Cadherin-7 precursor - Homo sapiens (Human)

Contribute

Send feedback

Read comments (?) or add your own

Q9ULB5 (CADH7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cadherin-7

Gene names

Name:	CDH7
Synonyms:	CDH7L1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adherens junction organization Traceable author statement. Source: Reactome cell junction assembly Traceable author statement. Source: Reactome homophilic cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

Potential

Propeptide

28 – 47

Potential

PRO_0000003769

Chain

48 – 785

738

Cadherin-7

PRO_0000003770

Regions

Topological domain

28 – 607

580

Extracellular Potential

Transmembrane

608 – 628

Helical; Potential

Topological domain

629 – 785

157

Cytoplasmic Potential

Domain

49 – 153

105

Cadherin 1

Domain

154 – 262

109

Cadherin 2

Domain

263 – 377

115

Cadherin 3

Domain

378 – 482

105

Cadherin 4

Domain

482 – 599

118

Cadherin 5

Amino acid modifications

Glycosylation

449

N-linked (GlcNAc...) Potential

Glycosylation

530

N-linked (GlcNAc...) Potential

Natural variations

Natural variant

370

D → E. [dbSNP:rs2306675]

VAR_061057

Natural variant

576

N → S. [dbSNP:rs2291343] Ref.1 Ref.2

VAR_060247

Experimental info

Sequence conflict

G → E in CAC13127. Ref.1

Sequence conflict

S → P in CAC13127. Ref.1

Sequence conflict

591 – 600

AQTCNAEAYV → TQTAMQRLC in CAC13127. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9ULB5 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 3C504CD1C620F4BC
Show »

FASTA

785

87,086

        10         20         30         40         50         60 
MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 

        70         80         90        100        110        120 
MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 

       130        140        150        160        170        180 
RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 

       190        200        210        220        230        240 
DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 

       250        260        270        280        290        300 
GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 

       310        320        330        340        350        360 
IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 

       370        380        390        400        410        420 
TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 

       430        440        450        460        470        480 
LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 

       490        500        510        520        530        540 
EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 

       550        560        570        580        590        600 
ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV 

       610        620        630        640        650        660 
LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI VRYDDEGGGE 

       670        680        690        700        710        720 
EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS IPDNVIFREF IWERLKEADV 

       730        740        750        760        770        780 
DPGAPPYDSL QTYAFEGNGS VAESLSSLDS ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ 


ESLYS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7." Kools P., Van Imschoot G., van Roy F. Genomics 68:283-295(2000) [PubMed: 10995570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-576.
[2]	"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Biochem. J. 349:159-167(2000) [PubMed: 10861224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-576.
[3]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007611 mRNA. Translation: CAC13127.1. AB035301 mRNA. Translation: BAA87415.1. AC023394 Genomic DNA. No translation available. AC090358 Genomic DNA. No translation available.
IPI	IPI00297181.
RefSeq	NP_004352.2. NM_004361.2. NP_387450.1. NM_033646.1.
UniGene	Hs.657522.
3D structure databases
ProteinModelPortal	Q9ULB5.
SMR	Q9ULB5. Positions 48-583, 681-779.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULB5. 1 interaction.
STRING	Q9ULB5.
PTM databases
PhosphoSite	Q9ULB5.
Polymorphism databases
DMDM	296434420.
Proteomic databases
PRIDE	Q9ULB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323011; ENSP00000319166; ENSG00000081138. ENST00000397966; ENSP00000381056; ENSG00000081138. ENST00000397968; ENSP00000381058; ENSG00000081138.
GeneID	1005.
KEGG	hsa:1005.
UCSC	uc002ljz.1. human.
Organism-specific databases
CTD	1005.
GeneCards	GC18P063390.
H-InvDB	HIX0027352.
HGNC	HGNC:1766. CDH7.
HPA	HPA010808.
MIM	605806. gene.
neXtProt	NX_Q9ULB5.
PharmGKB	PA26303.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084132.
HOGENOM	HBG505775.
HOVERGEN	HBG005217.
InParanoid	Q9ULB5.
OMA	IITIQKD.
OrthoDB	EOG40K7ZG.
PhylomeDB	Q9ULB5.
Enzyme and pathway databases
Reactome	REACT_111155. Cell-Cell communication.
Gene expression databases
ArrayExpress	Q9ULB5.
Bgee	Q9ULB5.
CleanEx	HS_CDH7.
Genevestigator	Q9ULB5.
GermOnline	ENSG00000081138. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
KO	K06799.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	4224.
SOURCE	Search...

Entry information

Entry name

CADH7_HUMAN

Accession

Primary (citable) accession number: Q9ULB5
Secondary accession number(s): Q9H157

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents