Q9ULD2 (MTUS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated tumor suppressor 1

Alternative name(s):
AT2 receptor-binding protein
Angiotensin-II type 2 receptor-interacting protein
Mitochondrial tumor suppressor 1

Gene names

Name:	MTUS1
Synonyms:	ATBP, ATIP, GK1, KIAA1288, MTSG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1270 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. Ref.2 Ref.16
Subunit structure	Homodimer. Interacts with AGTR2. Interacts with PTPN6 By similarity. Isoform 1 associates with microtubules. Ref.3
Subcellular location	Mitochondrion. Golgi apparatus By similarity. Cell membrane By similarity. Nucleus By similarity. Note: In neurons, translocates into the nucleus after treatment with angiotensin-II By similarity. Ref.1 Ref.2 Ref.16 Isoform 1: Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle. Note: Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis. Ref.1 Ref.2 Ref.16
Tissue specificity	Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. Ref.1 Ref.2 Ref.3 Ref.11 Ref.12 Ref.13 Ref.20
Induction	Isoform 1 is down-regulated in invasive breast carcinomas (at protein level). Ref.16
Involvement in disease	Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. Note: The gene represented in this entry may be involved in disease pathogenesis. Ref.19
Sequence similarities	Belongs to the MTUS1 family.
Sequence caution	The sequence AAH07328.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence AAH33842.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14894.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Cytoskeleton Golgi apparatus Membrane Microtubule Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Tumor suppressor
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULD2-1)

Also known as: ATIP3a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9ULD2-2)

Also known as: ATIP3b;

The sequence of this isoform differs from the canonical sequence as follows:
     763-817: GKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTGSTPSIASTHSELSTYSNNS → A

Isoform 3 (identifier: Q9ULD2-3)

Also known as: ATIP1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-834: Missing.
     835-874: QNGSSGSFYL...RKNLFTALNA → MLLSPKFSLS...FRRSTVVFHT

Isoform 4 (identifier: Q9ULD2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-928: Missing.
     929-946: GNTKFEALTVVIQHLLSE → MGCPSSKLCLYSPCAATR

Isoform 5 (identifier: Q9ULD2-5)

Also known as: ATIP2;

The sequence of this isoform differs from the canonical sequence as follows:
     763-770: GKPTSLKT → VLPKAAFS
     771-1270: Missing.

Note: Expressed at very low levels in most tissues.

Isoform 6 (identifier: Q9ULD2-6)

Also known as: ATIP4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.
     754-817: QRIRRVSSSG...SELSTYSNNS → MTVPGGFRSC...LLATFTGKKT

