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Protein

Protein-arginine deiminase type-1

Gene

PADI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.By similarity

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

Ca2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciMetaCyc:HS06945-MONOMER.
ZFISH:HS06945-MONOMER.
BRENDAi3.5.3.15. 2681.
ReactomeiR-HSA-3247509. Chromatin modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.15)
Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:PADI1
Synonyms:PAD1, PDI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18367. PADI1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi29943.
OpenTargetsiENSG00000142623.
ENSG00000281459.
PharmGKBiPA32899.

Chemistry databases

ChEMBLiCHEMBL1909486.
DrugBankiDB00155. L-Citrulline.
GuidetoPHARMACOLOGYi2894.

Polymorphism and mutation databases

BioMutaiPADI1.
DMDMi56757695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200231 – 663Protein-arginine deiminase type-1Add BLAST663

Proteomic databases

PaxDbiQ9ULC6.
PeptideAtlasiQ9ULC6.
PRIDEiQ9ULC6.

PTM databases

iPTMnetiQ9ULC6.
PhosphoSitePlusiQ9ULC6.

Expressioni

Tissue specificityi

Epidermis, prostate, testis, placenta, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000142623.
CleanExiHS_PADI1.
GenevisibleiQ9ULC6. HS.

Organism-specific databases

HPAiHPA062294.

Interactioni

Protein-protein interaction databases

BioGridi118980. 4 interactors.
IntActiQ9ULC6. 1 interactor.
STRINGi9606.ENSP00000364620.

Chemistry databases

BindingDBiQ9ULC6.

Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 13Combined sources3
Beta strandi15 – 20Combined sources6
Beta strandi25 – 27Combined sources3
Beta strandi39 – 53Combined sources15
Beta strandi55 – 57Combined sources3
Beta strandi60 – 62Combined sources3
Beta strandi68 – 70Combined sources3
Beta strandi72 – 74Combined sources3
Beta strandi77 – 80Combined sources4
Beta strandi90 – 97Combined sources8
Beta strandi105 – 121Combined sources17
Beta strandi124 – 128Combined sources5
Beta strandi147 – 150Combined sources4
Helixi165 – 167Combined sources3
Helixi175 – 179Combined sources5
Beta strandi180 – 189Combined sources10
Helixi191 – 194Combined sources4
Beta strandi197 – 202Combined sources6
Turni205 – 210Combined sources6
Beta strandi211 – 218Combined sources8
Helixi222 – 224Combined sources3
Beta strandi225 – 229Combined sources5
Beta strandi235 – 237Combined sources3
Beta strandi246 – 253Combined sources8
Beta strandi263 – 273Combined sources11
Beta strandi280 – 291Combined sources12
Beta strandi303 – 309Combined sources7
Beta strandi314 – 316Combined sources3
Helixi319 – 331Combined sources13
Beta strandi335 – 339Combined sources5
Helixi341 – 344Combined sources4
Turni351 – 353Combined sources3
Beta strandi354 – 360Combined sources7
Beta strandi365 – 371Combined sources7
Beta strandi376 – 378Combined sources3
Helixi381 – 384Combined sources4
Beta strandi392 – 395Combined sources4
Helixi405 – 407Combined sources3
Helixi409 – 411Combined sources3
Beta strandi412 – 414Combined sources3
Beta strandi418 – 420Combined sources3
Beta strandi423 – 425Combined sources3
Beta strandi430 – 435Combined sources6
Helixi446 – 454Combined sources9
Beta strandi461 – 464Combined sources4
Beta strandi468 – 470Combined sources3
Turni473 – 476Combined sources4
Beta strandi477 – 481Combined sources5
Beta strandi483 – 494Combined sources12
Helixi495 – 506Combined sources12
Beta strandi507 – 509Combined sources3
Helixi528 – 531Combined sources4
Helixi536 – 558Combined sources23
Turni562 – 564Combined sources3
Beta strandi565 – 569Combined sources5
Beta strandi572 – 575Combined sources4
Beta strandi578 – 583Combined sources6
Beta strandi586 – 588Combined sources3
Beta strandi590 – 592Combined sources3
Beta strandi595 – 599Combined sources5
Helixi611 – 620Combined sources10
Helixi621 – 623Combined sources3
Beta strandi626 – 630Combined sources5
Turni633 – 636Combined sources4
Helixi637 – 639Combined sources3
Helixi643 – 646Combined sources4
Beta strandi647 – 651Combined sources5
Helixi658 – 660Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HP5X-ray3.20A/B1-663[»]
ProteinModelPortaliQ9ULC6.
SMRiQ9ULC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9ULC6.
KOiK01481.
OMAiDIPQLFF.
OrthoDBiEOG091G02QG.
PhylomeDBiQ9ULC6.
TreeFamiTF331952.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ULC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV
60 70 80 90 100
FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ
110 120 130 140 150
EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL
160 170 180 190 200
LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV
210 220 230 240 250
LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY
260 270 280 290 300
VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT
310 320 330 340 350
QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI
360 370 380 390 400
QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL
410 420 430 440 450
PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN
460 470 480 490 500
FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK
510 520 530 540 550
LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN
560 570 580 590 600
RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK
610 620 630 640 650
PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR
660
RKPFPFKWWN MVP
Length:663
Mass (Da):74,666
Last modified:December 21, 2004 - v2
Checksum:i4674CEBC03A7E7CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti420V → G in BAA85771 (PubMed:12416996).Curated1
Sequence conflicti499L → P in BAA85771 (PubMed:12416996).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053557649V → M.Corresponds to variant rs16824215dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033768 mRNA. Translation: BAA85771.1.
AJ549502 Genomic DNA. Translation: CAE47741.1.
AL590644 Genomic DNA. Translation: CAH73165.1.
CH471134 Genomic DNA. Translation: EAW94833.1.
BC130574 mRNA. Translation: AAI30575.1.
BC136402 mRNA. Translation: AAI36403.1.
CCDSiCCDS178.1.
RefSeqiNP_037490.2. NM_013358.2.
UniGeneiHs.412941.

Genome annotation databases

EnsembliENST00000375471; ENSP00000364620; ENSG00000142623.
ENST00000631074; ENSP00000485803; ENSG00000281459.
GeneIDi29943.
KEGGihsa:29943.
UCSCiuc001bah.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033768 mRNA. Translation: BAA85771.1.
AJ549502 Genomic DNA. Translation: CAE47741.1.
AL590644 Genomic DNA. Translation: CAH73165.1.
CH471134 Genomic DNA. Translation: EAW94833.1.
BC130574 mRNA. Translation: AAI30575.1.
BC136402 mRNA. Translation: AAI36403.1.
CCDSiCCDS178.1.
RefSeqiNP_037490.2. NM_013358.2.
UniGeneiHs.412941.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HP5X-ray3.20A/B1-663[»]
ProteinModelPortaliQ9ULC6.
SMRiQ9ULC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118980. 4 interactors.
IntActiQ9ULC6. 1 interactor.
STRINGi9606.ENSP00000364620.

Chemistry databases

BindingDBiQ9ULC6.
ChEMBLiCHEMBL1909486.
DrugBankiDB00155. L-Citrulline.
GuidetoPHARMACOLOGYi2894.

PTM databases

iPTMnetiQ9ULC6.
PhosphoSitePlusiQ9ULC6.

Polymorphism and mutation databases

BioMutaiPADI1.
DMDMi56757695.

Proteomic databases

PaxDbiQ9ULC6.
PeptideAtlasiQ9ULC6.
PRIDEiQ9ULC6.

Protocols and materials databases

DNASUi29943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375471; ENSP00000364620; ENSG00000142623.
ENST00000631074; ENSP00000485803; ENSG00000281459.
GeneIDi29943.
KEGGihsa:29943.
UCSCiuc001bah.2. human.

Organism-specific databases

CTDi29943.
DisGeNETi29943.
GeneCardsiPADI1.
HGNCiHGNC:18367. PADI1.
HPAiHPA062294.
MIMi607934. gene.
neXtProtiNX_Q9ULC6.
OpenTargetsiENSG00000142623.
ENSG00000281459.
PharmGKBiPA32899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
GeneTreeiENSGT00390000008680.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiQ9ULC6.
KOiK01481.
OMAiDIPQLFF.
OrthoDBiEOG091G02QG.
PhylomeDBiQ9ULC6.
TreeFamiTF331952.

Enzyme and pathway databases

BioCyciMetaCyc:HS06945-MONOMER.
ZFISH:HS06945-MONOMER.
BRENDAi3.5.3.15. 2681.
ReactomeiR-HSA-3247509. Chromatin modifying enzymes.

Miscellaneous databases

GeneWikiiPADI1.
GenomeRNAii29943.
PROiQ9ULC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142623.
CleanExiHS_PADI1.
GenevisibleiQ9ULC6. HS.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPADI1_HUMAN
AccessioniPrimary (citable) accession number: Q9ULC6
Secondary accession number(s): A1L4K6, Q70SX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.