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Protein

Bromodomain and PHD finger-containing protein 3

Gene

BRPF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 262PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri266 – 299C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri323 – 387PHD-type 2PROSITE-ProRule annotationAdd BLAST65

GO - Molecular functioni

GO - Biological processi

  • histone H3 acetylation Source: UniProtKB
  • platelet degranulation Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096070-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain and PHD finger-containing protein 3
Gene namesi
Name:BRPF3
Synonyms:KIAA1286
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14256. BRPF3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular region Source: Reactome
  • MOZ/MORF histone acetyltransferase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000096070.
PharmGKBiPA25425.

Chemistry databases

ChEMBLiCHEMBL3108644.
GuidetoPHARMACOLOGYi2731.

Polymorphism and mutation databases

BioMutaiBRPF3.
DMDMi71153496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111881 – 1205Bromodomain and PHD finger-containing protein 3Add BLAST1205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei447N6-acetyllysineCombined sources1
Modified residuei449N6-acetyllysineCombined sources1
Modified residuei671N6-acetyllysineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei962PhosphoserineCombined sources1
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ULD4.
PaxDbiQ9ULD4.
PeptideAtlasiQ9ULD4.
PRIDEiQ9ULD4.

PTM databases

iPTMnetiQ9ULD4.
PhosphoSitePlusiQ9ULD4.

Expressioni

Gene expression databases

BgeeiENSG00000096070.
CleanExiHS_BRPF3.
ExpressionAtlasiQ9ULD4. baseline and differential.
GenevisibleiQ9ULD4. HS.

Organism-specific databases

HPAiHPA022787.

Interactioni

Subunit structurei

Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1753470,EBI-389883

Protein-protein interaction databases

BioGridi118036. 6 interactors.
IntActiQ9ULD4. 10 interactors.
MINTiMINT-7241520.
STRINGi9606.ENSP00000350267.

Chemistry databases

BindingDBiQ9ULD4.

Structurei

Secondary structure

11205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1079 – 1083Combined sources5
Beta strandi1089 – 1095Combined sources7
Beta strandi1104 – 1106Combined sources3
Beta strandi1109 – 1111Combined sources3
Helixi1116 – 1129Combined sources14
Beta strandi1133 – 1138Combined sources6
Beta strandi1145 – 1149Combined sources5
Helixi1150 – 1152Combined sources3
Beta strandi1153 – 1155Combined sources3
Helixi1160 – 1167Combined sources8
Turni1168 – 1172Combined sources5
Helixi1175 – 1193Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PFSX-ray1.90A/B1056-1195[»]
ProteinModelPortaliQ9ULD4.
SMRiQ9ULD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini606 – 676BromoPROSITE-ProRule annotationAdd BLAST71
Domaini1076 – 1159PWWPPROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi406 – 432Glu-richAdd BLAST27

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 262PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri266 – 299C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri323 – 387PHD-type 2PROSITE-ProRule annotationAdd BLAST65

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5076. LUCA.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
InParanoidiQ9ULD4.
KOiK11350.
OMAiLDADVEY.
OrthoDBiEOG091G00VK.
PhylomeDBiQ9ULD4.
TreeFamiTF316118.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH
60 70 80 90 100
RISIYDPLKI ITEDELTAQD ITECNSNKEN SEQPQFPGKS KKPSSKGKKK
110 120 130 140 150
ESCSKHASGT SFHLPQPSFR MVDSGIQPEA PPLPAAYYRY IEKPPEDLDA
160 170 180 190 200
EVEYDMDEED LAWLDMVNEK RRVDGHSLVS ADTFELLVDR LEKESYLESR
210 220 230 240 250
SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH QECYGVPYIP
260 270 280 290 300
EGQWLCRCCL QSPSRPVDCI LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC
310 320 330 340 350
FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV
360 370 380 390 400
TCAQRAGLFM KIEPMRETSL NGTIFTVRKT AYCEAHSPPG AATARRKGDS
410 420 430 440 450
PRSISETGDE EGLKEGDGEE EEEEEVEEEE QEAQGGVSGS LKGVPKKSKM
460 470 480 490 500
SLKQKIKKEP EEAGQDTPST LPMLAVPQIP SYRLNKICSG LSFQRKNQFM
510 520 530 540 550
QRLHNYWLLK RQARNGVPLI RRLHSHLQSQ RNAEQREQDE KTSAVKEELK
560 570 580 590 600
YWQKLRHDLE RARLLIELIR KREKLKREQV KVQQAAMELE LMPFNVLLRT
610 620 630 640 650
TLDLLQEKDP AHIFAEPVNL SEVPDYLEFI SKPMDFSTMR RKLESHLYRT
660 670 680 690 700
LEEFEEDFNL IVTNCMKYNA KDTIFHRAAV RLRDLGGAIL RHARRQAENI
710 720 730 740 750
GYDPERGTHL PESPKLEDFY RFSWEDVDNI LIPENRAHLS PEVQLKELLE
760 770 780 790 800
KLDLVSAMRS SGARTRRVRL LRREINALRQ KLAQPPPPQP PSLNKTVSNG
810 820 830 840 850
ELPAGPQGDA AVLEQALQEE PEDDGDRDDS KLPPPPTLEP TGPAPSLSEQ
860 870 880 890 900
ESPPEPPTLK PINDSKPPSR FLKPRKVEED ELLEKSPLQL GNEPLQRLLS
910 920 930 940 950
DNGINRLSLM APDTPAGTPL SGVGRRTSVL FKKAKNGVKL QRSPDRVLEN
960 970 980 990 1000
GEDHGVAGSP ASPASIEEER HSRKRPRSRS CSESEGERSP QQEEETGMTN
1010 1020 1030 1040 1050
GFGKHTESGS DSECSLGLSG GLAFEACSGL TPPKRSRGKP ALSRVPFLEG
1060 1070 1080 1090 1100
VNGDSDYNGS GRSLLLPFED RGDLEPLELV WAKCRGYPSY PALIIDPKMP
1110 1120 1130 1140 1150
REGLLHNGVP IPVPPLDVLK LGEQKQAEAG EKLFLVLFFD NKRTWQWLPR
1160 1170 1180 1190 1200
DKVLPLGVED TVDKLKMLEG RKTSIRKSVQ VAYDRAMIHL SRVRGPHSFV

TSSYL
Length:1,205
Mass (Da):135,745
Last modified:July 19, 2005 - v2
Checksum:iF51DCAB253ED35C7
GO
Isoform 2 (identifier: Q9ULD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-996: Missing.

Note: No experimental confirmation available.
Show »
Length:935
Mass (Da):106,187
Checksum:i1BCEE6338BAE1ABB
GO
Isoform 3 (identifier: Q9ULD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     727-996: Missing.
     997-1060: Missing.

Note: No experimental confirmation available.
Show »
Length:871
Mass (Da):99,713
Checksum:iED046A8987D83B7E
GO

Sequence cautioni

The sequence BAA86600 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1075E → K in BAA86600 (PubMed:10574462).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061042177S → G.Corresponds to variant rs45504893dbSNPEnsembl.1
Natural variantiVAR_048431278A → G.Corresponds to variant rs17658935dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055549727 – 996Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST270
Alternative sequenceiVSP_055550997 – 1060Missing in isoform 3. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033112 mRNA. Translation: BAA86600.1. Different initiation.
Z84485 Genomic DNA. Translation: CAI21669.1.
CH471081 Genomic DNA. Translation: EAX03878.1.
BC117387 mRNA. Translation: AAI17388.1.
BC143917 mRNA. Translation: AAI43918.1.
BC143918 mRNA. Translation: AAI43919.1.
CCDSiCCDS34437.1. [Q9ULD4-1]
RefSeqiNP_056510.2. NM_015695.2. [Q9ULD4-1]
XP_005249067.1. XM_005249010.2. [Q9ULD4-1]
XP_005249068.1. XM_005249011.3. [Q9ULD4-1]
XP_011512791.1. XM_011514489.1. [Q9ULD4-1]
UniGeneiHs.520096.

Genome annotation databases

EnsembliENST00000339717; ENSP00000345419; ENSG00000096070. [Q9ULD4-2]
ENST00000357641; ENSP00000350267; ENSG00000096070. [Q9ULD4-1]
ENST00000534694; ENSP00000434501; ENSG00000096070. [Q9ULD4-3]
GeneIDi27154.
KEGGihsa:27154.
UCSCiuc003olv.5. human. [Q9ULD4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033112 mRNA. Translation: BAA86600.1. Different initiation.
Z84485 Genomic DNA. Translation: CAI21669.1.
CH471081 Genomic DNA. Translation: EAX03878.1.
BC117387 mRNA. Translation: AAI17388.1.
BC143917 mRNA. Translation: AAI43918.1.
BC143918 mRNA. Translation: AAI43919.1.
CCDSiCCDS34437.1. [Q9ULD4-1]
RefSeqiNP_056510.2. NM_015695.2. [Q9ULD4-1]
XP_005249067.1. XM_005249010.2. [Q9ULD4-1]
XP_005249068.1. XM_005249011.3. [Q9ULD4-1]
XP_011512791.1. XM_011514489.1. [Q9ULD4-1]
UniGeneiHs.520096.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PFSX-ray1.90A/B1056-1195[»]
ProteinModelPortaliQ9ULD4.
SMRiQ9ULD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118036. 6 interactors.
IntActiQ9ULD4. 10 interactors.
MINTiMINT-7241520.
STRINGi9606.ENSP00000350267.

Chemistry databases

BindingDBiQ9ULD4.
ChEMBLiCHEMBL3108644.
GuidetoPHARMACOLOGYi2731.

PTM databases

iPTMnetiQ9ULD4.
PhosphoSitePlusiQ9ULD4.

Polymorphism and mutation databases

BioMutaiBRPF3.
DMDMi71153496.

Proteomic databases

EPDiQ9ULD4.
PaxDbiQ9ULD4.
PeptideAtlasiQ9ULD4.
PRIDEiQ9ULD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339717; ENSP00000345419; ENSG00000096070. [Q9ULD4-2]
ENST00000357641; ENSP00000350267; ENSG00000096070. [Q9ULD4-1]
ENST00000534694; ENSP00000434501; ENSG00000096070. [Q9ULD4-3]
GeneIDi27154.
KEGGihsa:27154.
UCSCiuc003olv.5. human. [Q9ULD4-1]

Organism-specific databases

CTDi27154.
GeneCardsiBRPF3.
H-InvDBHIX0005816.
HIX0200828.
HGNCiHGNC:14256. BRPF3.
HPAiHPA022787.
neXtProtiNX_Q9ULD4.
OpenTargetsiENSG00000096070.
PharmGKBiPA25425.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5076. LUCA.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000000705.
HOVERGENiHBG004895.
InParanoidiQ9ULD4.
KOiK11350.
OMAiLDADVEY.
OrthoDBiEOG091G00VK.
PhylomeDBiQ9ULD4.
TreeFamiTF316118.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096070-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-3214847. HATs acetylate histones.
R-HSA-6804758. Regulation of TP53 Activity through Acetylation.

Miscellaneous databases

ChiTaRSiBRPF3. human.
GenomeRNAii27154.
PROiQ9ULD4.

Gene expression databases

BgeeiENSG00000096070.
CleanExiHS_BRPF3.
ExpressionAtlasiQ9ULD4. baseline and differential.
GenevisibleiQ9ULD4. HS.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR000313. PWWP_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
SM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS50812. PWWP. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRPF3_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD4
Secondary accession number(s): A6ND56
, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.