Reviewed, UniProtKB/Swiss-Prot Q9ULB5 (CADH7_HUMAN)

Names and origin

Protein names

Recommended name:
    Cadherin-7

Gene names

Name:	CDH7
Synonyms:	CDH7L1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane
Ligand	Calcium
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	homophilic cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from Experiment. Source: Reactome
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Propeptide	28 – 47	20	Potential		PRO_0000003769
	Chain	48 – 785	738	Cadherin-7		PRO_0000003770
Regions
	Topological domain	28 – 607	580	Extracellular Potential
	Transmembrane	608 – 628	21	Potential
	Topological domain	629 – 785	157	Cytoplasmic Potential
	Domain	49 – 153	105	Cadherin 1
	Domain	154 – 262	109	Cadherin 2
	Domain	263 – 377	115	Cadherin 3
	Domain	378 – 482	105	Cadherin 4
	Domain	482 – 599	118	Cadherin 5
Amino acid modifications
	Glycosylation	449	1	N-linked (GlcNAc...) Potential
	Glycosylation	530	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	370	1	D → E: dbSNP rs2306675.		VAR_061057
	Natural variant	576	1	S → N: dbSNP rs2291343.		VAR_060247
Experimental info
	Sequence conflict	23	1	G → E in CAC13127. Ref.1
	Sequence conflict	32	1	S → P in CAC13127. Ref.1
	Sequence conflict	591 – 600	10	AQTCNAEAYV → TQTAMQRLC in CAC13127. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9ULB5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0D889FFFE105279B	FASTA	785	87,059
	10 20 30 40 50 60 MKLGKVEFCH FLQLIALFLC FSGMSQAELS RSRSKPYFQS GRSRTKRSWV WNQFFVLEEY 70 80 90 100 110 120 MGSDPLYVGK LHSDVDKGDG SIKYILSGEG ASSIFIIDEN TGDIHATKRL DREEQAYYTL 130 140 150 160 170 180 RAQALDRLTN KPVEPESEFV IKIQDINDNE PKFLDGPYTA GVPEMSPVGT SVVQVTATDA 190 200 210 220 230 240 DDPTYGNSAR VVYSILQGQP YFSVEPKTGV IKTALPNMDR EAKDQYLLVI QAKDMVGQNG 250 260 270 280 290 300 GLSGTTSVTV TLTDVNDNPP RFPRRSYQYN VPESLPVASV VARIKAADAD IGANAEMEYK 310 320 330 340 350 360 IVDGDGLGIF KISVDKETQE GIITIQKELD FEAKTSYTLR IEAANKDADP RFLSLGPFSD 370 380 390 400 410 420 TTTVKIIVED VDEPPVFSSP LYPMEVSEAT QVGNIIGTVA AHDPDSSNSP VRYSIDRNTD 430 440 450 460 470 480 LERYFNIDAN SGVITTAKSL DRETNAIHNI TVLAMESQNP SQVGRGYVAI TILDINDNAP 490 500 510 520 530 540 EFAMDYETTV CENAQPGQVI QKISAVDKDE PSNGHQFYFS LTTDATNNHN FSLKDNKDNT 550 560 570 580 590 600 ASILTRRNGF RRQEQSVYYL PIFIVDSGSP SLSSTSTLTI RVCDCDADGV AQTCNAEAYV 610 620 630 640 650 660 LPAGLSTGAL IAILACVLTL LVLILLIVTM RRRKKEPLIF DEERDIRENI VRYDDEGGGE 670 680 690 700 710 720 EDTEAFDMAA LRNLNVIRDT KTRRDVTPEI QFLSRPAFKS IPDNVIFREF IWERLKEADV 730 740 750 760 770 780 DPGAPPYDSL QTYAFEGNGS VAESLSSLDS ISSNSDQNYD YLSDWGPRFK RLADMYGTGQ ESLYS

References

[1]	"Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7." Kools P., Van Imschoot G., van Roy F. Genomics 68:283-295(2000) [PubMed: 10995570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Biochem. J. 349:159-167(2000) [PubMed: 10861224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007611 mRNA. Translation: CAC13127.1. AB035301 mRNA. Translation: BAA87415.1.
IPI	IPI00297181.
RefSeq	NP_004352.2. NP_387450.1.
UniGene	Hs.657522
3D structure databases
SMR	Q9ULB5. Positions 48-369, 383-584, 715-776.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ULB5.
Proteomic databases
PRIDE	Q9ULB5.
Genome annotation databases
Ensembl	ENST00000323011; ENSP00000319166; ENSG00000081138; Homo sapiens. [Genome view] ENST00000397966; ENSP00000381056; ENSG00000081138; Homo sapiens. [Genome view] ENST00000397968; ENSP00000381058; ENSG00000081138; Homo sapiens. [Genome view]
GeneID	1005.
KEGG	hsa:1005.
UCSC	uc002ljz.1. human.
Organism-specific databases
CTD	1005.
GeneCards	GC18P061568.
H-InvDB	HIX0027352.
HGNC	HGNC:1766. CDH7.
HPA	HPA010808.
MIM	605806. gene.
PharmGKB	PA26303.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG505775.
HOVERGEN	Q9ULB5.
InParanoid	Q9ULB5.
Enzyme and pathway databases
Reactome	REACT_20676. Cell junction organization.
Gene expression databases
ArrayExpress	Q9ULB5.
Bgee	Q9ULB5.
CleanEx	HS_CDH7.
Genevestigator	Q9ULB5.
GermOnline	ENSG00000081138. Homo sapiens.
Family and domain databases
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Gene3D	G3DSA:2.60.40.60. Cadherin. 5 hits.
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
PROSITE	PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4224.
SOURCE	Search...

Entry information

Entry name

CADH7_HUMAN

Accession

Primary (citable) accession number: Q9ULB5
Secondary accession number(s): Q9H157

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2001
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.