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Protein

Zinc transporter ZIP10

Gene

SLC39A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31289-MONOMER.
ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:SLC39A10
Synonyms:KIAA1265, ZIP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20861. SLC39A10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei759 – 779HelicalSequence analysisAdd BLAST21
Transmembranei801 – 821HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57181.
OpenTargetsiENSG00000196950.
PharmGKBiPA134944068.

Polymorphism and mutation databases

BioMutaiSLC39A10.
DMDMi156630627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000029763226 – 831Zinc transporter ZIP10Add BLAST806

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1
Modified residuei536PhosphothreonineCombined sources1
Modified residuei553PhosphothreonineCombined sources1
Modified residuei591PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9ULF5.
PaxDbiQ9ULF5.
PeptideAtlasiQ9ULF5.
PRIDEiQ9ULF5.

PTM databases

iPTMnetiQ9ULF5.
PhosphoSitePlusiQ9ULF5.
SwissPalmiQ9ULF5.

Expressioni

Gene expression databases

BgeeiENSG00000196950.
CleanExiHS_SLC39A10.
ExpressionAtlasiQ9ULF5. baseline and differential.
GenevisibleiQ9ULF5. HS.

Organism-specific databases

HPAiHPA036512.
HPA036513.
HPA066087.

Interactioni

Protein-protein interaction databases

BioGridi121430. 29 interactors.
IntActiQ9ULF5. 21 interactors.
STRINGi9606.ENSP00000352655.

Structurei

3D structure databases

ProteinModelPortaliQ9ULF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi26 – 40His-richAdd BLAST15
Compositional biasi101 – 197His-richAdd BLAST97
Compositional biasi458 – 483His-richAdd BLAST26
Compositional biasi607 – 656His-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ9ULF5.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG091G02WM.
PhylomeDBiQ9ULF5.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULF5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK
60 70 80 90 100
FSKQAAENEK KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN
110 120 130 140 150
HEDLGHDHVS HLDILAVQEG KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN
160 170 180 190 200
HKCDPEKETV EVSVKSDDKH MHDHNHRLRH HHRLHHHLDH NNTHHFHNDS
210 220 230 240 250
ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS NENSEVITPG
260 270 280 290 300
FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD
310 320 330 340 350
NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG
360 370 380 390 400
ANSPISTDLF TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA
410 420 430 440 450
NIGASAWICG IISITVISLL SLLGVILVPI INQGCFKFLL TFLVALAVGT
460 470 480 490 500
MSGDALLHLL PHSQGGHDHS HQHAHGHGHS HGHESNKFLE EYDAVLKGLV
510 520 530 540 550
ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST IGRKLSDHKL
560 570 580 590 600
NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE
610 620 630 640 650
EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH
660 670 680 690 700
SHGPCHSGSD LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI
710 720 730 740 750
STSIAVFCHE LPHELGDFAV LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT
760 770 780 790 800
AVGQYANNIT LWIFAVTAGM FLYVALVDML PEMLHGDGDN EEHGFCPVGQ
810 820 830
FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F
Length:831
Mass (Da):94,132
Last modified:August 21, 2007 - v2
Checksum:iE196111D12BC20ED
GO
Isoform 2 (identifier: Q9ULF5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-450: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):42,363
Checksum:i348C2C05EE85730E
GO

Sequence cautioni

The sequence BAA86579 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43393 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426I → T in CAB43393 (PubMed:17974005).Curated1
Sequence conflicti426I → T in CAH18673 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03465887T → S.Corresponds to variant rs13419724dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559911 – 450Missing in isoform 2. 1 PublicationAdd BLAST450

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033091 mRNA. Translation: BAA86579.1. Different initiation.
AK291241 mRNA. Translation: BAF83930.1.
AK294771 mRNA. Translation: BAG57901.1.
AL050294 mRNA. Translation: CAB43393.1. Sequence problems.
CR749813 mRNA. Translation: CAH18673.1.
AC013274 Genomic DNA. No translation available.
AC064834 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70116.1.
BC073909 mRNA. Translation: AAH73909.1.
BC101516 mRNA. Translation: AAI01517.1.
BC112223 mRNA. Translation: AAI12224.1.
CCDSiCCDS33353.1. [Q9ULF5-1]
PIRiT08684.
RefSeqiNP_001120729.1. NM_001127257.1. [Q9ULF5-1]
NP_065075.1. NM_020342.2. [Q9ULF5-1]
XP_005246746.2. XM_005246689.4. [Q9ULF5-1]
XP_011509806.1. XM_011511504.2. [Q9ULF5-1]
XP_011509807.1. XM_011511505.2. [Q9ULF5-1]
XP_011509808.1. XM_011511506.2. [Q9ULF5-1]
UniGeneiHs.650158.

