SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9ULH0

- KDIS_HUMAN

UniProt

Q9ULH0 - KDIS_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Kinase D-interacting substrate of 220 kDa

Gene
KIDINS220, ARMS, KIAA1250
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration By similarity. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.1 Publication

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPKK activity Source: Reactome
  2. cellular response to nerve growth factor stimulus Source: UniProtKB
  3. cytoplasmic transport Source: UniProtKB
  4. dendrite morphogenesis Source: Ensembl
  5. in utero embryonic development Source: Ensembl
  6. nerve growth factor signaling pathway Source: UniProtKB
  7. neurotrophin TRK receptor signaling pathway Source: Reactome
  8. positive regulation of neuron projection development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_12002. ARMS-mediated activation.
SignaLinkiQ9ULH0.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinase D-interacting substrate of 220 kDa
Alternative name(s):
Ankyrin repeat-rich membrane-spanning protein
Gene namesi
Synonyms:ARMS, KIAA1250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29508. KIDINS220.

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Late endosome By similarity
Note: Localized at late endosome before or after nerve growth factor (NGF) stimulation.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 499499Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei500 – 52021Helical; Reviewed predictionAdd
BLAST
Topological domaini521 – 5244Extracellular Reviewed prediction
Transmembranei525 – 54521Helical; Reviewed predictionAdd
BLAST
Topological domaini546 – 659114Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei660 – 68021Helical; Reviewed predictionAdd
BLAST
Topological domaini681 – 6855Extracellular Reviewed prediction
Transmembranei686 – 70621Helical; Reviewed predictionAdd
BLAST
Topological domaini707 – 17711065Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: UniProtKB
  4. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164721911.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17711771Kinase D-interacting substrate of 220 kDaPRO_0000322119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei918 – 9181Phosphoserine1 Publication
Modified residuei1365 – 13651Phosphoserine1 Publication
Modified residuei1521 – 15211Phosphoserine1 Publication
Modified residuei1555 – 15551Phosphoserine2 Publications
Modified residuei1633 – 16331Phosphoserine1 Publication

Post-translational modificationi

Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF) By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ULH0.
PaxDbiQ9ULH0.
PRIDEiQ9ULH0.

PTM databases

PhosphoSiteiQ9ULH0.

Expressioni

Tissue specificityi

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.1 Publication

Gene expression databases

ArrayExpressiQ9ULH0.
BgeeiQ9ULH0.
GenevestigatoriQ9ULH0.

Organism-specific databases

HPAiHPA014790.

Interactioni

Subunit structurei

Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZ domains. Interacts with EPHA4 and PRKD1 By similarity. Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner By similarity. Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation By similarity. Interacts (via C-terminal domain) with MAGI2 (via PDZ domain) By similarity.

Protein-protein interaction databases

BioGridi121565. 5 interactions.
IntActiQ9ULH0. 7 interactions.
MINTiMINT-1390552.
STRINGi9606.ENSP00000256707.

Structurei

3D structure databases

ProteinModelPortaliQ9ULH0.
SMRiQ9ULH0. Positions 5-422.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3330ANK 1Add
BLAST
Repeati37 – 6630ANK 2Add
BLAST
Repeati70 – 9930ANK 3Add
BLAST
Repeati103 – 13230ANK 4Add
BLAST
Repeati136 – 16530ANK 5Add
BLAST
Repeati169 – 19830ANK 6Add
BLAST
Repeati202 – 23130ANK 7Add
BLAST
Repeati235 – 26430ANK 8Add
BLAST
Repeati268 – 29730ANK 9Add
BLAST
Repeati301 – 33030ANK 10Add
BLAST
Repeati334 – 36330ANK 11Add
BLAST
Repeati367 – 39630ANK 12Add
BLAST
Domaini440 – 953514KAP NTPaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1089 – 10924Mediates interaction with CRKL By similarity
Regioni1767 – 17715Mediates interaction with SNTA1 By similarity

Domaini

The transmembrane domain mediates interaction with NTRK1 By similarity.

