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Q9ULD9

- ZN608_HUMAN

UniProt

Q9ULD9 - ZN608_HUMAN

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Protein

Zinc finger protein 608

Gene
ZNF608, KIAA1281
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri553 – 57826C2H2-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 608
Alternative name(s):
Renal carcinoma antigen NY-REN-36
Gene namesi
Name:ZNF608
Synonyms:KIAA1281
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:29238. ZNF608.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15121512Zinc finger protein 608PRO_0000280420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei782 – 7821Phosphoserine1 Publication
Modified residuei964 – 9641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ULD9.
PRIDEiQ9ULD9.

PTM databases

PhosphoSiteiQ9ULD9.

Expressioni

Gene expression databases

ArrayExpressiQ9ULD9.
BgeeiQ9ULD9.
CleanExiHS_ZNF608.
GenevestigatoriQ9ULD9.

Organism-specific databases

HPAiHPA005545.

Interactioni

Protein-protein interaction databases

BioGridi121571. 1 interaction.
DIPiDIP-29419N.

Structurei

3D structure databases

ProteinModelPortaliQ9ULD9.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili278 – 30427 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 574Poly-Thr
Compositional biasi310 – 3156Poly-Pro
Compositional biasi441 – 4444Poly-Ala
Compositional biasi754 – 76411Poly-ThrAdd
BLAST
Compositional biasi809 – 82214Poly-LysAdd
BLAST
Compositional biasi929 – 100779Ser-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri553 – 57826C2H2-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG86608.
HOGENOMiHOG000082539.
HOVERGENiHBG054557.
InParanoidiQ9ULD9.
OMAiYPGAYLS.
OrthoDBiEOG78M014.
PhylomeDBiQ9ULD9.
TreeFamiTF329775.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM     50
NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE 100
TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN 150
SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG 200
AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF 250
HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT 300
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV 350
GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT 400
YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS 450
FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR 500
KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP 550
VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE 600
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS 650
IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL 700
EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI 750
AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT 800
VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP 850
GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS 900
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG 950
SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY 1000
DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK 1050
KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA 1100
YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS 1150
ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA 1200
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK 1250
YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH 1300
PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP 1350
YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN 1400
TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD 1450
RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA 1500
SASGMFPGQR RE 1512
Length:1,512
Mass (Da):162,208
Last modified:May 18, 2010 - v4
Checksum:i46A41B939FEBD054
GO
Isoform 2 (identifier: Q9ULD9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.

Note: No experimental confirmation available.

Show »
Length:1,085
Mass (Da):118,140
Checksum:i403673466FB904E3
GO

Sequence cautioni

The sequence BAA86595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti721 – 7211T → N.4 Publications
Corresponds to variant rs6862252 [ dbSNP | Ensembl ].
VAR_031148

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 427427Missing in isoform 2. VSP_023664Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1512 – 15121E → G in CAH18418. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033107 mRNA. Translation: BAA86595.2. Different initiation.
CR749624 mRNA. Translation: CAH18418.1.
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1.
BC103742 mRNA. Translation: AAI03743.1.
BC151226 mRNA. Translation: AAI51227.1.
AF155106 mRNA. Translation: AAD42872.1.
CCDSiCCDS34219.1. [Q9ULD9-1]
RefSeqiNP_065798.2. NM_020747.2. [Q9ULD9-1]
XP_005272094.1. XM_005272037.1. [Q9ULD9-1]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1]
XP_006714725.1. XM_006714662.1. [Q9ULD9-1]
UniGeneiHs.266616.

Genome annotation databases

EnsembliENST00000306315; ENSP00000307746; ENSG00000168916. [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916. [Q9ULD9-2]
ENST00000509799; ENSP00000423279; ENSG00000168916.
GeneIDi57507.
KEGGihsa:57507.
UCSCiuc003ktq.1. human. [Q9ULD9-1]

Polymorphism databases

DMDMi296453083.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033107 mRNA. Translation: BAA86595.2 . Different initiation.
CR749624 mRNA. Translation: CAH18418.1 .
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1 .
BC103742 mRNA. Translation: AAI03743.1 .
BC151226 mRNA. Translation: AAI51227.1 .
AF155106 mRNA. Translation: AAD42872.1 .
CCDSi CCDS34219.1. [Q9ULD9-1 ]
RefSeqi NP_065798.2. NM_020747.2. [Q9ULD9-1 ]
XP_005272094.1. XM_005272037.1. [Q9ULD9-1 ]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1 ]
XP_006714725.1. XM_006714662.1. [Q9ULD9-1 ]
UniGenei Hs.266616.

3D structure databases

ProteinModelPortali Q9ULD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121571. 1 interaction.
DIPi DIP-29419N.

PTM databases

PhosphoSitei Q9ULD9.

Polymorphism databases

DMDMi 296453083.

Proteomic databases

PaxDbi Q9ULD9.
PRIDEi Q9ULD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306315 ; ENSP00000307746 ; ENSG00000168916 . [Q9ULD9-1 ]
ENST00000504926 ; ENSP00000427657 ; ENSG00000168916 . [Q9ULD9-2 ]
ENST00000509799 ; ENSP00000423279 ; ENSG00000168916 .
GeneIDi 57507.
KEGGi hsa:57507.
UCSCi uc003ktq.1. human. [Q9ULD9-1 ]

Organism-specific databases

CTDi 57507.
GeneCardsi GC05M123966.
HGNCi HGNC:29238. ZNF608.
HPAi HPA005545.
neXtProti NX_Q9ULD9.
PharmGKBi PA134945727.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86608.
HOGENOMi HOG000082539.
HOVERGENi HBG054557.
InParanoidi Q9ULD9.
OMAi YPGAYLS.
OrthoDBi EOG78M014.
PhylomeDBi Q9ULD9.
TreeFami TF329775.

Miscellaneous databases

ChiTaRSi ZNF608. human.
GenomeRNAii 57507.
NextBioi 63848.
PROi Q9ULD9.

Gene expression databases

ArrayExpressi Q9ULD9.
Bgeei Q9ULD9.
CleanExi HS_ZNF608.
Genevestigatori Q9ULD9.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-721.
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
    Tissue: PNS and Skin.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 584-810, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ASN-721.
    Tissue: Renal cell carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782 AND SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN608_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD9
Secondary accession number(s): A7E2W9
, Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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