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Protein

Zinc finger protein 777

Gene

ZNF777

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri546 – 56823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri664 – 68623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 777
Gene namesi
Name:ZNF777
Synonyms:KIAA1285
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22213. ZNF777.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410383.

Polymorphism and mutation databases

BioMutaiZNF777.
DMDMi152112417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Zinc finger protein 777PRO_0000293692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571PhosphoserineCombined sources
Modified residuei496 – 4961PhosphoserineCombined sources
Modified residuei502 – 5021PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ULD5.
PaxDbiQ9ULD5.
PRIDEiQ9ULD5.

PTM databases

iPTMnetiQ9ULD5.

Expressioni

Gene expression databases

BgeeiQ9ULD5.
CleanExiHS_ZNF777.
GenevisibleiQ9ULD5. HS.

Organism-specific databases

HPAiHPA003252.

Interactioni

Protein-protein interaction databases

BioGridi118035. 10 interactions.
STRINGi9606.ENSP00000247930.

Structurei

3D structure databases

ProteinModelPortaliQ9ULD5.
SMRiQ9ULD5. Positions 533-749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 35672KRABPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili240 – 26627Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi338 – 467130Glu-richAdd
BLAST
Compositional biasi627 – 6326Poly-Gly

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri546 – 56823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri574 – 59623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri636 – 65823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri664 – 68623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG108774.
InParanoidiQ9ULD5.
KOiK09228.
OMAiGPGFAPK.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9ULD5.
TreeFamiTF337777.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULD5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENQRSSPLS FPSVPQEETL RQAPAGLPRE TLFQSRVLPP KEIPSLSPTI
60 70 80 90 100
PRQGSLPQTS SAPKQETSGR MPHVLQKGPS LLCSAASEQE TSLQGPLASQ
110 120 130 140 150
EGTQYPPPAA AEQEVSLLSH SPHHQEAPVH SPEAPEKDPL TLSPTVPETD
160 170 180 190 200
MDPLLQSPVS QKDTPFQISS AVQKEQPLPT AEITRLAVWA AVQAVERKLE
210 220 230 240 250
AQAMRLLTLE GRTGTNEKKI ADCEKTAVEF ANHLESKWVV LGTLLQEYGL
260 270 280 290 300
LQRRLENMEN LLKNRNFWIL RLPPGSNGEV PKVPVTFDDV AVHFSEQEWG
310 320 330 340 350
NLSEWQKELY KNVMRGNYES LVSMDYAISK PDLMSQMERG ERPTMQEQED
360 370 380 390 400
SEEGETPTDP SAAHDGIVIK IEVQTNDEGS ESLETPEPLM GQVEEHGFQD
410 420 430 440 450
SELGDPCGEQ PDLDMQEPEN TLEESTEGSS EFSELKQMLV QQRNCTEGIV
460 470 480 490 500
IKTEEQDEEE EEEEEDELPQ HLQSLGQLSG RYEASMYQTP LPGEMSPEGE
510 520 530 540 550
ESPPPLQLGN PAVKRLAPSV HGERHLSENR GASSQQQRNR RGERPFTCME
560 570 580 590 600
CGKSFRLKIN LIIHQRNHIK EGPYECAECE ISFRHKQQLT LHQRIHRVRG
610 620 630 640 650
GCVSPERGPT FNPKHALKPR PKSPSSGSGG GGPKPYKCPE CDSSFSHKSS
660 670 680 690 700
LTKHQITHTG ERPYTCPECK KSFRLHISLV IHQRVHAGKH EVSFICSLCG
710 720 730 740 750
KSFSRPSHLL RHQRTHTGER PFKCPECEKS FSEKSKLTNH CRVHSRERPP
760
PRWSSSFCSL
Length:760
Mass (Da):85,176
Last modified:July 10, 2007 - v2
Checksum:i7E3470EB72D7E341
GO
Isoform 2 (identifier: Q9ULD5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-760: PPRWSSSFCSL → HACPECGKSF...KYHLRTHTGE

Note: No experimental confirmation available.
Show »
Length:831
Mass (Da):93,762
Checksum:i6AE3346E1A4EDF80
GO
Isoform 3 (identifier: Q9ULD5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: T → TA
     750-760: PPRWSSSFCSL → HACPECGKSF...KYHLRTHTGE

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):93,833
Checksum:i968092CF4EDED991
GO

Sequence cautioni

The sequence AAH23985.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA86599.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC11033.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701R → W.
Corresponds to variant rs3735318 [ dbSNP | Ensembl ].
VAR_057451
Natural varianti115 – 1151V → A.
Corresponds to variant rs3735319 [ dbSNP | Ensembl ].
VAR_057452
Natural varianti512 – 5121A → T.1 Publication
Corresponds to variant rs17852167 [ dbSNP | Ensembl ].
VAR_061965

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei446 – 4461T → TA in isoform 3. 1 PublicationVSP_026558
Alternative sequencei750 – 76011PPRWSSSFCSL → HACPECGKSFIRKHHLLEHR RIHTGERPYHCAECGKRFTQ KHHLLEHQRAHTGERPYPCT HCAKCFRYKQSLKYHLRTHT GE in isoform 2 and isoform 3. 2 PublicationsVSP_026559Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033111 mRNA. Translation: BAA86599.1. Different initiation.
BC023985 mRNA. Translation: AAH23985.2. Different initiation.
AK074515 mRNA. Translation: BAC11033.1. Different initiation.
CCDSiCCDS43675.1. [Q9ULD5-2]
RefSeqiNP_056509.2. NM_015694.2. [Q9ULD5-2]
XP_005250038.1. XM_005249981.1. [Q9ULD5-2]
XP_011514357.1. XM_011516055.1. [Q9ULD5-2]
UniGeneiHs.38512.

Genome annotation databases

EnsembliENST00000247930; ENSP00000247930; ENSG00000196453. [Q9ULD5-2]
GeneIDi27153.
KEGGihsa:27153.
UCSCiuc003wfv.4. human. [Q9ULD5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033111 mRNA. Translation: BAA86599.1. Different initiation.
BC023985 mRNA. Translation: AAH23985.2. Different initiation.
AK074515 mRNA. Translation: BAC11033.1. Different initiation.
CCDSiCCDS43675.1. [Q9ULD5-2]
RefSeqiNP_056509.2. NM_015694.2. [Q9ULD5-2]
XP_005250038.1. XM_005249981.1. [Q9ULD5-2]
XP_011514357.1. XM_011516055.1. [Q9ULD5-2]
UniGeneiHs.38512.

3D structure databases

ProteinModelPortaliQ9ULD5.
SMRiQ9ULD5. Positions 533-749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118035. 10 interactions.
STRINGi9606.ENSP00000247930.

PTM databases

iPTMnetiQ9ULD5.

Polymorphism and mutation databases

BioMutaiZNF777.
DMDMi152112417.

Proteomic databases

MaxQBiQ9ULD5.
PaxDbiQ9ULD5.
PRIDEiQ9ULD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247930; ENSP00000247930; ENSG00000196453. [Q9ULD5-2]
GeneIDi27153.
KEGGihsa:27153.
UCSCiuc003wfv.4. human. [Q9ULD5-1]

Organism-specific databases

CTDi27153.
GeneCardsiZNF777.
HGNCiHGNC:22213. ZNF777.
HPAiHPA003252.
neXtProtiNX_Q9ULD5.
PharmGKBiPA162410383.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063032.
HOGENOMiHOG000013125.
HOVERGENiHBG108774.
InParanoidiQ9ULD5.
KOiK09228.
OMAiGPGFAPK.
OrthoDBiEOG73JKWC.
PhylomeDBiQ9ULD5.
TreeFamiTF337777.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii27153.
NextBioi49919.
PROiQ9ULD5.

Gene expression databases

BgeeiQ9ULD5.
CleanExiHS_ZNF777.
GenevisibleiQ9ULD5. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR022137. DUF3669_Znf.
IPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12417. DUF3669. 1 hit.
PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-760 (ISOFORM 2), VARIANT THR-512.
    Tissue: Lung.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-760 (ISOFORM 3).
    Tissue: Embryo.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496 AND SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZN777_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD5
Secondary accession number(s): Q8N2R2, Q8N659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: March 16, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.