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Protein

Paladin

Gene

PALD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Paladin
Gene namesi
Name:PALD1
Synonyms:KIAA1274, PALD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107719.8.
HGNCiHGNC:23530. PALD1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi27143.
OpenTargetsiENSG00000107719.
PharmGKBiPA134986569.

Polymorphism and mutation databases

BioMutaiPALD1.
DMDMi146325028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002861302 – 856PaladinAdd BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei86PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9ULE6.
MaxQBiQ9ULE6.
PaxDbiQ9ULE6.
PeptideAtlasiQ9ULE6.
PRIDEiQ9ULE6.

PTM databases

iPTMnetiQ9ULE6.
PhosphoSitePlusiQ9ULE6.

Expressioni

Tissue specificityi

Expressed in endothelial cells, and in certain larger vessels, in mural cells. In the brain, possibly expressed in microglia. Expressed in peripheral blood mononuclear cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000107719.
CleanExiHS_KIAA1274.
ExpressionAtlasiQ9ULE6. baseline and differential.
GenevisibleiQ9ULE6. HS.

Organism-specific databases

HPAiHPA015696.
HPA017343.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118028. 15 interactors.
ELMiQ9ULE6.
IntActiQ9ULE6. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9ULE6.
SMRiQ9ULE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paladin family.Curated

Phylogenomic databases

eggNOGiENOG410IIZG. Eukaryota.
ENOG410YSN6. LUCA.
GeneTreeiENSGT00390000005448.
HOGENOMiHOG000068079.
HOVERGENiHBG108231.
InParanoidiQ9ULE6.
OMAiNFRRVPK.
OrthoDBiEOG091G01EJ.
PhylomeDBiQ9ULE6.
TreeFamiTF332292.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
SMARTiView protein in SMART
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF52799. SSF52799. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS
60 70 80 90 100
IIPNKVAPVV ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF
110 120 130 140 150
LVRDVTEKMD VLGTVGSCGA PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL
160 170 180 190 200
QKDGHRECVI FCVREEPVLF LRADEDFVSY TPRDKQNLHE NLQGLGPGVR
210 220 230 240 250
VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA IHGEDDLHVT
260 270 280 290 300
EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD
310 320 330 340 350
AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL
360 370 380 390 400
PMEQFQVIQS FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE
410 420 430 440 450
GIRPESPAQG SGSRHSVWQR ALWSLERYFY LILFNYYLHE QYPLAFALSF
460 470 480 490 500
SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA RGSLREDDLV SPDALSTVRE
510 520 530 540 550
MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR KVVWVSLREE
560 570 580 590 600
AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF
610 620 630 640 650
QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS
660 670 680 690 700
KDPGTGFVFS CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK
710 720 730 740 750
FTKGEFQVVM KVVQLLPDGH RVKKEVDAAL DTVSETMTPM HYHLREIIIC
760 770 780 790 800
TYRQAKAAKE AQEMRRLQLR SLQYLERYVC LILFNAYLHL EKADSWQRPF
810 820 830 840 850
STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW QEQSCSLEPS

APEDLL
Length:856
Mass (Da):96,754
Last modified:May 1, 2007 - v3
Checksum:iBFCDD78DB2D4BE3B
GO

Sequence cautioni

Q9ULE6: The sequence BAA86588 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Q9ULE6: The sequence CAI41274 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032076141S → L2 PublicationsCorresponds to variant dbSNP:rs2275060Ensembl.1
Natural variantiVAR_032077721R → C. Corresponds to variant dbSNP:rs3740447Ensembl.1
Natural variantiVAR_062188828G → R. Corresponds to variant dbSNP:rs10999406Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033100 mRNA. Translation: BAA86588.2. Different initiation.
AL355344, AC022532 Genomic DNA. Translation: CAI41274.1. Sequence problems.
AL355344 Genomic DNA. Translation: CAI41275.1.
BC136375 mRNA. Translation: AAI36376.1.
BC136376 mRNA. Translation: AAI36377.1.
CCDSiCCDS31215.1.
RefSeqiNP_055246.2. NM_014431.2.
XP_011537939.1. XM_011539637.2.
XP_011537940.1. XM_011539638.2.
XP_016871561.1. XM_017016072.1.
UniGeneiHs.202351.

Genome annotation databases

EnsembliENST00000263563; ENSP00000263563; ENSG00000107719.
GeneIDi27143.
KEGGihsa:27143.
UCSCiuc001jrd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPALD_HUMAN
AccessioniPrimary (citable) accession number: Q9ULE6
Secondary accession number(s): B2RMS1
, B9EGC6, Q5JTK7, Q5JTK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 25, 2017
This is version 113 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families