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Protein

Endomucin

Gene

EMCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Endomucin
Alternative name(s):
Endomucin-2
Gastric cancer antigen Ga34
Mucin-14
Short name:
MUC-14
Gene namesi
Name:EMCN
Synonyms:EMCN2, MUC14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:16041. EMCN.

Subcellular locationi

Isoform 1 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 190172ExtracellularSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 26150CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596436.

Polymorphism and mutation databases

BioMutaiEMCN.
DMDMi50400693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 261243EndomucinPRO_0000019290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Modified residuei237 – 2371PhosphoserineBy similarity

Post-translational modificationi

Highly O-glycosylated. Sialic acid-rich glycoprotein.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ULC0.
PeptideAtlasiQ9ULC0.
PRIDEiQ9ULC0.
TopDownProteomicsiQ9ULC0-2. [Q9ULC0-2]

PTM databases

iPTMnetiQ9ULC0.
PhosphoSiteiQ9ULC0.

Expressioni

Tissue specificityi

Expressed in heart, kidney and lung.2 Publications

Gene expression databases

BgeeiENSG00000164035.
CleanExiHS_EMCN.
ExpressionAtlasiQ9ULC0. baseline and differential.
GenevisibleiQ9ULC0. HS.

Organism-specific databases

HPAiHPA005928.

Interactioni

Protein-protein interaction databases

BioGridi119689. 2 interactions.
STRINGi9606.ENSP00000296420.

Structurei

3D structure databases

ProteinModelPortaliQ9ULC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 135102Thr-richAdd
BLAST

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MP. Eukaryota.
ENOG4111AC7. LUCA.
GeneTreeiENSGT00390000012139.
HOGENOMiHOG000013126.
HOVERGENiHBG052537.
InParanoidiQ9ULC0.
KOiK16664.
OMAiTTDVRKN.
OrthoDBiEOG091G16TF.
PhylomeDBiQ9ULC0.
TreeFamiTF337783.

Family and domain databases

InterProiIPR010740. Endomucin.
[Graphical view]
PANTHERiPTHR15869. PTHR15869. 1 hit.
PfamiPF07010. Endomucin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ULC0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK
60 70 80 90 100
NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS
110 120 130 140 150
IISNVTVTSV TLPNAVSTLQ SSKPKTETQS SIKTTEIPGS VLQPDASPSK
160 170 180 190 200
TGTLTSIPVT IPENTSQSQV IGTEGGKNAS TSATSRSYSS IILPVVIALI
210 220 230 240 250
VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL LTVKTISHES
260
GEHSAQGKTK N
Length:261
Mass (Da):27,452
Last modified:July 19, 2004 - v2
Checksum:i6C88C34F7A81F7D2
GO
Isoform 2 (identifier: Q9ULC0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-222: Missing.

Show »
Length:178
Mass (Da):18,848
Checksum:iEEED76BC1E27A383
GO
Isoform 3 (identifier: Q9ULC0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-139: TETQSSIKTTEIPG → S

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):26,066
Checksum:iB2951B67C96DE8C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721G → D in BAA86228 (PubMed:11418125).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 13914TETQS…TEIPG → S in isoform 3. 1 PublicationVSP_043264Add
BLAST
Alternative sequencei140 – 22283Missing in isoform 2. 2 PublicationsVSP_010826Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034695 mRNA. Translation: BAA86228.1.
AF205940 mRNA. Translation: AAF76295.1.
AK291831 mRNA. Translation: BAF84520.1.
AK304568 mRNA. Translation: BAG65359.1.
AC034150 Genomic DNA. No translation available.
AC097459 Genomic DNA. No translation available.
AC115623 Genomic DNA. No translation available.
AC116174 Genomic DNA. No translation available.
AC138606 Genomic DNA. No translation available.
AP001964 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06122.1.
BC017781 mRNA. Translation: AAH17781.1.
AY039241 mRNA. Translation: AAK68660.1.
CCDSiCCDS3655.1. [Q9ULC0-1]
CCDS54782.1. [Q9ULC0-3]
RefSeqiNP_001153166.1. NM_001159694.1. [Q9ULC0-3]
NP_057326.2. NM_016242.3. [Q9ULC0-1]
XP_011530326.1. XM_011532024.2. [Q9ULC0-1]
UniGeneiHs.152913.

