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Q9ULD9

- ZN608_HUMAN

UniProt

Q9ULD9 - ZN608_HUMAN

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Protein

Zinc finger protein 608

Gene

ZNF608

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri553 – 57826C2H2-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 608
Alternative name(s):
Renal carcinoma antigen NY-REN-36
Gene namesi
Name:ZNF608
Synonyms:KIAA1281
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:29238. ZNF608.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15121512Zinc finger protein 608PRO_0000280420Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei782 – 7821Phosphoserine1 Publication
Modified residuei964 – 9641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ULD9.
PRIDEiQ9ULD9.

PTM databases

PhosphoSiteiQ9ULD9.

Expressioni

Gene expression databases

BgeeiQ9ULD9.
CleanExiHS_ZNF608.
ExpressionAtlasiQ9ULD9. baseline and differential.
GenevestigatoriQ9ULD9.

Organism-specific databases

HPAiHPA005545.

Interactioni

Protein-protein interaction databases

BioGridi121571. 1 interaction.
DIPiDIP-29419N.

Structurei

3D structure databases

ProteinModelPortaliQ9ULD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili278 – 30427Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 574Poly-Thr
Compositional biasi310 – 3156Poly-Pro
Compositional biasi441 – 4444Poly-Ala
Compositional biasi754 – 76411Poly-ThrAdd
BLAST
Compositional biasi809 – 82214Poly-LysAdd
BLAST
Compositional biasi929 – 100779Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri553 – 57826C2H2-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG86608.
GeneTreeiENSGT00390000008748.
HOGENOMiHOG000082539.
HOVERGENiHBG054557.
InParanoidiQ9ULD9.
OMAiYPGAYLS.
OrthoDBiEOG78M014.
PhylomeDBiQ9ULD9.
TreeFamiTF329775.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULD9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVNISTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM
60 70 80 90 100
NNSTTTTSSS NSKDCGGPAS SGAGATAALA DGLKFASVQA SAPQGNSHKE
110 120 130 140 150
TSKSKVKRSK TSKDANKSLP SAALYGIPEI SSTGKRQEVQ GRPGEATGMN
160 170 180 190 200
SALGQSVSSG GSGNPNSNST STSTSAATAG AGSCGKSKEE KPGKSQSSRG
210 220 230 240 250
AKRDKDAGKS RKDKHDLLQG HQNGSGSQAP SGGHLYGFGA KSNGGGASPF
260 270 280 290 300
HCGGTGSGSV AAAGEVSKSA PDSGLMGNSM LVKKEEEEEE SHRRIKKLKT
310 320 330 340 350
EKVDPLFTVP APPPPISSSL TPQILPSYFS PSSSNIAAPV EQLLVRTRSV
360 370 380 390 400
GVNTCEVGVV TEPECLGPCE PGTSVNLEGI VWHETEEGVL VVNVTWRNKT
410 420 430 440 450
YVGTLLDCTK HDWAPPRFCE SPTSDLEMRG GRGRGKRARS AAAAPGSEAS
460 470 480 490 500
FTESRGLQNK NRGGANGKGR RGSLNASGRR TPPNCAAEDI KASPSSTNKR
510 520 530 540 550
KNKPPMELDL NSSSEDNKPG KRVRTNSRST PTTPQGKPET TFLDQGCSSP
560 570 580 590 600
VLIDCPHPNC NKKYKHINGL RYHQAHAHLD PENKLEFEPD SEDKISDCEE
610 620 630 640 650
GLSNVALECS EPSTSVSAYD QLKAPASPGA GNPPGTPKGK RELMSNGPGS
660 670 680 690 700
IIGAKAGKNS GKKKGLNNEL NNLPVISNMT AALDSCSAAD GSLAAEMPKL
710 720 730 740 750
EAEGLIDKKN LGDKEKGKKA TNCKTDKNLS KLKSARPIAP APAPTPPQLI
760 770 780 790 800
AIPTATFTTT TTGTIPGLPS LTTTVVQATP KSPPLKPIQP KPTIMGEPIT
810 820 830 840 850
VNPALVSLKD KKKKEKRKLK DKEGKETGSP KMDAKLGKLE DSKGASKDLP
860 870 880 890 900
GHFLKDHLNK NEGLANGLSE SQESRMASIK AEADKVYTFT DNAPSPSIGS
910 920 930 940 950
ASRLECSTLV NGQAPMAPLH VLTQNGAESS AAKTSSPAYS DISDAADDGG
960 970 980 990 1000
SDSRSEGMRS KASSPSDIIS SKDSVVKGHS STTAQSSQLK ESHSPYYHSY
1010 1020 1030 1040 1050
DPYYSPSYMH PGQVGAPAAG NSGSTQGMKI KKESEEDAEK KDKAEQLDSK
1060 1070 1080 1090 1100
KVDHNSASLQ PQHQSVITQR HPALAQSLYY GQYAYGLYMD QKSLMATSPA
1110 1120 1130 1140 1150
YRQQYEKYYE DQRLAEQKMA QTGRGDCERK SELPLKELGK EETKQKNMPS
1160 1170 1180 1190 1200
ATISKAPSTP EPNKNHSKLG PSVPNKTEET GKSQLLSNHQ QQLQADSFKA
1210 1220 1230 1240 1250
KQMENHQLIK EAVEMKSVMD SMKQTGVDPT SRFKQDPDSR TWHHYVYQPK
1260 1270 1280 1290 1300
YLDQQKSEEL DREKKLKEDS PRKTPNKESG VPSLPVSLTS IKEEPKEAKH
1310 1320 1330 1340 1350
PDSQSMEESK LKNDDRKTPV NWKDSRGTRV AVSSPMSQHQ SYIQYLHAYP
1360 1370 1380 1390 1400
YPQMYDPSHP AYRAVSPVLM HSYPGAYLSP GFHYPVYGKM SGREETEKVN
1410 1420 1430 1440 1450
TSPSVNTKTT TESKALDLLQ QHANQYRSKS PAPVEKATAE REREAERERD
1460 1470 1480 1490 1500
RHSPFGQRHL HTHHHTHVGM GYPLIPGQYD PFQGLTSAAL VASQQVAAQA
1510
SASGMFPGQR RE
Length:1,512
Mass (Da):162,208
Last modified:May 18, 2010 - v4
Checksum:i46A41B939FEBD054
GO
Isoform 2 (identifier: Q9ULD9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.

