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Q9ULB4

- CADH9_HUMAN

UniProt

Q9ULB4 - CADH9_HUMAN

Protein

Cadherin-9

Gene

CDH9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. cell-cell junction organization Source: Reactome
    3. cell junction assembly Source: Reactome
    4. homophilic cell adhesion Source: InterPro
    5. single organismal cell-cell adhesion Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadherin-9
    Gene namesi
    Name:CDH9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:1768. CDH9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26305.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 5332Sequence AnalysisPRO_0000003779Add
    BLAST
    Chaini54 – 789736Cadherin-9PRO_0000003780Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiQ9ULB4.
    PRIDEiQ9ULB4.

    PTM databases

    PhosphoSiteiQ9ULB4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ULB4.
    BgeeiQ9ULB4.
    CleanExiHS_CDH9.
    GenevestigatoriQ9ULB4.

    Organism-specific databases

    HPAiHPA007167.

    Interactioni

    Protein-protein interaction databases

    BioGridi107442. 2 interactions.
    STRINGi9606.ENSP00000231021.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ULB4.
    SMRiQ9ULB4. Positions 55-589, 689-783.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini54 – 615562ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini637 – 789153CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei616 – 63621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 608122Cadherin 5PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 5 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG235715.
    HOGENOMiHOG000231252.
    HOVERGENiHBG005217.
    InParanoidiQ9ULB4.
    KOiK06801.
    OMAiLFIWTYM.
    OrthoDBiEOG7GBFW7.
    PhylomeDBiQ9ULB4.
    TreeFamiTF329887.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 5 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ULB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR    50
    TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL 100
    FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH 150
    DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS 200
    ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG 250
    TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN 300
    AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS 350
    NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS 400
    IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES 450
    SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA 500
    KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM 550
    TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC 600
    TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD 650
    DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI 700
    RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL 750
    SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD 789
    Length:789
    Mass (Da):88,689
    Last modified:December 12, 2006 - v2
    Checksum:iC580DA16B769047C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181T → I in BAA87416. (PubMed:10861224)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61Y → C.1 Publication
    Corresponds to variant rs2288467 [ dbSNP | Ensembl ].
    VAR_029799
    Natural varianti38 – 381A → V.1 Publication
    Corresponds to variant rs2288466 [ dbSNP | Ensembl ].
    VAR_029800

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035302 mRNA. Translation: BAA87416.1.
    BC107594 mRNA. Translation: AAI07595.1.
    BC113745 mRNA. Translation: AAI13746.1.
    CCDSiCCDS3893.1.
    RefSeqiNP_057363.3. NM_016279.3.
    UniGeneiHs.272212.

    Genome annotation databases

    EnsembliENST00000231021; ENSP00000231021; ENSG00000113100.
    GeneIDi1007.
    KEGGihsa:1007.
    UCSCiuc003jgs.1. human.

    Polymorphism databases

    DMDMi119370307.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035302 mRNA. Translation: BAA87416.1 .
    BC107594 mRNA. Translation: AAI07595.1 .
    BC113745 mRNA. Translation: AAI13746.1 .
    CCDSi CCDS3893.1.
    RefSeqi NP_057363.3. NM_016279.3.
    UniGenei Hs.272212.

    3D structure databases

    ProteinModelPortali Q9ULB4.
    SMRi Q9ULB4. Positions 55-589, 689-783.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107442. 2 interactions.
    STRINGi 9606.ENSP00000231021.

    PTM databases

    PhosphoSitei Q9ULB4.

    Polymorphism databases

    DMDMi 119370307.

    Proteomic databases

    PaxDbi Q9ULB4.
    PRIDEi Q9ULB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000231021 ; ENSP00000231021 ; ENSG00000113100 .
    GeneIDi 1007.
    KEGGi hsa:1007.
    UCSCi uc003jgs.1. human.

    Organism-specific databases

    CTDi 1007.
    GeneCardsi GC05M026916.
    H-InvDB HIX0031940.
    HGNCi HGNC:1768. CDH9.
    HPAi HPA007167.
    MIMi 609974. gene.
    neXtProti NX_Q9ULB4.
    PharmGKBi PA26305.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235715.
    HOGENOMi HOG000231252.
    HOVERGENi HBG005217.
    InParanoidi Q9ULB4.
    KOi K06801.
    OMAi LFIWTYM.
    OrthoDBi EOG7GBFW7.
    PhylomeDBi Q9ULB4.
    TreeFami TF329887.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    GeneWikii CDH9.
    GenomeRNAii 1007.
    NextBioi 4234.
    PROi Q9ULB4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ULB4.
    Bgeei Q9ULB4.
    CleanExi HS_CDH9.
    Genevestigatori Q9ULB4.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
      Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
      Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-6 AND VAL-38.

    Entry informationi

    Entry nameiCADH9_HUMAN
    AccessioniPrimary (citable) accession number: Q9ULB4
    Secondary accession number(s): Q3B7I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3