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Q9ULD8 (KCNH3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Brain-specific eag-like channel 1
Short name=BEC1
Ether-a-go-go-like potassium channel 2
Short name=ELK channel 2
Short name=ELK2
Voltage-gated potassium channel subunit Kv12.2
Gene names
Name:KCNH3
Synonyms:KIAA1282
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1083 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Sequence caution

The sequence BAA86596.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

envP045783EBI-8079227,EBI-6163496From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10831083Potassium voltage-gated channel subfamily H member 3
PRO_0000054005

Regions

Topological domain1 – 228228Cytoplasmic Potential
Transmembrane229 – 24921Helical; Name=Segment S1; Potential
Topological domain250 – 25910Extracellular Potential
Transmembrane260 – 28021Helical; Name=Segment S2; Potential
Topological domain281 – 30222Cytoplasmic Potential
Transmembrane303 – 32321Helical; Name=Segment S3; Potential
Topological domain324 – 3318Extracellular Potential
Transmembrane332 – 35221Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain353 – 3619Cytoplasmic Potential
Transmembrane362 – 38221Helical; Name=Segment S5; Potential
Topological domain383 – 45371Extracellular Potential
Intramembrane454 – 47421Pore-forming; Name=Segment H5; Potential
Topological domain475 – 4795Extracellular Potential
Transmembrane480 – 50021Helical; Name=Segment S6; Potential
Topological domain501 – 1083583Cytoplasmic Potential
Domain18 – 9073PAS
Domain93 – 14553PAC
Nucleotide binding582 – 697116cNMP
Motif465 – 4706Selectivity filter By similarity
Compositional bias951 – 1057107Pro-rich

Amino acid modifications

Glycosylation4211N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ULD8 [UniParc].

Last modified November 28, 2002. Version 2.
Checksum: EF35C8968D7418CC

FASTA1,083117,129
        10         20         30         40         50         60 
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC DLTGFSRAEV 

        70         80         90        100        110        120 
MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY RKSGLPFWCL LDVIPIKNEK 

       130        140        150        160        170        180 
GEVALFLVSH KDISETKNRG GPDRWKETGG GRRRYGRARS KGFNANRRRS RAVLYHLSGH 

       190        200        210        220        230        240 
LQKQPKGKHK LNKGVFGEKP NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV 

       250        260        270        280        290        300 
TVPYSVCVST AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 

       310        320        330        340        350        360 
HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD RYSQYSAVVL 

       370        380        390        400        410        420 
TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ ELARRLETPY YLVGRRPAGG 

       430        440        450        460        470        480 
NSSGQSDNCS SSSEANGTGL ELLGGPSLRS AYITSLYFAL SSLTSVGFGN VSANTDTEKI 

       490        500        510        520        530        540 
FSICTMLIGA LMHAVVFGNV TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE 

       550        560        570        580        590        600 
YFQATWAVNN GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP 

       610        620        630        640        650        660 
AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP RREQVVKANA 

       670        680        690        700        710        720 
DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL SYNLGAGGGS AEVDTSSLSG 

       730        740        750        760        770        780 
DNTLMSTLEE KETDGEQGPT VSPAPADEPS SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG 

       790        800        810        820        830        840 
GRGRPGRAGA LKAEAGPSAP PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS 

       850        860        870        880        890        900 
FRVGQSGPEC SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ 

       910        920        930        940        950        960 
SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ PPAGSVLSGT 

       970        980        990       1000       1010       1020 
WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS EPPASGDLCS EPSTPASPPP 

      1030       1040       1050       1060       1070       1080 
SEEGARTGPA EPVSQAEATS TGEPPPGSGG LALPWDPHSL EMVLIGCHGS GTVQWTQEEG 


TGV 

« Hide

References

« Hide 'large scale' references
[1]"New ether-a-go-go K+ channel family members localized in human telencephalon."
Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB022696 mRNA. Translation: BAA83590.1.
AB033108 mRNA. Translation: BAA86596.1. Different initiation.
CCDSCCDS8786.1.
RefSeqNP_036416.1. NM_012284.1.
UniGeneHs.64064.

3D structure databases

ProteinModelPortalQ9ULD8.
SMRQ9ULD8. Positions 11-213, 451-505, 513-682.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9ULD8. 1 interaction.
MINTMINT-7968644.
STRING9606.ENSP00000257981.

Chemistry

ChEMBLCHEMBL2362996.
GuidetoPHARMACOLOGY576.

Protein family/group databases

TCDB1.A.1.20.5. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteQ9ULD8.

Polymorphism databases

DMDM26006814.

Proteomic databases

PaxDbQ9ULD8.
PRIDEQ9ULD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257981; ENSP00000257981; ENSG00000135519.
GeneID23416.
KEGGhsa:23416.
UCSCuc001ruh.1. human.

Organism-specific databases

CTD23416.
GeneCardsGC12P049933.
HGNCHGNC:6252. KCNH3.
HPAHPA051088.
MIM604527. gene.
neXtProtNX_Q9ULD8.
PharmGKBPA30038.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2202.
HOGENOMHOG000230794.
HOVERGENHBG052232.
InParanoidQ9ULD8.
KOK04906.
OMAPLMAPWP.
OrthoDBEOG7QG43V.
PhylomeDBQ9ULD8.
TreeFamTF313130.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ9ULD8.
BgeeQ9ULD8.
CleanExHS_KCNH3.
GenevestigatorQ9ULD8.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKCNH3.
GenomeRNAi23416.
NextBio45623.
PROQ9ULD8.
SOURCESearch...

Entry information

Entry nameKCNH3_HUMAN
AccessionPrimary (citable) accession number: Q9ULD8
Secondary accession number(s): Q9UQ06
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM