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Q9ULF5 (S39AA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name=ZIP-10
Gene names
Name:SLC39A10
Synonyms:KIAA1265, ZIP10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length831 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a zinc-influx transporter. Ref.6

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

High levels of expression are correlated with invasiveness in several breast cancer lines.

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]

Sequence caution

The sequence BAA86579.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAB43393.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   LigandZinc
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Traceable author statement. Source: Reactome

zinc ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmetal ion transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 831806Zinc transporter ZIP10
PRO_0000297632

Regions

Transmembrane411 – 43121Helical; Potential
Transmembrane438 – 45821Helical; Potential
Transmembrane495 – 51521Helical; Potential
Transmembrane687 – 70721Helical; Potential
Transmembrane732 – 75221Helical; Potential
Transmembrane759 – 77921Helical; Potential
Transmembrane801 – 82121Helical; Potential
Compositional bias26 – 4015His-rich
Compositional bias101 – 19797His-rich
Compositional bias458 – 48326His-rich
Compositional bias607 – 65650His-rich

Amino acid modifications

Modified residue5361Phosphothreonine Ref.8
Modified residue5531Phosphothreonine Ref.7
Modified residue5911Phosphoserine Ref.8
Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential
Glycosylation3391N-linked (GlcNAc...) Potential

Natural variations

Natural variant871T → S.
Corresponds to variant rs13419724 [ dbSNP | Ensembl ].
VAR_034658

Experimental info

Sequence conflict4261I → T in CAB43393. Ref.3
Sequence conflict4261I → T in CAH18673. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9ULF5 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: E196111D12BC20ED

FASTA83194,132
        10         20         30         40         50         60 
MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK FSKQAAENEK 

        70         80         90        100        110        120 
KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN HEDLGHDHVS HLDILAVQEG 

       130        140        150        160        170        180 
KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN HKCDPEKETV EVSVKSDDKH MHDHNHRLRH 

       190        200        210        220        230        240 
HHRLHHHLDH NNTHHFHNDS ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS 

       250        260        270        280        290        300 
NENSEVITPG FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD 

       310        320        330        340        350        360 
NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG ANSPISTDLF 

       370        380        390        400        410        420 
TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA NIGASAWICG IISITVISLL 

       430        440        450        460        470        480 
SLLGVILVPI INQGCFKFLL TFLVALAVGT MSGDALLHLL PHSQGGHDHS HQHAHGHGHS 

       490        500        510        520        530        540 
HGHESNKFLE EYDAVLKGLV ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST 

       550        560        570        580        590        600 
IGRKLSDHKL NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE 

       610        620        630        640        650        660 
EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH SHGPCHSGSD 

       670        680        690        700        710        720 
LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI STSIAVFCHE LPHELGDFAV 

       730        740        750        760        770        780 
LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT AVGQYANNIT LWIFAVTAGM FLYVALVDML 

       790        800        810        820        830 
PEMLHGDGDN EEHGFCPVGQ FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Colon carcinoma.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[6]"Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells."
Kagara N., Tanaka N., Noguchi S., Hirano T.
Cancer Sci. 98:692-697(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-536 AND SER-591, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033091 mRNA. Translation: BAA86579.1. Different initiation.
AK291241 mRNA. Translation: BAF83930.1.
AL050294 mRNA. Translation: CAB43393.1. Sequence problems.
CR749813 mRNA. Translation: CAH18673.1.
CH471063 Genomic DNA. Translation: EAW70116.1.
BC073909 mRNA. Translation: AAH73909.1.
BC101516 mRNA. Translation: AAI01517.1.
BC112223 mRNA. Translation: AAI12224.1.
CCDSCCDS33353.1.
PIRT08684.
RefSeqNP_001120729.1. NM_001127257.1.
NP_065075.1. NM_020342.2.
UniGeneHs.650158.

3D structure databases

ProteinModelPortalQ9ULF5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121430. 2 interactions.
IntActQ9ULF5. 1 interaction.
STRING9606.ENSP00000352655.

Protein family/group databases

TCDB2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSiteQ9ULF5.

Polymorphism databases

DMDM156630627.

Proteomic databases

MaxQBQ9ULF5.
PaxDbQ9ULF5.
PRIDEQ9ULF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359634; ENSP00000352655; ENSG00000196950.
ENST00000409086; ENSP00000386766; ENSG00000196950.
GeneID57181.
KEGGhsa:57181.
UCSCuc002utg.4. human.

Organism-specific databases

CTD57181.
GeneCardsGC02P196440.
H-InvDBHIX0002690.
HGNCHGNC:20861. SLC39A10.
HPAHPA036513.
MIM608733. gene.
neXtProtNX_Q9ULF5.
PharmGKBPA134944068.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0428.
HOGENOMHOG000013093.
HOVERGENHBG055748.
InParanoidQ9ULF5.
KOK14716.
OMADPGHGHQ.
OrthoDBEOG7H791W.
PhylomeDBQ9ULF5.
TreeFamTF318470.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9ULF5.
BgeeQ9ULF5.
CleanExHS_SLC39A10.
GenevestigatorQ9ULF5.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC39A10. human.
GeneWikiSLC39A10.
GenomeRNAi57181.
NextBio63227.
PROQ9ULF5.
SOURCESearch...

Entry information

Entry nameS39AA_HUMAN
AccessionPrimary (citable) accession number: Q9ULF5
Secondary accession number(s): A8K5C6 expand/collapse secondary AC list , Q3MJA4, Q68CR5, Q6DKH6, Q9Y3Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM