Q9ULB5 (CADH7_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 97.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cadherin-7 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 785 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Subcellular location | |
| Sequence similarities | Contains 5 cadherin domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane Transmembrane helix |
| Ligand | Calcium |
| PTM | Cleavage on pair of basic residues Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | adherens junction organization Traceable author statement. Source: Reactome cell junction assemblyTraceable author statement. Source: Reactome homophilic cell adhesionNon-traceable author statement. Source: UniProtKB |
| Cellular component | integral to membrane Non-traceable author statement. Source: UniProtKB plasma membraneTraceable author statement. Source: Reactome |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | Potential | ||||||
| Propeptide | 28 – 47 | 20 | Potential | PRO_0000003769 | |||||
| Chain | 48 – 785 | 738 | Cadherin-7 | PRO_0000003770 | |||||
Regions | |||||||||
| Topological domain | 28 – 607 | 580 | Extracellular Potential | ||||||
| Transmembrane | 608 – 628 | 21 | Helical; Potential | ||||||
| Topological domain | 629 – 785 | 157 | Cytoplasmic Potential | ||||||
| Domain | 49 – 153 | 105 | Cadherin 1 | ||||||
| Domain | 154 – 262 | 109 | Cadherin 2 | ||||||
| Domain | 263 – 377 | 115 | Cadherin 3 | ||||||
| Domain | 378 – 482 | 105 | Cadherin 4 | ||||||
| Domain | 482 – 599 | 118 | Cadherin 5 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 449 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 530 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 370 | 1 | D → E. [dbSNP:rs2306675] | VAR_061057 | |||||
| Natural variant | 576 | 1 | N → S. [dbSNP:rs2291343] Ref.1 Ref.2 | VAR_060247 | |||||
Experimental info | |||||||||
| Sequence conflict | 23 | 1 | G → E in CAC13127. Ref.1 | ||||||
| Sequence conflict | 32 | 1 | S → P in CAC13127. Ref.1 | ||||||
| Sequence conflict | 591 – 600 | 10 | AQTCNAEAYV → TQTAMQRLC in CAC13127. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7." Kools P., Van Imschoot G., van Roy F. Genomics 68:283-295(2000) [PubMed: 10995570] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-576. |
| [2] | "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Biochem. J. 349:159-167(2000) [PubMed: 10861224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-576. |
| [3] | "DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. Lander E.S.Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ007611 mRNA. Translation: CAC13127.1. AB035301 mRNA. Translation: BAA87415.1. AC023394 Genomic DNA. No translation available. AC090358 Genomic DNA. No translation available. |
| IPI | IPI00297181. |
| RefSeq | NP_004352.2. NM_004361.2. NP_387450.1. NM_033646.1. |
| UniGene | Hs.657522. |
3D structure databases | |
| ProteinModelPortal | Q9ULB5. |
| SMR | Q9ULB5. Positions 48-583, 681-779. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9ULB5. 1 interaction. |
| STRING | Q9ULB5. |
PTM databases | |
| PhosphoSite | Q9ULB5. |
Polymorphism databases | |
| DMDM | 296434420. |
Proteomic databases | |
| PRIDE | Q9ULB5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000323011; ENSP00000319166; ENSG00000081138. ENST00000397966; ENSP00000381056; ENSG00000081138. ENST00000397968; ENSP00000381058; ENSG00000081138. |
| GeneID | 1005. |
| KEGG | hsa:1005. |
| UCSC | uc002ljz.1. human. |
Organism-specific databases | |
| CTD | 1005. |
| GeneCards | GC18P063390. |
| H-InvDB | HIX0027352. |
| HGNC | HGNC:1766. CDH7. |
| HPA | HPA010808. |
| MIM | 605806. gene. |
| neXtProt | NX_Q9ULB5. |
| PharmGKB | PA26303. |
| GenAtlas | Search... |
Phylogenomic databases | |
| GeneTree | ENSGT00600000084132. |
| HOGENOM | HBG505775. |
| HOVERGEN | HBG005217. |
| InParanoid | Q9ULB5. |
| OMA | IITIQKD. |
| OrthoDB | EOG40K7ZG. |
| PhylomeDB | Q9ULB5. |
Enzyme and pathway databases | |
| Reactome | REACT_111155. Cell-Cell communication. |
Gene expression databases | |
| ArrayExpress | Q9ULB5. |
| Bgee | Q9ULB5. |
| CleanEx | HS_CDH7. |
| Genevestigator | Q9ULB5. |
| GermOnline | ENSG00000081138. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view] |
| Gene3D | G3DSA:2.60.40.60. Cadherin. 5 hits. |
| KO | K06799. |
| Pfam | PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view] |
| PRINTS | PR00205. CADHERIN. |
| SMART | SM00112. CA. 5 hits. [Graphical view] |
| SUPFAM | SSF49313. Cadherin. 5 hits. |
| PROSITE | PS00232. CADHERIN_1. 3 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 4224. |
| SOURCE | Search... |
Entry information
| Entry name | CADH7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9ULB5 Secondary accession number(s): Q9H157 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 18 Human chromosome 18: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with