Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable palmitoyltransferase ZDHHC8

Gene

ZDHHC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei134 – 1341S-palmitoyl cysteine intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri104 – 15451DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • locomotory behavior Source: Ensembl
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • protein palmitoylation Source: UniProtKB
  • regulation of mitophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC8 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 8
Short name:
DHHC-8
Zinc finger protein 378
Gene namesi
Name:ZDHHC8
Synonyms:KIAA1292, ZDHHCL1, ZNF378
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18474. ZDHHC8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 5218LumenalSequence analysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence analysisAdd
BLAST
Topological domaini74 – 14875CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Topological domaini170 – 19021LumenalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 765554CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38339.

Polymorphism and mutation databases

BioMutaiZDHHC8.
DMDMi57015419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Probable palmitoyltransferase ZDHHC8PRO_0000212877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei337 – 3371PhosphoserineBy similarity
Modified residuei627 – 6271PhosphoserineBy similarity
Modified residuei675 – 6751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9ULC8.
MaxQBiQ9ULC8.
PaxDbiQ9ULC8.
PRIDEiQ9ULC8.

PTM databases

iPTMnetiQ9ULC8.
PhosphoSiteiQ9ULC8.

Expressioni

Gene expression databases

BgeeiQ9ULC8.
CleanExiHS_ZDHHC8.
ExpressionAtlasiQ9ULC8. baseline and differential.
GenevisibleiQ9ULC8. HS.

Organism-specific databases

HPAiHPA003422.

Interactioni

Protein-protein interaction databases

BioGridi118925. 1 interaction.
STRINGi9606.ENSP00000384716.

Structurei

3D structure databases

ProteinModelPortaliQ9ULC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri104 – 15451DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ9ULC8.
KOiK18932.
OMAiTPHRSIF.
OrthoDBiEOG7WHH9B.
PhylomeDBiQ9ULC8.
TreeFamiTF354263.

Family and domain databases

InterProiIPR030291. ZDHHC8.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR12349:SF1. PTHR12349:SF1. 1 hit.
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULC8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRSPGTRLK PAKYIPVATA AALLVGSSTL FFVFTCPWLT RAVSPAVPVY
60 70 80 90 100
NGIIFLFVLA NFSMATFMDP GVFPRADEDE DKEDDFRAPL YKNVDVRGIQ
110 120 130 140 150
VRMKWCATCH FYRPPRCSHC SVCDNCVEDF DHHCPWVNNC IGRRNYRYFF
160 170 180 190 200
LFLLSLSAHM VGVVAFGLVY VLNHAEGLGA AHTTITMAVM CVAGLFFIPV
210 220 230 240 250
IGLTGFHVVL VTRGRTTNEQ VTGKFRGGVN PFTRGCCGNV EHVLCSPLAP
260 270 280 290 300
RYVVEPPRLP LAVSLKPPFL RPELLDRAAP LKVKLSDNGL KAGLGRSKSK
310 320 330 340 350
GSLDRLDEKP LDLGPPLPPK IEAGTFSSDL QTPRPGSAES ALSVQRTSPP
360 370 380 390 400
TPAMYKFRPA FPTGPKVPFC GPGEQVPGPD SLTLGDDSIR SLDFVSEPSL
410 420 430 440 450
DLPDYGPGGL HAAYPPSPPL SASDAFSGAL RSLSLKASSR RGGDHVALQP
460 470 480 490 500
LRSEGGPPTP HRSIFAPHAL PNRNGSLSYD SLLNPGSPGG HACPAHPAVG
510 520 530 540 550
VAGYHSPYLH PGATGDPPRP LPRSFSPVLG PRPREPSPVR YDNLSRTIMA
560 570 580 590 600
SIQERKDREE RERLLRSQAD SLFGDSGVYD APSSYSLQQA SVLSEGPRGP
610 620 630 640 650
ALRYGSRDDL VAGPGFGGAR NPALQTSLSS LSSSVSRAPR TSSSSLQADQ
660 670 680 690 700
ASSNAPGPRP SSGSHRSPAR QGLPSPPGTP HSPSYAGPKA VAFIHTDLPE
710 720 730 740 750
PPPSLTVQRD HPQLKTPPSK LNGQSPGLAR LGPATGPPGP SASPTRHTLV
760
KKVSGVGGTT YEISV
Length:765
Mass (Da):81,443
Last modified:January 4, 2005 - v3
Checksum:i005FCA33D7FD7397
GO
Isoform 2 (identifier: Q9ULC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-220: Missing.

Note: No experimental confirmation available.
Show »
Length:673
Mass (Da):71,235
Checksum:iF3D56B647811FEB9
GO
Isoform 3 (identifier: Q9ULC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-765: DHPQLKTPPS...VGGTTYEISV → GRIGTCTRGW...SSLFPSLSGP

Note: No experimental confirmation available.
Show »
Length:778
Mass (Da):83,173
Checksum:iD1C3554FD5C9BA17
GO

Sequence cautioni

The sequence BAD18420.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAG30243.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei129 – 22092Missing in isoform 2. 1 PublicationVSP_012572Add
BLAST
Alternative sequencei710 – 76556DHPQL…YEISV → GRIGTCTRGWGRRGQPWVPP GLHLCHLGRPEDRPPLRAPW SQAAGAPPRGAMCRLHLAAS SLFPSLSGP in isoform 3. 1 PublicationVSP_012573Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894890 mRNA. Translation: AAX73369.1.
AC006547 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX02984.1.
BC053544 mRNA. Translation: AAH53544.1.
AK131238 mRNA. Translation: BAD18420.1. Different initiation.
CR456357 mRNA. Translation: CAG30243.1. Different initiation.
AB033118 mRNA. Translation: BAA86606.1.
CCDSiCCDS13776.1. [Q9ULC8-1]
CCDS54502.1. [Q9ULC8-3]
RefSeqiNP_001171953.1. NM_001185024.1. [Q9ULC8-3]
NP_037505.1. NM_013373.3. [Q9ULC8-1]
XP_006724302.1. XM_006724239.2. [Q9ULC8-3]
UniGeneiHs.63128.

Genome annotation databases

EnsembliENST00000320602; ENSP00000317804; ENSG00000099904. [Q9ULC8-2]
ENST00000334554; ENSP00000334490; ENSG00000099904. [Q9ULC8-1]
ENST00000405930; ENSP00000384716; ENSG00000099904. [Q9ULC8-3]
GeneIDi29801.
KEGGihsa:29801.
UCSCiuc002zrq.4. human. [Q9ULC8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894890 mRNA. Translation: AAX73369.1.
AC006547 Genomic DNA. No translation available.
CH471176 Genomic DNA. Translation: EAX02984.1.
BC053544 mRNA. Translation: AAH53544.1.
AK131238 mRNA. Translation: BAD18420.1. Different initiation.
CR456357 mRNA. Translation: CAG30243.1. Different initiation.
AB033118 mRNA. Translation: BAA86606.1.
CCDSiCCDS13776.1. [Q9ULC8-1]
CCDS54502.1. [Q9ULC8-3]
RefSeqiNP_001171953.1. NM_001185024.1. [Q9ULC8-3]
NP_037505.1. NM_013373.3. [Q9ULC8-1]
XP_006724302.1. XM_006724239.2. [Q9ULC8-3]
UniGeneiHs.63128.

3D structure databases

ProteinModelPortaliQ9ULC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118925. 1 interaction.
STRINGi9606.ENSP00000384716.

PTM databases

iPTMnetiQ9ULC8.
PhosphoSiteiQ9ULC8.

Polymorphism and mutation databases

BioMutaiZDHHC8.
DMDMi57015419.

Proteomic databases

EPDiQ9ULC8.
MaxQBiQ9ULC8.
PaxDbiQ9ULC8.
PRIDEiQ9ULC8.

Protocols and materials databases

DNASUi29801.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320602; ENSP00000317804; ENSG00000099904. [Q9ULC8-2]
ENST00000334554; ENSP00000334490; ENSG00000099904. [Q9ULC8-1]
ENST00000405930; ENSP00000384716; ENSG00000099904. [Q9ULC8-3]
GeneIDi29801.
KEGGihsa:29801.
UCSCiuc002zrq.4. human. [Q9ULC8-1]

Organism-specific databases

CTDi29801.
GeneCardsiZDHHC8.
HGNCiHGNC:18474. ZDHHC8.
HPAiHPA003422.
MIMi608784. gene.
neXtProtiNX_Q9ULC8.
PharmGKBiPA38339.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000234346.
HOVERGENiHBG057186.
InParanoidiQ9ULC8.
KOiK18932.
OMAiTPHRSIF.
OrthoDBiEOG7WHH9B.
PhylomeDBiQ9ULC8.
TreeFamiTF354263.

Miscellaneous databases

GeneWikiiZDHHC8.
GenomeRNAii29801.
NextBioi52351.
PROiQ9ULC8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULC8.
CleanExiHS_ZDHHC8.
ExpressionAtlasiQ9ULC8. baseline and differential.
GenevisibleiQ9ULC8. HS.

Family and domain databases

InterProiIPR030291. ZDHHC8.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR12349:SF1. PTHR12349:SF1. 1 hit.
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A superfamily of membrane-associated DHHC type zinc finger proteins."
    Huang C.-H., Chen Y., Ye T.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-765 (ISOFORM 3).
    Tissue: Amygdala.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-765 (ISOFORM 1).
  7. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-673 (ISOFORM 2).
    Tissue: Brain.
  8. "Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8."
    Chen W.-Y., Shi Y.-Y., Zheng Y.-L., Zhao X.-Z., Zhang G.-J., Chen S.-Q., Yang P.-D., He L.
    Hum. Mol. Genet. 13:2991-2995(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO SCHIZOPHRENIA.
  9. "Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia."
    Mukai J., Liu H., Burt R.A., Swor D.E., Lai W.-S., Karayiorgou M., Gogos J.A.
    Nat. Genet. 36:725-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SUSCEPTIBILITY TO SCHIZOPHRENIA, SUBCELLULAR LOCATION.
  10. Cited for: ABSENCE OF INVOLVEMENT IN SUSCEPTIBILITY TO SCHIZOPHRENIA.
  11. "No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population."
    Saito S., Ikeda M., Iwata N., Suzuki T., Kitajima T., Yamanouchi Y., Kinoshita Y., Takahashi N., Inada T., Ozaki N.
    Neurosci. Lett. 374:21-24(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF INVOLVEMENT IN SUSCEPTIBILITY TO SCHIZOPHRENIA.
  12. "The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia."
    Otani K., Ujike H., Tanaka Y., Morita Y., Kishimoto M., Morio A., Uchida N., Nomura A., Kuroda S.
    Neurosci. Lett. 390:166-170(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF INVOLVEMENT IN SUSCEPTIBILITY TO SCHIZOPHRENIA.
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  15. "Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function."
    Singaraja R.R., Kang M.H., Vaid K., Sanders S.S., Vilas G.L., Arstikaitis P., Coutinho J., Drisdel R.C., El-Husseini Ael D., Green W.N., Berthiaume L., Hayden M.R.
    Circ. Res. 105:138-147(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiZDHC8_HUMAN
AccessioniPrimary (citable) accession number: Q9ULC8
Secondary accession number(s): Q2TGE9
, Q6ICL1, Q6ZNF5, Q7Z6L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: January 4, 2005
Last modified: March 16, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.