Isoform 7 (identifier: Q9ULD2-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-855: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1270	1270	Microtubule-associated tumor suppressor 1		PRO_0000305197
Regions
	Coiled coil	940 – 1231	292	Potential
Amino acid modifications
	Modified residue	381	1	Phosphoserine By similarity
	Modified residue	620	1	Phosphoserine By similarity
	Modified residue	1224	1	Phosphoserine Ref.18
	Modified residue	1245	1	Phosphoserine By similarity
	Modified residue	1255	1	Phosphoserine By similarity
	Modified residue	1264	1	Phosphoserine Ref.17
	Modified residue	1266	1	Phosphoserine By similarity
	Modified residue	1268	1	Phosphoserine Ref.17 Ref.18
Natural variations
	Alternative sequence	1 – 928	928	Missing in isoform 4.		VSP_028270
	Alternative sequence	1 – 855	855	Missing in isoform 7.		VSP_044849
	Alternative sequence	1 – 834	834	Missing in isoform 3.		VSP_028271
	Alternative sequence	1 – 753	753	Missing in isoform 6.		VSP_028272
	Alternative sequence	754 – 817	64	QRIRR…YSNNS → MTVPGGFRSCTETDISSKIF INSTLTPPAGSERHYDATLL TLLVVGSYSLCIIPLLATFT GKKT in isoform 6.		VSP_028273
	Alternative sequence	763 – 817	55	GKPTS…YSNNS → A in isoform 2.		VSP_028274
	Alternative sequence	763 – 770	8	GKPTSLKT → VLPKAAFS in isoform 5.		VSP_028275
	Alternative sequence	771 – 1270	500	Missing in isoform 5.		VSP_028276
	Alternative sequence	835 – 874	40	QNGSS…TALNA → MLLSPKFSLSTIHIRLTAKG LLRNLRLPSGFRRSTVVFHT in isoform 3.		VSP_028277
	Alternative sequence	929 – 946	18	GNTKF…HLLSE → MGCPSSKLCLYSPCAATR in isoform 4.		VSP_028278
	Natural variant	75	1	Q → K in HCC. Ref.19		VAR_035173
	Natural variant	148	1	C → R. Ref.7 Ref.8 Ref.9 Ref.19 Ref.20 Corresponds to variant rs3739407 [ dbSNP | Ensembl ].		VAR_035174
	Natural variant	186	1	T → S in HNSCC cell lines. Ref.20		VAR_035175
	Natural variant	425	1	T → M. Ref.19		VAR_035176
	Natural variant	453	1	K → T. Ref.19 Ref.20 Corresponds to variant rs17690844 [ dbSNP | Ensembl ].		VAR_035177
	Natural variant	563	1	A → S in HCC. Ref.19		VAR_035178
	Natural variant	575	1	H → R. Ref.9 Ref.19 Corresponds to variant rs209569 [ dbSNP | Ensembl ].		VAR_035179
	Natural variant	873	1	N → H in HCC. Ref.19		VAR_035180
	Natural variant	911	1	K → T. Ref.19		VAR_035181
	Natural variant	1063	1	K → T. Ref.8 Corresponds to variant rs17853231 [ dbSNP | Ensembl ].		VAR_035182
	Natural variant	1105	1	E → Q. Ref.19		VAR_035183
	Natural variant	1201	1	Q → R in HCC. Ref.19		VAR_035184
Experimental info
	Sequence conflict	266	1	C → G in CAB50791. Ref.5
	Sequence conflict	918	1	F → L in BAG37243. Ref.4
	Sequence conflict	999	1	E → G in CAH56128. Ref.5
	Sequence conflict	1149	1	I → T in BAB14894. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ATIP3a) [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 2EAE962F627BFFE3	FASTA	1,270	141,397
	10 20 30 40 50 60 MTDDNSDDKI EDELQTFFTS DKDGNTHAYN PKSPPTQNSS ASSVNWNSAN PDDMVVDYET 70 80 90 100 110 120 DPAVVTGENI SLSLQGVEVF GHEKSSSDFI SKQVLDMHKD SICQCPALVG TEKPKYLQHS 130 140 150 160 170 180 CHSLEAVEGQ SVEPSLPFVW KPNDNLNCAG YCDALELNQT FDMTVDKVNC TFISHHAIGK 190 200 210 220 230 240 SQSFHTAGSL PPTGRRSGST SSLSYSTWTS SHSDKTHARE TTYDRESFEN PQVTPSEAQD 250 260 270 280 290 300 MTYTAFSDVV MQSEVFVSDI GNQCACSSGK VTSEYTDGSQ QRLVGEKETQ ALTPVSDGME 310 320 330 340 350 360 VPNDSALQEF FCLSHDESNS EPHSQSSYRH KEMGQNLRET VSYCLIDDEC PLMVPAFDKS 370 380 390 400 410 420 EAQVLNPEHK VTETEDTQMV SKGKDLGTQN HTSELILSSP PGQKVGSSFG LTWDANDMVI 430 440 450 460 470 480 STDKTMCMST PVLEPTKVTF SVSPIEATEK CKKVEKGNRG LKNIPDSKEA PVNLCKPSLG 490 500 510 520 530 540 KSTIKTNTPI GCKVRKTEII SYPRPNFKNV KAKVMSRAVL QPKDAALSKV TPRPQQTSAS 550 560 570 580 590 600 SPSSVNSRQQ TVLSRTPRSD LNADKKAEIL INKTHKQQFN KLITSQAVHV TTHSKNASHR 610 620 630 640 650 660 VPRTTSAVKS NQEDVDKASS SNSACETGSV SALFQKIKGI LPVKMESAEC LEMTYVPNID 670 680 690 700 710 720 RISPEKKGEK ENGTSMEKQE LKQEIMNETF EYGSLFLGSA SKTTTTSGRN ISKPDSCGLR 730 740 750 760 770 780 QIAAPKAKVG PPVSCLRRNS DNRNPSADRA VSPQRIRRVS SSGKPTSLKT AQSSWVNLPR 790 800 810 820 830 840 PLPKSKASLK SPALRRTGST PSIASTHSEL STYSNNSGNA AVIKYEEKPP KPAFQNGSSG 850 860 870 880 890 900 SFYLKPLVSR AHVHLMKTPP KGPSRKNLFT ALNAVEKSRQ KNPRSLCIQP QTAPDALPPE 910 920 930 940 950 960 KTLELTQYKT KCENQSGFIL QLKQLLACGN TKFEALTVVI QHLLSEREEA LKQHKTLSQE 970 980 990 1000 1010 1020 LVNLRGELVT ASTTCEKLEK ARNELQTVYE AFVQQHQAEK TERENRLKEF YTREYEKLRD 1030 1040 1050 1060 1070 1080 TYIEEAEKYK MQLQEQFDNL NAAHETSKLE IEASHSEKLE LLKKAYEASL SEIKKGHEIE 1090 1100 1110 1120 1130 1140 KKSLEDLLSE KQESLEKQIN DLKSENDALN EKLKSEEQKR RAREKANLKN PQIMYLEQEL 1150 1160 1170 1180 1190 1200 ESLKAVLEIK NEKLHQQDIK LMKMEKLVDN NTALVDKLKR FQQENEELKA RMDKHMAISR 1210 1220 1230 1240 1250 1260 QLSTEQAVLQ ESLEKESKVN KRLSMENEEL LWKLHNGDLC SPKRSPTSSA IPLQSPRNSG 1270 SFPSPSISPR
	Isoform 2 (ATIP3b) [UniParc]. Checksum: ECC10DC1CA22BF72	FASTA	1,216	135,661
	10 20 30 40 50 60 MTDDNSDDKI EDELQTFFTS DKDGNTHAYN PKSPPTQNSS ASSVNWNSAN PDDMVVDYET 70 80 90 100 110 120 DPAVVTGENI SLSLQGVEVF GHEKSSSDFI SKQVLDMHKD SICQCPALVG TEKPKYLQHS 130 140 150 160 170 180 CHSLEAVEGQ SVEPSLPFVW KPNDNLNCAG YCDALELNQT FDMTVDKVNC TFISHHAIGK 190 200 210 220 230 240 SQSFHTAGSL PPTGRRSGST SSLSYSTWTS SHSDKTHARE TTYDRESFEN PQVTPSEAQD 250 260 270 280 290 300 MTYTAFSDVV MQSEVFVSDI GNQCACSSGK VTSEYTDGSQ QRLVGEKETQ ALTPVSDGME 310 320 330 340 350 360 VPNDSALQEF FCLSHDESNS EPHSQSSYRH KEMGQNLRET VSYCLIDDEC PLMVPAFDKS 370 380 390 400 410 420 EAQVLNPEHK VTETEDTQMV SKGKDLGTQN HTSELILSSP PGQKVGSSFG LTWDANDMVI 430 440 450 460 470 480 STDKTMCMST PVLEPTKVTF SVSPIEATEK CKKVEKGNRG LKNIPDSKEA PVNLCKPSLG 490 500 510 520 530 540 KSTIKTNTPI GCKVRKTEII SYPRPNFKNV KAKVMSRAVL QPKDAALSKV TPRPQQTSAS 550 560 570 580 590 600 SPSSVNSRQQ TVLSRTPRSD LNADKKAEIL INKTHKQQFN KLITSQAVHV TTHSKNASHR 610 620 630 640 650 660 VPRTTSAVKS NQEDVDKASS SNSACETGSV SALFQKIKGI LPVKMESAEC LEMTYVPNID 670 680 690 700 710 720 RISPEKKGEK ENGTSMEKQE LKQEIMNETF EYGSLFLGSA SKTTTTSGRN ISKPDSCGLR 730 740 750 760 770 780 QIAAPKAKVG PPVSCLRRNS DNRNPSADRA VSPQRIRRVS SSAGNAAVIK YEEKPPKPAF 790 800 810 820 830 840 QNGSSGSFYL KPLVSRAHVH LMKTPPKGPS RKNLFTALNA VEKSRQKNPR SLCIQPQTAP 850 860 870 880 890 900 DALPPEKTLE LTQYKTKCEN QSGFILQLKQ LLACGNTKFE ALTVVIQHLL SEREEALKQH 910 920 930 940 950 960 KTLSQELVNL RGELVTASTT CEKLEKARNE LQTVYEAFVQ QHQAEKTERE NRLKEFYTRE 970 980 990 1000 1010 1020 YEKLRDTYIE EAEKYKMQLQ EQFDNLNAAH ETSKLEIEAS HSEKLELLKK AYEASLSEIK 1030 1040 1050 1060 1070 1080 KGHEIEKKSL EDLLSEKQES LEKQINDLKS ENDALNEKLK SEEQKRRARE KANLKNPQIM 1090 1100 1110 1120 1130 1140 YLEQELESLK AVLEIKNEKL HQQDIKLMKM EKLVDNNTAL VDKLKRFQQE NEELKARMDK 1150 1160 1170 1180 1190 1200 HMAISRQLST EQAVLQESLE KESKVNKRLS MENEELLWKL HNGDLCSPKR SPTSSAIPLQ 1210 SPRNSGSFPS PSISPR
	Isoform 3 (ATIP1) [UniParc]. Checksum: 196002F8C8D9A6DD	FASTA	436	50,544
	10 20 30 40 50 60 MLLSPKFSLS TIHIRLTAKG LLRNLRLPSG FRRSTVVFHT VEKSRQKNPR SLCIQPQTAP 70 80 90 100 110 120 DALPPEKTLE LTQYKTKCEN QSGFILQLKQ LLACGNTKFE ALTVVIQHLL SEREEALKQH 130 140 150 160 170 180 KTLSQELVNL RGELVTASTT CEKLEKARNE LQTVYEAFVQ QHQAEKTERE NRLKEFYTRE 190 200 210 220 230 240 YEKLRDTYIE EAEKYKMQLQ EQFDNLNAAH ETSKLEIEAS HSEKLELLKK AYEASLSEIK 250 260 270 280 290 300 KGHEIEKKSL EDLLSEKQES LEKQINDLKS ENDALNEKLK SEEQKRRARE KANLKNPQIM 310 320 330 340 350 360 YLEQELESLK AVLEIKNEKL HQQDIKLMKM EKLVDNNTAL VDKLKRFQQE NEELKARMDK 370 380 390 400 410 420 HMAISRQLST EQAVLQESLE KESKVNKRLS MENEELLWKL HNGDLCSPKR SPTSSAIPLQ 430 SPRNSGSFPS PSISPR
	Isoform 4 [UniParc]. Checksum: 20C0995FFE927E24	FASTA	342	39,775
	10 20 30 40 50 60 MGCPSSKLCL YSPCAATRRE EALKQHKTLS QELVNLRGEL VTASTTCEKL EKARNELQTV 70 80 90 100 110 120 YEAFVQQHQA EKTERENRLK EFYTREYEKL RDTYIEEAEK YKMQLQEQFD NLNAAHETSK 130 140 150 160 170 180 LEIEASHSEK LELLKKAYEA SLSEIKKGHE IEKKSLEDLL SEKQESLEKQ INDLKSENDA 190 200 210 220 230 240 LNEKLKSEEQ KRRAREKANL KNPQIMYLEQ ELESLKAVLE IKNEKLHQQD IKLMKMEKLV 250 260 270 280 290 300 DNNTALVDKL KRFQQENEEL KARMDKHMAI SRQLSTEQAV LQESLEKESK VNKRLSMENE 310 320 330 340 ELLWKLHNGD LCSPKRSPTS SAIPLQSPRN SGSFPSPSIS PR
	Isoform 5 (ATIP2) [UniParc]. Checksum: 46E8EA82686165D8	FASTA	770	84,252
	10 20 30 40 50 60 MTDDNSDDKI EDELQTFFTS DKDGNTHAYN PKSPPTQNSS ASSVNWNSAN PDDMVVDYET 70 80 90 100 110 120 DPAVVTGENI SLSLQGVEVF GHEKSSSDFI SKQVLDMHKD SICQCPALVG TEKPKYLQHS 130 140 150 160 170 180 CHSLEAVEGQ SVEPSLPFVW KPNDNLNCAG YCDALELNQT FDMTVDKVNC TFISHHAIGK 190 200 210 220 230 240 SQSFHTAGSL PPTGRRSGST SSLSYSTWTS SHSDKTHARE TTYDRESFEN PQVTPSEAQD 250 260 270 280 290 300 MTYTAFSDVV MQSEVFVSDI GNQCACSSGK VTSEYTDGSQ QRLVGEKETQ ALTPVSDGME 310 320 330 340 350 360 VPNDSALQEF FCLSHDESNS EPHSQSSYRH KEMGQNLRET VSYCLIDDEC PLMVPAFDKS 370 380 390 400 410 420 EAQVLNPEHK VTETEDTQMV SKGKDLGTQN HTSELILSSP PGQKVGSSFG LTWDANDMVI 430 440 450 460 470 480 STDKTMCMST PVLEPTKVTF SVSPIEATEK CKKVEKGNRG LKNIPDSKEA PVNLCKPSLG 490 500 510 520 530 540 KSTIKTNTPI GCKVRKTEII SYPRPNFKNV KAKVMSRAVL QPKDAALSKV TPRPQQTSAS 550 560 570 580 590 600 SPSSVNSRQQ TVLSRTPRSD LNADKKAEIL INKTHKQQFN KLITSQAVHV TTHSKNASHR 610 620 630 640 650 660 VPRTTSAVKS NQEDVDKASS SNSACETGSV SALFQKIKGI LPVKMESAEC LEMTYVPNID 670 680 690 700 710 720 RISPEKKGEK ENGTSMEKQE LKQEIMNETF EYGSLFLGSA SKTTTTSGRN ISKPDSCGLR 730 740 750 760 770 QIAAPKAKVG PPVSCLRRNS DNRNPSADRA VSPQRIRRVS SSVLPKAAFS
	Isoform 6 (ATIP4) [UniParc]. Checksum: 43755CC4B064F012	FASTA	517	58,988
	10 20 30 40 50 60 MTVPGGFRSC TETDISSKIF INSTLTPPAG SERHYDATLL TLLVVGSYSL CIIPLLATFT 70 80 90 100 110 120 GKKTGNAAVI KYEEKPPKPA FQNGSSGSFY LKPLVSRAHV HLMKTPPKGP SRKNLFTALN 130 140 150 160 170 180 AVEKSRQKNP RSLCIQPQTA PDALPPEKTL ELTQYKTKCE NQSGFILQLK QLLACGNTKF 190 200 210 220 230 240 EALTVVIQHL LSEREEALKQ HKTLSQELVN LRGELVTAST TCEKLEKARN ELQTVYEAFV 250 260 270 280 290 300 QQHQAEKTER ENRLKEFYTR EYEKLRDTYI EEAEKYKMQL QEQFDNLNAA HETSKLEIEA 310 320 330 340 350 360 SHSEKLELLK KAYEASLSEI KKGHEIEKKS LEDLLSEKQE SLEKQINDLK SENDALNEKL 370 380 390 400 410 420 KSEEQKRRAR EKANLKNPQI MYLEQELESL KAVLEIKNEK LHQQDIKLMK MEKLVDNNTA 430 440 450 460 470 480 LVDKLKRFQQ ENEELKARMD KHMAISRQLS TEQAVLQESL EKESKVNKRL SMENEELLWK 490 500 510 LHNGDLCSPK RSPTSSAIPL QSPRNSGSFP SPSISPR
	Isoform 7 [UniParc]. Checksum: 91955F97EA18D77D	FASTA	415	48,050
	10 20 30 40 50 60 MKTPPKGPSR KNLFTALNAV EKSRQKNPRS LCIQPQTAPD ALPPEKTLEL TQYKTKCENQ 70 80 90 100 110 120 SGFILQLKQL LACGNTKFEA LTVVIQHLLS EREEALKQHK TLSQELVNLR GELVTASTTC 130 140 150 160 170 180 EKLEKARNEL QTVYEAFVQQ HQAEKTEREN RLKEFYTREY EKLRDTYIEE AEKYKMQLQE 190 200 210 220 230 240 QFDNLNAAHE TSKLEIEASH SEKLELLKKA YEASLSEIKK GHEIEKKSLE DLLSEKQESL 250 260 270 280 290 300 EKQINDLKSE NDALNEKLKS EEQKRRAREK ANLKNPQIMY LEQELESLKA VLEIKNEKLH 310 320 330 340 350 360 QQDIKLMKME KLVDNNTALV DKLKRFQQEN EELKARMDKH MAISRQLSTE QAVLQESLEK 370 380 390 400 410 ESKVNKRLSM ENEELLWKLH NGDLCSPKRS PTSSAIPLQS PRNSGSFPSP SISPR

References

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[1]	"Molecular cloning and characterization of two novel genes on chromosome 8p21.3." Kinjo T., Isomura M., Iwamasa T., Nakamura Y. J. Hum. Genet. 45:12-17(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[2]	"Identification of a new tumor suppressor gene located at chromosome 8p21.3-22." Seibold S., Rudroff C., Weber M., Galle J., Wanner C., Marx M. FASEB J. 17:1180-1182(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]	"Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP." Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., Alleaume A.-M., Di Benedetto M., Boden C., Masson M., Strosberg A.D., Horiuchi M., Couraud P.-O., Nahmias C. J. Biol. Chem. 279:28989-28997(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 1; 5 AND 6), SUBUNIT, TISSUE SPECIFICITY. Tissue: Lung.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6 AND 7), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 875-1270 (ISOFORM 1). Tissue: Brain, Fetal brain and Placenta.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 266-1270 (ISOFORM 5). Tissue: Salivary gland and Uterus.
[6]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-148.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS ARG-148 AND THR-1063. Tissue: Ovary, Skin and Testis.
[9]	"Differential expression in normal trophoblast and gestational tumors." Abadie P.A., Genti-Raimondi S. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-891 (ISOFORM 2), VARIANTS ARG-148 AND ARG-575.
[10]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-1270 (ISOFORM 1). Tissue: Brain.
[11]	"Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival." Pils D., Horak P., Gleiss A., Sax C., Fabjani G., Moebus V.J., Zielinski C., Reinthaller A., Zeillinger R., Krainer M. Cancer 104:2417-2429(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[12]	"Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP." Di Benedetto M., Bieche I., Deshayes F., Vacher S., Nouet S., Collura V., Seitz I., Louis S., Pineau P., Amsellem-Ouazana D., Couraud P.-O., Strosberg A.D., Stoppa-Lyonnet D., Lidereau R., Nahmias C. Gene 380:127-136(2006) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[13]	"Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon." Lee S., Bang S., Song K., Lee I. Oncol. Rep. 16:747-754(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[15]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"8p22 MTUS1 gene product ATIP3 is a novel anti-mitotic protein underexpressed in invasive breast carcinoma of poor prognosis." Rodrigues-Ferreira S., Di Tommaso A., Dimitrov A., Cazaubon S., Gruel N., Colasson H., Nicolas A., Chaverot N., Molinie V., Reyal F., Sigal-Zafrani B., Terris B., Delattre O., Radvanyi F., Perez F., Vincent-Salomon A., Nahmias C. PLoS ONE 4:E7239-E7239(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, ASSOCIATION WITH MICROTUBULES, SUBCELLULAR LOCATION, INDUCTION.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1264 AND SER-1268, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[18]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1224 AND SER-1268, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma." Di Benedetto M., Pineau P., Nouet S., Berhouet S., Seitz I., Louis S., Dejean A., Couraud P.-O., Strosberg A.D., Stoppa-Lyonnet D., Nahmias C. Mol. Cell. Endocrinol. 252:207-215(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HCC LYS-75; SER-563; HIS-873 AND ARG-1201, VARIANTS ARG-148; MET-425; THR-453; ARG-575; THR-911 AND GLN-1105.
