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Q9ULF5

- S39AA_HUMAN

UniProt

Q9ULF5 - S39AA_HUMAN

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Protein

Zinc transporter ZIP10

Gene

SLC39A10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May act as a zinc-influx transporter.1 Publication

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: Reactome
  2. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20603. Zinc influx into cells by the SLC39 gene family.

Protein family/group databases

TCDBi2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter ZIP10
Alternative name(s):
Solute carrier family 39 member 10
Zrt- and Irt-like protein 10
Short name:
ZIP-10
Gene namesi
Name:SLC39A10
Synonyms:KIAA1265, ZIP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20861. SLC39A10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei411 – 43121HelicalSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST
Transmembranei687 – 70721HelicalSequence AnalysisAdd
BLAST
Transmembranei732 – 75221HelicalSequence AnalysisAdd
BLAST
Transmembranei759 – 77921HelicalSequence AnalysisAdd
BLAST
Transmembranei801 – 82121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 831806Zinc transporter ZIP10PRO_0000297632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Modified residuei536 – 5361Phosphothreonine1 Publication
Modified residuei553 – 5531Phosphothreonine1 Publication
Modified residuei591 – 5911Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9ULF5.
PaxDbiQ9ULF5.
PRIDEiQ9ULF5.

PTM databases

PhosphoSiteiQ9ULF5.

Expressioni

Gene expression databases

BgeeiQ9ULF5.
CleanExiHS_SLC39A10.
ExpressionAtlasiQ9ULF5. baseline and differential.
GenevestigatoriQ9ULF5.

Organism-specific databases

HPAiHPA036513.

Interactioni

Protein-protein interaction databases

BioGridi121430. 5 interactions.
IntActiQ9ULF5. 1 interaction.
STRINGi9606.ENSP00000352655.

Structurei

3D structure databases

ProteinModelPortaliQ9ULF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 4015His-richAdd
BLAST
Compositional biasi101 – 19797His-richAdd
BLAST
Compositional biasi458 – 48326His-richAdd
BLAST
Compositional biasi607 – 65650His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000013093.
HOVERGENiHBG055748.
InParanoidiQ9ULF5.
KOiK14716.
OMAiDPGHGHQ.
OrthoDBiEOG7H791W.
PhylomeDBiQ9ULF5.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULF5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK
60 70 80 90 100
FSKQAAENEK KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN
110 120 130 140 150
HEDLGHDHVS HLDILAVQEG KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN
160 170 180 190 200
HKCDPEKETV EVSVKSDDKH MHDHNHRLRH HHRLHHHLDH NNTHHFHNDS
210 220 230 240 250
ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS NENSEVITPG
260 270 280 290 300
FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD
310 320 330 340 350
NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG
360 370 380 390 400
ANSPISTDLF TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA
410 420 430 440 450
NIGASAWICG IISITVISLL SLLGVILVPI INQGCFKFLL TFLVALAVGT
460 470 480 490 500
MSGDALLHLL PHSQGGHDHS HQHAHGHGHS HGHESNKFLE EYDAVLKGLV
510 520 530 540 550
ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST IGRKLSDHKL
560 570 580 590 600
NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE
610 620 630 640 650
EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH
660 670 680 690 700
SHGPCHSGSD LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI
710 720 730 740 750
STSIAVFCHE LPHELGDFAV LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT
760 770 780 790 800
AVGQYANNIT LWIFAVTAGM FLYVALVDML PEMLHGDGDN EEHGFCPVGQ
810 820 830
FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F
Length:831
Mass (Da):94,132
Last modified:August 21, 2007 - v2
Checksum:iE196111D12BC20ED
GO
Isoform 2 (identifier: Q9ULF5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-450: Missing.

Note: No experimental confirmation available.

