Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ULG6 (CCPG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell cycle progression protein 1
Alternative name(s):
Cell cycle progression restoration protein 8
Gene names
Name:CCPG1
Synonyms:CCP8, CPR8, KIAA1254
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 By similarity. May be involved in cell cycle regulation. Ref.8

Subunit structure

Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC By similarity.

Subcellular location

Cytoplasmic granule membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the CCPG1 family.

Sequence caution

The sequence AAB69314.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH15203.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence AAH29398.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence BAA86568.2 differs from that shown. Reason: Erroneous initiation.

Isoform 4: The sequence AAK14914.1 differs from that shown. Reason: Frameshift at position 594.

Isoform 4: The sequence AAB69314.1 differs from that shown. Reason: Frameshift at position 594.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ULG6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ULG6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-151: TFCQPET → MSTFFLI
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9ULG6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     312-694: Missing.
     745-757: RSVYIKPCHYSSL → SRPDKKQRMV...LGQLPFDPQY
Isoform 4 (identifier: Q9ULG6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     582-598: HNRGPTMQNDGRKEKPV → SRPYYAKRWKERKASSL
     599-757: Missing.
Isoform 5 (identifier: Q9ULG6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     745-757: RSVYIKPCHYSSL → SRPDKKQRMV...LGQLPFDPQY
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Cell cycle progression protein 1
PRO_0000310538

Regions

Topological domain1 – 217217Cytoplasmic Potential
Transmembrane218 – 23821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain239 – 757519Lumenal Potential
Region1 – 308308Interaction with MCF2L and SRC By similarity
Coiled coil248 – 27225 Potential
Coiled coil306 – 450145 Potential
Coiled coil504 – 53027 Potential
Compositional bias176 – 1816Poly-Arg

Natural variations

Alternative sequence1 – 144144Missing in isoform 2.
VSP_029311
Alternative sequence145 – 1517TFCQPET → MSTFFLI in isoform 2.
VSP_029312
Alternative sequence312 – 694383Missing in isoform 3.
VSP_029313
Alternative sequence582 – 59817HNRGP…KEKPV → SRPYYAKRWKERKASSL in isoform 4.
VSP_029314
Alternative sequence599 – 757159Missing in isoform 4.
VSP_029315
Alternative sequence745 – 75713RSVYI…HYSSL → SRPDKKQRMVNIENSRHRKQ EQKHLQPQPYKREGKWHKYG RTNGRQMANLEIELGQLPFD PQY in isoform 3 and isoform 5.
VSP_029316
Natural variant441S → P.
Corresponds to variant rs11555304 [ dbSNP | Ensembl ].
VAR_037063
Natural variant1611E → V. Ref.7
Corresponds to variant rs17853336 [ dbSNP | Ensembl ].
VAR_037064
Natural variant4181Y → H.
Corresponds to variant rs34958422 [ dbSNP | Ensembl ].
VAR_037065
Natural variant4361R → L. Ref.7
Corresponds to variant rs17857026 [ dbSNP | Ensembl ].
VAR_037066
Natural variant4771A → V. Ref.8
Corresponds to variant rs1063562 [ dbSNP | Ensembl ].
VAR_037067
Natural variant5171A → D. Ref.8
Corresponds to variant rs1063563 [ dbSNP | Ensembl ].
VAR_037068
Natural variant5531G → D.
Corresponds to variant rs1063565 [ dbSNP | Ensembl ].
VAR_037069
Natural variant5531G → S.
Corresponds to variant rs1063564 [ dbSNP | Ensembl ].
VAR_037070
Natural variant5901N → K.
Corresponds to variant rs1063566 [ dbSNP | Ensembl ].
VAR_037071
Natural variant6271K → E. Ref.7
Corresponds to variant rs17853335 [ dbSNP | Ensembl ].
VAR_037072
Natural variant6461T → I. Ref.7
Corresponds to variant rs17857027 [ dbSNP | Ensembl ].
VAR_037073
Natural variant6731H → R.
Corresponds to variant rs1063567 [ dbSNP | Ensembl ].
VAR_037074

Experimental info

Sequence conflict1961A → G in BAA86568. Ref.1
Sequence conflict2701E → G in BAB14042. Ref.4
Sequence conflict4831E → G in AAH29398. Ref.7
Sequence conflict4831E → G in AAB69314. Ref.8
Sequence conflict5531G → N in AAB69314. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 13, 2007. Version 3.
Checksum: DDF496D4431A7976

FASTA75787,340
        10         20         30         40         50         60 
MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL QALQIEQGES 

        70         80         90        100        110        120 
SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA SDDSDIVTLE PPKLEEIGNQ 

       130        140        150        160        170        180 
EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA 

       190        200        210        220        230        240 
RKKTVSASES EDRLVAEQET EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI 

       250        260        270        280        290        300 
QKRQQLVRKI HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK 

       310        320        330        340        350        360 
TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE NQKLKQHLEE 

       370        380        390        400        410        420 
EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL QQLSGSQLHG KSDSPNVYTE 

       430        440        450        460        470        480 
KKEIAILRER LTELERKLTF EQQRSDLWER LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK 

       490        500        510        520        530        540 
SKETFLGSVK ETFDAMKNST KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT 

       550        560        570        580        590        600 
KNIFDEKGNK RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF 

       610        620        630        640        650        660 
KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP IRMDEFRQII 

       670        680        690        700        710        720 
QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF VNDVKDYLRN MKEYEVDNDG 

       730        740        750 
VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK PCHYSSL 

« Hide

Isoform 2 [UniParc].

