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Q9ULD9

- ZN608_HUMAN

UniProt

Q9ULD9 - ZN608_HUMAN

Protein

Zinc finger protein 608

Gene

ZNF608

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri553 – 57826C2H2-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 608
    Alternative name(s):
    Renal carcinoma antigen NY-REN-36
    Gene namesi
    Name:ZNF608
    Synonyms:KIAA1281
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29238. ZNF608.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134945727.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15121512Zinc finger protein 608PRO_0000280420Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei782 – 7821Phosphoserine1 Publication
    Modified residuei964 – 9641Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9ULD9.
    PRIDEiQ9ULD9.

    PTM databases

    PhosphoSiteiQ9ULD9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULD9.
    BgeeiQ9ULD9.
    CleanExiHS_ZNF608.
    GenevestigatoriQ9ULD9.

    Organism-specific databases

    HPAiHPA005545.

    Interactioni

    Protein-protein interaction databases

    BioGridi121571. 1 interaction.
    DIPiDIP-29419N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili278 – 30427Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 574Poly-Thr
    Compositional biasi310 – 3156Poly-Pro
    Compositional biasi441 – 4444Poly-Ala
    Compositional biasi754 – 76411Poly-ThrAdd
    BLAST
    Compositional biasi809 – 82214Poly-LysAdd
    BLAST
    Compositional biasi929 – 100779Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri553 – 57826C2H2-typeAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG86608.
    HOGENOMiHOG000082539.
    HOVERGENiHBG054557.
    InParanoidiQ9ULD9.
    OMAiYPGAYLS.
    OrthoDBiEOG78M014.
    PhylomeDBiQ9ULD9.
    TreeFamiTF329775.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM     50
    NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE 100
    TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN 150
    SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG 200
    AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF 250
    HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT 300
    EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV 350
    GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT 400
    YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS 450
    FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR 500
    KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP 550
    VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE 600
    GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS 650
    IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL 700
    EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI 750
    AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT 800
    VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP 850
    GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS 900
    ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG 950
    SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY 1000
    DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK 1050
    KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA 1100
    YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS 1150
    ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA 1200
    KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK 1250
    YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH 1300
    PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP 1350
    YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN 1400
    TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD 1450
    RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA 1500
    SASGMFPGQR RE 1512
    Length:1,512
    Mass (Da):162,208
    Last modified:May 18, 2010 - v4
    Checksum:i46A41B939FEBD054
    GO
    Isoform 2 (identifier: Q9ULD9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-427: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,085
    Mass (Da):118,140
    Checksum:i403673466FB904E3
    GO

    Sequence cautioni

    The sequence BAA86595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1512 – 15121E → G in CAH18418. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti721 – 7211T → N.4 Publications
    Corresponds to variant rs6862252 [ dbSNP | Ensembl ].
    VAR_031148

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 427427Missing in isoform 2. 1 PublicationVSP_023664Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033107 mRNA. Translation: BAA86595.2. Different initiation.
    CR749624 mRNA. Translation: CAH18418.1.
    AC112196 Genomic DNA. No translation available.
    AC113398 Genomic DNA. No translation available.
    BC038370 mRNA. Translation: AAH38370.1.
    BC103742 mRNA. Translation: AAI03743.1.
    BC151226 mRNA. Translation: AAI51227.1.
    AF155106 mRNA. Translation: AAD42872.1.
    CCDSiCCDS34219.1. [Q9ULD9-1]
    RefSeqiNP_065798.2. NM_020747.2. [Q9ULD9-1]
    XP_005272094.1. XM_005272037.1. [Q9ULD9-1]
    XP_005272095.1. XM_005272038.1. [Q9ULD9-1]
    XP_006714725.1. XM_006714662.1. [Q9ULD9-1]
    UniGeneiHs.266616.

    Genome annotation databases

    EnsembliENST00000306315; ENSP00000307746; ENSG00000168916. [Q9ULD9-1]
    ENST00000504926; ENSP00000427657; ENSG00000168916. [Q9ULD9-2]
    ENST00000509799; ENSP00000423279; ENSG00000168916.
    GeneIDi57507.
    KEGGihsa:57507.
    UCSCiuc003ktq.1. human. [Q9ULD9-1]

    Polymorphism databases

    DMDMi296453083.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033107 mRNA. Translation: BAA86595.2 . Different initiation.
    CR749624 mRNA. Translation: CAH18418.1 .
    AC112196 Genomic DNA. No translation available.
    AC113398 Genomic DNA. No translation available.
    BC038370 mRNA. Translation: AAH38370.1 .
    BC103742 mRNA. Translation: AAI03743.1 .
    BC151226 mRNA. Translation: AAI51227.1 .
    AF155106 mRNA. Translation: AAD42872.1 .
    CCDSi CCDS34219.1. [Q9ULD9-1 ]
    RefSeqi NP_065798.2. NM_020747.2. [Q9ULD9-1 ]
    XP_005272094.1. XM_005272037.1. [Q9ULD9-1 ]
    XP_005272095.1. XM_005272038.1. [Q9ULD9-1 ]
    XP_006714725.1. XM_006714662.1. [Q9ULD9-1 ]
    UniGenei Hs.266616.

    3D structure databases

    ProteinModelPortali Q9ULD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121571. 1 interaction.
    DIPi DIP-29419N.

    PTM databases

    PhosphoSitei Q9ULD9.

    Polymorphism databases

    DMDMi 296453083.

    Proteomic databases

    PaxDbi Q9ULD9.
    PRIDEi Q9ULD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306315 ; ENSP00000307746 ; ENSG00000168916 . [Q9ULD9-1 ]
    ENST00000504926 ; ENSP00000427657 ; ENSG00000168916 . [Q9ULD9-2 ]
    ENST00000509799 ; ENSP00000423279 ; ENSG00000168916 .
    GeneIDi 57507.
    KEGGi hsa:57507.
    UCSCi uc003ktq.1. human. [Q9ULD9-1 ]

    Organism-specific databases

    CTDi 57507.
    GeneCardsi GC05M123966.
    HGNCi HGNC:29238. ZNF608.
    HPAi HPA005545.
    neXtProti NX_Q9ULD9.
    PharmGKBi PA134945727.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86608.
    HOGENOMi HOG000082539.
    HOVERGENi HBG054557.
    InParanoidi Q9ULD9.
    OMAi YPGAYLS.
    OrthoDBi EOG78M014.
    PhylomeDBi Q9ULD9.
    TreeFami TF329775.

    Miscellaneous databases

    ChiTaRSi ZNF608. human.
    GenomeRNAii 57507.
    NextBioi 63848.
    PROi Q9ULD9.

    Gene expression databases

    ArrayExpressi Q9ULD9.
    Bgeei Q9ULD9.
    CleanExi HS_ZNF608.
    Genevestigatori Q9ULD9.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-721.
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
      Tissue: PNS and Skin.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 584-810, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ASN-721.
      Tissue: Renal cell carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782 AND SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZN608_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULD9
    Secondary accession number(s): A7E2W9
    , Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 89 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3