Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9ULB5 (CADH7_HUMAN)

Last modified February 9, 2010. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cadherin-7
Gene names
Name: CDH7
Synonyms: CDH7L1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 5 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
   LigandCalcium
   PTMCleavage on pair of basic residues
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhomophilic cell adhesion

Non-traceable author statement. Source: UniProtKB

   Cellular componentintegral to membrane

Non-traceable author statement. Source: UniProtKB

plasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Propeptide28 – 4720 Potential
PRO_0000003769
Chain48 – 785738Cadherin-7
PRO_0000003770

Regions

Topological domain28 – 607580Extracellular Potential
Transmembrane608 – 62821 Potential
Topological domain629 – 785157Cytoplasmic Potential
Domain49 – 153105Cadherin 1
Domain154 – 262109Cadherin 2
Domain263 – 377115Cadherin 3
Domain378 – 482105Cadherin 4
Domain482 – 599118Cadherin 5

Amino acid modifications

Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation5301N-linked (GlcNAc...) Potential

Natural variations

Natural variant3701D → E: dbSNP rs2306675.
VAR_061057
Natural variant5761S → N: dbSNP rs2291343.
VAR_060247

Experimental info

Sequence conflict231G → E in CAC13127. Ref.1
Sequence conflict321S → P in CAC13127. Ref.1
Sequence conflict591 – 60010AQTCNAEAYV → TQTAMQRLC in CAC13127. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9ULB5-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0D889FFFE105279B

FASTA78587,059
        10         20         30         40         50         60 
MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 

        70         80         90        100        110        120 
MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 

       130        140        150        160        170        180 
RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 

       190        200        210        220        230        240 
DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 

       250        260        270        280        290        300 
GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 

       310        320        330        340        350        360 
IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 

       370        380        390        400        410        420 
TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 

       430        440        450        460        470        480 
LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 

       490        500        510        520        530        540 
EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 

       550        560        570        580        590        600 
ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTSTLTI RVCDCDADGV AQTCNAEAYV 

       610        620        630        640        650        660 
LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI VRYDDEGGGE 

       670        680        690        700        710        720 
EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS IPDNVIFREF IWERLKEADV 

       730        740        750        760        770        780 
DPGAPPYDSL QTYAFEGNGS VAESLSSLDS ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ 


ESLYS 

« Hide

References

[1]"Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7."
Kools P., Van Imschoot G., van Roy F.
Genomics 68:283-295(2000) [PubMed: 10995570] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
Biochem. J. 349:159-167(2000) [PubMed: 10861224] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ007611 mRNA. Translation: CAC13127.1.
AB035301 mRNA. Translation: BAA87415.1.
IPIIPI00297181.
RefSeqNP_004352.2.
NP_387450.1.
UniGeneHs.657522

3D structure databases

SMRQ9ULB5. Positions 48-369, 383-584, 715-776.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ULB5.

Proteomic databases

PRIDEQ9ULB5.

Genome annotation databases

EnsemblENST00000323011; ENSP00000319166; ENSG00000081138; Homo sapiens. [Genome view]
ENST00000397966; ENSP00000381056; ENSG00000081138; Homo sapiens. [Genome view]
ENST00000397968; ENSP00000381058; ENSG00000081138; Homo sapiens. [Genome view]
GeneID1005.
KEGGhsa:1005.
UCSCuc002ljz.1. human.

Organism-specific databases

CTD1005.
GeneCardsGC18P061568.
H-InvDBHIX0027352.
HGNCHGNC:1766. CDH7.
HPAHPA010808.
MIM605806. gene.
PharmGKBPA26303.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG505775.
HOVERGENQ9ULB5.
InParanoidQ9ULB5.

Enzyme and pathway databases

ReactomeREACT_20676. Cell junction organization.

Gene expression databases

ArrayExpressQ9ULB5.
BgeeQ9ULB5.
CleanExHS_CDH7.
GenevestigatorQ9ULB5.
GermOnlineENSG00000081138. Homo sapiens.

Family and domain databases

InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
[Graphical view]
Gene3DG3DSA:2.60.40.60. Cadherin. 5 hits.
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4224.
SOURCESearch...

Entry information

Entry nameCADH7_HUMAN
AccessionPrimary (citable) accession number: Q9ULB5
Secondary accession number(s): Q9H157
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: May 1, 2000
Last modified: February 9, 2010
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents