Q9ULB1 (NRX1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurexin-1

Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha

Gene names

Name:	NRXN1
Synonyms:	KIAA0578

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1477 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom By similarity.
Subunit structure	Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2, NLGN3, NLGN4X and NLGN4Y; these interactions are calcium-dependent. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 By similarity. Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 By similarity. Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latroxin from spider venom. The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. Interacts with SYT13 and SYTL1 By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein Probable. Cell junction › synapse Probable. Note: Localized on the pre-synaptic membrane By similarity.
Tissue specificity	Brain. Ref.3
Post-translational modification	N-glycosylated By similarity. O-glycosylated By similarity.
Sequence similarities	Belongs to the neurexin family. Contains 3 EGF-like domains. Contains 6 laminin G-like domains.
Sequence caution	The sequence BAA25504.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative promoter usage Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult behavior Inferred from sequence or structural similarity PubMed 19822762. Source: BHF-UCL axon guidance Traceable author statement PubMed 1621094. Source: ProtInc cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW gephyrin clustering Inferred from sequence or structural similarity. Source: BHF-UCL learning Inferred from sequence or structural similarity PubMed 19822762. Source: BHF-UCL neuroligin clustering Inferred from sequence or structural similarity. Source: BHF-UCL neuromuscular process controlling balance Inferred from sequence or structural similarity PubMed 19822762. Source: BHF-UCL neurotransmitter secretion Inferred from electronic annotation. Source: Compara positive regulation of excitatory postsynaptic membrane potential Inferred from sequence or structural similarity PubMed 19822762. Source: BHF-UCL positive regulation of synapse assembly Inferred from electronic annotation. Source: Compara positive regulation of synapse maturation Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission, glutamatergic Inferred from sequence or structural similarity PubMed 19822762. Source: BHF-UCL postsynaptic density protein 95 clustering Inferred from sequence or structural similarity. Source: BHF-UCL postsynaptic membrane assembly Inferred from sequence or structural similarity. Source: BHF-UCL prepulse inhibition Inferred from sequence or structural similarity PubMed 19822762. Source: BHF-UCL regulation of grooming behavior Inferred from electronic annotation. Source: Compara social behavior Inferred from mutant phenotype PubMed 18057082. Source: BHF-UCL vocalization behavior Inferred from mutant phenotype PubMed 18057082PubMed 19896112. Source: BHF-UCL
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cell surface Inferred from direct assay PubMed 21424692. Source: BHF-UCL integral to plasma membrane Traceable author statement PubMed 1621094. Source: ProtInc presynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular_function	calcium channel regulator activity Inferred from electronic annotation. Source: Compara cell adhesion molecule binding Inferred from sequence or structural similarity. Source: BHF-UCL metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW neuroligin family protein binding Inferred from sequence or structural similarity. Source: BHF-UCL receptor activity Traceable author statement PubMed 1621094. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Note: A number of isoforms are produced by alternative promoter usage including the alpha-type and beta-type isoforms which differ in their N-terminus. Additional isoforms may be produced by alternative splicing.

Isoform 1a (identifier: Q9ULB1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2a (identifier: Q9ULB1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     379-386: Missing.
     1240-1240: G → GNNDNERLAIARQRIPYRLGRVVDEWLLDKG

Note: Produced by alternative splicing. No experimental confirmation available.

Isoform 3a (identifier: Q9ULB1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     258-258: E → EIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEK
     386-386: M → MVNKLHCS
     1239-1239: A → AGNNDNERLAIARQRIPYRLGRVVDEWLLDK

Note: Produced by alternative splicing.

Isoform 1b (identifier: P58400-1)

The sequence of this isoform can be found in the external entry P58400.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	By similarity
	Chain	31 – 1477	1447	Neurexin-1		PRO_0000019490
Regions
	Topological domain	31 – 1401	1371	Extracellular Potential
	Transmembrane	1402 – 1422	21	Helical; Potential
	Topological domain	1423 – 1477	55	Cytoplasmic Potential
	Domain	31 – 217	187	Laminin G-like 1
	Domain	213 – 256	44	EGF-like 1
	Domain	283 – 473	191	Laminin G-like 2
	Domain	480 – 672	193	Laminin G-like 3
	Domain	676 – 713	38	EGF-like 2
	Domain	718 – 891	174	Laminin G-like 4
	Domain	905 – 1080	176	Laminin G-like 5
	Domain	1083 – 1120	38	EGF-like 3
	Domain	1126 – 1294	169	Laminin G-like 6
	Compositional bias	1324 – 1327	4	Poly-Thr
	Compositional bias	1409 – 1412	4	Poly-Ala
Sites
	Metal binding	329	1	Calcium By similarity
	Metal binding	329	1	Calcium 1 By similarity
	Metal binding	346	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	407	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	765	1	Calcium 2 By similarity
	Metal binding	782	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	841	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	1176	1	Calcium 3 By similarity
	Metal binding	1193	1	Calcium 3; via carbonyl oxygen By similarity
	Metal binding	1245	1	Calcium 3; via carbonyl oxygen By similarity
	Metal binding	1247	1	Calcium 3 By similarity
Amino acid modifications
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	790	1	N-linked (GlcNAc...) Potential
	Glycosylation	1223	1	N-linked (GlcNAc...) Potential
	Disulfide bond	228 ↔ 243		By similarity
	Disulfide bond	245 ↔ 255		By similarity
	Disulfide bond	437 ↔ 473		By similarity
	Disulfide bond	643 ↔ 672		By similarity
	Disulfide bond	680 ↔ 691		By similarity
	Disulfide bond	685 ↔ 700		By similarity
	Disulfide bond	702 ↔ 712		By similarity
	Disulfide bond	1052 ↔ 1080		By similarity
	Disulfide bond	1087 ↔ 1098		By similarity
	Disulfide bond	1092 ↔ 1107		By similarity
	Disulfide bond	1109 ↔ 1119		By similarity
Natural variations
	Alternative sequence	258	1	E → EIKFGLQCVLPVLLHDNDQG KYCCINTAKPLTEK in isoform 3a.		VSP_041353
	Alternative sequence	379 – 386	8	Missing in isoform 2a.		VSP_014541
	Alternative sequence	386	1	M → MVNKLHCS in isoform 3a.		VSP_041354
	Alternative sequence	1239	1	A → AGNNDNERLAIARQRIPYRL GRVVDEWLLDK in isoform 3a.		VSP_041355
	Alternative sequence	1240	1	G → GNNDNERLAIARQRIPYRLG RVVDEWLLDKG in isoform 2a.		VSP_014542
	Natural variant	400	1	Y → N. Corresponds to variant rs17040901 [ dbSNP | Ensembl ].		VAR_050265
Experimental info
	Sequence conflict	1373 – 1375	3	Missing in BAA25504. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1a [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FF845FB428B1A683	FASTA	1,477	161,883
	10 20 30 40 50 60 MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQHS GIGHAMVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP 430 440 450 460 470 480 STADLPGSPV SNNFMGCLKE VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD 490 500 510 520 530 540 PITFETPESF ISLPKWNAKK TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF 550 560 570 580 590 600 FAIEMLDGHL YLLLDMGSGT IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA 610 620 630 640 650 660 PGESEILDLD DELYLGGLPE NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA 670 680 690 700 710 720 EVQSTAGVKP SCSKETAKPC LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS 730 740 750 760 770 780 YDGSMFMKIQ LPVVMHTEAE DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV 790 800 810 820 830 840 NLDCIRINCN SSKGPETLFA GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT 850 860 870 880 890 900 RLEFHNIETG IITERRYLSS VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR 910 920 930 940 950 960 NIIADPVTFK TKSSYVALAT LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG 970 980 990 1000 1010 1020 YLHYVFDLGN GANLIKGSSN KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL 1030 1040 1050 1060 1070 1080 DLKSDLYIGG VAKETYKSLP KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC 1090 1100 1110 1120 1130 1140 EGPSTTCQED SCSNQGVCLQ QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP 1150 1160 1170 1180 1190 1200 PNDRPSTRAD RLAIGFSTVQ KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI 1210 1220 1230 1240 1250 1260 EESNAIINDG KYHVVRFTRS GGNATLQVDS WPVIERYPAG RQLTIFNSQA TIIIGGKEQG 1270 1280 1290 1300 1310 1320 QPFQGQLSGL YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA TAMQSEMSTS 1330 1340 1350 1360 1370 1380 IMETTTTLAT STARRGKPPT KEPISQTTDD ILVASAECPS DDEDIDPCEP SSGGLANPTR 1390 1400 1410 1420 1430 1440 AGGREPYPGS AEVIRESSST TGMVVGIVAA AALCILILLY AMYKYRNRDE GSYHVDESRN 1450 1460 1470 YISNSAQSNG AVVKEKQPSS AKSSNKNKKN KDKEYYV
