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Q9ULB4 (CADH9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin-9
Gene names
Name:CDH9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length789 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 5 cadherin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 5332 Potential
PRO_0000003779
Chain54 – 789736Cadherin-9
PRO_0000003780

Regions

Topological domain54 – 615562Extracellular Potential
Transmembrane616 – 63621Helical; Potential
Topological domain637 – 789153Cytoplasmic Potential
Domain54 – 159106Cadherin 1
Domain160 – 268109Cadherin 2
Domain269 – 383115Cadherin 3
Domain384 – 486103Cadherin 4
Domain487 – 608122Cadherin 5

Amino acid modifications

Glycosylation2551N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4551N-linked (GlcNAc...) Potential
Glycosylation5361N-linked (GlcNAc...) Potential

Natural variations

Natural variant61Y → C. Ref.2
Corresponds to variant rs2288467 [ dbSNP | Ensembl ].
VAR_029799
Natural variant381A → V. Ref.2
Corresponds to variant rs2288466 [ dbSNP | Ensembl ].
VAR_029800

Experimental info

Sequence conflict181T → I in BAA87416. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9ULB4 [UniParc].

Last modified December 12, 2006. Version 2.
Checksum: C580DA16B769047C

FASTA78988,689
        10         20         30         40         50         60 
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR TKRGWMWNQF 

        70         80         90        100        110        120 
FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE 

       130        140        150        160        170        180 
KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KDLYTASVPE MSGVGTSVIQ 

       190        200        210        220        230        240 
VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD 

       250        260        270        280        290        300 
MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN 

       310        320        330        340        350        360 
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS NTHPDPRFLH 

       370        380        390        400        410        420 
LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS IIGQVTAYDP DARNNLIKYS 

       430        440        450        460        470        480 
VDRHTDMDRI FGIHSENGSI FTLKALDRES SPWHNITVTA TEINNPKQSS HIPVFIRILD 

       490        500        510        520        530        540 
INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV 

       550        560        570        580        590        600 
DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC 

       610        620        630        640        650        660 
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD DVRDNIVTYN 

       670        680        690        700        710        720 
DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQDFIHRRL 

       730        740        750        760        770        780 
KENDADPSAP PYDSLATYAY EGNDSIADSL SSLESLTADC NQDYDYLSDW GPRFKKLADM 


YGGDDSDRD 

« Hide

References

« Hide 'large scale' references
[1]"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-6 AND VAL-38.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB035302 mRNA. Translation: BAA87416.1.
BC107594 mRNA. Translation: AAI07595.1.
BC113745 mRNA. Translation: AAI13746.1.
RefSeqNP_057363.3. NM_016279.3.
UniGeneHs.272212.

3D structure databases

ProteinModelPortalQ9ULB4.
SMRQ9ULB4. Positions 55-589, 689-783.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107442. 2 interactions.
STRING9606.ENSP00000231021.

PTM databases

PhosphoSiteQ9ULB4.

Polymorphism databases

DMDM119370307.

Proteomic databases

PaxDbQ9ULB4.
PRIDEQ9ULB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231021; ENSP00000231021; ENSG00000113100.
GeneID1007.
KEGGhsa:1007.
UCSCuc003jgs.1. human.

Organism-specific databases

CTD1007.
GeneCardsGC05M026916.
H-InvDBHIX0031940.
HGNCHGNC:1768. CDH9.
HPAHPA007167.
MIM609974. gene.
neXtProtNX_Q9ULB4.
PharmGKBPA26305.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG235715.
HOGENOMHOG000231252.
HOVERGENHBG005217.
InParanoidQ9ULB4.
KOK06801.
OMALFIWTYM.
OrthoDBEOG7GBFW7.
PhylomeDBQ9ULB4.
TreeFamTF329887.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressQ9ULB4.
BgeeQ9ULB4.
CleanExHS_CDH9.
GenevestigatorQ9ULB4.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 5 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCDH9.
GenomeRNAi1007.
NextBio4234.
PROQ9ULB4.
SOURCESearch...

Entry information

Entry nameCADH9_HUMAN
AccessionPrimary (citable) accession number: Q9ULB4
Secondary accession number(s): Q3B7I5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM