Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ULD8

- KCNH3_HUMAN

UniProt

Q9ULD8 - KCNH3_HUMAN

Protein

Potassium voltage-gated channel subfamily H member 3

Gene

KCNH3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (28 Nov 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi582 – 697116cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. protein binding Source: IntAct
    3. voltage-gated potassium channel activity Source: UniProtKB

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. potassium ion transport Source: UniProtKB
    3. regulation of membrane potential Source: RefGenome
    4. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Protein family/group databases

    TCDBi1.A.1.20.5. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 3
    Alternative name(s):
    Brain-specific eag-like channel 1
    Short name:
    BEC1
    Ether-a-go-go-like potassium channel 2
    Short name:
    ELK channel 2
    Short name:
    ELK2
    Voltage-gated potassium channel subunit Kv12.2
    Gene namesi
    Name:KCNH3
    Synonyms:KIAA1282
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6252. KCNH3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: RefGenome
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30038.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10831083Potassium voltage-gated channel subfamily H member 3PRO_0000054005Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9ULD8.
    PRIDEiQ9ULD8.

    PTM databases

    PhosphoSiteiQ9ULD8.

    Expressioni

    Tissue specificityi

    Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.

    Gene expression databases

    ArrayExpressiQ9ULD8.
    BgeeiQ9ULD8.
    CleanExiHS_KCNH3.
    GenevestigatoriQ9ULD8.

    Organism-specific databases

    HPAiHPA051088.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    envP045783EBI-8079227,EBI-6163496From a different organism.

    Protein-protein interaction databases

    IntActiQ9ULD8. 1 interaction.
    MINTiMINT-7968644.
    STRINGi9606.ENSP00000257981.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULD8.
    SMRiQ9ULD8. Positions 11-213, 451-505, 513-682.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 228228CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini250 – 25910ExtracellularSequence Analysis
    Topological domaini281 – 30222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 3318ExtracellularSequence Analysis
    Topological domaini353 – 3619CytoplasmicSequence Analysis
    Topological domaini383 – 45371ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini475 – 4795ExtracellularSequence Analysis
    Topological domaini501 – 1083583CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei454 – 47421Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei229 – 24921Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9073PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi465 – 4706Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi951 – 1057107Pro-richAdd
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230794.
    HOVERGENiHBG052232.
    InParanoidiQ9ULD8.
    KOiK04906.
    OMAiPLMAPWP.
    OrthoDBiEOG7QG43V.
    PhylomeDBiQ9ULD8.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ULD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC     50
    DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 100
    RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDRWKETGG 150
    GRRRYGRARS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 200
    NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 250
    AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 300
    HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD 350
    RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ 400
    ELARRLETPY YLVGRRPAGG NSSGQSDNCS SSSEANGTGL ELLGGPSLRS 450
    AYITSLYFAL SSLTSVGFGN VSANTDTEKI FSICTMLIGA LMHAVVFGNV 500
    TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE YFQATWAVNN 550
    GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP 600
    AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP 650
    RREQVVKANA DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL 700
    SYNLGAGGGS AEVDTSSLSG DNTLMSTLEE KETDGEQGPT VSPAPADEPS 750
    SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG GRGRPGRAGA LKAEAGPSAP 800
    PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS FRVGQSGPEC 850
    SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ 900
    SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ 950
    PPAGSVLSGT WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS 1000
    EPPASGDLCS EPSTPASPPP SEEGARTGPA EPVSQAEATS TGEPPPGSGG 1050
    LALPWDPHSL EMVLIGCHGS GTVQWTQEEG TGV 1083
    Length:1,083
    Mass (Da):117,129
    Last modified:November 28, 2002 - v2
    Checksum:iEF35C8968D7418CC
    GO

    Sequence cautioni

    The sequence BAA86596.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022696 mRNA. Translation: BAA83590.1.
    AB033108 mRNA. Translation: BAA86596.1. Different initiation.
    CCDSiCCDS8786.1.
    RefSeqiNP_036416.1. NM_012284.1.
    UniGeneiHs.64064.

    Genome annotation databases

    EnsembliENST00000257981; ENSP00000257981; ENSG00000135519.
    GeneIDi23416.
    KEGGihsa:23416.
    UCSCiuc001ruh.1. human.

    Polymorphism databases

    DMDMi26006814.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB022696 mRNA. Translation: BAA83590.1 .
    AB033108 mRNA. Translation: BAA86596.1 . Different initiation.
    CCDSi CCDS8786.1.
    RefSeqi NP_036416.1. NM_012284.1.
    UniGenei Hs.64064.

    3D structure databases

    ProteinModelPortali Q9ULD8.
    SMRi Q9ULD8. Positions 11-213, 451-505, 513-682.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ULD8. 1 interaction.
    MINTi MINT-7968644.
    STRINGi 9606.ENSP00000257981.

    Chemistry

    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 576.

    Protein family/group databases

    TCDBi 1.A.1.20.5. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q9ULD8.

    Polymorphism databases

    DMDMi 26006814.

    Proteomic databases

    PaxDbi Q9ULD8.
    PRIDEi Q9ULD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000257981 ; ENSP00000257981 ; ENSG00000135519 .
    GeneIDi 23416.
    KEGGi hsa:23416.
    UCSCi uc001ruh.1. human.

    Organism-specific databases

    CTDi 23416.
    GeneCardsi GC12P049933.
    HGNCi HGNC:6252. KCNH3.
    HPAi HPA051088.
    MIMi 604527. gene.
    neXtProti NX_Q9ULD8.
    PharmGKBi PA30038.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230794.
    HOVERGENi HBG052232.
    InParanoidi Q9ULD8.
    KOi K04906.
    OMAi PLMAPWP.
    OrthoDBi EOG7QG43V.
    PhylomeDBi Q9ULD8.
    TreeFami TF313130.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNH3.
    GenomeRNAii 23416.
    NextBioi 45623.
    PROi Q9ULD8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULD8.
    Bgeei Q9ULD8.
    CleanExi HS_KCNH3.
    Genevestigatori Q9ULD8.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "New ether-a-go-go K+ channel family members localized in human telencephalon."
      Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
      J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNH3_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULD8
    Secondary accession number(s): Q9UQ06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: November 28, 2002
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3