Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ULC6

- PADI1_HUMAN

UniProt

Q9ULC6 - PADI1_HUMAN

Protein

Protein-arginine deiminase type-1

Gene

PADI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the deimination of arginine residues of proteins.By similarity

    Catalytic activityi

    Protein L-arginine + H2O = protein L-citrulline + NH3.

    Cofactori

    Calcium.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein-arginine deiminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein citrullination Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    BioCyciMetaCyc:HS06945-MONOMER.
    BRENDAi3.5.3.15. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-arginine deiminase type-1 (EC:3.5.3.15)
    Alternative name(s):
    Peptidylarginine deiminase I
    Protein-arginine deiminase type I
    Gene namesi
    Name:PADI1
    Synonyms:PDI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18367. PADI1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32899.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 663663Protein-arginine deiminase type-1PRO_0000220023Add
    BLAST

    Proteomic databases

    PaxDbiQ9ULC6.
    PeptideAtlasiQ9ULC6.
    PRIDEiQ9ULC6.

    PTM databases

    PhosphoSiteiQ9ULC6.

    Expressioni

    Tissue specificityi

    Epidermis, prostate, testis, placenta, spleen and thymus.1 Publication

    Gene expression databases

    ArrayExpressiQ9ULC6.
    BgeeiQ9ULC6.
    CleanExiHS_PADI1.
    GenevestigatoriQ9ULC6.

    Organism-specific databases

    HPAiHPA028133.

    Interactioni

    Protein-protein interaction databases

    BioGridi118980. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULC6.
    SMRiQ9ULC6. Positions 6-663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein arginine deiminase family.Curated

    Phylogenomic databases

    eggNOGiNOG42085.
    HOGENOMiHOG000220908.
    HOVERGENiHBG053016.
    InParanoidiQ9ULC6.
    KOiK01481.
    OMAiNCDRDSL.
    OrthoDBiEOG7P5T09.
    PhylomeDBiQ9ULC6.
    TreeFamiTF331952.

    Family and domain databases

    InterProiIPR008972. Cupredoxin.
    IPR004303. PAD.
    IPR013530. PAD_C.
    IPR013732. PAD_N.
    IPR013733. Prot_Arg_deaminase_cen_dom.
    IPR016296. Protein-arginine_deiminase_sub.
    [Graphical view]
    PANTHERiPTHR10837. PTHR10837. 1 hit.
    PfamiPF03068. PAD. 1 hit.
    PF08527. PAD_M. 1 hit.
    PF08526. PAD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
    SUPFAMiSSF110083. SSF110083. 1 hit.
    SSF49503. SSF49503. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ULC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKRVVQLS LKMPTHAVCV VGVEAHVDIH SDVPKGANSF RVSGSSGVEV    50
    FMVYNRTRVK EPIGKARWPL DTDADMVVSV GTASKELKDF KVRVSYFGEQ 100
    EDQALGRSVL YLTGVDISLE VDTGRTGKVK RSQGDKKTWR WGPEGYGAIL 150
    LVNCDRDNHR SAEPDLTHSW LMSLADLQDM SPMLLSCNGP DKLFDSHKLV 200
    LNVPFSDSKR VRVFCARGGN SLSDYKQVLG PQCLSYEVER QPGEQEIKFY 250
    VEGLTFPDAD FLGLVSLSVS LVDPGTLPEV TLFTDTVGFR MAPWIMTPNT 300
    QPPEELYVCR VMDTHGSNEK FLEDMSYLTL KANCKLTICP QVENRNDRWI 350
    QDEMEFGYIE APHKSFPVVF DSPRNRGLKD FPYKRILGPD FGYVTREIPL 400
    PGPSSLDSFG NLDVSPPVTV GGTEYPLGRI LIGSSFPKSG GRQMARAVRN 450
    FLKAQQVQAP VELYSDWLSV GHVDEFLTFV PTSDQKGFRL LLASPSACLK 500
    LFQEKKEEGY GEAAQFDGLK HQAKRSINEM LADRHLQRDN LHAQKCIDWN 550
    RNVLKRELGL AESDIVDIPQ LFFLKNFYAE AFFPDMVNMV VLGKYLGIPK 600
    PYGPIINGRC CLEEKVQSLL EPLGLHCIFI DDYLSYHELQ GEIHCGTNVR 650
    RKPFPFKWWN MVP 663
    Length:663
    Mass (Da):74,666
    Last modified:December 21, 2004 - v2
    Checksum:i4674CEBC03A7E7CA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti420 – 4201V → G in BAA85771. (PubMed:12416996)Curated
    Sequence conflicti499 – 4991L → P in BAA85771. (PubMed:12416996)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti649 – 6491V → M.
    Corresponds to variant rs16824215 [ dbSNP | Ensembl ].
    VAR_053557

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033768 mRNA. Translation: BAA85771.1.
    AJ549502 Genomic DNA. Translation: CAE47741.1.
    AL590644 Genomic DNA. Translation: CAH73165.1.
    CH471134 Genomic DNA. Translation: EAW94833.1.
    BC130574 mRNA. Translation: AAI30575.1.
    BC136402 mRNA. Translation: AAI36403.1.
    CCDSiCCDS178.1.
    RefSeqiNP_037490.2. NM_013358.2.
    UniGeneiHs.412941.

    Genome annotation databases

    EnsembliENST00000375471; ENSP00000364620; ENSG00000142623.
    GeneIDi29943.
    KEGGihsa:29943.
    UCSCiuc001bah.1. human.

    Polymorphism databases

    DMDMi56757695.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033768 mRNA. Translation: BAA85771.1 .
    AJ549502 Genomic DNA. Translation: CAE47741.1 .
    AL590644 Genomic DNA. Translation: CAH73165.1 .
    CH471134 Genomic DNA. Translation: EAW94833.1 .
    BC130574 mRNA. Translation: AAI30575.1 .
    BC136402 mRNA. Translation: AAI36403.1 .
    CCDSi CCDS178.1.
    RefSeqi NP_037490.2. NM_013358.2.
    UniGenei Hs.412941.

    3D structure databases

    ProteinModelPortali Q9ULC6.
    SMRi Q9ULC6. Positions 6-663.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118980. 1 interaction.

    Chemistry

    BindingDBi Q9ULC6.
    ChEMBLi CHEMBL1909486.
    DrugBanki DB00155. L-Citrulline.

    PTM databases

    PhosphoSitei Q9ULC6.

    Polymorphism databases

    DMDMi 56757695.

    Proteomic databases

    PaxDbi Q9ULC6.
    PeptideAtlasi Q9ULC6.
    PRIDEi Q9ULC6.

    Protocols and materials databases

    DNASUi 29943.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375471 ; ENSP00000364620 ; ENSG00000142623 .
    GeneIDi 29943.
    KEGGi hsa:29943.
    UCSCi uc001bah.1. human.

    Organism-specific databases

    CTDi 29943.
    GeneCardsi GC01P017531.
    HGNCi HGNC:18367. PADI1.
    HPAi HPA028133.
    MIMi 607934. gene.
    neXtProti NX_Q9ULC6.
    PharmGKBi PA32899.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42085.
    HOGENOMi HOG000220908.
    HOVERGENi HBG053016.
    InParanoidi Q9ULC6.
    KOi K01481.
    OMAi NCDRDSL.
    OrthoDBi EOG7P5T09.
    PhylomeDBi Q9ULC6.
    TreeFami TF331952.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS06945-MONOMER.
    BRENDAi 3.5.3.15. 2681.

    Miscellaneous databases

    GeneWikii PADI1.
    GenomeRNAii 29943.
    NextBioi 52603.
    PROi Q9ULC6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULC6.
    Bgeei Q9ULC6.
    CleanExi HS_PADI1.
    Genevestigatori Q9ULC6.

    Family and domain databases

    InterProi IPR008972. Cupredoxin.
    IPR004303. PAD.
    IPR013530. PAD_C.
    IPR013732. PAD_N.
    IPR013733. Prot_Arg_deaminase_cen_dom.
    IPR016296. Protein-arginine_deiminase_sub.
    [Graphical view ]
    PANTHERi PTHR10837. PTHR10837. 1 hit.
    Pfami PF03068. PAD. 1 hit.
    PF08527. PAD_M. 1 hit.
    PF08526. PAD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001247. Protein-arginine_deiminase. 1 hit.
    SUPFAMi SSF110083. SSF110083. 1 hit.
    SSF49503. SSF49503. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I."
      Guerrin M., Ishigami A., Mechin M.-C., Nachat R., Valmary S., Sebbag M., Simon M., Senshu T., Serre G.
      Biochem. J. 370:167-174(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Epidermis.
    2. "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
      Chavanas S., Mechin M.-C., Takahara H., Kawada A., Nachat R., Serre G., Simon M.
      Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPADI1_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULC6
    Secondary accession number(s): A1L4K6, Q70SX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3