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Q9ULF5

- S39AA_HUMAN

UniProt

Q9ULF5 - S39AA_HUMAN

Protein

Zinc transporter ZIP10

Gene

SLC39A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    May act as a zinc-influx transporter.1 Publication

    GO - Molecular functioni

    1. metal ion transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: Reactome
    2. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

    Protein family/group databases

    TCDBi2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter ZIP10
    Alternative name(s):
    Solute carrier family 39 member 10
    Zrt- and Irt-like protein 10
    Short name:
    ZIP-10
    Gene namesi
    Name:SLC39A10
    Synonyms:KIAA1265, ZIP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20861. SLC39A10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134944068.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 831806Zinc transporter ZIP10PRO_0000297632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
    Modified residuei536 – 5361Phosphothreonine1 Publication
    Modified residuei553 – 5531Phosphothreonine1 Publication
    Modified residuei591 – 5911Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9ULF5.
    PaxDbiQ9ULF5.
    PRIDEiQ9ULF5.

    PTM databases

    PhosphoSiteiQ9ULF5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULF5.
    BgeeiQ9ULF5.
    CleanExiHS_SLC39A10.
    GenevestigatoriQ9ULF5.

    Organism-specific databases

    HPAiHPA036513.

    Interactioni

    Protein-protein interaction databases

    BioGridi121430. 2 interactions.
    IntActiQ9ULF5. 1 interaction.
    STRINGi9606.ENSP00000352655.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei687 – 70721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei732 – 75221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei759 – 77921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei801 – 82121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi26 – 4015His-richAdd
    BLAST
    Compositional biasi101 – 19797His-richAdd
    BLAST
    Compositional biasi458 – 48326His-richAdd
    BLAST
    Compositional biasi607 – 65650His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    HOGENOMiHOG000013093.
    HOVERGENiHBG055748.
    InParanoidiQ9ULF5.
    KOiK14716.
    OMAiDPGHGHQ.
    OrthoDBiEOG7H791W.
    PhylomeDBiQ9ULF5.
    TreeFamiTF318470.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULF5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK    50
    FSKQAAENEK KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN 100
    HEDLGHDHVS HLDILAVQEG KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN 150
    HKCDPEKETV EVSVKSDDKH MHDHNHRLRH HHRLHHHLDH NNTHHFHNDS 200
    ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS NENSEVITPG 250
    FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD 300
    NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG 350
    ANSPISTDLF TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA 400
    NIGASAWICG IISITVISLL SLLGVILVPI INQGCFKFLL TFLVALAVGT 450
    MSGDALLHLL PHSQGGHDHS HQHAHGHGHS HGHESNKFLE EYDAVLKGLV 500
    ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST IGRKLSDHKL 550
    NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE 600
    EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH 650
    SHGPCHSGSD LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI 700
    STSIAVFCHE LPHELGDFAV LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT 750
    AVGQYANNIT LWIFAVTAGM FLYVALVDML PEMLHGDGDN EEHGFCPVGQ 800
    FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F 831
    Length:831
    Mass (Da):94,132
    Last modified:August 21, 2007 - v2
    Checksum:iE196111D12BC20ED
    GO
    Isoform 2 (identifier: Q9ULF5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-450: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:381
    Mass (Da):42,363
    Checksum:i348C2C05EE85730E
    GO

    Sequence cautioni

    The sequence CAB43393.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAA86579.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti426 – 4261I → T in CAB43393. (PubMed:17974005)Curated
    Sequence conflicti426 – 4261I → T in CAH18673. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871T → S.
    Corresponds to variant rs13419724 [ dbSNP | Ensembl ].
    VAR_034658

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 450450Missing in isoform 2. 1 PublicationVSP_055991Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033091 mRNA. Translation: BAA86579.1. Different initiation.
    AK291241 mRNA. Translation: BAF83930.1.
    AK294771 mRNA. Translation: BAG57901.1.
    AL050294 mRNA. Translation: CAB43393.1. Sequence problems.
    CR749813 mRNA. Translation: CAH18673.1.
    AC013274 Genomic DNA. No translation available.
    AC064834 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70116.1.
    BC073909 mRNA. Translation: AAH73909.1.
    BC101516 mRNA. Translation: AAI01517.1.
    BC112223 mRNA. Translation: AAI12224.1.
    CCDSiCCDS33353.1.
    PIRiT08684.
    RefSeqiNP_001120729.1. NM_001127257.1.
    NP_065075.1. NM_020342.2.
    XP_005246749.1. XM_005246692.2.
    UniGeneiHs.650158.

