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Protein

Cell cycle progression protein 1

Gene

CCPG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.By similarity1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • regulation of Rho guanyl-nucleotide exchange factor activity Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciZFISH:G66-32967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle progression protein 1
Alternative name(s):
Cell cycle progression restoration protein 8
Gene namesi
Name:CCPG1
Synonyms:CCP8, CPR8, KIAA1254
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:24227. CCPG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 217CytoplasmicSequence analysisAdd BLAST217
Transmembranei218 – 238Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini239 – 757LumenalSequence analysisAdd BLAST519

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000260916.
PharmGKBiPA134967250.

Polymorphism and mutation databases

BioMutaiCCPG1.
DMDMi160380597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003105381 – 757Cell cycle progression protein 1Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ULG6.
PeptideAtlasiQ9ULG6.
PRIDEiQ9ULG6.

PTM databases

iPTMnetiQ9ULG6.
PhosphoSitePlusiQ9ULG6.

Expressioni

Gene expression databases

BgeeiENSG00000260916.
CleanExiHS_CCPG1.
ExpressionAtlasiQ9ULG6. baseline and differential.
GenevisibleiQ9ULG6. HS.

Organism-specific databases

HPAiHPA026861.

Interactioni

Subunit structurei

Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).By similarity

Protein-protein interaction databases

BioGridi114665. 29 interactors.
IntActiQ9ULG6. 3 interactors.
STRINGi9606.ENSP00000403400.

Structurei

3D structure databases

ProteinModelPortaliQ9ULG6.
SMRiQ9ULG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 308Interaction with MCF2L and SRCBy similarityAdd BLAST308

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili248 – 272Sequence analysisAdd BLAST25
Coiled coili306 – 450Sequence analysisAdd BLAST145
Coiled coili504 – 530Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi176 – 181Poly-Arg6

Sequence similaritiesi

Belongs to the CCPG1 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0Z. Eukaryota.
ENOG4110N7Q. LUCA.
GeneTreeiENSGT00530000063862.
HOGENOMiHOG000013199.
HOVERGENiHBG097118.
InParanoidiQ9ULG6.
OMAiCSGVFEC.
OrthoDBiEOG091G02B9.
PhylomeDBiQ9ULG6.
TreeFamiTF333202.

Family and domain databases

InterProiIPR033588. CCPG1.
[Graphical view]
PANTHERiPTHR28638:SF2. PTHR28638:SF2. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL
60 70 80 90 100
QALQIEQGES SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA
110 120 130 140 150
SDDSDIVTLE PPKLEEIGNQ EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE
160 170 180 190 200
TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA RKKTVSASES EDRLVAEQET
210 220 230 240 250
EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI QKRQQLVRKI
260 270 280 290 300
HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK
310 320 330 340 350
TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE
360 370 380 390 400
NQKLKQHLEE EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL
410 420 430 440 450
QQLSGSQLHG KSDSPNVYTE KKEIAILRER LTELERKLTF EQQRSDLWER
460 470 480 490 500
LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK SKETFLGSVK ETFDAMKNST
510 520 530 540 550
KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT KNIFDEKGNK
560 570 580 590 600
RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF
610 620 630 640 650
KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP
660 670 680 690 700
IRMDEFRQII QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF
710 720 730 740 750
VNDVKDYLRN MKEYEVDNDG VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK

PCHYSSL
Length:757
Mass (Da):87,340
Last modified:November 13, 2007 - v3
Checksum:iDDF496D4431A7976
GO
Isoform 2 (identifier: Q9ULG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-151: TFCQPET → MSTFFLI

Note: No experimental confirmation available.
Show »
Length:613
Mass (Da):71,854
Checksum:i0114FEFFF8D22908
GO
Isoform 3 (identifier: Q9ULG6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-694: Missing.
     745-757: RSVYIKPCHYSSL → SRPDKKQRMV...LGQLPFDPQY

Show »
Length:424
Mass (Da):48,569
Checksum:iB8A999B9C6722C32
GO
Isoform 4 (identifier: Q9ULG6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     582-598: HNRGPTMQNDGRKEKPV → SRPYYAKRWKERKASSL
     599-757: Missing.

Show »
Length:598
Mass (Da):68,395
Checksum:i6307C36112F2E2F1
GO
Isoform 5 (identifier: Q9ULG6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-757: RSVYIKPCHYSSL → SRPDKKQRMV...LGQLPFDPQY

Note: No experimental confirmation available.
Show »
Length:807
Mass (Da):93,488
Checksum:i0C87EB9BE5B8AFD0
GO

Sequence cautioni

Isoform 4 : The sequence AAB69314 differs from that shown. Reason: Frameshift at position 594.Curated
The sequence AAB69314 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH15203 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH29398 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Isoform 4 : The sequence AAK14914 differs from that shown. Reason: Frameshift at position 594.Curated
The sequence BAA86568 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196A → G in BAA86568 (PubMed:10574462).Curated1
Sequence conflicti270E → G in BAB14042 (PubMed:14702039).Curated1
Sequence conflicti483E → G in AAH29398 (PubMed:15489334).Curated1
Sequence conflicti483E → G in AAB69314 (PubMed:9383053).Curated1
Sequence conflicti553G → N in AAB69314 (PubMed:9383053).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03706344S → P.Corresponds to variant rs11555304dbSNPEnsembl.1
Natural variantiVAR_037064161E → V.1 PublicationCorresponds to variant rs17853336dbSNPEnsembl.1
Natural variantiVAR_037065418Y → H.Corresponds to variant rs34958422dbSNPEnsembl.1
Natural variantiVAR_037066436R → L.1 PublicationCorresponds to variant rs17857026dbSNPEnsembl.1
Natural variantiVAR_037067477A → V.1 PublicationCorresponds to variant rs1063562dbSNPEnsembl.1
Natural variantiVAR_037068517A → D.1 PublicationCorresponds to variant rs1063563dbSNPEnsembl.1
Natural variantiVAR_037069553G → D.Corresponds to variant rs1063565dbSNPEnsembl.1
Natural variantiVAR_037070553G → S.Corresponds to variant rs1063564dbSNPEnsembl.1
Natural variantiVAR_037071590N → K.Corresponds to variant rs1063566dbSNPEnsembl.1
Natural variantiVAR_037072627K → E.1 PublicationCorresponds to variant rs17853335dbSNPEnsembl.1
Natural variantiVAR_037073646T → I.1 PublicationCorresponds to variant rs17857027dbSNPEnsembl.1
Natural variantiVAR_037074673H → R.Corresponds to variant rs1063567dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0293111 – 144Missing in isoform 2. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_029312145 – 151TFCQPET → MSTFFLI in isoform 2. 1 Publication7
Alternative sequenceiVSP_029313312 – 694Missing in isoform 3. 1 PublicationAdd BLAST383
Alternative sequenceiVSP_029314582 – 598HNRGP…KEKPV → SRPYYAKRWKERKASSL in isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_029315599 – 757Missing in isoform 4. 2 PublicationsAdd BLAST159
Alternative sequenceiVSP_029316745 – 757RSVYI…HYSSL → SRPDKKQRMVNIENSRHRKQ EQKHLQPQPYKREGKWHKYG RTNGRQMANLEIELGQLPFD PQY in isoform 3 and isoform 5. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033080 mRNA. Translation: BAA86568.2. Different initiation.
AF212228 mRNA. Translation: AAK14914.1. Frameshift.
AK022459 mRNA. Translation: BAB14042.1.
AK292795 mRNA. Translation: BAF85484.1.
AC013355 Genomic DNA. No translation available.
AC018926 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77481.1.
BC015203 mRNA. Translation: AAH15203.1. Sequence problems.
BC029398 mRNA. Translation: AAH29398.1. Sequence problems.
BC034914 mRNA. Translation: AAH34914.1.
BC039871 mRNA. Translation: AAH39871.1.
AF011794 mRNA. Translation: AAB69314.1. Sequence problems.
CCDSiCCDS42039.1. [Q9ULG6-1]
CCDS55966.1. [Q9ULG6-5]
CCDS55967.1. [Q9ULG6-3]
RefSeqiNP_001191379.1. NM_001204450.1. [Q9ULG6-5]
NP_001191380.1. NM_001204451.1. [Q9ULG6-3]
NP_004739.3. NM_004748.4. [Q9ULG6-1]
NP_065790.2. NM_020739.3. [Q9ULG6-1]
UniGeneiHs.285051.

Genome annotation databases

EnsembliENST00000310958; ENSP00000311656; ENSG00000260916. [Q9ULG6-1]
ENST00000425574; ENSP00000415128; ENSG00000260916. [Q9ULG6-3]
ENST00000442196; ENSP00000403400; ENSG00000260916. [Q9ULG6-5]
ENST00000569205; ENSP00000454456; ENSG00000260916. [Q9ULG6-1]
GeneIDi9236.
KEGGihsa:9236.
UCSCiuc002acv.3. human. [Q9ULG6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033080 mRNA. Translation: BAA86568.2. Different initiation.
AF212228 mRNA. Translation: AAK14914.1. Frameshift.
AK022459 mRNA. Translation: BAB14042.1.
AK292795 mRNA. Translation: BAF85484.1.
AC013355 Genomic DNA. No translation available.
AC018926 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77481.1.
BC015203 mRNA. Translation: AAH15203.1. Sequence problems.
BC029398 mRNA. Translation: AAH29398.1. Sequence problems.
BC034914 mRNA. Translation: AAH34914.1.
BC039871 mRNA. Translation: AAH39871.1.
AF011794 mRNA. Translation: AAB69314.1. Sequence problems.
CCDSiCCDS42039.1. [Q9ULG6-1]
CCDS55966.1. [Q9ULG6-5]
CCDS55967.1. [Q9ULG6-3]
RefSeqiNP_001191379.1. NM_001204450.1. [Q9ULG6-5]
NP_001191380.1. NM_001204451.1. [Q9ULG6-3]
NP_004739.3. NM_004748.4. [Q9ULG6-1]
NP_065790.2. NM_020739.3. [Q9ULG6-1]
UniGeneiHs.285051.

3D structure databases

ProteinModelPortaliQ9ULG6.
SMRiQ9ULG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114665. 29 interactors.
IntActiQ9ULG6. 3 interactors.
STRINGi9606.ENSP00000403400.

PTM databases

iPTMnetiQ9ULG6.
PhosphoSitePlusiQ9ULG6.

Polymorphism and mutation databases

BioMutaiCCPG1.
DMDMi160380597.

Proteomic databases

PaxDbiQ9ULG6.
PeptideAtlasiQ9ULG6.
PRIDEiQ9ULG6.

Protocols and materials databases

DNASUi9236.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310958; ENSP00000311656; ENSG00000260916. [Q9ULG6-1]
ENST00000425574; ENSP00000415128; ENSG00000260916. [Q9ULG6-3]
ENST00000442196; ENSP00000403400; ENSG00000260916. [Q9ULG6-5]
ENST00000569205; ENSP00000454456; ENSG00000260916. [Q9ULG6-1]
GeneIDi9236.
KEGGihsa:9236.
UCSCiuc002acv.3. human. [Q9ULG6-1]

Organism-specific databases

CTDi9236.
GeneCardsiCCPG1.
HGNCiHGNC:24227. CCPG1.
HPAiHPA026861.
MIMi611326. gene.
neXtProtiNX_Q9ULG6.
OpenTargetsiENSG00000260916.
PharmGKBiPA134967250.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0Z. Eukaryota.
ENOG4110N7Q. LUCA.
GeneTreeiENSGT00530000063862.
HOGENOMiHOG000013199.
HOVERGENiHBG097118.
InParanoidiQ9ULG6.
OMAiCSGVFEC.
OrthoDBiEOG091G02B9.
PhylomeDBiQ9ULG6.
TreeFamiTF333202.

Enzyme and pathway databases

BioCyciZFISH:G66-32967-MONOMER.

Miscellaneous databases

ChiTaRSiCCPG1. human.
GenomeRNAii9236.
PROiQ9ULG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000260916.
CleanExiHS_CCPG1.
ExpressionAtlasiQ9ULG6. baseline and differential.
GenevisibleiQ9ULG6. HS.

Family and domain databases

InterProiIPR033588. CCPG1.
[Graphical view]
PANTHERiPTHR28638:SF2. PTHR28638:SF2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCPG1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULG6
Secondary accession number(s): A0PJH3
, A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.