Show »
Length:381
Mass (Da):42,363
Checksum:i348C2C05EE85730E
GO

Sequence cautioni

The sequence BAA86579.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB43393.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti426 – 4261I → T in CAB43393. (PubMed:17974005)Curated
Sequence conflicti426 – 4261I → T in CAH18673. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871T → S.
Corresponds to variant rs13419724 [ dbSNP | Ensembl ].
VAR_034658

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 450450Missing in isoform 2. 1 PublicationVSP_055991Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033091 mRNA. Translation: BAA86579.1. Different initiation.
AK291241 mRNA. Translation: BAF83930.1.
AK294771 mRNA. Translation: BAG57901.1.
AL050294 mRNA. Translation: CAB43393.1. Sequence problems.
CR749813 mRNA. Translation: CAH18673.1.
AC013274 Genomic DNA. No translation available.
AC064834 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70116.1.
BC073909 mRNA. Translation: AAH73909.1.
BC101516 mRNA. Translation: AAI01517.1.
BC112223 mRNA. Translation: AAI12224.1.
CCDSiCCDS33353.1. [Q9ULF5-1]
PIRiT08684.
RefSeqiNP_001120729.1. NM_001127257.1. [Q9ULF5-1]
NP_065075.1. NM_020342.2. [Q9ULF5-1]
XP_005246749.1. XM_005246692.2. [Q9ULF5-2]
UniGeneiHs.650158.

Genome annotation databases

EnsembliENST00000359634; ENSP00000352655; ENSG00000196950. [Q9ULF5-1]
ENST00000409086; ENSP00000386766; ENSG00000196950. [Q9ULF5-1]
GeneIDi57181.
KEGGihsa:57181.
UCSCiuc002utg.4. human. [Q9ULF5-1]

Polymorphism databases

DMDMi156630627.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033091 mRNA. Translation: BAA86579.1 . Different initiation.
AK291241 mRNA. Translation: BAF83930.1 .
AK294771 mRNA. Translation: BAG57901.1 .
AL050294 mRNA. Translation: CAB43393.1 . Sequence problems.
CR749813 mRNA. Translation: CAH18673.1 .
AC013274 Genomic DNA. No translation available.
AC064834 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70116.1 .
BC073909 mRNA. Translation: AAH73909.1 .
BC101516 mRNA. Translation: AAI01517.1 .
BC112223 mRNA. Translation: AAI12224.1 .
CCDSi CCDS33353.1. [Q9ULF5-1 ]
PIRi T08684.
RefSeqi NP_001120729.1. NM_001127257.1. [Q9ULF5-1 ]
NP_065075.1. NM_020342.2. [Q9ULF5-1 ]
XP_005246749.1. XM_005246692.2. [Q9ULF5-2 ]
UniGenei Hs.650158.

3D structure databases

ProteinModelPortali Q9ULF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121430. 5 interactions.
IntActi Q9ULF5. 1 interaction.
STRINGi 9606.ENSP00000352655.

Protein family/group databases

TCDBi 2.A.5.4.6. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

PhosphoSitei Q9ULF5.

Polymorphism databases

DMDMi 156630627.

Proteomic databases

MaxQBi Q9ULF5.
PaxDbi Q9ULF5.
PRIDEi Q9ULF5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359634 ; ENSP00000352655 ; ENSG00000196950 . [Q9ULF5-1 ]
ENST00000409086 ; ENSP00000386766 ; ENSG00000196950 . [Q9ULF5-1 ]
GeneIDi 57181.
KEGGi hsa:57181.
UCSCi uc002utg.4. human. [Q9ULF5-1 ]

Organism-specific databases

CTDi 57181.
GeneCardsi GC02P196440.
H-InvDB HIX0002690.
HGNCi HGNC:20861. SLC39A10.
HPAi HPA036513.
MIMi 608733. gene.
neXtProti NX_Q9ULF5.
PharmGKBi PA134944068.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00760000119115.
HOGENOMi HOG000013093.
HOVERGENi HBG055748.
InParanoidi Q9ULF5.
KOi K14716.
OMAi DPGHGHQ.
OrthoDBi EOG7H791W.
PhylomeDBi Q9ULF5.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_20603. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi SLC39A10. human.
GeneWikii SLC39A10.
GenomeRNAii 57181.
NextBioi 35471838.
PROi Q9ULF5.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULF5.
CleanExi HS_SLC39A10.
ExpressionAtlasi Q9ULF5. baseline and differential.
Genevestigatori Q9ULF5.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Colon carcinoma.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  7. "Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells."
    Kagara N., Tanaka N., Noguchi S., Hirano T.
    Cancer Sci. 98:692-697(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-536 AND SER-591, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS39AA_HUMAN
AccessioniPrimary (citable) accession number: Q9ULF5
Secondary accession number(s): A8K5C6
, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9Y3Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 26, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

High levels of expression are correlated with invasiveness in several breast cancer lines.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3