15551Phosphoserine2 Publications
    Modified residuei1633 – 16331Phosphoserine1 Publication

    Post-translational modificationi

    Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULH0.
    PaxDbiQ9ULH0.
    PRIDEiQ9ULH0.

    PTM databases

    PhosphoSiteiQ9ULH0.

    Expressioni

    Tissue specificityi

    Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ9ULH0.
    BgeeiQ9ULH0.
    GenevestigatoriQ9ULH0.

    Organism-specific databases

    HPAiHPA014790.

    Interactioni

    Subunit structurei

    Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZ domains. Interacts with EPHA4 and PRKD1 By similarity. Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner By similarity. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation By similarity. Interacts (via C-terminal domain) with MAGI2 (via PDZ domain) By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121565. 5 interactions.
    IntActiQ9ULH0. 7 interactions.
    MINTiMINT-1390552.
    STRINGi9606.ENSP00000256707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULH0.
    SMRiQ9ULH0. Positions 5-422.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 499499CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini521 – 5244ExtracellularSequence Analysis
    Topological domaini546 – 659114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini681 – 6855ExtracellularSequence Analysis
    Topological domaini707 – 17711065CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei500 – 52021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei525 – 54521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei660 – 68021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei686 – 70621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 3330ANK 1Add
    BLAST
    Repeati37 – 6630ANK 2Add
    BLAST
    Repeati70 – 9930ANK 3Add
    BLAST
    Repeati103 – 13230ANK 4Add
    BLAST
    Repeati136 – 16530ANK 5Add
    BLAST
    Repeati169 – 19830ANK 6Add
    BLAST
    Repeati202 – 23130ANK 7Add
    BLAST
    Repeati235 – 26430ANK 8Add
    BLAST
    Repeati268 – 29730ANK 9Add
    BLAST
    Repeati301 – 33030ANK 10Add
    BLAST
    Repeati334 – 36330ANK 11Add
    BLAST
    Repeati367 – 39630ANK 12Add
    BLAST
    Domaini440 – 953514KAP NTPaseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1089 – 10924Mediates interaction with CRKLBy similarity
    Regioni1767 – 17715Mediates interaction with SNTA1By similarity

    Domaini

    The transmembrane domain mediates interaction with NTRK1.By similarity

    Sequence similaritiesi

    Contains 12 ANK repeats.PROSITE-ProRule annotation
    Contains 1 KAP NTPase domain.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0666.
    InParanoidiQ9ULH0.
    KOiK12460.
    OMAiFKTEDTQ.
    PhylomeDBiQ9ULH0.
    TreeFamiTF344032.

    Family and domain databases

    Gene3Di1.25.40.20. 4 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011646. KAP_NTPase.
    IPR013761. SAM/pointed.
    [Graphical view]
    PfamiPF00023. Ank. 3 hits.
    PF12796. Ank_2. 3 hits.
    PF07693. KAP_NTPase. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 11 hits.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 10 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULH0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN     50
    LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR 100
    DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA 150
    DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG 200
    ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHTE 250
    IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ 300
    DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV 350
    VELLLDKGAK VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP 400
    NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI 450
    LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL 500
    IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF IVIYFGGRRE 550
    GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT 600
    DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK 650
    WKKTCCLPSF VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV 700
    GLAFVLNCRT WWQVLDSLLN SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE 750
    LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF 800
    IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS 850
    NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR 900
    RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG 950
    RLLRANQISF NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT 1000
    IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC 1050
    TVNLDPKLRE IIADVRAARE QISIGGLAYP PLPLHEGPPR APSGYSQPPS 1100
    VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF FAPYLYTPRY 1150
    YPGGSQHLIS RPSVKTSLPR DQNNGLEVIK EDAAEGLSSP TDSSRGSGPA 1200
    PGPVVLLNSL NVDAVCEKLK QIEGLDQSML PQYCTTIKKA NINGRVLAQC 1250
    NIDELKKEMN MNFGDWHLFR STVLEMRNAE SHVVPEDPRF LSESSSGPAP 1300
    HGEPARRASH NELPHTELSS QTPYTLNFSF EELNTLGLDE GAPRHSNLSW 1350
    QSQTRRTPSL SSLNSQDSSI EISKLTDKVQ AEYRDAYREY IAQMSQLEGG 1400
    PGSTTISGRS SPHSTYYMGQ SSSGGSIHSN LEQEKGKDSE PKPDDGRKSF 1450
    LMKRGDVIDY SSSGVSTNDA SPLDPITEED EKSDQSGSKL LPGKKSSERS 1500
    SLFQTDLKLK GSGLRYQKLP SDEDESGTEE SDNTPLLKDD KDRKAEGKVE 1550
    RVPKSPEHSA EPIRTFIKAK EYLSDALLDK KDSSDSGVRS SESSPNHSLH 1600
    NEVADDSQLE KANLIELEDD SHSGKRGIPH SLSGLQDPII ARMSICSEDK 1650
    KSPSECSLIA SSPEENWPAC QKAYNLNRTP STVTLNNNSA PANRANQNFD 1700
    EMEGIRETSQ VILRPSSSPN PTTIQNENLK SMTHKRSQRS SYTRLSKDPP 1750
    ELHAAASSES TGFGEERESI L 1771
    Length:1,771
    Mass (Da):196,542
    Last modified:February 26, 2008 - v3
    Checksum:iFD1F99DB88B6996D
    GO
    Isoform 2 (identifier: Q9ULH0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         1138-1194: Missing.

    Show »
    Length:1,672
    Mass (Da):185,546
    Checksum:i103CE2C56521F5A8
    GO
    Isoform 3 (identifier: Q9ULH0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-135: L → LQ
         1005-1030: ISKNIPTTKDVEPLLEIDGDIRNFEV → CCGADSCDRDRIGISKSVLVAMLMES
         1031-1771: Missing.

    Show »
    Length:1,031
    Mass (Da):115,312
    Checksum:iD9E866461C13A2F5
    GO
    Isoform 4 (identifier: Q9ULH0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1177-1195: Missing.

    Show »
    Length:1,752
    Mass (Da):194,569
    Checksum:iC8FBB42BE1147C90
    GO
    Isoform 5 (identifier: Q9ULH0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1228: Missing.

    Show »
    Length:543
    Mass (Da):59,967
    Checksum:iB4A46C01CC4C1F37
    GO

    Sequence cautioni

    The sequence BAA86564.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14728.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1335 – 13351T → P in CAE45935. (PubMed:17974005)Curated
    Sequence conflicti1613 – 16131N → D in BAB14285. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti538 – 5381I → T.
    Corresponds to variant rs2289229 [ dbSNP | Ensembl ].
    VAR_048285
    Natural varianti1307 – 13071R → H.
    Corresponds to variant rs2304591 [ dbSNP | Ensembl ].
    VAR_039399
    Natural varianti1608 – 16081Q → H.3 Publications
    Corresponds to variant rs1044280 [ dbSNP | Ensembl ].
    VAR_039400

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 12281228Missing in isoform 5. 1 PublicationVSP_031861Add
    BLAST
    Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_031862Add
    BLAST
    Alternative sequencei135 – 1351L → LQ in isoform 3. 1 PublicationVSP_031863
    Alternative sequencei1005 – 103026ISKNI…RNFEV → CCGADSCDRDRIGISKSVLV AMLMES in isoform 3. 1 PublicationVSP_031864Add
    BLAST
    Alternative sequencei1031 – 1771741Missing in isoform 3. 1 PublicationVSP_031865Add
    BLAST
    Alternative sequencei1138 – 119457Missing in isoform 2. 1 PublicationVSP_031866Add
    BLAST
    Alternative sequencei1177 – 119519Missing in isoform 4. 1 PublicationVSP_031867Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033076 mRNA. Translation: BAA86564.2. Different initiation.
    AK022873 mRNA. Translation: BAB14285.1.
    AK023926 mRNA. Translation: BAB14728.1. Different initiation.
    AL133620 mRNA. Translation: CAB63746.1.
    AL137553 mRNA. Translation: CAB70807.1.
    BX640878 mRNA. Translation: CAE45935.1.
    BC094714 mRNA. Translation: AAH94714.1.
    BC130610 mRNA. Translation: AAI30611.1.
    CCDSiCCDS42650.1. [Q9ULH0-1]
    PIRiT43458.
    RefSeqiNP_065789.1. NM_020738.2. [Q9ULH0-1]
    UniGeneiHs.9873.

