Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein WWC3

Gene

WWC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL

GO - Biological processi

  • negative regulation of hippo signaling Source: BHF-UCL
  • negative regulation of organ growth Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WWC3
Gene namesi
Name:WWC3
Synonyms:KIAA1280
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:29237. WWC3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485672.

Polymorphism and mutation databases

BioMutaiWWC3.
DMDMi160261727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10921092Protein WWC3PRO_0000244494Add
BLAST

Proteomic databases

EPDiQ9ULE0.
MaxQBiQ9ULE0.
PaxDbiQ9ULE0.
PeptideAtlasiQ9ULE0.
PRIDEiQ9ULE0.

PTM databases

iPTMnetiQ9ULE0.
PhosphoSiteiQ9ULE0.

Expressioni

Gene expression databases

BgeeiQ9ULE0.
CleanExiHS_WWC3.
ExpressionAtlasiQ9ULE0. baseline and differential.
GenevisibleiQ9ULE0. HS.

Organism-specific databases

HPAiHPA039814.

Interactioni

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL

Protein-protein interaction databases

BioGridi120944. 8 interactions.
STRINGi9606.ENSP00000370242.

Structurei

3D structure databases

ProteinModelPortaliQ9ULE0.
SMRiQ9ULE0. Positions 600-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini617 – 70690C2Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 12687Sequence analysisAdd
BLAST
Coiled coili230 – 344115Sequence analysisAdd
BLAST
Coiled coili761 – 81252Sequence analysisAdd
BLAST
Coiled coili967 – 103670Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi347 – 466120Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the WWC family.Curated
Contains 1 C2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ISXH. Eukaryota.
ENOG410XSXK. LUCA.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ9ULE0.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ9ULE0.
TreeFamiTF324040.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDHINKLTQI EDPREQWRRE QERMLKEYLI VAQEALNAKK EIYQIKQQRF
60 70 80 90 100
ELAQEEYQQL HKMCEDDSRS YASSFSGYST NTKYDPHQIK AEIASRRDRL
110 120 130 140 150
SRLKRELTQM KQELQYKEKG VETLQEIDRK MSSTHTSYKL DEAQAIMSEL
160 170 180 190 200
RTIKKAICTG EKERRDLMHS LAKLTDSFKN SCSVTDSLVD FPHHVGVPGD
210 220 230 240 250
AGVPQQFCDA GSQTDIIGEF VFDDKTRLVD RVRLNWQYEE ARKRVANIQQ
260 270 280 290 300
QLARLDNESW PSTAEADRDR LQLIKEKEAL LQELQLIIAQ RRSAGDVARL
310 320 330 340 350
EEERERLEEE LRRARATSAQ GATERILLQE KRNCLLMQLE EATRLTSYLQ
360 370 380 390 400
SQLKSLCAST LTVSSGSSRG SLASSRGSLA SSRGSLSSVS FTDIYGLPQY
410 420 430 440 450
EKPDAEGSQL LRFDLIPFDS LGRDAPFSEP PGPSGFHKQR RSLDTPQSLA
460 470 480 490 500
SLSSRSSLSS LSPPSSPLDT PFLPASRDSP LAQLADSCEG PGLGALDRLR
510 520 530 540 550
AHASAMGDED LPGMAALQPH GVPGDGEGPH ERGPPPASAP VGGTVTLRED
560 570 580 590 600
SAKRLERRAR RISACLSDYS LASDSGVFEP LTKRNEDAEE PAYGDTASNG
610 620 630 640 650
DPQIHVGLLR DSGSECLLVH VLQLKNPAGL AVKEDCKVHI RVYLPPLDSG
660 670 680 690 700
TPNTYCSKAL EFQVPLVFNE VFRIPVHSSA LTLKSLQLYV CSVTPQLQEE
710 720 730 740 750
LLGIAQINLA DYDSLSEMQL RWHSVQVFTS SEPSRTREAG CAGESSARDP
760 770 780 790 800
AHTISISGKT DAVTVLLART TAQLQAVERE LAEERAKLEY TEEEVLEMER
810 820 830 840 850
KEEQAEAISE RSWQADSVDS GCSNCTQTSP PYPEPCCMGI DSILGHPFAA
860 870 880 890 900
QAGPYSPEKF QPSPLKVDKE TNTEDLFLEE AASLVKERPS RRARGSPFVR
910 920 930 940 950
SGTIVRSQTF SPGARSQYVC RLYRSDSDSS TLPRKSPFVR NTLERRTLRY
960 970 980 990 1000
KQSCRSSLAE LMARTSLDLE LDLQASRTRQ RQLNEELCAL RELRQRLEDA
1010 1020 1030 1040 1050
QLRGQTDLPP WVLRDERLRG LLREAERQTR QTKLDYRHEQ AAEKMLKKAS
1060 1070 1080 1090
KEIYQLRGQS HKEPIQVQTF REKIAFFTRP RINIPPLPAD DV
Length:1,092
Mass (Da):122,676
Last modified:November 13, 2007 - v3
Checksum:i742C698715617C2C
GO
Isoform 2 (identifier: Q9ULE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-582: TVTLREDSAK...SDSGVFEPLT → SKCSLSDSSR...LFASQRQWGV
     583-1092: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:582
Mass (Da):65,049
Checksum:iA043FE4E2158F906
GO

