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Q9ULD8

- KCNH3_HUMAN

UniProt

Q9ULD8 - KCNH3_HUMAN

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Protein

Potassium voltage-gated channel subfamily H member 3

Gene

KCNH3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi582 – 697116cNMPAdd
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: UniProtKB

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. potassium ion transport Source: UniProtKB
  3. regulation of membrane potential Source: RefGenome
  4. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.20.5. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Brain-specific eag-like channel 1
Short name:
BEC1
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
ELK2
Voltage-gated potassium channel subunit Kv12.2
Gene namesi
Name:KCNH3
Synonyms:KIAA1282
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6252. KCNH3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. integral component of plasma membrane Source: RefGenome
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10831083Potassium voltage-gated channel subfamily H member 3PRO_0000054005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ULD8.
PRIDEiQ9ULD8.

PTM databases

PhosphoSiteiQ9ULD8.

Expressioni

Tissue specificityi

Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.

Gene expression databases

BgeeiQ9ULD8.
CleanExiHS_KCNH3.
ExpressionAtlasiQ9ULD8. baseline and differential.
GenevestigatoriQ9ULD8.

Organism-specific databases

HPAiHPA051088.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
envP045783EBI-8079227,EBI-6163496From a different organism.

Protein-protein interaction databases

IntActiQ9ULD8. 1 interaction.
MINTiMINT-7968644.
STRINGi9606.ENSP00000257981.

Structurei

3D structure databases

ProteinModelPortaliQ9ULD8.
SMRiQ9ULD8. Positions 11-213, 451-505, 513-682.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 228228CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini250 – 25910ExtracellularSequence Analysis
Topological domaini281 – 30222CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini324 – 3318ExtracellularSequence Analysis
Topological domaini353 – 3619CytoplasmicSequence Analysis
Topological domaini383 – 45371ExtracellularSequence AnalysisAdd
BLAST
Topological domaini475 – 4795ExtracellularSequence Analysis
Topological domaini501 – 1083583CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei454 – 47421Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei229 – 24921Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei362 – 38221Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei480 – 50021Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 9073PASPROSITE-ProRule annotationAdd
BLAST
Domaini93 – 14553PACPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi465 – 4706Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi951 – 1057107Pro-richAdd
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00760000118772.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiQ9ULD8.
KOiK04906.
OMAiPLMAPWP.
OrthoDBiEOG7QG43V.
PhylomeDBiQ9ULD8.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ULD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC
60 70 80 90 100
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY
110 120 130 140 150
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDRWKETGG
160 170 180 190 200
GRRRYGRARS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP
210 220 230 240 250
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST
260 270 280 290 300
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
310 320 330 340 350
HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD
360 370 380 390 400
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ
410 420 430 440 450
ELARRLETPY YLVGRRPAGG NSSGQSDNCS SSSEANGTGL ELLGGPSLRS
460 470 480 490 500
AYITSLYFAL SSLTSVGFGN VSANTDTEKI FSICTMLIGA LMHAVVFGNV
510 520 530 540 550
TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE YFQATWAVNN
560 570 580 590 600
GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP
610 620 630 640 650
AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP
660 670 680 690 700
RREQVVKANA DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL
710 720 730 740 750
SYNLGAGGGS AEVDTSSLSG DNTLMSTLEE KETDGEQGPT VSPAPADEPS
760 770 780 790 800
SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG GRGRPGRAGA LKAEAGPSAP
810 820 830 840 850
PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS FRVGQSGPEC
860 870 880 890 900
SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ
910 920 930 940 950
SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ
960 970 980 990 1000
PPAGSVLSGT WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS
1010 1020 1030 1040 1050
EPPASGDLCS EPSTPASPPP SEEGARTGPA EPVSQAEATS TGEPPPGSGG
1060 1070 1080
LALPWDPHSL EMVLIGCHGS GTVQWTQEEG TGV
Length:1,083
Mass (Da):117,129
Last modified:November 28, 2002 - v2
Checksum:iEF35C8968D7418CC
GO

Sequence cautioni

The sequence BAA86596.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022696 mRNA. Translation: BAA83590.1.
AB033108 mRNA. Translation: BAA86596.1. Different initiation.
CCDSiCCDS8786.1.
RefSeqiNP_036416.1. NM_012284.1.
UniGeneiHs.64064.

Genome annotation databases

EnsembliENST00000257981; ENSP00000257981; ENSG00000135519.
GeneIDi23416.
KEGGihsa:23416.
UCSCiuc001ruh.1. human.

Polymorphism databases

DMDMi26006814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB022696 mRNA. Translation: BAA83590.1 .
AB033108 mRNA. Translation: BAA86596.1 . Different initiation.
CCDSi CCDS8786.1.
RefSeqi NP_036416.1. NM_012284.1.
UniGenei Hs.64064.

3D structure databases

ProteinModelPortali Q9ULD8.
SMRi Q9ULD8. Positions 11-213, 451-505, 513-682.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ULD8. 1 interaction.
MINTi MINT-7968644.
STRINGi 9606.ENSP00000257981.

Chemistry

ChEMBLi CHEMBL2362996.
GuidetoPHARMACOLOGYi 576.

Protein family/group databases

TCDBi 1.A.1.20.5. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q9ULD8.

Polymorphism databases

DMDMi 26006814.

Proteomic databases

PaxDbi Q9ULD8.
PRIDEi Q9ULD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000257981 ; ENSP00000257981 ; ENSG00000135519 .
GeneIDi 23416.
KEGGi hsa:23416.
UCSCi uc001ruh.1. human.

Organism-specific databases

CTDi 23416.
GeneCardsi GC12P049933.
HGNCi HGNC:6252. KCNH3.
HPAi HPA051088.
MIMi 604527. gene.
neXtProti NX_Q9ULD8.
PharmGKBi PA30038.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00760000118772.
HOGENOMi HOG000230794.
HOVERGENi HBG052232.
InParanoidi Q9ULD8.
KOi K04906.
OMAi PLMAPWP.
OrthoDBi EOG7QG43V.
PhylomeDBi Q9ULD8.
TreeFami TF313130.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNH3.
GenomeRNAii 23416.
NextBioi 45623.
PROi Q9ULD8.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULD8.
CleanExi HS_KCNH3.
ExpressionAtlasi Q9ULD8. baseline and differential.
Genevestigatori Q9ULD8.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New ether-a-go-go K+ channel family members localized in human telencephalon."
    Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
    J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNH3_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD8
Secondary accession number(s): Q9UQ06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: October 29, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3