	Isoform 2a [UniParc]. Checksum: F8481191C84C9CD7	FASTA	1,499	164,655
	10 20 30 40 50 60 MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 310 320 330 340 350 360 IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 370 380 390 400 410 420 KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 430 440 450 460 470 480 PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE 490 500 510 520 530 540 SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG 550 560 570 580 590 600 HLYLLLDMGS GTIKIKALLK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 610 620 630 640 650 660 LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEVQSTAGV 670 680 690 700 710 720 KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 730 740 750 760 770 780 IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN 790 800 810 820 830 840 CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE 850 860 870 880 890 900 TGIITERRYL SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 910 920 930 940 950 960 FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL 970 980 990 1000 1010 1020 GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 1030 1040 1050 1060 1070 1080 GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ 1090 1100 1110 1120 1130 1140 EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR 1150 1160 1170 1180 1190 1200 ADRLAIGFST VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 1210 1220 1230 1240 1250 1260 DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD 1270 1280 1290 1300 1310 1320 KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 1330 1340 1350 1360 1370 1380 EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC 1390 1400 1410 1420 1430 1440 PSDDEDIDPC EPSSGGLANP TRAGGREPYP GSAEVIRESS STTGMVVGIV AAAALCILIL 1450 1460 1470 1480 1490 LYAMYKYRNR DEGSYHVDES RNYISNSAQS NGAVVKEKQP SSAKSSNKNK KNKDKEYYV
	Isoform 3a [UniParc]. Checksum: 2F6A3FBB6E53AA2E	FASTA	1,547	169,913
	10 20 30 40 50 60 MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 70 80 90 100 110 120 RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 130 140 150 160 170 180 RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 190 200 210 220 230 240 KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 250 260 270 280 290 300 AVCDCSRTGF RGKDCSQEIK FGLQCVLPVL LHDNDQGKYC CINTAKPLTE KDNNVEGLAH 310 320 330 340 350 360 LMMGDQGKSK GKEEYIATFK GSEYFCYDLS QNPIQSSSDE ITLSFKTLQR NGLMLHTGKS 370 380 390 400 410 420 ADYVNLALKN GAVSLVINLG SGAFEALVEP VNGKFNDNAW HDVKVTRNLR QHSGIGHAMV 430 440 450 460 470 480 NKLHCSVTIS VDGILTTTGY TQEDYTMLGS DDFFYVGGSP STADLPGSPV SNNFMGCLKE 490 500 510 520 530 540 VVYKNNDVRL ELSRLAKQGD PKMKIHGVVA FKCENVATLD PITFETPESF ISLPKWNAKK 550 560 570 580 590 600 TGSISFDFRT TEPNGLILFS HGKPRHQKDA KHPQMIKVDF FAIEMLDGHL YLLLDMGSGT 610 620 630 640 650 660 IKIKALLKKV NDGEWYHVDF QRDGRSGTIS VNTLRTPYTA PGESEILDLD DELYLGGLPE 670 680 690 700 710 720 NKAGLVFPTE VWTALLNYGY VGCIRDLFID GQSKDIRQMA EVQSTAGVKP SCSKETAKPC 730 740 750 760 770 780 LSNPCKNNGM CRDGWNRYVC DCSGTGYLGR SCEREATVLS YDGSMFMKIQ LPVVMHTEAE 790 800 810 820 830 840 DVSLRFRSQR AYGILMATTS RDSADTLRLE LDAGRVKLTV NLDCIRINCN SSKGPETLFA 850 860 870 880 890 900 GYNLNDNEWH TVRVVRRGKS LKLTVDDQQA MTGQMAGDHT RLEFHNIETG IITERRYLSS 910 920 930 940 950 960 VPSNFIGHLQ SLTFNGMAYI DLCKNGDIDY CELNARFGFR NIIADPVTFK TKSSYVALAT 970 980 990 1000 1010 1020 LQAYTSMHLF FQFKTTSLDG LILYNSGDGN DFIVVELVKG YLHYVFDLGN GANLIKGSSN 1030 1040 1050 1060 1070 1080 KPLNDNQWHN VMISRDTSNL HTVKIDTKIT TQITAGARNL DLKSDLYIGG VAKETYKSLP 1090 1100 1110 1120 1130 1140 KLVHAKEGFQ GCLASVDLNG RLPDLISDAL FCNGQIERGC EGPSTTCQED SCSNQGVCLQ 1150 1160 1170 1180 1190 1200 QWDGFSCDCS MTSFSGPLCN DPGTTYIFSK GGGQITYKWP PNDRPSTRAD RLAIGFSTVQ 1210 1220 1230 1240 1250 1260 KEAVLVRVDS SSGLGDYLEL HIHQGKIGVK FNVGTDDIAI EESNAIINDG KYHVVRFTRS 1270 1280 1290 1300 1310 1320 GGNATLQVDS WPVIERYPAG NNDNERLAIA RQRIPYRLGR VVDEWLLDKG RQLTIFNSQA 1330 1340 1350 1360 1370 1380 TIIIGGKEQG QPFQGQLSGL YYNGLKVLNM AAENDANIAI VGNVRLVGEV PSSMTTESTA 1390 1400 1410 1420 1430 1440 TAMQSEMSTS IMETTTTLAT STARRGKPPT KEPISQTTDD ILVASAECPS DDEDIDPCEP 1450 1460 1470 1480 1490 1500 SSGGLANPTR AGGREPYPGS AEVIRESSST TGMVVGIVAA AALCILILLY AMYKYRNRDE 1510 1520 1530 1540 GSYHVDESRN YISNSAQSNG AVVKEKQPSS AKSSNKNKKN KDKEYYV
	Isoform 1b [UniParc]. See P58400.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Disruption of neurexin 1 associated with autism spectrum disorder." Kim H.G., Kishikawa S., Higgins A.W., Seong I.S., Donovan D.J., Shen Y., Lally E., Weiss L.A., Najm J., Kutsche K., Descartes M., Holt L., Braddock S., Troxell R., Kaplan L., Volkmar F., Klin A., Tsatsanis K. , Harris D.J., Noens I., Pauls D.L., Daly M.J., MacDonald M.E., Morton C.C., Quade B.J., Gusella J.F. Am. J. Hum. Genet. 82:199-207(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3A).
[2]	"Human neurexin I-alpha." Seki N., Yoshikawa T., Azuma T., Saito T., Muramatsu M. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A). Tissue: Brain.
[3]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A), TISSUE SPECIFICITY. Tissue: Brain.
[4]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION, ALTERNATIVE SPLICING.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity." Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps D.L., Qin S., Minx P., Wilson R.K., Hood L., Graveley B.R. Genomics 79:587-597(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF539882 mRNA. Translation: ABS86974.1. AB035356 mRNA. Translation: BAA87821.1. AB011150 mRNA. Translation: BAA25504.2. Different initiation. AC007462 Genomic DNA. Translation: AAF03536.1. AC007682 Genomic DNA. Translation: AAY14894.1. AC009234 Genomic DNA. Translation: AAY14944.1. AC068725 Genomic DNA. Translation: AAG59602.1. AC069550 Genomic DNA. Translation: AAG38120.1. AC078994 Genomic DNA. Translation: AAK06387.1. AC068715 Genomic DNA. Translation: AAG59642.1.
IPI	IPI00442299. IPI00855821. IPI01010752.
RefSeq	NP_001129131.1. NM_001135659.1. NP_004792.1. NM_004801.4. NP_620072.1. NM_138735.2.
UniGene	Hs.637685.
3D structure databases
ProteinModelPortal	Q9ULB1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ULB1. 4 interactions.
PTM databases
PhosphoSite	Q9ULB1.
Polymorphism databases
DMDM	17369704.
Proteomic databases
PaxDb	Q9ULB1.
PRIDE	Q9ULB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000404971; ENSP00000385142; ENSG00000179915. ENST00000405472; ENSP00000434015; ENSG00000179915. ENST00000406316; ENSP00000384311; ENSG00000179915.
GeneID	9378.
KEGG	hsa:9378.
UCSC	uc021vhg.1. human. uc021vhh.1. human.
Organism-specific databases
CTD	9378.
GeneCards	GC02M050145.
HGNC	HGNC:8008. NRXN1.
MIM	600565. gene.
neXtProt	NX_Q9ULB1.
Orphanet	106. Autism. 221150. Pitt-Hopkins-like syndrome. 3140. Schizophrenia.
PharmGKB	PA31786.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302266.
HOVERGEN	HBG052670.
KO	K07377.
OrthoDB	EOG41G339.
Gene expression databases
ArrayExpress	Q9ULB1.
Bgee	Q9ULB1.
CleanEx	HS_NRXN1.
Genevestigator	Q9ULB1.
Family and domain databases
Gene3D	2.60.120.200. 6 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR001791. Laminin_G. IPR003585. Neurexin-like. IPR027158. NRXN1-alpha. [Graphical view]
PANTHER	PTHR10127:SF309. PTHR10127:SF309. 1 hit.
Pfam	PF02210. Laminin_G_2. 6 hits. [Graphical view]
SMART	SM00294. 4.1m. 1 hit. SM00181. EGF. 3 hits. SM00282. LamG. 6 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 6 hits.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. False negative. PS50026. EGF_3. 3 hits. PS50025. LAM_G_DOMAIN. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NRXN1. human.
GenomeRNAi	9378.
NextBio	35134.
SOURCE	Search...

Entry information

Entry name

NRX1A_HUMAN

Accession

Primary (citable) accession number: Q9ULB1
Secondary accession number(s): A7KRL9 , O60323, Q53TJ9, Q53TQ1, Q9C079, Q9C080, Q9C081, Q9H3M2, Q9UDM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.