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Q9ULC3

- RAB23_HUMAN

UniProt

Q9ULC3 - RAB23_HUMAN

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Protein

Ras-related protein Rab-23

Gene
RAB23, HSPC137
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTP By similarity
Nucleotide bindingi64 – 685GTP By similarity
Nucleotide bindingi121 – 1244GTP By similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. autophagic vacuole assembly Source: UniProtKB
  2. cellular defense response Source: UniProtKB
  3. craniofacial suture morphogenesis Source: UniProtKB
  4. embryonic digit morphogenesis Source: Ensembl
  5. GTP catabolic process Source: UniProtKB
  6. negative regulation of proteolysis Source: Ensembl
  7. negative regulation of transcription factor import into nucleus Source: UniProtKB
  8. protein transport Source: UniProtKB-KW
  9. regulation of smoothened signaling pathway Source: Ensembl
  10. small GTPase mediated signal transduction Source: InterPro
  11. spinal cord dorsal/ventral patterning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9ULC3.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-23
Gene namesi
Name:RAB23
ORF Names:HSPC137
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14263. RAB23.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Cell membrane. Cytoplasm. Cytoplasmic vesicleautophagosome. Endosome membrane By similarity. Cytoplasmic vesiclephagosome. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis.2 Publications

GO - Cellular componenti

  1. autophagic vacuole Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. endosome membrane Source: UniProtKB-SubCell
  4. extracellular vesicular exosome Source: UniProt
  5. phagocytic vesicle Source: UniProtKB
  6. phagocytic vesicle membrane Source: UniProtKB-SubCell
  7. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Carpenter syndrome 1 (CRPT1) [MIM:201000]: A rare autosomal recessive disorder characterized by acrocephaly with variable synostosis of the sagittal, lambdoid, and coronal sutures; peculiar facies; brachydactyly of the hands with syndactyly; preaxial polydactyly and syndactyly of the feet; congenital heart defects; growth retardation; mental retardation; hypogenitalism; and obesity. In addition, cerebral malformations, oral and dental abnormalities, coxa valga, genu valgum, hydronephrosis, precocious puberty, and hearing loss may be observed.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121M → K in CRPT1. 1 Publication
VAR_065294
Natural varianti79 – 791Missing in CRPT1. 1 Publication
VAR_065295
Natural varianti85 – 851C → R in CRPT1. 1 Publication
VAR_034902

Keywords - Diseasei

Craniosynostosis, Disease mutation

Organism-specific databases

MIMi201000. phenotype.
Orphaneti65759. Carpenter syndrome.
PharmGKBiPA34113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Ras-related protein Rab-23PRO_0000121211Add
BLAST
Propeptidei235 – 2373Removed in mature form Reviewed predictionPRO_0000370771

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341Cysteine methyl ester Reviewed prediction
Lipidationi234 – 2341S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ9ULC3.
PaxDbiQ9ULC3.
PRIDEiQ9ULC3.

PTM databases

PhosphoSiteiQ9ULC3.

Expressioni

Gene expression databases

BgeeiQ9ULC3.
CleanExiHS_RAB23.
GenevestigatoriQ9ULC3.

Organism-specific databases

HPAiHPA029135.
HPA029136.

Interactioni

Subunit structurei

Interacts with SUFU.1 Publication

Protein-protein interaction databases

BioGridi119694. 3 interactions.
IntActiQ9ULC3. 3 interactions.
MINTiMINT-6783510.
STRINGi9606.ENSP00000320413.

Structurei

3D structure databases

ProteinModelPortaliQ9ULC3.
SMRiQ9ULC3. Positions 8-171.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi38 – 469Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG100144.
InParanoidiQ9ULC3.
KOiK06234.
OMAiVTEVFKY.
OrthoDBiEOG72C51B.
PhylomeDBiQ9ULC3.
TreeFamiTF317494.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULC3-1 [UniParc]FASTAAdd to Basket

« Hide

MLEEDMEVAI KMVVVGNGAV GKSSMIQRYC KGIFTKDYKK TIGVDFLERQ    50
IQVNDEDVRL MLWDTAGQEE FDAITKAYYR GAQACVLVFS TTDRESFEAV 100
SSWREKVVAE VGDIPTVLVQ NKIDLLDDSC IKNEEAEALA KRLKLRFYRT 150
SVKEDLNVNE VFKYLAEKYL QKLKQQIAED PELTHSSSNK IGVFNTSGGS 200
HSGQNSGTLN GGDVINLRPN KQRTKKNRNP FSSCSIP 237
Length:237
Mass (Da):26,659
Last modified:May 1, 2000 - v1
Checksum:iB9CB96E94DDF6036
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121M → K in CRPT1. 1 Publication
VAR_065294
Natural varianti13 – 131Missing.1 Publication
VAR_034900
Natural varianti40 – 401K → R.1 Publication
Corresponds to variant rs45442500 [ dbSNP | Ensembl ].
VAR_034901
Natural varianti79 – 791Missing in CRPT1. 1 Publication
VAR_065295
Natural varianti85 – 851C → R in CRPT1. 1 Publication
VAR_034902
Natural varianti101 – 1011S → A.1 Publication
Corresponds to variant rs45479896 [ dbSNP | Ensembl ].
VAR_034903
Natural varianti207 – 2071G → S.2 Publications
Corresponds to variant rs1040461 [ dbSNP | Ensembl ].
VAR_017159

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951E → G in AAF29101. 1 Publication
Sequence conflicti144 – 1441K → R in AAF29101. 1 Publication
Sequence conflicti225 – 2251K → N in AAF29101. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB034244 mRNA. Translation: BAA87324.1.
AB025427 mRNA. Translation: BAB40309.1.
AF161486 mRNA. Translation: AAF29101.1.
AF498951 mRNA. Translation: AAM21099.1.
AK313796 mRNA. Translation: BAG36532.1.
AY585189 mRNA. Translation: AAT79492.1.
CR749371 mRNA. Translation: CAH18224.1.
AL031321 Genomic DNA. Translation: CAI21564.1.
CH471081 Genomic DNA. Translation: EAX04476.1.
BC015021 mRNA. Translation: AAH15021.1.
CCDSiCCDS4962.1.
RefSeqiNP_001265595.1. NM_001278666.1.
NP_001265596.1. NM_001278667.1.
NP_001265597.1. NM_001278668.1.
NP_057361.3. NM_016277.4.
NP_899050.1. NM_183227.2.
UniGeneiHs.555016.

Genome annotation databases

EnsembliENST00000317483; ENSP00000320413; ENSG00000112210.
ENST00000468148; ENSP00000417610; ENSG00000112210.
GeneIDi51715.
KEGGihsa:51715.
UCSCiuc003pds.3. human.

Polymorphism databases

DMDMi12643897.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB034244 mRNA. Translation: BAA87324.1 .
AB025427 mRNA. Translation: BAB40309.1 .
AF161486 mRNA. Translation: AAF29101.1 .
AF498951 mRNA. Translation: AAM21099.1 .
AK313796 mRNA. Translation: BAG36532.1 .
AY585189 mRNA. Translation: AAT79492.1 .
CR749371 mRNA. Translation: CAH18224.1 .
AL031321 Genomic DNA. Translation: CAI21564.1 .
CH471081 Genomic DNA. Translation: EAX04476.1 .
BC015021 mRNA. Translation: AAH15021.1 .
CCDSi CCDS4962.1.
RefSeqi NP_001265595.1. NM_001278666.1.
NP_001265596.1. NM_001278667.1.
NP_001265597.1. NM_001278668.1.
NP_057361.3. NM_016277.4.
NP_899050.1. NM_183227.2.
UniGenei Hs.555016.

3D structure databases

ProteinModelPortali Q9ULC3.
SMRi Q9ULC3. Positions 8-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119694. 3 interactions.
IntActi Q9ULC3. 3 interactions.
MINTi MINT-6783510.
STRINGi 9606.ENSP00000320413.

PTM databases

PhosphoSitei Q9ULC3.

Polymorphism databases

DMDMi 12643897.

Proteomic databases

MaxQBi Q9ULC3.
PaxDbi Q9ULC3.
PRIDEi Q9ULC3.

Protocols and materials databases

DNASUi 51715.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317483 ; ENSP00000320413 ; ENSG00000112210 .
ENST00000468148 ; ENSP00000417610 ; ENSG00000112210 .
GeneIDi 51715.
KEGGi hsa:51715.
UCSCi uc003pds.3. human.

Organism-specific databases

CTDi 51715.
GeneCardsi GC06M057100.
HGNCi HGNC:14263. RAB23.
HPAi HPA029135.
HPA029136.
MIMi 201000. phenotype.
606144. gene.
neXtProti NX_Q9ULC3.
Orphaneti 65759. Carpenter syndrome.
PharmGKBi PA34113.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG100144.
InParanoidi Q9ULC3.
KOi K06234.
OMAi VTEVFKY.
OrthoDBi EOG72C51B.
PhylomeDBi Q9ULC3.
TreeFami TF317494.

Enzyme and pathway databases

SignaLinki Q9ULC3.

Miscellaneous databases

GeneWikii RAB23.
GenomeRNAii 51715.
NextBioi 55759.
PROi Q9ULC3.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULC3.
CleanExi HS_RAB23.
Genevestigatori Q9ULC3.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human mRNA for RAB23 protein."
    Seki N., Yoshikawa T., Azuma T., Saito T., Muramatsu M.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Expression of RAB-23 in human hair follicle."
    Ikeda A., Yamashita M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair follicle.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-207.
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-207.
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon carcinoma.
  7. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
    Seto S., Tsujimura K., Koide Y.
    Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during group A Streptococcus infection."
    Nozawa T., Aikawa C., Goda A., Maruyama F., Hamada S., Nakagawa I.
    Cell. Microbiol. 14:1149-1165(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "Rab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent manner."
    Chi S., Xie G., Liu H., Chen K., Zhang X., Li C., Xie J.
    Cell. Signal. 24:1222-1228(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SUFU, FUNCTION, GTPASE ACTIVITY, SUBCELLULAR LOCATION.
  16. Cited for: VARIANTS VAL-13 DEL; ARG-40 AND ALA-101, VARIANT CRPT1 ARG-85.
  17. "Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay."
    Jenkins D., Baynam G., De Catte L., Elcioglu N., Gabbett M.T., Hudgins L., Hurst J.A., Jehee F.S., Oley C., Wilkie A.O.
    Hum. Mutat. 32:E2069-E2078(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS CRPT1 LYS-12 AND TYR-79 DEL.

Entry informationi

Entry nameiRAB23_HUMAN
AccessioniPrimary (citable) accession number: Q9ULC3
Secondary accession number(s): B2R9I5
, Q68DJ6, Q8NI06, Q9P023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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