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Protein

Cadherin-7

Gene

CDH7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-7
Gene namesi
Name:CDH7
Synonyms:CDH7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:1766. CDH7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 607580ExtracellularSequence analysisAdd
BLAST
Transmembranei608 – 62821HelicalSequence analysisAdd
BLAST
Topological domaini629 – 785157CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26303.

Polymorphism and mutation databases

BioMutaiCDH7.
DMDMi296434420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 4720Sequence analysisPRO_0000003769Add
BLAST
Chaini48 – 785738Cadherin-7PRO_0000003770Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence analysis
Modified residuei785 – 7851PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ULB5.
PRIDEiQ9ULB5.

PTM databases

iPTMnetiQ9ULB5.
PhosphoSiteiQ9ULB5.

Expressioni

Gene expression databases

BgeeiQ9ULB5.
CleanExiHS_CDH7.
ExpressionAtlasiQ9ULB5. baseline and differential.
GenevisibleiQ9ULB5. HS.

Organism-specific databases

HPAiHPA010808.

Interactioni

Protein-protein interaction databases

BioGridi107440. 2 interactions.
IntActiQ9ULB5. 1 interaction.
STRINGi9606.ENSP00000319166.

Structurei

3D structure databases

ProteinModelPortaliQ9ULB5.
SMRiQ9ULB5. Positions 48-583, 682-779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 153105Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini154 – 262109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini263 – 377115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 482105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini482 – 599118Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9ULB5.
KOiK06799.
OMAiITIQKDL.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9ULB5.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV
60 70 80 90 100
WNQFFVLEEY MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN
110 120 130 140 150
TGDIHATKRL DREEQAYYTL RAQALDRLTN KPVEPESEFV IKIQDINDNE
160 170 180 190 200
PKFLDGPYTA GVPEMSPVGT SVVQVTATDA DDPTYGNSAR VVYSILQGQP
210 220 230 240 250
YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG GLSGTTSVTV
260 270 280 290 300
TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK
310 320 330 340 350
IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP
360 370 380 390 400
RFLSLGPFSD TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA
410 420 430 440 450
AHDPDSSNSP VRYSIDRNTD LERYFNIDAN SGVITTAKSL DRETNAIHNI
460 470 480 490 500
TVLAMESQNP SQVGRGYVAI TILDINDNAP EFAMDYETTV CENAQPGQVI
510 520 530 540 550
QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT ASILTRRNGF
560 570 580 590 600
RRQEQSVYYL PIFIVDSGSP SLSSTNTLTI RVCDCDADGV AQTCNAEAYV
610 620 630 640 650
LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI
660 670 680 690 700
VRYDDEGGGE EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS
710 720 730 740 750
IPDNVIFREF IWERLKEADV DPGAPPYDSL QTYAFEGNGS VAESLSSLDS
760 770 780
ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ ESLYS
Length:785
Mass (Da):87,086
Last modified:May 18, 2010 - v2
Checksum:i3C504CD1C620F4BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231G → E in CAC13127 (PubMed:10995570).Curated
Sequence conflicti32 – 321S → P in CAC13127 (PubMed:10995570).Curated
Sequence conflicti591 – 60010AQTCNAEAYV → TQTAMQRLC in CAC13127 (PubMed:10995570).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti370 – 3701D → E.
Corresponds to variant rs2306675 [ dbSNP | Ensembl ].
VAR_061057
Natural varianti576 – 5761N → S.2 Publications
Corresponds to variant rs2291343 [ dbSNP | Ensembl ].
VAR_060247

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007611 mRNA. Translation: CAC13127.1.
AB035301 mRNA. Translation: BAA87415.1.
AC023394 Genomic DNA. No translation available.
AC090358 Genomic DNA. No translation available.
CCDSiCCDS11993.1.
RefSeqiNP_001304143.1. NM_001317214.1.
NP_004352.2. NM_004361.3.
NP_387450.1. NM_033646.2.
UniGeneiHs.541003.
Hs.657522.

Genome annotation databases

EnsembliENST00000323011; ENSP00000319166; ENSG00000081138.
ENST00000397968; ENSP00000381058; ENSG00000081138.
GeneIDi1005.
KEGGihsa:1005.
UCSCiuc002ljz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007611 mRNA. Translation: CAC13127.1.
AB035301 mRNA. Translation: BAA87415.1.
AC023394 Genomic DNA. No translation available.
AC090358 Genomic DNA. No translation available.
CCDSiCCDS11993.1.
RefSeqiNP_001304143.1. NM_001317214.1.
NP_004352.2. NM_004361.3.
NP_387450.1. NM_033646.2.
UniGeneiHs.541003.
Hs.657522.

3D structure databases

ProteinModelPortaliQ9ULB5.
SMRiQ9ULB5. Positions 48-583, 682-779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107440. 2 interactions.
IntActiQ9ULB5. 1 interaction.
STRINGi9606.ENSP00000319166.

PTM databases

iPTMnetiQ9ULB5.
PhosphoSiteiQ9ULB5.

Polymorphism and mutation databases

BioMutaiCDH7.
DMDMi296434420.

Proteomic databases

PaxDbiQ9ULB5.
PRIDEiQ9ULB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323011; ENSP00000319166; ENSG00000081138.
ENST00000397968; ENSP00000381058; ENSG00000081138.
GeneIDi1005.
KEGGihsa:1005.
UCSCiuc002ljz.3. human.

Organism-specific databases

CTDi1005.
GeneCardsiCDH7.
H-InvDBHIX0027352.
HGNCiHGNC:1766. CDH7.
HPAiHPA010808.
MIMi605806. gene.
neXtProtiNX_Q9ULB5.
PharmGKBiPA26303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9ULB5.
KOiK06799.
OMAiITIQKDL.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9ULB5.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

GenomeRNAii1005.
PROiQ9ULB5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ULB5.
CleanExiHS_CDH7.
ExpressionAtlasiQ9ULB5. baseline and differential.
GenevisibleiQ9ULB5. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7."
    Kools P., Van Imschoot G., van Roy F.
    Genomics 68:283-295(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-576.
  2. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
    Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
    Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-576.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCADH7_HUMAN
AccessioniPrimary (citable) accession number: Q9ULB5
Secondary accession number(s): Q9H157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.