Q9ULB4 (CADH9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin-9

Gene names

Name:

CDH9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	789 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 5 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adherens junction organization Traceable author statement. Source: Reactome cell junction assembly Traceable author statement. Source: Reactome homophilic cell adhesion Non-traceable author statement. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 53	32	Potential		PRO_0000003779
	Chain	54 – 789	736	Cadherin-9		PRO_0000003780
Regions
	Topological domain	54 – 615	562	Extracellular Potential
	Transmembrane	616 – 636	21	Helical; Potential
	Topological domain	637 – 789	153	Cytoplasmic Potential
	Domain	54 – 159	106	Cadherin 1
	Domain	160 – 268	109	Cadherin 2
	Domain	269 – 383	115	Cadherin 3
	Domain	384 – 486	103	Cadherin 4
	Domain	487 – 608	122	Cadherin 5
Amino acid modifications
	Glycosylation	255	1	N-linked (GlcNAc...) Potential
	Glycosylation	437	1	N-linked (GlcNAc...) Potential
	Glycosylation	455	1	N-linked (GlcNAc...) Potential
	Glycosylation	536	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	6	1	Y → C. Ref.2 Corresponds to variant rs2288467 [ dbSNP | Ensembl ].		VAR_029799
	Natural variant	38	1	A → V. Ref.2 Corresponds to variant rs2288466 [ dbSNP | Ensembl ].		VAR_029800
Experimental info
	Sequence conflict	18	1	T → I in BAA87416. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9ULB4 [UniParc]. Last modified December 12, 2006. Version 2. Checksum: C580DA16B769047C	FASTA	789	88,689
	10 20 30 40 50 60 MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR TKRGWMWNQF 70 80 90 100 110 120 FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE 130 140 150 160 170 180 KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KDLYTASVPE MSGVGTSVIQ 190 200 210 220 230 240 VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD 250 260 270 280 290 300 MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN 310 320 330 340 350 360 AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS NTHPDPRFLH 370 380 390 400 410 420 LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS IIGQVTAYDP DARNNLIKYS 430 440 450 460 470 480 VDRHTDMDRI FGIHSENGSI FTLKALDRES SPWHNITVTA TEINNPKQSS HIPVFIRILD 490 500 510 520 530 540 INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV 550 560 570 580 590 600 DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC 610 620 630 640 650 660 TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD DVRDNIVTYN 670 680 690 700 710 720 DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQDFIHRRL 730 740 750 760 770 780 KENDADPSAP PYDSLATYAY EGNDSIADSL SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." Shimoyama Y., Tsujimoto G., Kitajima M., Natori M. Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-6 AND VAL-38.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB035302 mRNA. Translation: BAA87416.1. BC107594 mRNA. Translation: AAI07595.1. BC113745 mRNA. Translation: AAI13746.1.
IPI	IPI00297180.
RefSeq	NP_057363.3. NM_016279.3.
UniGene	Hs.272212.
3D structure databases
ProteinModelPortal	Q9ULB4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000231021.
PTM databases
PhosphoSite	Q9ULB4.
Polymorphism databases
DMDM	119370307.
Proteomic databases
PaxDb	Q9ULB4.
PRIDE	Q9ULB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000231021; ENSP00000231021; ENSG00000113100.
GeneID	1007.
KEGG	hsa:1007.
UCSC	uc003jgs.1. human.
Organism-specific databases
CTD	1007.
GeneCards	GC05M026916.
H-InvDB	HIX0031940.
HGNC	HGNC:1768. CDH9.
HPA	HPA007167.
MIM	609974. gene.
neXtProt	NX_Q9ULB4.
PharmGKB	PA26305.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG235715.
HOGENOM	HOG000231252.
HOVERGEN	HBG005217.
InParanoid	Q9ULB4.
KO	K06801.
OMA	PLFIWTY.
OrthoDB	EOG4CZBF8.
PhylomeDB	Q9ULB4.
Enzyme and pathway databases
Reactome	REACT_111155. Cell-Cell communication.
Gene expression databases
ArrayExpress	Q9ULB4.
Bgee	Q9ULB4.
CleanEx	HS_CDH9.
Genevestigator	Q9ULB4.
GermOnline	ENSG00000113100. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 5 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	1007.
NextBio	4234.
SOURCE	Search...

Entry information

Entry name

CADH9_HUMAN

Accession

Primary (citable) accession number: Q9ULB4
Secondary accession number(s): Q3B7I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.