Sequence similaritiesi

Contains 12 ANK repeats.
Contains 1 KAP NTPase domain.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0666.
InParanoidiQ9ULH0.
KOiK12460.
OMAiFKTEDTQ.
PhylomeDBiQ9ULH0.
TreeFamiTF344032.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011646. KAP_NTPase.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 3 hits.
PF07693. KAP_NTPase. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 11 hits.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 10 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULH0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMIAAEQGN     50
LEIVKELIKN GANCNLEDLD NWTALISASK EGHVHIVEEL LKCGVNLEHR 100
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA 150
DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG 200
ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHTE 250
IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ 300
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV 350
VELLLDKGAK VSAVDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP 400
NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI 450
LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ IEPLFQFSWL 500
IVFLTLLLCG GLGLLFAFTV HPNLGIAVSL SFLALLYIFF IVIYFGGRRE 550
GESWNWAWVL STRLARHIGY LELLLKLMFV NPPELPEQTT KALPVRFLFT 600
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF KTEDTQGKKK 650
WKKTCCLPSF VIFLFIIGCI ISGITLLAIF RVDPKHLTVN AVLISIASVV 700
GLAFVLNCRT WWQVLDSLLN SQRKRLHNAA SKLHKLKSEG FMKVLKCEVE 750
LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF 800
IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS 850
NARKFLVTSA TNGDVPCSDT TGIQEDADRR VSQNSLGEMT KLGSKTALNR 900
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG 950
RLLRANQISF NWDRLASWIN LTEQWPYRTS WLILYLEETE GIPDQMTLKT 1000
IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKVFLPC 1050
TVNLDPKLRE IIADVRAARE QISIGGLAYP PLPLHEGPPR APSGYSQPPS 1100
VCSSTSFNGP FAGGVVSPQP HSSYYSGMTG PQHPFYNRPF FAPYLYTPRY 1150
YPGGSQHLIS RPSVKTSLPR DQNNGLEVIK EDAAEGLSSP TDSSRGSGPA 1200
PGPVVLLNSL NVDAVCEKLK QIEGLDQSML PQYCTTIKKA NINGRVLAQC 1250
NIDELKKEMN MNFGDWHLFR STVLEMRNAE SHVVPEDPRF LSESSSGPAP 1300
HGEPARRASH NELPHTELSS QTPYTLNFSF EELNTLGLDE GAPRHSNLSW 1350
QSQTRRTPSL SSLNSQDSSI EISKLTDKVQ AEYRDAYREY IAQMSQLEGG 1400
PGSTTISGRS SPHSTYYMGQ SSSGGSIHSN LEQEKGKDSE PKPDDGRKSF 1450
LMKRGDVIDY SSSGVSTNDA SPLDPITEED EKSDQSGSKL LPGKKSSERS 1500
SLFQTDLKLK GSGLRYQKLP SDEDESGTEE SDNTPLLKDD KDRKAEGKVE 1550
RVPKSPEHSA EPIRTFIKAK EYLSDALLDK KDSSDSGVRS SESSPNHSLH 1600
NEVADDSQLE KANLIELEDD SHSGKRGIPH SLSGLQDPII ARMSICSEDK 1650
KSPSECSLIA SSPEENWPAC QKAYNLNRTP STVTLNNNSA PANRANQNFD 1700
EMEGIRETSQ VILRPSSSPN PTTIQNENLK SMTHKRSQRS SYTRLSKDPP 1750
ELHAAASSES TGFGEERESI L 1771
Length:1,771
Mass (Da):196,542
Last modified:February 26, 2008 - v3
Checksum:iFD1F99DB88B6996D
GO
Isoform 2 (identifier: Q9ULH0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     1138-1194: Missing.

Show »
Length:1,672
Mass (Da):185,546
Checksum:i103CE2C56521F5A8
GO
Isoform 3 (identifier: Q9ULH0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: L → LQ
     1005-1030: ISKNIPTTKDVEPLLEIDGDIRNFEV → CCGADSCDRDRIGISKSVLVAMLMES
     1031-1771: Missing.

Show »
Length:1,031
Mass (Da):115,312
Checksum:iD9E866461C13A2F5
GO
Isoform 4 (identifier: Q9ULH0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1195: Missing.

Show »
Length:1,752
Mass (Da):194,569
Checksum:iC8FBB42BE1147C90
GO
Isoform 5 (identifier: Q9ULH0-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1228: Missing.

Show »
Length:543
Mass (Da):59,967
Checksum:iB4A46C01CC4C1F37
GO

Sequence cautioni

The sequence BAA86564.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAB14728.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti538 – 5381I → T.
Corresponds to variant rs2289229 [ dbSNP | Ensembl ].
VAR_048285
Natural varianti1307 – 13071R → H.
Corresponds to variant rs2304591 [ dbSNP | Ensembl ].
VAR_039399
Natural varianti1608 – 16081Q → H.3 Publications
Corresponds to variant rs1044280 [ dbSNP | Ensembl ].
VAR_039400

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12281228Missing in isoform 5. VSP_031861Add
BLAST
Alternative sequencei1 – 4242Missing in isoform 2. VSP_031862Add
BLAST
Alternative sequencei135 – 1351L → LQ in isoform 3. VSP_031863
Alternative sequencei1005 – 103026ISKNI…RNFEV → CCGADSCDRDRIGISKSVLV AMLMES in isoform 3. VSP_031864Add
BLAST
Alternative sequencei1031 – 1771741Missing in isoform 3. VSP_031865Add
BLAST
Alternative sequencei1138 – 119457Missing in isoform 2. VSP_031866Add
BLAST
Alternative sequencei1177 – 119519Missing in isoform 4. VSP_031867Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1335 – 13351T → P in CAE45935. 1 Publication
Sequence conflicti1613 – 16131N → D in BAB14285. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033076 mRNA. Translation: BAA86564.2. Different initiation.
AK022873 mRNA. Translation: BAB14285.1.
AK023926 mRNA. Translation: BAB14728.1. Different initiation.
AL133620 mRNA. Translation: CAB63746.1.
AL137553 mRNA. Translation: CAB70807.1.
BX640878 mRNA. Translation: CAE45935.1.
BC094714 mRNA. Translation: AAH94714.1.
BC130610 mRNA. Translation: AAI30611.1.
CCDSiCCDS42650.1. [Q9ULH0-1]
PIRiT43458.
RefSeqiNP_065789.1. NM_020738.2. [Q9ULH0-1]
UniGeneiHs.9873.

Genome annotation databases

EnsembliENST00000256707; ENSP00000256707; ENSG00000134313. [Q9ULH0-1]
ENST00000319688; ENSP00000319947; ENSG00000134313. [Q9ULH0-3]
ENST00000418530; ENSP00000414923; ENSG00000134313. [Q9ULH0-2]
ENST00000427284; ENSP00000411849; ENSG00000134313. [Q9ULH0-4]
ENST00000473731; ENSP00000418974; ENSG00000134313. [Q9ULH0-4]
GeneIDi57498.
KEGGihsa:57498.
UCSCiuc002qzc.2. human. [Q9ULH0-1]
uc002qzd.2. human. [Q9ULH0-2]

Polymorphism databases

DMDMi172044825.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033076 mRNA. Translation: BAA86564.2 . Different initiation.
AK022873 mRNA. Translation: BAB14285.1 .
AK023926 mRNA. Translation: BAB14728.1 . Different initiation.
AL133620 mRNA. Translation: CAB63746.1 .
AL137553 mRNA. Translation: CAB70807.1 .
BX640878 mRNA. Translation: CAE45935.1 .
BC094714 mRNA. Translation: AAH94714.1 .
BC130610 mRNA. Translation: AAI30611.1 .
CCDSi CCDS42650.1. [Q9ULH0-1 ]
PIRi T43458.
RefSeqi NP_065789.1. NM_020738.2. [Q9ULH0-1 ]
UniGenei Hs.9873.

3D structure databases

ProteinModelPortali Q9ULH0.
SMRi Q9ULH0. Positions 5-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121565. 5 interactions.
IntActi Q9ULH0. 7 interactions.
MINTi MINT-1390552.
STRINGi 9606.ENSP00000256707.

PTM databases

PhosphoSitei Q9ULH0.

Polymorphism databases

DMDMi 172044825.

Proteomic databases

MaxQBi Q9ULH0.
PaxDbi Q9ULH0.
PRIDEi Q9ULH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256707 ; ENSP00000256707 ; ENSG00000134313 . [Q9ULH0-1 ]
ENST00000319688 ; ENSP00000319947 ; ENSG00000134313 . [Q9ULH0-3 ]
ENST00000418530 ; ENSP00000414923 ; ENSG00000134313 . [Q9ULH0-2 ]
ENST00000427284 ; ENSP00000411849 ; ENSG00000134313 . [Q9ULH0-4 ]
ENST00000473731 ; ENSP00000418974 ; ENSG00000134313 . [Q9ULH0-4 ]
GeneIDi 57498.
KEGGi hsa:57498.
UCSCi uc002qzc.2. human. [Q9ULH0-1 ]
uc002qzd.2. human. [Q9ULH0-2 ]

Organism-specific databases

CTDi 57498.
GeneCardsi GC02M008865.
HGNCi HGNC:29508. KIDINS220.
HPAi HPA014790.
neXtProti NX_Q9ULH0.
PharmGKBi PA164721911.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
InParanoidi Q9ULH0.
KOi K12460.
OMAi FKTEDTQ.
PhylomeDBi Q9ULH0.
TreeFami TF344032.

Enzyme and pathway databases

Reactomei REACT_12002. ARMS-mediated activation.
SignaLinki Q9ULH0.

Miscellaneous databases

ChiTaRSi KIDINS220. human.
GeneWikii KIDINS220.
GenomeRNAii 57498.
NextBioi 63816.
PROi Q9ULH0.

Gene expression databases

ArrayExpressi Q9ULH0.
Bgeei Q9ULH0.
Genevestigatori Q9ULH0.

Family and domain databases

Gene3Di 1.25.40.20. 4 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011646. KAP_NTPase.
IPR013761. SAM/pointed.
[Graphical view ]
Pfami PF00023. Ank. 3 hits.
PF12796. Ank_2. 3 hits.
PF07693. KAP_NTPase. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 11 hits.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1636-1771 (ISOFORM 1), VARIANT HIS-1608.
    Tissue: Thyroid.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1089-1771 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1526-1771 (ISOFORM 1), VARIANT HIS-1608.
    Tissue: Esophageal carcinoma and Testis.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1478-1771, VARIANT HIS-1608.
  6. "ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma."
    Liao Y.-H., Hsu S.-M., Huang P.-H.
    Cancer Res. 67:11547-11556(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918; SER-1365 AND SER-1521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1555 AND SER-1633, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKDIS_HUMAN
AccessioniPrimary (citable) accession number: Q9ULH0
Secondary accession number(s): A1L4N4
, Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi