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Q9ULD0

- OGDHL_HUMAN

UniProt

Q9ULD0 - OGDHL_HUMAN

Protein

2-oxoglutarate dehydrogenase-like, mitochondrial

Gene

OGDHL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Thiamine pyrophosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi141 – 1411CalciumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi141 – 1455By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
    3. protein binding Source: IntAct
    4. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Calcium, Metal-binding, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase-like, mitochondrial (EC:1.2.4.-)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1-like
    Short name:
    OGDC-E1-like
    Alpha-ketoglutarate dehydrogenase-like
    Gene namesi
    Name:OGDHL
    Synonyms:KIAA1290
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:25590. OGDHL.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 7373MitochondrionSequence AnalysisAdd
    BLAST
    Chaini74 – 10109372-oxoglutarate dehydrogenase-like, mitochondrialPRO_0000310983Add
    BLAST

    Proteomic databases

    MaxQBiQ9ULD0.
    PaxDbiQ9ULD0.
    PRIDEiQ9ULD0.

    PTM databases

    PhosphoSiteiQ9ULD0.

    Expressioni

    Gene expression databases

    BgeeiQ9ULD0.
    CleanExiHS_OGDHL.
    GenevestigatoriQ9ULD0.

    Organism-specific databases

    HPAiHPA052497.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    STAT3P407632EBI-3940481,EBI-518675

    Protein-protein interaction databases

    BioGridi120871. 4 interactions.
    IntActiQ9ULD0. 2 interactions.
    MINTiMINT-3043902.
    STRINGi9606.ENSP00000363216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULD0.
    SMRiQ9ULD0. Positions 111-1000.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi45 – 484Poly-Gly

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0567.
    HOGENOMiHOG000259586.
    HOVERGENiHBG001892.
    InParanoidiQ9ULD0.
    KOiK00164.
    OMAiDMTRKRT.
    OrthoDBiEOG7FXZXH.
    PhylomeDBiQ9ULD0.
    TreeFamiTF300695.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    InterProiIPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.
    PfamiPF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9ULD0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQLRLLPSR LGVQAARLLA AHDVPVFGWR SRSSGPPATF PSSKGGGGSS     50
    YMEEMYFAWL ENPQSVHKSW DSFFREASEE AFSGSAQPRP PSVVHESRSA 100
    VSSRTKTSKL VEDHLAVQSL IRAYQIRGHH VAQLDPLGIL DADLDSFVPS 150
    DLITTIDKLA FYDLQEADLD KEFQLPTTTF IGGSENTLSL REIIRRLENT 200
    YCQHIGLEFM FINDVEQCQW IRQKFETPGV MQFSSEEKRT LLARLVRSMR 250
    FEDFLARKWS SEKRFGLEGC EVMIPALKTI IDKSSEMGIE NVILGMPHRG 300
    RLNVLANVIR KDLEQIFCQF DPKLEAADEG SGDVKYHLGM YHERINRVTN 350
    RNITLSLVAN PSHLEAVDPV VQGKTKAEQF YRGDAQGKKV MSILVHGDAA 400
    FAGQGVVYET FHLSDLPSYT TNGTVHVVVN NQIGFTTDPR MARSSPYPTD 450
    VARVVNAPIF HVNADDPEAV IYVCSVAAEW RNTFNKDVVV DLVCYRRRGH 500
    NEMDEPMFTQ PLMYKQIHRQ VPVLKKYADK LIAEGTVTLQ EFEEEIAKYD 550
    RICEEAYGRS KDKKILHIKH WLDSPWPGFF NVDGEPKSMT CPATGIPEDM 600
    LTHIGSVASS VPLEDFKIHT GLSRILRGRA DMTKNRTVDW ALAEYMAFGS 650
    LLKEGIHVRL SGQDVERGTF SHRHHVLHDQ EVDRRTCVPM NHLWPDQAPY 700
    TVCNSSLSEY GVLGFELGYA MASPNALVLW EAQFGDFHNT AQCIIDQFIS 750
    TGQAKWVRHN GIVLLLPHGM EGMGPEHSSA RPERFLQMSN DDSDAYPAFT 800
    KDFEVSQLYD CNWIVVNCST PANYFHVLRR QILLPFRKPL IIFTPKSLLR 850
    HPEAKSSFDQ MVSGTSFQRV IPEDGAAARA PEQVQRLIFC TGKVYYDLVK 900
    ERSSQDLEEK VAITRLEQIS PFPFDLIKQE AEKYPGAELA WCQEEHKNMG 950
    YYDYISPRFM TILRRARPIW YVGRDPAAAP ATGNRNTHLV SLKKFLDTAF 1000
    NLQAFEGKTF 1010
    Length:1,010
    Mass (Da):114,481
    Last modified:November 13, 2007 - v3
    Checksum:i95A836DE079E804C
    GO
    Isoform 2 (identifier: Q9ULD0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         69-125: Missing.

    Show »
    Length:953
    Mass (Da):108,148
    Checksum:i70EB6121D698658F
    GO
    Isoform 3 (identifier: Q9ULD0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-209: Missing.

    Show »
    Length:801
    Mass (Da):91,232
    Checksum:i611D2A4D3E43C51B
    GO

    Sequence cautioni

    The sequence BAA86604.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971S → G in BAA91855. (PubMed:14702039)Curated
    Sequence conflicti319 – 3191Q → R in BAA91855. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti511 – 5111P → L.1 Publication
    Corresponds to variant rs17856755 [ dbSNP | Ensembl ].
    VAR_037125
    Natural varianti573 – 5731D → N.1 Publication
    Corresponds to variant rs17852386 [ dbSNP | Ensembl ].
    VAR_037126
    Natural varianti623 – 6231S → C.
    Corresponds to variant rs34877195 [ dbSNP | Ensembl ].
    VAR_037127
    Natural varianti637 – 6371T → M.1 Publication
    Corresponds to variant rs11101224 [ dbSNP | Ensembl ].
    VAR_037128
    Natural varianti725 – 7251N → S.
    Corresponds to variant rs2293239 [ dbSNP | Ensembl ].
    VAR_037129

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 209209Missing in isoform 3. 1 PublicationVSP_041351Add
    BLAST
    Alternative sequencei69 – 12557Missing in isoform 2. 1 PublicationVSP_041350Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033116 mRNA. Translation: BAA86604.2. Different initiation.
    AK001713 mRNA. Translation: BAA91855.1.
    AK290226 mRNA. Translation: BAF82915.1.
    AK296551 mRNA. Translation: BAG59174.1.
    AK303729 mRNA. Translation: BAG64705.1.
    AC069546 Genomic DNA. No translation available.
    BC026320 mRNA. Translation: AAH26320.1.
    CCDSiCCDS44390.1. [Q9ULD0-2]
    CCDS44391.1. [Q9ULD0-3]
    CCDS7234.1. [Q9ULD0-1]
    RefSeqiNP_001137468.1. NM_001143996.1. [Q9ULD0-2]
    NP_001137469.1. NM_001143997.1. [Q9ULD0-3]
    NP_060715.2. NM_018245.2. [Q9ULD0-1]
    UniGeneiHs.17860.

    Genome annotation databases

    EnsembliENST00000374103; ENSP00000363216; ENSG00000197444. [Q9ULD0-1]
    ENST00000419399; ENSP00000401356; ENSG00000197444. [Q9ULD0-2]
    ENST00000432695; ENSP00000390240; ENSG00000197444. [Q9ULD0-3]
    GeneIDi55753.
    KEGGihsa:55753.
    UCSCiuc001jie.3. human. [Q9ULD0-1]
    uc009xoh.2. human. [Q9ULD0-3]
    uc010qgt.2. human. [Q9ULD0-2]

    Polymorphism databases

    DMDMi160419019.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033116 mRNA. Translation: BAA86604.2 . Different initiation.
    AK001713 mRNA. Translation: BAA91855.1 .
    AK290226 mRNA. Translation: BAF82915.1 .
    AK296551 mRNA. Translation: BAG59174.1 .
    AK303729 mRNA. Translation: BAG64705.1 .
    AC069546 Genomic DNA. No translation available.
    BC026320 mRNA. Translation: AAH26320.1 .
    CCDSi CCDS44390.1. [Q9ULD0-2 ]
    CCDS44391.1. [Q9ULD0-3 ]
    CCDS7234.1. [Q9ULD0-1 ]
    RefSeqi NP_001137468.1. NM_001143996.1. [Q9ULD0-2 ]
    NP_001137469.1. NM_001143997.1. [Q9ULD0-3 ]
    NP_060715.2. NM_018245.2. [Q9ULD0-1 ]
    UniGenei Hs.17860.

    3D structure databases

    ProteinModelPortali Q9ULD0.
    SMRi Q9ULD0. Positions 111-1000.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120871. 4 interactions.
    IntActi Q9ULD0. 2 interactions.
    MINTi MINT-3043902.
    STRINGi 9606.ENSP00000363216.

    PTM databases

    PhosphoSitei Q9ULD0.

    Polymorphism databases

    DMDMi 160419019.

    Proteomic databases

    MaxQBi Q9ULD0.
    PaxDbi Q9ULD0.
    PRIDEi Q9ULD0.

    Protocols and materials databases

    DNASUi 55753.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374103 ; ENSP00000363216 ; ENSG00000197444 . [Q9ULD0-1 ]
    ENST00000419399 ; ENSP00000401356 ; ENSG00000197444 . [Q9ULD0-2 ]
    ENST00000432695 ; ENSP00000390240 ; ENSG00000197444 . [Q9ULD0-3 ]
    GeneIDi 55753.
    KEGGi hsa:55753.
    UCSCi uc001jie.3. human. [Q9ULD0-1 ]
    uc009xoh.2. human. [Q9ULD0-3 ]
    uc010qgt.2. human. [Q9ULD0-2 ]

    Organism-specific databases

    CTDi 55753.
    GeneCardsi GC10M050942.
    HGNCi HGNC:25590. OGDHL.
    HPAi HPA052497.
    neXtProti NX_Q9ULD0.
    PharmGKBi PA134878907.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0567.
    HOGENOMi HOG000259586.
    HOVERGENi HBG001892.
    InParanoidi Q9ULD0.
    KOi K00164.
    OMAi DMTRKRT.
    OrthoDBi EOG7FXZXH.
    PhylomeDBi Q9ULD0.
    TreeFami TF300695.

    Miscellaneous databases

    GenomeRNAii 55753.
    NextBioi 60749.
    PROi Q9ULD0.

    Gene expression databases

    Bgeei Q9ULD0.
    CleanExi HS_OGDHL.
    Genevestigatori Q9ULD0.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    InterProi IPR011603. 2oxoglutarate_DH_E1.
    IPR001017. DH_E1.
    IPR029061. THDP-binding.
    IPR005475. Transketolase-like_Pyr-bd.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    Pfami PF00676. E1_dh. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT MET-637.
      Tissue: Kidney and Thalamus.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-511 AND ASN-573.
      Tissue: Brain.

    Entry informationi

    Entry nameiOGDHL_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULD0
    Secondary accession number(s): A8K2G1
    , B4DKG2, B4E193, Q8TAN9, Q9NVA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3