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Protein

Cadherin-9

Gene

CDH9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113100-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-9
Gene namesi
Name:CDH9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1768. CDH9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini54 – 615ExtracellularSequence analysisAdd BLAST562
Transmembranei616 – 636HelicalSequence analysisAdd BLAST21
Topological domaini637 – 789CytoplasmicSequence analysisAdd BLAST153

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1007.
OpenTargetsiENSG00000113100.
PharmGKBiPA26305.

Polymorphism and mutation databases

BioMutaiCDH9.
DMDMi119370307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000377922 – 53Sequence analysisAdd BLAST32
ChainiPRO_000000378054 – 789Cadherin-9Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi255N-linked (GlcNAc...)Sequence analysis1
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Glycosylationi455N-linked (GlcNAc...)Sequence analysis1
Glycosylationi536N-linked (GlcNAc...)Sequence analysis1
Modified residuei786PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9ULB4.
PaxDbiQ9ULB4.
PeptideAtlasiQ9ULB4.
PRIDEiQ9ULB4.

PTM databases

iPTMnetiQ9ULB4.
PhosphoSitePlusiQ9ULB4.

Expressioni

Gene expression databases

BgeeiENSG00000113100.
CleanExiHS_CDH9.
ExpressionAtlasiQ9ULB4. baseline and differential.
GenevisibleiQ9ULB4. HS.

Organism-specific databases

HPAiHPA007167.

Interactioni

Protein-protein interaction databases

BioGridi107442. 3 interactors.
STRINGi9606.ENSP00000231021.

Structurei

3D structure databases

ProteinModelPortaliQ9ULB4.
SMRiQ9ULB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 159Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini160 – 268Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini269 – 383Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini384 – 486Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini487 – 608Cadherin 5PROSITE-ProRule annotationAdd BLAST122

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9ULB4.
KOiK06801.
OMAiFIWTYMF.
OrthoDBiEOG091G0298.
PhylomeDBiQ9ULB4.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR
60 70 80 90 100
TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL
110 120 130 140 150
FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH
160 170 180 190 200
DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN
310 320 330 340 350
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS
360 370 380 390 400
NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS
410 420 430 440 450
IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES
460 470 480 490 500
SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA
510 520 530 540 550
KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM
560 570 580 590 600
TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC
610 620 630 640 650
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD
660 670 680 690 700
DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI
710 720 730 740 750
RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL
760 770 780
SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD
Length:789
Mass (Da):88,689
Last modified:December 12, 2006 - v2
Checksum:iC580DA16B769047C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18T → I in BAA87416 (PubMed:10861224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0297996Y → C.1 PublicationCorresponds to variant rs2288467dbSNPEnsembl.1
Natural variantiVAR_02980038A → V.1 PublicationCorresponds to variant rs2288466dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035302 mRNA. Translation: BAA87416.1.
BC107594 mRNA. Translation: AAI07595.1.
BC113745 mRNA. Translation: AAI13746.1.
CCDSiCCDS3893.1.
RefSeqiNP_057363.3. NM_016279.3.
UniGeneiHs.272212.

Genome annotation databases

EnsembliENST00000231021; ENSP00000231021; ENSG00000113100.
GeneIDi1007.
KEGGihsa:1007.
UCSCiuc003jgs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035302 mRNA. Translation: BAA87416.1.
BC107594 mRNA. Translation: AAI07595.1.
BC113745 mRNA. Translation: AAI13746.1.
CCDSiCCDS3893.1.
RefSeqiNP_057363.3. NM_016279.3.
UniGeneiHs.272212.

3D structure databases

ProteinModelPortaliQ9ULB4.
SMRiQ9ULB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107442. 3 interactors.
STRINGi9606.ENSP00000231021.

PTM databases

iPTMnetiQ9ULB4.
PhosphoSitePlusiQ9ULB4.

Polymorphism and mutation databases

BioMutaiCDH9.
DMDMi119370307.

Proteomic databases

MaxQBiQ9ULB4.
PaxDbiQ9ULB4.
PeptideAtlasiQ9ULB4.
PRIDEiQ9ULB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231021; ENSP00000231021; ENSG00000113100.
GeneIDi1007.
KEGGihsa:1007.
UCSCiuc003jgs.2. human.

Organism-specific databases

CTDi1007.
DisGeNETi1007.
GeneCardsiCDH9.
H-InvDBHIX0031940.
HGNCiHGNC:1768. CDH9.
HPAiHPA007167.
MIMi609974. gene.
neXtProtiNX_Q9ULB4.
OpenTargetsiENSG00000113100.
PharmGKBiPA26305.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9ULB4.
KOiK06801.
OMAiFIWTYMF.
OrthoDBiEOG091G0298.
PhylomeDBiQ9ULB4.
TreeFamiTF329887.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000113100-MONOMER.
ReactomeiR-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

GeneWikiiCDH9.
GenomeRNAii1007.
PROiQ9ULB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113100.
CleanExiHS_CDH9.
ExpressionAtlasiQ9ULB4. baseline and differential.
GenevisibleiQ9ULB4. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH9_HUMAN
AccessioniPrimary (citable) accession number: Q9ULB4
Secondary accession number(s): Q3B7I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.