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Protein

Paladin

Gene

PALD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Paladin
Gene namesi
Name:PALD1
Synonyms:KIAA1274, PALD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23530. PALD1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986569.

Polymorphism and mutation databases

BioMutaiPALD1.
DMDMi146325028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 856855PaladinPRO_0000286130Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei86 – 861PhosphoserineBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9ULE6.
MaxQBiQ9ULE6.
PaxDbiQ9ULE6.
PeptideAtlasiQ9ULE6.
PRIDEiQ9ULE6.

PTM databases

iPTMnetiQ9ULE6.
PhosphoSiteiQ9ULE6.

Expressioni

Tissue specificityi

Expressed in endothelial cells, and in certain larger vessels, in mural cells. In the brain, possibly expressed in microglia. Expressed in peripheral blood mononuclear cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000107719.
CleanExiHS_KIAA1274.
ExpressionAtlasiQ9ULE6. baseline and differential.
GenevisibleiQ9ULE6. HS.

Organism-specific databases

HPAiHPA015696.
HPA017343.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IRF7Q929852EBI-3957166,EBI-968267
Zbp1A2APF72EBI-3957166,EBI-6115394From a different organism.

Protein-protein interaction databases

BioGridi118028. 10 interactions.
IntActiQ9ULE6. 6 interactions.
STRINGi9606.ENSP00000263563.

Structurei

3D structure databases

ProteinModelPortaliQ9ULE6.
SMRiQ9ULE6. Positions 621-681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paladin family.Curated

Phylogenomic databases

eggNOGiENOG410IIZG. Eukaryota.
ENOG410YSN6. LUCA.
GeneTreeiENSGT00390000005448.
HOGENOMiHOG000068079.
HOVERGENiHBG108231.
InParanoidiQ9ULE6.
OMAiLECDGHT.
OrthoDBiEOG091G01EJ.
PhylomeDBiQ9ULE6.
TreeFamiTF332292.

Family and domain databases

Gene3Di3.90.190.10. 5 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS
60 70 80 90 100
IIPNKVAPVV ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF
110 120 130 140 150
LVRDVTEKMD VLGTVGSCGA PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL
160 170 180 190 200
QKDGHRECVI FCVREEPVLF LRADEDFVSY TPRDKQNLHE NLQGLGPGVR
210 220 230 240 250
VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA IHGEDDLHVT
260 270 280 290 300
EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD
310 320 330 340 350
AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL
360 370 380 390 400
PMEQFQVIQS FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE
410 420 430 440 450
GIRPESPAQG SGSRHSVWQR ALWSLERYFY LILFNYYLHE QYPLAFALSF
460 470 480 490 500
SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA RGSLREDDLV SPDALSTVRE
510 520 530 540 550
MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR KVVWVSLREE
560 570 580 590 600
AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF
610 620 630 640 650
QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS
660 670 680 690 700
KDPGTGFVFS CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK
710 720 730 740 750
FTKGEFQVVM KVVQLLPDGH RVKKEVDAAL DTVSETMTPM HYHLREIIIC
760 770 780 790 800
TYRQAKAAKE AQEMRRLQLR SLQYLERYVC LILFNAYLHL EKADSWQRPF
810 820 830 840 850
STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW QEQSCSLEPS

APEDLL
Length:856
Mass (Da):96,754
Last modified:May 1, 2007 - v3
Checksum:iBFCDD78DB2D4BE3B
GO

Sequence cautioni

The sequence BAA86588 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI41274 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411S → L.2 Publications
Corresponds to variant rs2275060 [ dbSNP | Ensembl ].
VAR_032076
Natural varianti721 – 7211R → C.
Corresponds to variant rs3740447 [ dbSNP | Ensembl ].
VAR_032077
Natural varianti828 – 8281G → R.
Corresponds to variant rs10999406 [ dbSNP | Ensembl ].
VAR_062188

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033100 mRNA. Translation: BAA86588.2. Different initiation.
AL355344, AC022532 Genomic DNA. Translation: CAI41274.1. Sequence problems.
AL355344 Genomic DNA. Translation: CAI41275.1.
BC136375 mRNA. Translation: AAI36376.1.
BC136376 mRNA. Translation: AAI36377.1.
CCDSiCCDS31215.1.
RefSeqiNP_055246.2. NM_014431.2.
XP_011537939.1. XM_011539637.2.
XP_011537940.1. XM_011539638.2.
UniGeneiHs.202351.

Genome annotation databases

EnsembliENST00000263563; ENSP00000263563; ENSG00000107719.
GeneIDi27143.
KEGGihsa:27143.
UCSCiuc001jrd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033100 mRNA. Translation: BAA86588.2. Different initiation.
AL355344, AC022532 Genomic DNA. Translation: CAI41274.1. Sequence problems.
AL355344 Genomic DNA. Translation: CAI41275.1.
BC136375 mRNA. Translation: AAI36376.1.
BC136376 mRNA. Translation: AAI36377.1.
CCDSiCCDS31215.1.
RefSeqiNP_055246.2. NM_014431.2.
XP_011537939.1. XM_011539637.2.
XP_011537940.1. XM_011539638.2.
UniGeneiHs.202351.

3D structure databases

ProteinModelPortaliQ9ULE6.
SMRiQ9ULE6. Positions 621-681.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118028. 10 interactions.
IntActiQ9ULE6. 6 interactions.
STRINGi9606.ENSP00000263563.

PTM databases

iPTMnetiQ9ULE6.
PhosphoSiteiQ9ULE6.

Polymorphism and mutation databases

BioMutaiPALD1.
DMDMi146325028.

Proteomic databases

EPDiQ9ULE6.
MaxQBiQ9ULE6.
PaxDbiQ9ULE6.
PeptideAtlasiQ9ULE6.
PRIDEiQ9ULE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263563; ENSP00000263563; ENSG00000107719.
GeneIDi27143.
KEGGihsa:27143.
UCSCiuc001jrd.5. human.

Organism-specific databases

CTDi27143.
GeneCardsiPALD1.
H-InvDBHIX0008898.
HGNCiHGNC:23530. PALD1.
HPAiHPA015696.
HPA017343.
MIMi614656. gene.
neXtProtiNX_Q9ULE6.
PharmGKBiPA134986569.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZG. Eukaryota.
ENOG410YSN6. LUCA.
GeneTreeiENSGT00390000005448.
HOGENOMiHOG000068079.
HOVERGENiHBG108231.
InParanoidiQ9ULE6.
OMAiLECDGHT.
OrthoDBiEOG091G01EJ.
PhylomeDBiQ9ULE6.
TreeFamiTF332292.

Miscellaneous databases

GenomeRNAii27143.
PROiQ9ULE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107719.
CleanExiHS_KIAA1274.
ExpressionAtlasiQ9ULE6. baseline and differential.
GenevisibleiQ9ULE6. HS.

Family and domain databases

Gene3Di3.90.190.10. 5 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR003595. Tyr_Pase_cat.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPALD_HUMAN
AccessioniPrimary (citable) accession number: Q9ULE6
Secondary accession number(s): B2RMS1
, B9EGC6, Q5JTK7, Q5JTK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.