Genome annotation databases

EnsembliENST00000296420; ENSP00000296420; ENSG00000164035. [Q9ULC0-1]
ENST00000305864; ENSP00000304780; ENSG00000164035. [Q9ULC0-2]
ENST00000511970; ENSP00000422432; ENSG00000164035. [Q9ULC0-3]
GeneIDi51705.
KEGGihsa:51705.
UCSCiuc003hvr.3. human. [Q9ULC0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034695 mRNA. Translation: BAA86228.1.
AF205940 mRNA. Translation: AAF76295.1.
AK291831 mRNA. Translation: BAF84520.1.
AK304568 mRNA. Translation: BAG65359.1.
AC034150 Genomic DNA. No translation available.
AC097459 Genomic DNA. No translation available.
AC115623 Genomic DNA. No translation available.
AC116174 Genomic DNA. No translation available.
AC138606 Genomic DNA. No translation available.
AP001964 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06122.1.
BC017781 mRNA. Translation: AAH17781.1.
AY039241 mRNA. Translation: AAK68660.1.
CCDSiCCDS3655.1. [Q9ULC0-1]
CCDS54782.1. [Q9ULC0-3]
RefSeqiNP_001153166.1. NM_001159694.1. [Q9ULC0-3]
NP_057326.2. NM_016242.3. [Q9ULC0-1]
XP_011530326.1. XM_011532024.2. [Q9ULC0-1]
UniGeneiHs.152913.

3D structure databases

ProteinModelPortaliQ9ULC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119689. 2 interactions.
STRINGi9606.ENSP00000296420.

PTM databases

iPTMnetiQ9ULC0.
PhosphoSiteiQ9ULC0.

Polymorphism and mutation databases

BioMutaiEMCN.
DMDMi50400693.

Proteomic databases

PaxDbiQ9ULC0.
PeptideAtlasiQ9ULC0.
PRIDEiQ9ULC0.
TopDownProteomicsiQ9ULC0-2. [Q9ULC0-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296420; ENSP00000296420; ENSG00000164035. [Q9ULC0-1]
ENST00000305864; ENSP00000304780; ENSG00000164035. [Q9ULC0-2]
ENST00000511970; ENSP00000422432; ENSG00000164035. [Q9ULC0-3]
GeneIDi51705.
KEGGihsa:51705.
UCSCiuc003hvr.3. human. [Q9ULC0-1]

Organism-specific databases

CTDi51705.
GeneCardsiEMCN.
HGNCiHGNC:16041. EMCN.
HPAiHPA005928.
MIMi608350. gene.
neXtProtiNX_Q9ULC0.
PharmGKBiPA144596436.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0MP. Eukaryota.
ENOG4111AC7. LUCA.
GeneTreeiENSGT00390000012139.
HOGENOMiHOG000013126.
HOVERGENiHBG052537.
InParanoidiQ9ULC0.
KOiK16664.
OMAiTTDVRKN.
OrthoDBiEOG091G16TF.
PhylomeDBiQ9ULC0.
TreeFamiTF337783.

Miscellaneous databases

GeneWikiiEMCN.
GenomeRNAii51705.
PROiQ9ULC0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164035.
CleanExiHS_EMCN.
ExpressionAtlasiQ9ULC0. baseline and differential.
GenevisibleiQ9ULC0. HS.

Family and domain databases

InterProiIPR010740. Endomucin.
[Graphical view]
PANTHERiPTHR15869. PTHR15869. 1 hit.
PfamiPF07010. Endomucin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUCEN_HUMAN
AccessioniPrimary (citable) accession number: Q9ULC0
Secondary accession number(s): A8K716
, B4E347, Q8NEY5, Q8WWE7, Q9NRM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.