Q9ULC6 (PADI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-arginine deiminase type-1
EC=3.5.3.15

Alternative name(s):
Peptidylarginine deiminase I
Protein-arginine deiminase type I

Gene names

Name:	PADI1
Synonyms:	PDI1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	663 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the deimination of arginine residues of proteins By similarity.
Catalytic activity	Protein L-arginine + H2O = protein L-citrulline + NH3.
Cofactor	Calcium By similarity.
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Epidermis, prostate, testis, placenta, spleen and thymus. Ref.1
Sequence similarities	Belongs to the protein arginine deiminase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Calcium
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-citrulline biosynthetic process from peptidyl-arginine Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein-arginine deiminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 663	663	Protein-arginine deiminase type-1		PRO_0000220023
Natural variations
	Natural variant	649	1	V → M. Corresponds to variant rs16824215 [ dbSNP | Ensembl ].		VAR_053557
Experimental info
	Sequence conflict	420	1	V → G in BAA85771. Ref.1
	Sequence conflict	499	1	L → P in BAA85771. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9ULC6 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 4674CEBC03A7E7CA	FASTA	663	74,666
	10 20 30 40 50 60 MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV FMVYNRTRVK 70 80 90 100 110 120 EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ EDQALGRSVL YLTGVDISLE 130 140 150 160 170 180 VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL LVNCDRDNHR SAEPDLTHSW LMSLADLQDM 190 200 210 220 230 240 SPMLLSCNGP DKLFDSHKLV LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER 250 260 270 280 290 300 QPGEQEIKFY VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT 310 320 330 340 350 360 QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI QDEMEFGYIE 370 380 390 400 410 420 APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL PGPSSLDSFG NLDVSPPVTV 430 440 450 460 470 480 GGTEYPLGRI LIGSSFPKSG GRQMARAVRN FLKAQQVQAP VELYSDWLSV GHVDEFLTFV 490 500 510 520 530 540 PTSDQKGFRL LLASPSACLK LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN 550 560 570 580 590 600 LHAQKCIDWN RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK 610 620 630 640 650 660 PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR RKPFPFKWWN MVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I." Guerrin M., Ishigami A., Mechin M.-C., Nachat R., Valmary S., Sebbag M., Simon M., Senshu T., Serre G. Biochem. J. 370:167-174(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION. Tissue: Epidermis.
[2]	"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6." Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M. Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB033768 mRNA. Translation: BAA85771.1. AJ549502 Genomic DNA. Translation: CAE47741.1. AL590644 Genomic DNA. Translation: CAH73165.1. CH471134 Genomic DNA. Translation: EAW94833.1. BC130574 mRNA. Translation: AAI30575.1. BC136402 mRNA. Translation: AAI36403.1.
IPI	IPI00008040.
RefSeq	NP_037490.2. NM_013358.2.
UniGene	Hs.412941.
3D structure databases
ProteinModelPortal	Q9ULC6.
ModBase	Search...
PTM databases
PhosphoSite	Q9ULC6.
Polymorphism databases
DMDM	56757695.
Proteomic databases
PaxDb	Q9ULC6.
PeptideAtlas	Q9ULC6.
PRIDE	Q9ULC6.
Protocols and materials databases
DNASU	29943.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375471; ENSP00000364620; ENSG00000142623.
GeneID	29943.
KEGG	hsa:29943.
UCSC	uc001bah.1. human.
Organism-specific databases
CTD	29943.
GeneCards	GC01P017531.
HGNC	HGNC:18367. PADI1.
HPA	HPA028133.
MIM	607934. gene.
neXtProt	NX_Q9ULC6.
PharmGKB	PA32899.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42085.
HOGENOM	HOG000220908.
HOVERGEN	HBG053016.
InParanoid	Q9ULC6.
KO	K01481.
OMA	DIPQLFF.
OrthoDB	EOG4VHK60.
PhylomeDB	Q9ULC6.
Enzyme and pathway databases
BioCyc	MetaCyc:HS06945-MONOMER.
BRENDA	3.5.3.15. 2681.
Gene expression databases
ArrayExpress	Q9ULC6.
Bgee	Q9ULC6.
CleanEx	HS_PADI1.
Genevestigator	Q9ULC6.
GermOnline	ENSG00000142623. Homo sapiens.
Family and domain databases
InterPro	IPR008972. Cupredoxin. IPR004303. PAD. IPR013530. PAD_C. IPR013732. PAD_N. IPR013733. Prot_Arg_deaminase_cen_dom. IPR016296. Protein-arginine_deiminase_sub. [Graphical view]
PANTHER	PTHR10837. PTHR10837. 1 hit.
Pfam	PF03068. PAD. 1 hit. PF08527. PAD_M. 1 hit. PF08526. PAD_N. 1 hit. [Graphical view]
PIRSF	PIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF110083. PAD_central. 1 hit.
ProtoNet	Search...
Other
BindingDB	Q9ULC6.
ChEMBL	CHEMBL1909486.
DrugBank	DB00155. L-Citrulline.
GenomeRNAi	29943.
NextBio	52603.
SOURCE	Search...

Entry information

Entry name

PADI1_HUMAN

Accession

Primary (citable) accession number: Q9ULC6
Secondary accession number(s): A1L4K6, Q70SX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.