Note: No experimental confirmation available.

Show »
Length:1,085
Mass (Da):118,140
Checksum:i403673466FB904E3
GO

Sequence cautioni

The sequence BAA86595.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1512 – 15121E → G in CAH18418. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti721 – 7211T → N.4 Publications
Corresponds to variant rs6862252 [ dbSNP | Ensembl ].
VAR_031148

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 427427Missing in isoform 2. 1 PublicationVSP_023664Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033107 mRNA. Translation: BAA86595.2. Different initiation.
CR749624 mRNA. Translation: CAH18418.1.
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1.
BC103742 mRNA. Translation: AAI03743.1.
BC151226 mRNA. Translation: AAI51227.1.
AF155106 mRNA. Translation: AAD42872.1.
CCDSiCCDS34219.1. [Q9ULD9-1]
RefSeqiNP_065798.2. NM_020747.2. [Q9ULD9-1]
XP_005272094.1. XM_005272037.1. [Q9ULD9-1]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1]
XP_006714725.1. XM_006714662.1. [Q9ULD9-1]
UniGeneiHs.266616.

Genome annotation databases

EnsembliENST00000306315; ENSP00000307746; ENSG00000168916. [Q9ULD9-1]
ENST00000504926; ENSP00000427657; ENSG00000168916. [Q9ULD9-2]
ENST00000509799; ENSP00000423279; ENSG00000168916.
GeneIDi57507.
KEGGihsa:57507.
UCSCiuc003ktq.1. human. [Q9ULD9-1]

Polymorphism databases

DMDMi296453083.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB033107 mRNA. Translation: BAA86595.2 . Different initiation.
CR749624 mRNA. Translation: CAH18418.1 .
AC112196 Genomic DNA. No translation available.
AC113398 Genomic DNA. No translation available.
BC038370 mRNA. Translation: AAH38370.1 .
BC103742 mRNA. Translation: AAI03743.1 .
BC151226 mRNA. Translation: AAI51227.1 .
AF155106 mRNA. Translation: AAD42872.1 .
CCDSi CCDS34219.1. [Q9ULD9-1 ]
RefSeqi NP_065798.2. NM_020747.2. [Q9ULD9-1 ]
XP_005272094.1. XM_005272037.1. [Q9ULD9-1 ]
XP_005272095.1. XM_005272038.1. [Q9ULD9-1 ]
XP_006714725.1. XM_006714662.1. [Q9ULD9-1 ]
UniGenei Hs.266616.

3D structure databases

ProteinModelPortali Q9ULD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121571. 1 interaction.
DIPi DIP-29419N.

PTM databases

PhosphoSitei Q9ULD9.

Polymorphism databases

DMDMi 296453083.

Proteomic databases

PaxDbi Q9ULD9.
PRIDEi Q9ULD9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306315 ; ENSP00000307746 ; ENSG00000168916 . [Q9ULD9-1 ]
ENST00000504926 ; ENSP00000427657 ; ENSG00000168916 . [Q9ULD9-2 ]
ENST00000509799 ; ENSP00000423279 ; ENSG00000168916 .
GeneIDi 57507.
KEGGi hsa:57507.
UCSCi uc003ktq.1. human. [Q9ULD9-1 ]

Organism-specific databases

CTDi 57507.
GeneCardsi GC05M123966.
HGNCi HGNC:29238. ZNF608.
HPAi HPA005545.
neXtProti NX_Q9ULD9.
PharmGKBi PA134945727.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86608.
GeneTreei ENSGT00390000008748.
HOGENOMi HOG000082539.
HOVERGENi HBG054557.
InParanoidi Q9ULD9.
OMAi YPGAYLS.
OrthoDBi EOG78M014.
PhylomeDBi Q9ULD9.
TreeFami TF329775.

Miscellaneous databases

ChiTaRSi ZNF608. human.
GenomeRNAii 57507.
NextBioi 63848.
PROi Q9ULD9.

Gene expression databases

Bgeei Q9ULD9.
CleanExi HS_ZNF608.
ExpressionAtlasi Q9ULD9. baseline and differential.
Genevestigatori Q9ULD9.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASN-721.
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASN-721.
    Tissue: PNS and Skin.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 584-810, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ASN-721.
    Tissue: Renal cell carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782 AND SER-964, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN608_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD9
Secondary accession number(s): A7E2W9
, Q3SYM6, Q68D12, Q8IY05, Q9Y5A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 90 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3