Checksum: 0114FEFFF8D22908
Show »

FASTA61371,854
Isoform 3 [UniParc].

Checksum: B8A999B9C6722C32
Show »

FASTA42448,569
Isoform 4 [UniParc].

Checksum: 6307C36112F2E2F1
Show »

FASTA59868,395
Isoform 5 [UniParc].

Checksum: 0C87EB9BE5B8AFD0
Show »

FASTA80793,488

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"A novel gene expressed in human liver non-tumor tissues."
Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Liver.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
Tissue: Mammary gland and Trachea.
[5]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS VAL-161; LEU-436; GLU-627 AND ILE-646.
Tissue: Brain, Lymph, Placenta and Skin.
[8]"Human CPR (cell cycle progression restoration) genes impart a Far-phenotype on yeast cells."
Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr., Tyers M., Elledge S.J.
Genetics 147:1063-1076(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 379-757 (ISOFORM 4), FUNCTION, VARIANTS VAL-477 AND ASP-517.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033080 mRNA. Translation: BAA86568.2. Different initiation.
AF212228 mRNA. Translation: AAK14914.1. Frameshift.
AK022459 mRNA. Translation: BAB14042.1.
AK292795 mRNA. Translation: BAF85484.1.
AC013355 Genomic DNA. No translation available.
AC018926 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77481.1.
BC015203 mRNA. Translation: AAH15203.1. Sequence problems.
BC029398 mRNA. Translation: AAH29398.1. Sequence problems.
BC034914 mRNA. Translation: AAH34914.1.
BC039871 mRNA. Translation: AAH39871.1.
AF011794 mRNA. Translation: AAB69314.1. Sequence problems.
RefSeqNP_001191379.1. NM_001204450.1.
NP_001191380.1. NM_001204451.1.
NP_004739.3. NM_004748.4.
NP_065790.2. NM_020739.3.
UniGeneHs.285051.

3D structure databases

ProteinModelPortalQ9ULG6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114665. 2 interactions.
IntActQ9ULG6. 1 interaction.
STRING9606.ENSP00000311656.

PTM databases

PhosphoSiteQ9ULG6.

Polymorphism databases

DMDM160380597.

Proteomic databases

PaxDbQ9ULG6.
PRIDEQ9ULG6.

Protocols and materials databases

DNASU9236.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000310958; ENSP00000311656; ENSG00000260916. [Q9ULG6-1]
ENST00000425574; ENSP00000415128; ENSG00000260916. [Q9ULG6-3]
ENST00000442196; ENSP00000403400; ENSG00000260916. [Q9ULG6-5]
ENST00000569205; ENSP00000454456; ENSG00000260916. [Q9ULG6-1]
GeneID9236.
KEGGhsa:9236.
UCSCuc002acu.2. human. [Q9ULG6-2]
uc002acv.2. human. [Q9ULG6-1]
uc002acx.3. human. [Q9ULG6-3]
uc002acy.3. human.

Organism-specific databases

CTD9236.
GeneCardsGC15M055647.
HGNCHGNC:24227. CCPG1.
HPAHPA026861.
MIM611326. gene.
neXtProtNX_Q9ULG6.
PharmGKBPA134967250.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38815.
HOVERGENHBG097118.
InParanoidQ9ULG6.
OMAELGQLPF.
OrthoDBEOG76T9R5.
PhylomeDBQ9ULG6.
TreeFamTF333202.

Gene expression databases

ArrayExpressQ9ULG6.
BgeeQ9ULG6.
CleanExHS_CCPG1.
GenevestigatorQ9ULG6.

Family and domain databases

InterProIPR024889. Ccpg1.
[Graphical view]
PANTHERPTHR15199. PTHR15199. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCCPG1. human.
GenomeRNAi9236.
NextBio34627.
PROQ9ULG6.
SOURCESearch...

Entry information

Entry nameCCPG1_HUMAN
AccessionPrimary (citable) accession number: Q9ULG6
Secondary accession number(s): A0PJH3 expand/collapse secondary AC list , A8K9T0, O14712, Q05DG4, Q5U5S7, Q8IYV8, Q9BY53, Q9HA17
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM