Q9ULC5 (ACSL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Long-chain-fatty-acid--CoA ligase 5
EC=6.2.1.3

Alternative name(s):
Long-chain acyl-CoA synthetase 5
Short name=LACS 5

Gene names

Name:	ACSL5
Synonyms:	ACS5, FACL5
ORF Names:	UNQ633/PRO1250

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	683 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage By similarity. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids By similarity. It was suggested that it may also stimulate fatty acid oxidation By similarity. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. Ref.8 Ref.10 Ref.11
Catalytic activity	ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Magnesium By similarity.
Subcellular location	Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass type III membrane protein By similarity Ref.8 Ref.11.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.
Biophysicochemical properties	Kinetic parameters: KM=0.11 µM for palmitic acid (isoform 1 at pH 7.5) Ref.8 KM=0.38 µM for palmitic acid (isoform 1 at pH 9.5) KM=0.04 µM for palmitic acid (isoform 3 at pH 7.5) KM=0.15 µM for palmitic acid (isoform 3 at pH 8.5) pH dependence: Optimum pH is 9.5 (isoform 1), 7.5-8.5 (isoform 3).
Sequence caution	The sequence BAA85979.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA86054.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Endoplasmic reticulum Membrane Mitochondrion Mitochondrion outer membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	long-chain fatty acid metabolic process Inferred from electronic annotation. Source: GOC long-chain fatty-acyl-CoA biosynthetic process Traceable author statement. Source: Reactome regulation of apoptotic process Inferred from direct assay Ref.8. Source: UniProtKB triglyceride biosynthetic process Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum Inferred from direct assay Ref.8. Source: UniProtKB endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: Compara mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay Ref.8. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid-CoA ligase activity Inferred from direct assay Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9ULC5-1)

Also known as: ACSL5b; ACSL5-fl;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Localize in mitochondrion and endoplasmic reticulum.

Isoform 2 (identifier: Q9ULC5-3)

Also known as: ACSL5a;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKM

Note: Contains a phosphoserine at position 32.

Isoform 3 (identifier: Q9ULC5-4)

Also known as: ACSL5delta20;

The sequence of this isoform differs from the canonical sequence as follows:
     614-637: Missing.

Note: Localize in mitochondrion and endoplasmic reticulum.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 683	683	Long-chain-fatty-acid--CoA ligase 5		PRO_0000193112
Regions
	Transmembrane	12 – 32	21	Helical; Signal-anchor for type III membrane protein; Potential
	Topological domain	33 – 683	651	Cytoplasmic Potential
Natural variations
	Alternative sequence	1	1	M → MDALKPPCLWRNHERGKKDR DSCGRKNSEPGSPHSLEALR DAAPSQGLNFLLLFTKM in isoform 2.		VSP_037947
	Alternative sequence	614 – 637	24	Missing in isoform 3.		VSP_038233
	Natural variant	182	1	M → V. Corresponds to variant rs3736946 [ dbSNP | Ensembl ].		VAR_022117
	Natural variant	388	1	K → R in a colorectal cancer sample; somatic mutation. Ref.13		VAR_036377
	Natural variant	466	1	G → D in a colorectal cancer sample; somatic mutation. Ref.13		VAR_036378
	Natural variant	486	1	T → A. Corresponds to variant rs12254915 [ dbSNP | Ensembl ].		VAR_048240

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (ACSL5b) (ACSL5-fl) [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 781AFE1A7A78C286	FASTA	683	75,991
	10 20 30 40 50 60 MLFIFNFLFS PLPTPALICI LTFGAAIFLW LITRPQPVLP LLDLNNQSVG IEGGARKGVS 70 80 90 100 110 120 QKNNDLTSCC FSDAKTMYEV FQRGLAVSDN GPCLGYRKPN QPYRWLSYKQ VSDRAEYLGS 130 140 150 160 170 180 CLLHKGYKSS PDQFVGIFAQ NRPEWIISEL ACYTYSMVAV PLYDTLGPEA IVHIVNKADI 190 200 210 220 230 240 AMVICDTPQK ALVLIGNVEK GFTPSLKVII LMDPFDDDLK QRGEKSGIEI LSLYDAENLG 250 260 270 280 290 300 KEHFRKPVPP SPEDLSVICF TSGTTGDPKG AMITHQNIVS NAAAFLKCVE HAYEPTPDDV 310 320 330 340 350 360 AISYLPLAHM FERIVQAVVY SCGARVGFFQ GDIRLLADDM KTLKPTLFPA VPRLLNRIYD 370 380 390 400 410 420 KVQNEAKTPL KKFLLKLAVS SKFKELQKGI IRHDSFWDKL IFAKIQDSLG GRVRVIVTGA 430 440 450 460 470 480 APMSTSVMTF FRAAMGCQVY EAYGQTECTG GCTFTLPGDW TSGHVGVPLA CNYVKLEDVA 490 500 510 520 530 540 DMNYFTVNNE GEVCIKGTNV FKGYLKDPEK TQEALDSDGW LHTGDIGRWL PNGTLKIIDR 550 560 570 580 590 600 KKNIFKLAQG EYIAPEKIEN IYNRSQPVLQ IFVHGESLRS SLVGVVVPDT DVLPSFAAKL 610 620 630 640 650 660 GVKGSFEELC QNQVVREAIL EDLQKIGKES GLKTFEQVKA IFLHPEPFSI ENGLLTPTLK 670 680 AKRGELSKYF RTQIDSLYEH IQD
	Isoform 2 (ACSL5a) [UniParc]. Checksum: C3A1ABCA53717BCE	FASTA	739	82,263
	10 20 30 40 50 60 MDALKPPCLW RNHERGKKDR DSCGRKNSEP GSPHSLEALR DAAPSQGLNF LLLFTKMLFI 70 80 90 100 110 120 FNFLFSPLPT PALICILTFG AAIFLWLITR PQPVLPLLDL NNQSVGIEGG ARKGVSQKNN 130 140 150 160 170 180 DLTSCCFSDA KTMYEVFQRG LAVSDNGPCL GYRKPNQPYR WLSYKQVSDR AEYLGSCLLH 190 200 210 220 230 240 KGYKSSPDQF VGIFAQNRPE WIISELACYT YSMVAVPLYD TLGPEAIVHI VNKADIAMVI 250 260 270 280 290 300 CDTPQKALVL IGNVEKGFTP SLKVIILMDP FDDDLKQRGE KSGIEILSLY DAENLGKEHF 310 320 330 340 350 360 RKPVPPSPED LSVICFTSGT TGDPKGAMIT HQNIVSNAAA FLKCVEHAYE PTPDDVAISY 370 380 390 400 410 420 LPLAHMFERI VQAVVYSCGA RVGFFQGDIR LLADDMKTLK PTLFPAVPRL LNRIYDKVQN 430 440 450 460 470 480 EAKTPLKKFL LKLAVSSKFK ELQKGIIRHD SFWDKLIFAK IQDSLGGRVR VIVTGAAPMS 490 500 510 520 530 540 TSVMTFFRAA MGCQVYEAYG QTECTGGCTF TLPGDWTSGH VGVPLACNYV KLEDVADMNY 550 560 570 580 590 600 FTVNNEGEVC IKGTNVFKGY LKDPEKTQEA LDSDGWLHTG DIGRWLPNGT LKIIDRKKNI 610 620 630 640 650 660 FKLAQGEYIA PEKIENIYNR SQPVLQIFVH GESLRSSLVG VVVPDTDVLP SFAAKLGVKG 670 680 690 700 710 720 SFEELCQNQV VREAILEDLQ KIGKESGLKT FEQVKAIFLH PEPFSIENGL LTPTLKAKRG 730 ELSKYFRTQI DSLYEHIQD
	Isoform 3 (ACSL5delta20) [UniParc]. Checksum: 8FA678B997F35EF7	FASTA	659	73,278
	10 20 30 40 50 60 MLFIFNFLFS PLPTPALICI LTFGAAIFLW LITRPQPVLP LLDLNNQSVG IEGGARKGVS 70 80 90 100 110 120 QKNNDLTSCC FSDAKTMYEV FQRGLAVSDN GPCLGYRKPN QPYRWLSYKQ VSDRAEYLGS 130 140 150 160 170 180 CLLHKGYKSS PDQFVGIFAQ NRPEWIISEL ACYTYSMVAV PLYDTLGPEA IVHIVNKADI 190 200 210 220 230 240 AMVICDTPQK ALVLIGNVEK GFTPSLKVII LMDPFDDDLK QRGEKSGIEI LSLYDAENLG 250 260 270 280 290 300 KEHFRKPVPP SPEDLSVICF TSGTTGDPKG AMITHQNIVS NAAAFLKCVE HAYEPTPDDV 310 320 330 340 350 360 AISYLPLAHM FERIVQAVVY SCGARVGFFQ GDIRLLADDM KTLKPTLFPA VPRLLNRIYD 370 380 390 400 410 420 KVQNEAKTPL KKFLLKLAVS SKFKELQKGI IRHDSFWDKL IFAKIQDSLG GRVRVIVTGA 430 440 450 460 470 480 APMSTSVMTF FRAAMGCQVY EAYGQTECTG GCTFTLPGDW TSGHVGVPLA CNYVKLEDVA 490 500 510 520 530 540 DMNYFTVNNE GEVCIKGTNV FKGYLKDPEK TQEALDSDGW LHTGDIGRWL PNGTLKIIDR 550 560 570 580 590 600 KKNIFKLAQG EYIAPEKIEN IYNRSQPVLQ IFVHGESLRS SLVGVVVPDT DVLPSFAAKL 610 620 630 640 650 GVKGSFEELC QNQVKAIFLH PEPFSIENGL LTPTLKAKRG ELSKYFRTQI DSLYEHIQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Hepatoma.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Liver.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Colon.