Sequence cautioni

Isoform 2 : The sequence CAH56367.1 differs from that shown. Reason: Frameshift at position 544. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti495 – 4951A → T.
Corresponds to variant rs5934750 [ dbSNP | Ensembl ].
VAR_036969
Natural varianti593 – 5931Y → C.
Corresponds to variant rs36076296 [ dbSNP | Ensembl ].
VAR_036970
Natural varianti831 – 8311P → L.
Corresponds to variant rs55787431 [ dbSNP | Ensembl ].
VAR_062109

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei544 – 58239TVTLR…FEPLT → SKCSLSDSSRRQCQEVGEEG TPHLRMSVGLFASQRQWGV in isoform 2. 1 PublicationVSP_029220Add
BLAST
Alternative sequencei583 – 1092510Missing in isoform 2. 1 PublicationVSP_029221Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292961 mRNA. Translation: BAF85650.1.
AC002359 Genomic DNA. No translation available.
AC002364 Genomic DNA. No translation available.
AC121345 Genomic DNA. No translation available.
AB033106 mRNA. Translation: BAA86594.1.
AL353937 mRNA. Translation: CAH56367.1. Frameshift.
CH471074 Genomic DNA. Translation: EAW98775.1.
BC003527 mRNA. Translation: AAH03527.1.
CCDSiCCDS14136.1. [Q9ULE0-1]
RefSeqiNP_056506.2. NM_015691.3. [Q9ULE0-1]
UniGeneiHs.527524.

Genome annotation databases

EnsembliENST00000380861; ENSP00000370242; ENSG00000047644. [Q9ULE0-1]
GeneIDi55841.
KEGGihsa:55841.
UCSCiuc004csx.5. human. [Q9ULE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292961 mRNA. Translation: BAF85650.1.
AC002359 Genomic DNA. No translation available.
AC002364 Genomic DNA. No translation available.
AC121345 Genomic DNA. No translation available.
AB033106 mRNA. Translation: BAA86594.1.
AL353937 mRNA. Translation: CAH56367.1. Frameshift.
CH471074 Genomic DNA. Translation: EAW98775.1.
BC003527 mRNA. Translation: AAH03527.1.
CCDSiCCDS14136.1. [Q9ULE0-1]
RefSeqiNP_056506.2. NM_015691.3. [Q9ULE0-1]
UniGeneiHs.527524.

3D structure databases

ProteinModelPortaliQ9ULE0.
SMRiQ9ULE0. Positions 600-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120944. 8 interactions.
STRINGi9606.ENSP00000370242.

PTM databases

iPTMnetiQ9ULE0.
PhosphoSiteiQ9ULE0.

Polymorphism and mutation databases

BioMutaiWWC3.
DMDMi160261727.

Proteomic databases

EPDiQ9ULE0.
MaxQBiQ9ULE0.
PaxDbiQ9ULE0.
PeptideAtlasiQ9ULE0.
PRIDEiQ9ULE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380861; ENSP00000370242; ENSG00000047644. [Q9ULE0-1]
GeneIDi55841.
KEGGihsa:55841.
UCSCiuc004csx.5. human. [Q9ULE0-1]

Organism-specific databases

CTDi55841.
GeneCardsiWWC3.
H-InvDBHIX0016648.
HGNCiHGNC:29237. WWC3.
HPAiHPA039814.
neXtProtiNX_Q9ULE0.
PharmGKBiPA143485672.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISXH. Eukaryota.
ENOG410XSXK. LUCA.
GeneTreeiENSGT00410000025556.
HOGENOMiHOG000013211.
HOVERGENiHBG058082.
InParanoidiQ9ULE0.
OrthoDBiEOG7DJSNR.
PhylomeDBiQ9ULE0.
TreeFamiTF324040.

Miscellaneous databases

ChiTaRSiWWC3. human.
GenomeRNAii55841.
PROiQ9ULE0.

Gene expression databases

BgeeiQ9ULE0.
CleanExiHS_WWC3.
ExpressionAtlasiQ9ULE0. baseline and differential.
GenevisibleiQ9ULE0. HS.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-1092 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1092 (ISOFORM 2).
    Tissue: Amygdala.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 876-1092 (ISOFORM 1).
    Tissue: Uterus.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiWWC3_HUMAN
AccessioniPrimary (citable) accession number: Q9ULE0
Secondary accession number(s): A8KA96, Q659C1, Q9BTQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 13, 2007
Last modified: July 6, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.