Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9ULD0

- OGDHL_HUMAN

UniProt

Q9ULD0 - OGDHL_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

2-oxoglutarate dehydrogenase-like, mitochondrial

Gene

OGDHL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411CalciumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi141 – 1455By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  3. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Calcium, Metal-binding, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase-like, mitochondrial (EC:1.2.4.-)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1-like
Short name:
OGDC-E1-like
Alpha-ketoglutarate dehydrogenase-like
Gene namesi
Name:OGDHL
Synonyms:KIAA1290
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:25590. OGDHL.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7373MitochondrionSequence AnalysisAdd
BLAST
Chaini74 – 10109372-oxoglutarate dehydrogenase-like, mitochondrialPRO_0000310983Add
BLAST

Proteomic databases

MaxQBiQ9ULD0.
PaxDbiQ9ULD0.
PRIDEiQ9ULD0.

PTM databases

PhosphoSiteiQ9ULD0.

Expressioni

Gene expression databases

BgeeiQ9ULD0.
CleanExiHS_OGDHL.
GenevestigatoriQ9ULD0.

Organism-specific databases

HPAiHPA052497.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
STAT3P407632EBI-3940481,EBI-518675

Protein-protein interaction databases

BioGridi120871. 7 interactions.
IntActiQ9ULD0. 2 interactions.
MINTiMINT-3043902.
STRINGi9606.ENSP00000363216.

Structurei

3D structure databases

ProteinModelPortaliQ9ULD0.
SMRiQ9ULD0. Positions 111-1000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 484Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0567.
GeneTreeiENSGT00530000063092.
HOGENOMiHOG000259586.
HOVERGENiHBG001892.
InParanoidiQ9ULD0.
KOiK00164.
OMAiDMTRKRT.
OrthoDBiEOG7FXZXH.
PhylomeDBiQ9ULD0.
TreeFamiTF300695.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9ULD0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQLRLLPSR LGVQAARLLA AHDVPVFGWR SRSSGPPATF PSSKGGGGSS
60 70 80 90 100
YMEEMYFAWL ENPQSVHKSW DSFFREASEE AFSGSAQPRP PSVVHESRSA
110 120 130 140 150
VSSRTKTSKL VEDHLAVQSL IRAYQIRGHH VAQLDPLGIL DADLDSFVPS
160 170 180 190 200
DLITTIDKLA FYDLQEADLD KEFQLPTTTF IGGSENTLSL REIIRRLENT
210 220 230 240 250
YCQHIGLEFM FINDVEQCQW IRQKFETPGV MQFSSEEKRT LLARLVRSMR
260 270 280 290 300
FEDFLARKWS SEKRFGLEGC EVMIPALKTI IDKSSEMGIE NVILGMPHRG
310 320 330 340 350
RLNVLANVIR KDLEQIFCQF DPKLEAADEG SGDVKYHLGM YHERINRVTN
360 370 380 390 400
RNITLSLVAN PSHLEAVDPV VQGKTKAEQF YRGDAQGKKV MSILVHGDAA
410 420 430 440 450
FAGQGVVYET FHLSDLPSYT TNGTVHVVVN NQIGFTTDPR MARSSPYPTD
460 470 480 490 500
VARVVNAPIF HVNADDPEAV IYVCSVAAEW RNTFNKDVVV DLVCYRRRGH
510 520 530 540 550
NEMDEPMFTQ PLMYKQIHRQ VPVLKKYADK LIAEGTVTLQ EFEEEIAKYD
560 570 580 590 600
RICEEAYGRS KDKKILHIKH WLDSPWPGFF NVDGEPKSMT CPATGIPEDM
610 620 630 640 650
LTHIGSVASS VPLEDFKIHT GLSRILRGRA DMTKNRTVDW ALAEYMAFGS
660 670 680 690 700
LLKEGIHVRL SGQDVERGTF SHRHHVLHDQ EVDRRTCVPM NHLWPDQAPY
710 720 730 740 750
TVCNSSLSEY GVLGFELGYA MASPNALVLW EAQFGDFHNT AQCIIDQFIS
760 770 780 790 800
TGQAKWVRHN GIVLLLPHGM EGMGPEHSSA RPERFLQMSN DDSDAYPAFT
810 820 830 840 850
KDFEVSQLYD CNWIVVNCST PANYFHVLRR QILLPFRKPL IIFTPKSLLR
860 870 880 890 900
HPEAKSSFDQ MVSGTSFQRV IPEDGAAARA PEQVQRLIFC TGKVYYDLVK
910 920 930 940 950
ERSSQDLEEK VAITRLEQIS PFPFDLIKQE AEKYPGAELA WCQEEHKNMG
960 970 980 990 1000
YYDYISPRFM TILRRARPIW YVGRDPAAAP ATGNRNTHLV SLKKFLDTAF
1010
NLQAFEGKTF
Length:1,010
Mass (Da):114,481
Last modified:November 13, 2007 - v3
Checksum:i95A836DE079E804C
GO
Isoform 2 (identifier: Q9ULD0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-125: Missing.

Show »
Length:953
Mass (Da):108,148
Checksum:i70EB6121D698658F
GO
Isoform 3 (identifier: Q9ULD0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:801
Mass (Da):91,232
Checksum:i611D2A4D3E43C51B
GO

Sequence cautioni

The sequence BAA86604.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971S → G in BAA91855. (PubMed:14702039)Curated
Sequence conflicti319 – 3191Q → R in BAA91855. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti511 – 5111P → L.1 Publication
Corresponds to variant rs17856755 [ dbSNP | Ensembl ].
VAR_037125
Natural varianti573 – 5731D → N.1 Publication
Corresponds to variant rs17852386 [ dbSNP | Ensembl ].
VAR_037126
Natural varianti623 – 6231S → C.
Corresponds to variant rs34877195 [ dbSNP | Ensembl ].
VAR_037127
Natural varianti637 – 6371T → M.1 Publication
Corresponds to variant rs11101224 [ dbSNP | Ensembl ].
VAR_037128
Natural varianti725 – 7251N → S.
Corresponds to variant rs2293239 [ dbSNP | Ensembl ].
VAR_037129

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 209209Missing in isoform 3. 1 PublicationVSP_041351Add
BLAST
Alternative sequencei69 – 12557Missing in isoform 2. 1 PublicationVSP_041350Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033116 mRNA. Translation: BAA86604.2. Different initiation.
AK001713 mRNA. Translation: BAA91855.1.
AK290226 mRNA. Translation: BAF82915.1.
AK296551 mRNA. Translation: BAG59174.1.
AK303729 mRNA. Translation: BAG64705.1.
AC069546 Genomic DNA. No translation available.
BC026320 mRNA. Translation: AAH26320.1.
CCDSiCCDS44390.1. [Q9ULD0-2]
CCDS44391.1. [Q9ULD0-3]
CCDS7234.1. [Q9ULD0-1]
RefSeqiNP_001137468.1. NM_001143996.1. [Q9ULD0-2]
NP_001137469.1. NM_001143997.1. [Q9ULD0-3]
NP_060715.2. NM_018245.2. [Q9ULD0-1]
UniGeneiHs.17860.

Genome annotation databases

EnsembliENST00000374103; ENSP00000363216; ENSG00000197444. [Q9ULD0-1]
ENST00000419399; ENSP00000401356; ENSG00000197444. [Q9ULD0-2]
ENST00000432695; ENSP00000390240; ENSG00000197444. [Q9ULD0-3]
GeneIDi55753.
KEGGihsa:55753.
UCSCiuc001jie.3. human. [Q9ULD0-1]
uc009xoh.2. human. [Q9ULD0-3]
uc010qgt.2. human. [Q9ULD0-2]

Polymorphism databases

DMDMi160419019.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033116 mRNA. Translation: BAA86604.2 . Different initiation.
AK001713 mRNA. Translation: BAA91855.1 .
AK290226 mRNA. Translation: BAF82915.1 .
AK296551 mRNA. Translation: BAG59174.1 .
AK303729 mRNA. Translation: BAG64705.1 .
AC069546 Genomic DNA. No translation available.
BC026320 mRNA. Translation: AAH26320.1 .
CCDSi CCDS44390.1. [Q9ULD0-2 ]
CCDS44391.1. [Q9ULD0-3 ]
CCDS7234.1. [Q9ULD0-1 ]
RefSeqi NP_001137468.1. NM_001143996.1. [Q9ULD0-2 ]
NP_001137469.1. NM_001143997.1. [Q9ULD0-3 ]
NP_060715.2. NM_018245.2. [Q9ULD0-1 ]
UniGenei Hs.17860.

3D structure databases

ProteinModelPortali Q9ULD0.
SMRi Q9ULD0. Positions 111-1000.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120871. 7 interactions.
IntActi Q9ULD0. 2 interactions.
MINTi MINT-3043902.
STRINGi 9606.ENSP00000363216.

PTM databases

PhosphoSitei Q9ULD0.

Polymorphism databases

DMDMi 160419019.

Proteomic databases

MaxQBi Q9ULD0.
PaxDbi Q9ULD0.
PRIDEi Q9ULD0.

Protocols and materials databases

DNASUi 55753.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374103 ; ENSP00000363216 ; ENSG00000197444 . [Q9ULD0-1 ]
ENST00000419399 ; ENSP00000401356 ; ENSG00000197444 . [Q9ULD0-2 ]
ENST00000432695 ; ENSP00000390240 ; ENSG00000197444 . [Q9ULD0-3 ]
GeneIDi 55753.
KEGGi hsa:55753.
UCSCi uc001jie.3. human. [Q9ULD0-1 ]
uc009xoh.2. human. [Q9ULD0-3 ]
uc010qgt.2. human. [Q9ULD0-2 ]

Organism-specific databases

CTDi 55753.
GeneCardsi GC10M050942.
HGNCi HGNC:25590. OGDHL.
HPAi HPA052497.
neXtProti NX_Q9ULD0.
PharmGKBi PA134878907.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0567.
GeneTreei ENSGT00530000063092.
HOGENOMi HOG000259586.
HOVERGENi HBG001892.
InParanoidi Q9ULD0.
KOi K00164.
OMAi DMTRKRT.
OrthoDBi EOG7FXZXH.
PhylomeDBi Q9ULD0.
TreeFami TF300695.

Miscellaneous databases

ChiTaRSi OGDHL. human.
GenomeRNAii 55753.
NextBioi 60749.
PROi Q9ULD0.

Gene expression databases

Bgeei Q9ULD0.
CleanExi HS_OGDHL.
Genevestigatori Q9ULD0.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT MET-637.
    Tissue: Kidney and Thalamus.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-511 AND ASN-573.
    Tissue: Brain.

Entry informationi

Entry nameiOGDHL_HUMAN
AccessioniPrimary (citable) accession number: Q9ULD0
Secondary accession number(s): A8K2G1
, B4DKG2, B4E193, Q8TAN9, Q9NVA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3