[7]	"Human FACL5 (or ACS5)." Yamashita Y. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
[8]	"Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing." Gassler N., Roth W., Funke B., Schneider A., Herzog F., Ehemann V., Sykora J., Haas T.L., Walczak H., Ganten T., Zentgraf H., Erb P., Alonso A., Autschbach F., Schirmacher P., Knuechel R., Kopitz J. Gastroenterology 133:587-598(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, BIOPHYSICOCHEMICAL PROPERTIES.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 (ISOFORM 2), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide." Mashima T., Sato S., Okabe S., Miyata S., Matsuura M., Sugimoto Y., Tsuruo T., Seimiya H. Cancer Sci. 100:1556-1562(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[11]	"Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions." Mashima T., Sato S., Sugimoto Y., Tsuruo T., Seimiya H. Oncogene 28:9-19(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-388 AND ASP-466.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358520 mRNA. Translation: AAQ88884.1. AK000339 mRNA. No translation available. AK222782 mRNA. No translation available. AL157786 Genomic DNA. Translation: CAH72510.1. CH471066 Genomic DNA. Translation: EAW49532.1. CH471066 Genomic DNA. Translation: EAW49535.1. CH471066 Genomic DNA. Translation: EAW49536.1. CH471066 Genomic DNA. Translation: EAW49539.1. BC007985 mRNA. Translation: AAH07985.2. AB033899 mRNA. Translation: BAA85979.1. Different initiation. AB033920 Genomic DNA. Translation: BAA86054.1. Sequence problems.
IPI	IPI00008037. IPI00401990. IPI00854706.
RefSeq	NP_057318.2. NM_016234.3. NP_976313.1. NM_203379.1. NP_976314.1. NM_203380.1.
UniGene	Hs.11638.
3D structure databases
ProteinModelPortal	Q9ULC5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000348429.
PTM databases
PhosphoSite	Q9ULC5.
Polymorphism databases
DMDM	13431659.
Proteomic databases
PaxDb	Q9ULC5.
PRIDE	Q9ULC5.
Protocols and materials databases
DNASU	51703.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000354273; ENSP00000346223; ENSG00000197142. ENST00000354655; ENSP00000346680; ENSG00000197142. ENST00000356116; ENSP00000348429; ENSG00000197142. ENST00000393081; ENSP00000376796; ENSG00000197142. ENST00000433418; ENSP00000403647; ENSG00000197142.
GeneID	51703.
KEGG	hsa:51703.
UCSC	uc001kzs.3. human. uc001kzu.3. human.
Organism-specific databases
CTD	51703.
GeneCards	GC10P114123.
HGNC	HGNC:16526. ACSL5.
MIM	605677. gene.
neXtProt	NX_Q9ULC5.
PharmGKB	PA27969.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1022.
HOGENOM	HOG000159459.
HOVERGEN	HBG050452.
InParanoid	Q9ULC5.
KO	K01897.
OMA	FAKIQDS.
OrthoDB	EOG4P2Q1T.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9ULC5.
Bgee	Q9ULC5.
CleanEx	HS_ACSL5.
Genevestigator	Q9ULC5.
GermOnline	ENSG00000197142. Homo sapiens.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ACSL5. human.
GenomeRNAi	51703.
NextBio	55732.
SOURCE	Search...

Entry information

Entry name

ACSL5_HUMAN

Accession

Primary (citable) accession number: Q9ULC5
Secondary accession number(s): D3DRB3, Q6UX44, Q9UIU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.