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Q9ULD9 (ZN608_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 608
Alternative name(s):
Renal carcinoma antigen NY-REN-36
Gene names
Name:ZNF608
Synonyms:KIAA1281
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1512 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

Sequence similarities

Contains 1 C2H2-type zinc finger.

Sequence caution

The sequence BAA86595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9ULD9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9ULD9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15121512Zinc finger protein 608
PRO_0000280420

Regions

Zinc finger553 – 57826C2H2-type
Coiled coil278 – 30427 Potential
Compositional bias54 – 574Poly-Thr
Compositional bias310 – 3156Poly-Pro
Compositional bias441 – 4444Poly-Ala
Compositional bias754 – 76411Poly-Thr
Compositional bias809 – 82214Poly-Lys
Compositional bias929 – 100779Ser-rich

Amino acid modifications

Modified residue7821Phosphoserine Ref.9
Modified residue9641Phosphoserine Ref.9

Natural variations

Alternative sequence1 – 427427Missing in isoform 2.
VSP_023664
Natural variant7211T → N. Ref.1 Ref.3 Ref.5 Ref.6
Corresponds to variant rs6862252 [ dbSNP | Ensembl ].
VAR_031148

Experimental info

Sequence conflict15121E → G in CAH18418. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 4.
Checksum: 46A41B939FEBD054

FASTA1,512162,208
        10         20         30         40         50         60 
MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM NNSTTTTSSS 

        70         80         90        100        110        120 
NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE TSKSKVKRSK TSKDANKSLP 

       130        140        150        160        170        180 
SAALYGIPEI SSTGKRQEVQ GRPGEATGMN SALGQSVSSG GSGNPNSNST STSTSAATAG 

       190        200        210        220        230        240 
AGSCGKSKEE KPGKSQSSRG AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA 

       250        260        270        280        290        300 
KSNGGGASPF HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT 

       310        320        330        340        350        360 
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV GVNTCEVGVV 

       370        380        390        400        410        420 
TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT YVGTLLDCTK HDWAPPRFCE 

       430        440        450        460        470        480 
SPTSDLEMRG GRGRGKRARS AAAAPGSEAS FTESRGLQNK NRGGANGKGR RGSLNASGRR 

       490        500        510        520        530        540 
TPPNCAAEDI KASPSSTNKR KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET 

       550        560        570        580        590        600 
TFLDQGCSSP VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE 

       610        620        630        640        650        660 
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS IIGAKAGKNS 

       670        680        690        700        710        720 
GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL EAEGLIDKKN LGDKEKGKKA 

       730        740        750        760        770        780 
TNCKTDKNLS KLKSARPIAP APAPTPPQLI AIPTATFTTT TTGTIPGLPS LTTTVVQATP 

       790        800        810        820        830        840 
KSPPLKPIQP KPTIMGEPIT VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE 

       850        860        870        880        890        900 
DSKGASKDLP GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS 

       910        920        930        940        950        960 
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG SDSRSEGMRS 

       970        980        990       1000       1010       1020 
KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY DPYYSPSYMH PGQVGAPAAG 

      1030       1040       1050       1060       1070       1080 
NSGSTQGMKI KKESEEDAEK KDKAEQLDSK KVDHNSASLQ PQHQSVITQR HPALAQSLYY 

      1090       1100       1110       1120       1130       1140 
GQYAYGLYMD QKSLMATSPA YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK 

      1150       1160       1170       1180       1190       1200 
EETKQKNMPS ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA 

      1210       1220       1230       1240       1250       1260 
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK YLDQQKSEEL 

      1270       1280       1290       1300       1310       1320 
DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH PDSQSMEESK LKNDDRKTPV 

      1330       1340       1350       1360       1370       1380 
NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP 

      1390       1400       1410       1420       1430       1440 
GFHYPVYGKM SGREETEKVN TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE 

      1450       1460       1470       1480       1490       1500 
REREAERERD RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA 

      1510 
SASGMFPGQR RE 

« Hide

Isoform 2 [UniParc].

Checksum: 403673466FB904E3
Show »

FASTA1,085118,140

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-721.
Tissue: Testis.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
Tissue: PNS and Skin.
[6]"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 584-810, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ASN-721.
Tissue: Renal cell carcinoma.
[7]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782 AND SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB033107 mRNA. Translation: BAA86595.2. Different initiation.
CR749624 mRNA. Translation: CAH18418.1.
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1.
BC103742 mRNA. Translation: AAI03743.1.
BC151226 mRNA. Translation: AAI51227.1.
AF155106 mRNA. Translation: AAD42872.1.
CCDSCCDS34219.1. [Q9ULD9-1]
RefSeqNP_065798.2. NM_020747.2. [Q9ULD9-1]
XP_005272094.1. XM_005272037.1. [Q9ULD9-1]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1]
XP_006714725.1. XM_006714662.1. [Q9ULD9-1]
UniGeneHs.266616.

3D structure databases

ProteinModelPortalQ9ULD9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121571. 1 interaction.
DIPDIP-29419N.

PTM databases

PhosphoSiteQ9ULD9.

Polymorphism databases

DMDM296453083.

Proteomic databases

PaxDbQ9ULD9.
PRIDEQ9ULD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306315; ENSP00000307746; ENSG00000168916. [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916. [Q9ULD9-2]
ENST00000509799; ENSP00000423279; ENSG00000168916.
GeneID57507.
KEGGhsa:57507.
UCSCuc003ktq.1. human. [Q9ULD9-1]

Organism-specific databases

CTD57507.
GeneCardsGC05M123966.
HGNCHGNC:29238. ZNF608.
HPAHPA005545.
neXtProtNX_Q9ULD9.
PharmGKBPA134945727.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86608.
HOGENOMHOG000082539.
HOVERGENHBG054557.
InParanoidQ9ULD9.
OMAYPGAYLS.
OrthoDBEOG78M014.
PhylomeDBQ9ULD9.
TreeFamTF329775.

Gene expression databases

ArrayExpressQ9ULD9.
BgeeQ9ULD9.
CleanExHS_ZNF608.
GenevestigatorQ9ULD9.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF608. human.
GenomeRNAi57507.
NextBio63848.
PROQ9ULD9.

Entry information

Entry nameZN608_HUMAN
AccessionPrimary (citable) accession number: Q9ULD9
Secondary accession number(s): A7E2W9 expand/collapse secondary AC list , Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 88 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM