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Q9ULB4

- CADH9_HUMAN

UniProt

Q9ULB4 - CADH9_HUMAN

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Protein

Cadherin-9

Gene

CDH9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. cell-cell junction organization Source: Reactome
  3. cell junction assembly Source: Reactome
  4. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  5. single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-9
Gene namesi
Name:CDH9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:1768. CDH9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 615562ExtracellularSequence AnalysisAdd
BLAST
Transmembranei616 – 63621HelicalSequence AnalysisAdd
BLAST
Topological domaini637 – 789153CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 5332Sequence AnalysisPRO_0000003779Add
BLAST
Chaini54 – 789736Cadherin-9PRO_0000003780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ9ULB4.
PRIDEiQ9ULB4.

PTM databases

PhosphoSiteiQ9ULB4.

Expressioni

Gene expression databases

BgeeiQ9ULB4.
CleanExiHS_CDH9.
ExpressionAtlasiQ9ULB4. baseline and differential.
GenevestigatoriQ9ULB4.

Organism-specific databases

HPAiHPA007167.

Interactioni

Protein-protein interaction databases

BioGridi107442. 3 interactions.
STRINGi9606.ENSP00000231021.

Structurei

3D structure databases

ProteinModelPortaliQ9ULB4.
SMRiQ9ULB4. Positions 55-589, 689-783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini487 – 608122Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235715.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9ULB4.
KOiK06801.
OMAiLFIWTYM.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9ULB4.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ULB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTYHYIPLF IWTYMFHTVD TILLQEKPNS YLSSKKIAGL TKDDGKMLRR
60 70 80 90 100
TKRGWMWNQF FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL
110 120 130 140 150
FVIDENTGDI HAAKKLDREE KSLYILRAKA IDRKTGRQVE PESEFIIKIH
160 170 180 190 200
DINDNEPKFT KDLYTASVPE MSGVGTSVIQ VTATDADDAN YGNSAKVVYS
210 220 230 240 250
ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD MGGQMGGLSG
260 270 280 290 300
TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDVGEN
310 320 330 340 350
AEMEYSIAEG DGADMFDVIT DKDTQEGIIT VKQNLDFENQ MLYTLRVDAS
360 370 380 390 400
NTHPDPRFLH LGPFKDTAVV KISVEDIDEP PVFTKVSYLI EVDEDVKEGS
410 420 430 440 450
IIGQVTAYDP DARNNLIKYS VDRHTDMDRI FGIHSENGSI FTLKALDRES
460 470 480 490 500
SPWHNITVTA TEINNPKQSS HIPVFIRILD INDHAPEFAM YYETFVCENA
510 520 530 540 550
KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FTLNPNFTIV DNKDNTAGIM
560 570 580 590 600
TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDNQGNMQSC
610 620 630 640 650
TAEALILSAG LSTGALVAIL LCVLILLILV VLFAALKRQR KKEPLIISKD
660 670 680 690 700
DVRDNIVTYN DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI
710 720 730 740 750
RRTVPLWENI DVQDFIHRRL KENDADPSAP PYDSLATYAY EGNDSIADSL
760 770 780
SSLESLTADC NQDYDYLSDW GPRFKKLADM YGGDDSDRD
Length:789
Mass (Da):88,689
Last modified:December 12, 2006 - v2
Checksum:iC580DA16B769047C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181T → I in BAA87416. (PubMed:10861224)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61Y → C.1 Publication
Corresponds to variant rs2288467 [ dbSNP | Ensembl ].
VAR_029799
Natural varianti38 – 381A → V.1 Publication
Corresponds to variant rs2288466 [ dbSNP | Ensembl ].
VAR_029800

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035302 mRNA. Translation: BAA87416.1.
BC107594 mRNA. Translation: AAI07595.1.
BC113745 mRNA. Translation: AAI13746.1.
CCDSiCCDS3893.1.
RefSeqiNP_057363.3. NM_016279.3.
UniGeneiHs.272212.

Genome annotation databases

EnsembliENST00000231021; ENSP00000231021; ENSG00000113100.
GeneIDi1007.
KEGGihsa:1007.
UCSCiuc003jgs.1. human.

Polymorphism databases

DMDMi119370307.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035302 mRNA. Translation: BAA87416.1 .
BC107594 mRNA. Translation: AAI07595.1 .
BC113745 mRNA. Translation: AAI13746.1 .
CCDSi CCDS3893.1.
RefSeqi NP_057363.3. NM_016279.3.
UniGenei Hs.272212.

3D structure databases

ProteinModelPortali Q9ULB4.
SMRi Q9ULB4. Positions 55-589, 689-783.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107442. 3 interactions.
STRINGi 9606.ENSP00000231021.

PTM databases

PhosphoSitei Q9ULB4.

Polymorphism databases

DMDMi 119370307.

Proteomic databases

PaxDbi Q9ULB4.
PRIDEi Q9ULB4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000231021 ; ENSP00000231021 ; ENSG00000113100 .
GeneIDi 1007.
KEGGi hsa:1007.
UCSCi uc003jgs.1. human.

Organism-specific databases

CTDi 1007.
GeneCardsi GC05M026916.
H-InvDB HIX0031940.
HGNCi HGNC:1768. CDH9.
HPAi HPA007167.
MIMi 609974. gene.
neXtProti NX_Q9ULB4.
PharmGKBi PA26305.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235715.
GeneTreei ENSGT00760000118954.
HOGENOMi HOG000231252.
HOVERGENi HBG005217.
InParanoidi Q9ULB4.
KOi K06801.
OMAi LFIWTYM.
OrthoDBi EOG7GBFW7.
PhylomeDBi Q9ULB4.
TreeFami TF329887.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.

Miscellaneous databases

GeneWikii CDH9.
GenomeRNAii 1007.
NextBioi 4234.
PROi Q9ULB4.
SOURCEi Search...

Gene expression databases

Bgeei Q9ULB4.
CleanExi HS_CDH9.
ExpressionAtlasi Q9ULB4. baseline and differential.
Genevestigatori Q9ULB4.

Family and domain databases

Gene3Di 2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 5 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
    Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
    Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-6 AND VAL-38.

Entry informationi

Entry nameiCADH9_HUMAN
AccessioniPrimary (citable) accession number: Q9ULB4
Secondary accession number(s): Q3B7I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3