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Protein

Zinc finger protein 608

Gene

ZNF608

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri553 – 578C2H2-typeAdd BLAST26

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168916-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 608
Alternative name(s):
Renal carcinoma antigen NY-REN-36
Gene namesi
Name:ZNF608
Synonyms:KIAA1281
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29238. ZNF608.

Pathology & Biotechi

Organism-specific databases

DisGeNETi57507.
OpenTargetsiENSG00000168916.
PharmGKBiPA134945727.

Polymorphism and mutation databases

BioMutaiZNF608.
DMDMi296453083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804201 – 1512Zinc finger protein 608Add BLAST1512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei421PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei481PhosphothreonineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei627PhosphoserineCombined sources1
Modified residuei782PhosphoserineCombined sources1
Cross-linki880Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei895PhosphoserineCombined sources1
Modified residuei964PhosphoserineCombined sources1
Modified residuei1098PhosphoserineCombined sources1
Cross-linki1292Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ULD9.
PaxDbiQ9ULD9.
PeptideAtlasiQ9ULD9.
PRIDEiQ9ULD9.

PTM databases

iPTMnetiQ9ULD9.
PhosphoSitePlusiQ9ULD9.

Expressioni

Gene expression databases

BgeeiENSG00000168916.
CleanExiHS_ZNF608.
ExpressionAtlasiQ9ULD9. baseline and differential.
GenevisibleiQ9ULD9. HS.

Organism-specific databases

HPAiHPA005545.

Interactioni

Protein-protein interaction databases

BioGridi121571. 3 interactors.
DIPiDIP-29419N.
STRINGi9606.ENSP00000307746.

Structurei

3D structure databases

ProteinModelPortaliQ9ULD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili278 – 304Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 57Poly-Thr4
Compositional biasi310 – 315Poly-Pro6
Compositional biasi441 – 444Poly-Ala4
Compositional biasi754 – 764Poly-ThrAdd BLAST11
Compositional biasi809 – 822Poly-LysAdd BLAST14
Compositional biasi929 – 1007Ser-richAdd BLAST79

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri553 – 578C2H2-typeAdd BLAST26

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIE1. Eukaryota.
ENOG410Z79M. LUCA.
GeneTreeiENSGT00390000008748.
HOGENOMiHOG000082539.
HOVERGENiHBG054557.
InParanoidiQ9ULD9.
OMAiSYPGAYL.
OrthoDBiEOG091G00Q9.
PhylomeDBiQ9ULD9.
TreeFamiTF329775.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM
60 70 80 90 100
NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE
110 120 130 140 150
TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN
160 170 180 190 200
SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG
210 220 230 240 250
AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF
260 270 280 290 300
HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT
310 320 330 340 350
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV
360 370 380 390 400
GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT
410 420 430 440 450
YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS
460 470 480 490 500
FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR
510 520 530 540 550
KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP
560 570 580 590 600
VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE
610 620 630 640 650
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS
660 670 680 690 700
IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL
710 720 730 740 750
EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI
760 770 780 790 800
AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT
810 820 830 840 850
VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP
860 870 880 890 900
GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS
910 920 930 940 950
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG
960 970 980 990 1000
SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY
1010 1020 1030 1040 1050
DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK
1060 1070 1080 1090 1100
KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA
1110 1120 1130 1140 1150
YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS
1160 1170 1180 1190 1200
ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA
1210 1220 1230 1240 1250
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK
1260 1270 1280 1290 1300
YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH
1310 1320 1330 1340 1350
PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP
1360 1370 1380 1390 1400
YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN
1410 1420 1430 1440 1450
TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD
1460 1470 1480 1490 1500
RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA
1510
SASGMFPGQR RE
Length:1,512
Mass (Da):162,208
Last modified:May 18, 2010 - v4
Checksum:i46A41B939FEBD054
GO
Isoform 2 (identifier: Q9ULD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.

Note: No experimental confirmation available.
Show »
Length:1,085
Mass (Da):118,140
Checksum:i403673466FB904E3
GO

Sequence cautioni

The sequence BAA86595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1512E → G in CAH18418 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031148721T → N.4 PublicationsCorresponds to variant rs6862252dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0236641 – 427Missing in isoform 2. 1 PublicationAdd BLAST427

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033107 mRNA. Translation: BAA86595.2. Different initiation.
CR749624 mRNA. Translation: CAH18418.1.
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1.
BC103742 mRNA. Translation: AAI03743.1.
BC151226 mRNA. Translation: AAI51227.1.
AF155106 mRNA. Translation: AAD42872.1.
CCDSiCCDS34219.1. [Q9ULD9-1]
RefSeqiNP_065798.2. NM_020747.2. [Q9ULD9-1]
XP_005272094.1. XM_005272037.2. [Q9ULD9-1]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1]
UniGeneiHs.266616.

Genome annotation databases

EnsembliENST00000306315; ENSP00000307746; ENSG00000168916. [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916. [Q9ULD9-2]
GeneIDi57507.
KEGGihsa:57507.
UCSCiuc003ktq.2. human. [Q9ULD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033107 mRNA. Translation: BAA86595.2. Different initiation.
CR749624 mRNA. Translation: CAH18418.1.
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1.
BC103742 mRNA. Translation: AAI03743.1.
BC151226 mRNA. Translation: AAI51227.1.
AF155106 mRNA. Translation: AAD42872.1.
CCDSiCCDS34219.1. [Q9ULD9-1]
RefSeqiNP_065798.2. NM_020747.2. [Q9ULD9-1]
XP_005272094.1. XM_005272037.2. [Q9ULD9-1]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1]
UniGeneiHs.266616.

3D structure databases

ProteinModelPortaliQ9ULD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121571. 3 interactors.
DIPiDIP-29419N.
STRINGi9606.ENSP00000307746.

PTM databases

iPTMnetiQ9ULD9.
PhosphoSitePlusiQ9ULD9.

Polymorphism and mutation databases

BioMutaiZNF608.
DMDMi296453083.

Proteomic databases

EPDiQ9ULD9.
PaxDbiQ9ULD9.
PeptideAtlasiQ9ULD9.
PRIDEiQ9ULD9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306315; ENSP00000307746; ENSG00000168916. [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916. [Q9ULD9-2]
GeneIDi57507.
KEGGihsa:57507.
UCSCiuc003ktq.2. human. [Q9ULD9-1]

Organism-specific databases

CTDi57507.
DisGeNETi57507.
GeneCardsiZNF608.
HGNCiHGNC:29238. ZNF608.
HPAiHPA005545.
neXtProtiNX_Q9ULD9.
OpenTargetsiENSG00000168916.
PharmGKBiPA134945727.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIE1. Eukaryota.
ENOG410Z79M. LUCA.
GeneTreeiENSGT00390000008748.
HOGENOMiHOG000082539.
HOVERGENiHBG054557.
InParanoidiQ9ULD9.
OMAiSYPGAYL.
OrthoDBiEOG091G00Q9.
PhylomeDBiQ9ULD9.
TreeFamiTF329775.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168916-MONOMER.

Miscellaneous databases

ChiTaRSiZNF608. human.
GenomeRNAii57507.
PROiQ9ULD9.

Gene expression databases

BgeeiENSG00000168916.
CleanExiHS_ZNF608.
ExpressionAtlasiQ9ULD9. baseline and differential.
GenevisibleiQ9ULD9. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN608_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD9
Secondary accession number(s): A7E2W9
, Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.