Genome annotation databases

EnsembliENST00000359634; ENSP00000352655; ENSG00000196950. [Q9ULF5-1]
ENST00000409086; ENSP00000386766; ENSG00000196950. [Q9ULF5-1]
GeneIDi57181.
KEGGihsa:57181.
UCSCiuc002utg.5. human. [Q9ULF5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033091 mRNA. Translation: BAA86579.1. Different initiation.
AK291241 mRNA. Translation: BAF83930.1.
AK294771 mRNA. Translation: BAG57901.1.
AL050294 mRNA. Translation: CAB43393.1. Sequence problems.
CR749813 mRNA. Translation: CAH18673.1.
AC013274 Genomic DNA. No translation available.
AC064834 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70116.1.
BC073909 mRNA. Translation: AAH73909.1.
BC101516 mRNA. Translation: AAI01517.1.
BC112223 mRNA. Translation: AAI12224.1.
CCDSiCCDS33353.1. [Q9ULF5-1]
PIRiT08684.
RefSeqiNP_001120729.1. NM_001127257.1. [Q9ULF5-1]
NP_065075.1. NM_020342.2. [Q9ULF5-1]
XP_005246746.2. XM_005246689.4. [Q9ULF5-1]
XP_011509806.1. XM_011511504.2. [Q9ULF5-1]
XP_011509807.1. XM_011511505.2. [Q9ULF5-1]
XP_011509808.1. XM_011511506.2. [Q9ULF5-1]
UniGeneiHs.650158.

3D structure databases

ProteinModelPortaliQ9ULF5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121430. 29 interactors.
IntActiQ9ULF5. 21 interactors.
STRINGi9606.ENSP00000352655.

Protein family/group databases

TCDBi2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiQ9ULF5.
PhosphoSitePlusiQ9ULF5.
SwissPalmiQ9ULF5.

Polymorphism and mutation databases

BioMutaiSLC39A10.
DMDMi156630627.

Proteomic databases

EPDiQ9ULF5.
PaxDbiQ9ULF5.
PeptideAtlasiQ9ULF5.
PRIDEiQ9ULF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359634; ENSP00000352655; ENSG00000196950. [Q9ULF5-1]
ENST00000409086; ENSP00000386766; ENSG00000196950. [Q9ULF5-1]
GeneIDi57181.
KEGGihsa:57181.
UCSCiuc002utg.5. human. [Q9ULF5-1]

Organism-specific databases

CTDi57181.
DisGeNETi57181.
GeneCardsiSLC39A10.
H-InvDBHIX0002690.
HGNCiHGNC:20861. SLC39A10.
HPAiHPA036512.
HPA036513.
HPA066087.
MIMi608733. gene.
neXtProtiNX_Q9ULF5.
OpenTargetsiENSG00000196950.
PharmGKBiPA134944068.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ9ULF5.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG091G02WM.
PhylomeDBiQ9ULF5.
TreeFamiTF318470.

Enzyme and pathway databases

BioCyciZFISH:G66-31289-MONOMER.
ReactomeiR-HSA-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSiSLC39A10. human.
GeneWikiiSLC39A10.
GenomeRNAii57181.
PROiQ9ULF5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196950.
CleanExiHS_SLC39A10.
ExpressionAtlasiQ9ULF5. baseline and differential.
GenevisibleiQ9ULF5. HS.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39AA_HUMAN
AccessioniPrimary (citable) accession number: Q9ULF5
Secondary accession number(s): A8K5C6
, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9Y3Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

High levels of expression are correlated with invasiveness in several breast cancer lines.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.