[20]	"Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma." Ye H., Pungpravat N., Huang B.-L., Muzio L.L., Mariggio M.A., Chen Z., Wong D.T., Zhou X. Cancer Genet. Cytogenet. 176:100-106(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ARG-148 AND THR-453, VARIANT HNSCC SER-186, TISSUE SPECIFICITY.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF121259 mRNA. Translation: AAG33674.1. AF293357 mRNA. Translation: AAL37035.1. AK024357 mRNA. Translation: BAB14894.1. Different initiation. AK125188 mRNA. Translation: BAG54161.1. AK289750 mRNA. Translation: BAF82439.1. AK294860 mRNA. Translation: BAG57964.1. AK314692 mRNA. Translation: BAG37243.1. AL096842 mRNA. Translation: CAB50791.1. BX648879 mRNA. Translation: CAH56128.1. AC027117 Genomic DNA. No translation available. AC124069 Genomic DNA. No translation available. CH471080 Genomic DNA. Translation: EAW63804.1. CH471080 Genomic DNA. Translation: EAW63805.1. CH471080 Genomic DNA. Translation: EAW63810.1. BC007328 mRNA. Translation: AAH07328.1. Sequence problems. BC033842 mRNA. Translation: AAH33842.1. Different initiation. BC136320 mRNA. Translation: AAI36321.1. BC142971 mRNA. Translation: AAI42972.1. AY363099 mRNA. Translation: AAQ24172.1. AB033114 mRNA. Translation: BAA86602.1.
IPI	IPI00102820. IPI00428447. IPI00428450. IPI00470640. IPI00472533. IPI00867528. IPI00953513.
RefSeq	NP_001001924.1. NM_001001924.2. NP_001001925.1. NM_001001925.2. NP_001001931.1. NM_001001931.2. NP_001159865.1. NM_001166393.1. NP_065800.1. NM_020749.4.
UniGene	Hs.7946.
3D structure databases
ProteinModelPortal	Q9ULD2.
SMR	Q9ULD2. Positions 1205-1232.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULD2. 2 interactions.
PTM databases
PhosphoSite	Q9ULD2.
Polymorphism databases
DMDM	158706128.
Proteomic databases
PaxDb	Q9ULD2.
PRIDE	Q9ULD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262102; ENSP00000262102; ENSG00000129422. ENST00000297488; ENSP00000297488; ENSG00000129422. ENST00000381861; ENSP00000371285; ENSG00000129422. ENST00000381862; ENSP00000371286; ENSG00000129422. ENST00000381869; ENSP00000371293; ENSG00000129422. ENST00000400046; ENSP00000382921; ENSG00000129422. ENST00000519263; ENSP00000430167; ENSG00000129422. ENST00000544260; ENSP00000445738; ENSG00000129422.
GeneID	57509.
KEGG	hsa:57509.
UCSC	uc003wxs.3. human. uc003wxt.3. human. uc003wxv.3. human. uc003wxw.3. human.
Organism-specific databases
CTD	57509.
GeneCards	GC08M017501.
HGNC	HGNC:29789. MTUS1.
MIM	114550. phenotype. 609589. gene.
neXtProt	NX_Q9ULD2.
PharmGKB	PA134968054.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG117251.
HOVERGEN	HBG108158.
InParanoid	Q9ULD2.
OMA	IHVRLTA.
Gene expression databases
ArrayExpress	Q9ULD2.
Bgee	Q9ULD2.
CleanEx	HS_MTUS1.
Genevestigator	Q9ULD2.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	MTUS1. human.
GenomeRNAi	57509.
NextBio	63856.
SOURCE	Search...

Entry information

Entry name

MTUS1_HUMAN

Accession

Primary (citable) accession number: Q9ULD2
Secondary accession number(s): A8K135 , B2RBJ6, B3KWJ9, B4DH03, B9EGA1, D3DSP8, Q63HJ6, Q659F4, Q6PK49, Q6URW7, Q8N4M6, Q8WTT9, Q9H7T2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.