    Genome annotation databases

    EnsembliENST00000359634; ENSP00000352655; ENSG00000196950.
    ENST00000409086; ENSP00000386766; ENSG00000196950.
    ENST00000541054; ENSP00000437787; ENSG00000196950.
    GeneIDi57181.
    KEGGihsa:57181.
    UCSCiuc002utg.4. human.

    Polymorphism databases

    DMDMi156630627.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033091 mRNA. Translation: BAA86579.1 . Different initiation.
    AK291241 mRNA. Translation: BAF83930.1 .
    AK294771 mRNA. Translation: BAG57901.1 .
    AL050294 mRNA. Translation: CAB43393.1 . Sequence problems.
    CR749813 mRNA. Translation: CAH18673.1 .
    AC013274 Genomic DNA. No translation available.
    AC064834 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70116.1 .
    BC073909 mRNA. Translation: AAH73909.1 .
    BC101516 mRNA. Translation: AAI01517.1 .
    BC112223 mRNA. Translation: AAI12224.1 .
    CCDSi CCDS33353.1.
    PIRi T08684.
    RefSeqi NP_001120729.1. NM_001127257.1.
    NP_065075.1. NM_020342.2.
    XP_005246749.1. XM_005246692.2.
    UniGenei Hs.650158.

    3D structure databases

    ProteinModelPortali Q9ULF5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121430. 2 interactions.
    IntActi Q9ULF5. 1 interaction.
    STRINGi 9606.ENSP00000352655.

    Protein family/group databases

    TCDBi 2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    PTM databases

    PhosphoSitei Q9ULF5.

    Polymorphism databases

    DMDMi 156630627.

    Proteomic databases

    MaxQBi Q9ULF5.
    PaxDbi Q9ULF5.
    PRIDEi Q9ULF5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359634 ; ENSP00000352655 ; ENSG00000196950 .
    ENST00000409086 ; ENSP00000386766 ; ENSG00000196950 .
    ENST00000541054 ; ENSP00000437787 ; ENSG00000196950 .
    GeneIDi 57181.
    KEGGi hsa:57181.
    UCSCi uc002utg.4. human.

    Organism-specific databases

    CTDi 57181.
    GeneCardsi GC02P196440.
    H-InvDB HIX0002690.
    HGNCi HGNC:20861. SLC39A10.
    HPAi HPA036513.
    MIMi 608733. gene.
    neXtProti NX_Q9ULF5.
    PharmGKBi PA134944068.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0428.
    HOGENOMi HOG000013093.
    HOVERGENi HBG055748.
    InParanoidi Q9ULF5.
    KOi K14716.
    OMAi DPGHGHQ.
    OrthoDBi EOG7H791W.
    PhylomeDBi Q9ULF5.
    TreeFami TF318470.

    Enzyme and pathway databases

    Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A10. human.
    GeneWikii SLC39A10.
    GenomeRNAii 57181.
    NextBioi 63227.
    PROi Q9ULF5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULF5.
    Bgeei Q9ULF5.
    CleanExi HS_SLC39A10.
    Genevestigatori Q9ULF5.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Colon carcinoma.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Testis.
    7. "Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells."
      Kagara N., Tanaka N., Noguchi S., Hirano T.
      Cancer Sci. 98:692-697(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-536 AND SER-591, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS39AA_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULF5
    Secondary accession number(s): A8K5C6
    , B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9Y3Z1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    High levels of expression are correlated with invasiveness in several breast cancer lines.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3