    Genome annotation databases

    EnsembliENST00000256707; ENSP00000256707; ENSG00000134313. [Q9ULH0-1]
    ENST00000319688; ENSP00000319947; ENSG00000134313. [Q9ULH0-3]
    ENST00000473731; ENSP00000418974; ENSG00000134313. [Q9ULH0-4]
    GeneIDi57498.
    KEGGihsa:57498.
    UCSCiuc002qzc.2. human. [Q9ULH0-1]
    uc002qzd.2. human. [Q9ULH0-2]

    Polymorphism databases

    DMDMi172044825.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033076 mRNA. Translation: BAA86564.2 . Different initiation.
    AK022873 mRNA. Translation: BAB14285.1 .
    AK023926 mRNA. Translation: BAB14728.1 . Different initiation.
    AL133620 mRNA. Translation: CAB63746.1 .
    AL137553 mRNA. Translation: CAB70807.1 .
    BX640878 mRNA. Translation: CAE45935.1 .
    BC094714 mRNA. Translation: AAH94714.1 .
    BC130610 mRNA. Translation: AAI30611.1 .
    CCDSi CCDS42650.1. [Q9ULH0-1 ]
    PIRi T43458.
    RefSeqi NP_065789.1. NM_020738.2. [Q9ULH0-1 ]
    UniGenei Hs.9873.

    3D structure databases

    ProteinModelPortali Q9ULH0.
    SMRi Q9ULH0. Positions 5-422.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121565. 5 interactions.
    IntActi Q9ULH0. 7 interactions.
    MINTi MINT-1390552.
    STRINGi 9606.ENSP00000256707.

    PTM databases

    PhosphoSitei Q9ULH0.

    Polymorphism databases

    DMDMi 172044825.

    Proteomic databases

    MaxQBi Q9ULH0.
    PaxDbi Q9ULH0.
    PRIDEi Q9ULH0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256707 ; ENSP00000256707 ; ENSG00000134313 . [Q9ULH0-1 ]
    ENST00000319688 ; ENSP00000319947 ; ENSG00000134313 . [Q9ULH0-3 ]
    ENST00000473731 ; ENSP00000418974 ; ENSG00000134313 . [Q9ULH0-4 ]
    GeneIDi 57498.
    KEGGi hsa:57498.
    UCSCi uc002qzc.2. human. [Q9ULH0-1 ]
    uc002qzd.2. human. [Q9ULH0-2 ]

    Organism-specific databases

    CTDi 57498.
    GeneCardsi GC02M008865.
    HGNCi HGNC:29508. KIDINS220.
    HPAi HPA014790.
    neXtProti NX_Q9ULH0.
    PharmGKBi PA164721911.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    InParanoidi Q9ULH0.
    KOi K12460.
    OMAi FKTEDTQ.
    PhylomeDBi Q9ULH0.
    TreeFami TF344032.

    Enzyme and pathway databases

    Reactomei REACT_12002. ARMS-mediated activation.
    SignaLinki Q9ULH0.

    Miscellaneous databases

    ChiTaRSi KIDINS220. human.
    GeneWikii KIDINS220.
    GenomeRNAii 57498.
    NextBioi 63816.
    PROi Q9ULH0.

    Gene expression databases

    ArrayExpressi Q9ULH0.
    Bgeei Q9ULH0.
    Genevestigatori Q9ULH0.

    Family and domain databases

    Gene3Di 1.25.40.20. 4 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR011646. KAP_NTPase.
    IPR013761. SAM/pointed.
    [Graphical view ]
    Pfami PF00023. Ank. 3 hits.
    PF12796. Ank_2. 3 hits.
    PF07693. KAP_NTPase. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 11 hits.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1636-1771 (ISOFORM 1), VARIANT HIS-1608.
      Tissue: Thyroid.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1089-1771 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1526-1771 (ISOFORM 1), VARIANT HIS-1608.
      Tissue: Esophageal carcinoma and Testis.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1478-1771, VARIANT HIS-1608.
    6. "ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma."
      Liao Y.-H., Hsu S.-M., Huang P.-H.
      Cancer Res. 67:11547-11556(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918; SER-1365 AND SER-1521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555 AND SER-1633, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKDIS_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULH0
    Secondary accession number(s): A1L4N4
    , Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3