MYT1L

Functionⁱ

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	22 – 65	CCHHC-type 1PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	497 – 540	CCHHC-type 2PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	541 – 584	CCHHC-type 3PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	896 – 939	CCHHC-type 4PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	945 – 988	CCHHC-type 5PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	998 – 1041	CCHHC-type 6PROSITE-ProRule annotationAdd BLAST	44

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: UniProtKB
zinc ion binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
nervous system development Source: UniProtKB
neuron development Source: UniProtKB
neuron differentiation Source: UniProtKB
neuron fate commitment Source: UniProtKB
neuron fate specification Source: UniProtKB
regulation of transcription from RNA polymerase II promoter Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myelin transcription factor 1-like protein1 Publication Short name: MyT1-L1 Publication Short name: MyT1L1 Publication
Gene namesⁱ	Name:MYT1L1 PublicationImported Synonyms:KIAA11061 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7623. MYT1L.

HGNCⁱ

HGNC:7623. MYT1L.

Subcellular locationⁱ

Nucleus
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P97500 (MYT1L_MOUSE)
Chromosome
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P97500 (MYT1L_MOUSE)

Note:

Preferentially binds to DNA binding sites that are in an open chromatin configuration.By similarity

GO - Cellular componentⁱ

nucleus Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mental retardation, autosomal dominant 39 (MRD39)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features.

Keywords - Diseaseⁱ

Autism spectrum disorder, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23040.
MalaCards human disease database More...MalaCardsⁱ	MYT1L.
MIMⁱ	616521. phenotype.
Open Targets More...OpenTargetsⁱ	ENSG00000186487.
PharmGKBⁱ	PA31427.

Polymorphism and mutation databases

BioMutaⁱ	MYT1L.
DMDMⁱ	327478568.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096673	1 – 1186	Myelin transcription factor 1-like proteinAdd BLAST		1186

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	250	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9UL68.
PeptideAtlas More...PeptideAtlasⁱ	Q9UL68.
PRIDEⁱ	Q9UL68.

PTM databases

iPTMnetⁱ	Q9UL68.
PhosphoSitePlusⁱ	Q9UL68.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186487.
CleanExⁱ	HS_MYT1L.
ExpressionAtlasⁱ	Q9UL68. baseline and differential.
Genevisibleⁱ	Q9UL68. HS.

Interactionⁱ

Subunit structureⁱ

Interacts with SIN3B.By similarity

Protein-protein interaction databases

BioGridⁱ	116679. 3 interactors.
IntActⁱ	Q9UL68. 5 interactors.
STRINGⁱ	9606.ENSP00000396103.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UL68.
SMRⁱ	Q9UL68.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1056 – 1130	Sequence analysisAdd BLAST		75

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	97 – 169	Asp/Glu-richAdd BLAST		73
Compositional biasⁱ	686 – 719	Ser-richAdd BLAST		34

Sequence similaritiesⁱ

Belongs to the MYT1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	22 – 65	CCHHC-type 1PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	497 – 540	CCHHC-type 2PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	541 – 584	CCHHC-type 3PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	896 – 939	CCHHC-type 4PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	945 – 988	CCHHC-type 5PROSITE-ProRule annotationAdd BLAST	44
Zinc fingerⁱ	998 – 1041	CCHHC-type 6PROSITE-ProRule annotationAdd BLAST	44

Keywords - Domainⁱ

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3803. Eukaryota. ENOG410ZPWS. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000038465.
HOGENOMⁱ	HOG000234099.
HOVERGENⁱ	HBG006433.
InParanoidⁱ	Q9UL68.
OMAⁱ	PYYGKDP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0135.
PhylomeDBⁱ	Q9UL68.
TreeFamⁱ	TF317299.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013681. Myelin_TF. IPR002515. Znf_C2HC.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08474. MYT1. 1 hit. PF01530. zf-C2HC. 6 hits.
SUPFAMⁱ	SSF103637. SSF103637. 6 hits.
PROSITEⁱ	View protein in PROSITE PS51802. ZF_CCHHC. 6 hits.

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9UL68-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR 
        60         70         80         90        100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD 
       110        120        130        140        150
EKEEDEGEEY SEDNDEPGDE DEEDEEGDRE EEEEIEEEDE DDDEDGEDVE 
       160        170        180        190        200
DEEEEEEEEE EEEEEEENED HQMNCHNTRI MQDTEKDDNN NDEYDNYDEL 
       210        220        230        240        250
VAKSLLNLGK IAEDAAYRAR TESEMNSNTS NSLEDDSDKN ENLGRKSELS 
       260        270        280        290        300
LDLDSDVVRE TVDSLKLLAQ GHGVVLSENM NDRNYADSMS QQDSRNMNYV 
       310        320        330        340        350
MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN 
       360        370        380        390        400
PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA 
       410        420        430        440        450
KEDGCHERDD DTTSVNSDRS EEVFDMTKGN LTLLEKAIAL ETERAKAMRE 
       460        470        480        490        500
KMAMEAGRRD NMRSYEDQSP RQLPGEDRKP KSSDSHVKKP YYGKDPSRTE 
       510        520        530        540        550
KKESKCPTPG CDGTGHVTGL YPHHRSLSGC PHKDRVPPEI LAMHESVLKC 
       560        570        580        590        600
PTPGCTGRGH VNSNRNSHRS LSGCPIAAAE KLAKAQEKHQ SCDVSKSSQA 
       610        620        630        640        650
SDRVLRPMCF VKQLEIPQYG YRNNVPTTTP RSNLAKELEK YSKTSFEYNS 
       660        670        680        690        700
YDNHTYGKRA IAPKVQTRDI SPKGYDDAKR YCKDPSPSSS STSSYAPSSS 
       710        720        730        740        750
SNLSCGGGSS ASSTCSKSSF DYTHDMEAAH MAATAILNLS TRCREMPQNL 
       760        770        780        790        800
STKPQDLCAT RNPDMEVDEN GTLDLSMNKQ RPRDSCCPIL TPLEPMSPQQ 
       810        820        830        840        850
QAVMNNRCFQ LGEGDCWDLP VDYTKMKPRR IDEDESKDIT PEDLDPFQEA 
       860        870        880        890        900
LEERRYPGEV TIPSPKPKYP QCKESKKDLI TLSGCPLADK SIRSMLATSS 
       910        920        930        940        950
QELKCPTPGC DGSGHITGNY ASHRSLSGCP RAKKSGIRIA QSKEDKEDQE 
       960        970        980        990       1000
PIRCPVPGCD GQGHITGKYA SHRSASGCPL AAKRQKDGYL NGSQFSWKSV 
      1010       1020       1030       1040       1050
KTEGMSCPTP GCDGSGHVSG SFLTHRSLSG CPRATSAMKK AKLSGEQMLT 
      1060       1070       1080       1090       1100
IKQRASNGIE NDEEIKQLDE EIKELNESNS QMEADMIKLR TQITTMESNL 
      1110       1120       1130       1140       1150
KTIEEENKVI EQQNESLLHE LANLSQSLIH SLANIQLPHM DPINEQNFDA 
      1160       1170       1180 
YVTTLTEMYT NQDRYQSPEN KALLENIKQA VRGIQV

Length:1,186

Mass (Da):133,043

Last modified:April 5, 2011 - v3

Checksum:ⁱAEF068692263FA8C

GO

Isoform 2 (identifier: Q9UL68-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
108-159: Missing.
493-494: Missing.

« Hide

        10         20         30         40         50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR 
        60         70         80         90        100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD 
       110        120        130        140        150
EKEEDEGEEE EEEEENEDHQ MNCHNTRIMQ DTEKDDNNND EYDNYDELVA 
       160        170        180        190        200
KSLLNLGKIA EDAAYRARTE SEMNSNTSNS LEDDSDKNEN LGRKSELSLD 
       210        220        230        240        250
LDSDVVRETV DSLKLLAQGH GVVLSENMND RNYADSMSQQ DSRNMNYVML 
       260        270        280        290        300
GKPMNNGLME KMVEESDEEV CLSSLECLRN QCFDLARKLS ETNPQERNPQ 
       310        320        330        340        350
QNMNIRQHVR PEEDFPGRTP DRNYSDMLNL MRLEEQLSPR SRVFASCAKE 
       360        370        380        390        400
DGCHERDDDT TSVNSDRSEE VFDMTKGNLT LLEKAIALET ERAKAMREKM 
       410        420        430        440        450
AMEAGRRDNM RSYEDQSPRQ LPGEDRKPKS SDSHVKKPYY DPSRTEKKES 
       460        470        480        490        500
KCPTPGCDGT GHVTGLYPHH RSLSGCPHKD RVPPEILAMH ESVLKCPTPG 
       510        520        530        540        550
CTGRGHVNSN RNSHRSLSGC PIAAAEKLAK AQEKHQSCDV SKSSQASDRV 
       560        570        580        590        600
LRPMCFVKQL EIPQYGYRNN VPTTTPRSNL AKELEKYSKT SFEYNSYDNH 
       610        620        630        640        650
TYGKRAIAPK VQTRDISPKG YDDAKRYCKD PSPSSSSTSS YAPSSSSNLS 
       660        670        680        690        700
CGGGSSASST CSKSSFDYTH DMEAAHMAAT AILNLSTRCR EMPQNLSTKP 
       710        720        730        740        750
QDLCATRNPD MEVDENGTLD LSMNKQRPRD SCCPILTPLE PMSPQQQAVM 
       760        770        780        790        800
NNRCFQLGEG DCWDLPVDYT KMKPRRIDED ESKDITPEDL DPFQEALEER 
       810        820        830        840        850
RYPGEVTIPS PKPKYPQCKE SKKDLITLSG CPLADKSIRS MLATSSQELK 
       860        870        880        890        900
CPTPGCDGSG HITGNYASHR SLSGCPRAKK SGIRIAQSKE DKEDQEPIRC 
       910        920        930        940        950
PVPGCDGQGH ITGKYASHRS ASGCPLAAKR QKDGYLNGSQ FSWKSVKTEG 
       960        970        980        990       1000
MSCPTPGCDG SGHVSGSFLT HRSLSGCPRA TSAMKKAKLS GEQMLTIKQR 
      1010       1020       1030       1040       1050
ASNGIENDEE IKQLDEEIKE LNESNSQMEA DMIKLRTQIT TMESNLKTIE 
      1060       1070       1080       1090       1100
EENKVIEQQN ESLLHELANL SQSLIHSLAN IQLPHMDPIN EQNFDAYVTT 
      1110       1120       1130 
LTEMYTNQDR YQSPENKALL ENIKQAVRGI QV

Note: No experimental confirmation available.

Show »

Length:1,132

Mass (Da):126,617

Checksum:ⁱ0864D75EB5CAA8CE

GO

Isoform 3 (identifier: Q9UL68-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1004: Missing.
1092-1092: Q → QVT

« Hide

        10         20         30         40         50
MSCPTPGCDG SGHVSGSFLT HRSLSGCPRA TSAMKKAKLS GEQMLTIKQR 
        60         70         80         90        100
ASNGIENDEE IKQLDEEIKE LNESNSQMEA DMIKLRTQVT ITTMESNLKT 
       110        120        130        140        150
IEEENKVIEQ QNESLLHELA NLSQSLIHSL ANIQLPHMDP INEQNFDAYV 
       160        170        180 
TTLTEMYTNQ DRYQSPENKA LLENIKQAVR GIQV

Note: No experimental confirmation available.

Show »

Length:184

Mass (Da):20,620

Checksum:ⁱ40104F07E2F61130

GO

Isoform 4 (identifier: Q9UL68-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
493-494: Missing.

« Hide

        10         20         30         40         50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR 
        60         70         80         90        100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD 
       110        120        130        140        150
EKEEDEGEEY SEDNDEPGDE DEEDEEGDRE EEEEIEEEDE DDDEDGEDVE 
       160        170        180        190        200
DEEEEEEEEE EEEEEEENED HQMNCHNTRI MQDTEKDDNN NDEYDNYDEL 
       210        220        230        240        250
VAKSLLNLGK IAEDAAYRAR TESEMNSNTS NSLEDDSDKN ENLGRKSELS 
       260        270        280        290        300
LDLDSDVVRE TVDSLKLLAQ GHGVVLSENM NDRNYADSMS QQDSRNMNYV 
       310        320        330        340        350
MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN 
       360        370        380        390        400
PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA 
       410        420        430        440        450
KEDGCHERDD DTTSVNSDRS EEVFDMTKGN LTLLEKAIAL ETERAKAMRE 
       460        470        480        490        500
KMAMEAGRRD NMRSYEDQSP RQLPGEDRKP KSSDSHVKKP YYDPSRTEKK 
       510        520        530        540        550
ESKCPTPGCD GTGHVTGLYP HHRSLSGCPH KDRVPPEILA MHESVLKCPT 
       560        570        580        590        600
PGCTGRGHVN SNRNSHRSLS GCPIAAAEKL AKAQEKHQSC DVSKSSQASD 
       610        620        630        640        650
RVLRPMCFVK QLEIPQYGYR NNVPTTTPRS NLAKELEKYS KTSFEYNSYD 
       660        670        680        690        700
NHTYGKRAIA PKVQTRDISP KGYDDAKRYC KDPSPSSSST SSYAPSSSSN 
       710        720        730        740        750
LSCGGGSSAS STCSKSSFDY THDMEAAHMA ATAILNLSTR CREMPQNLST 
       760        770        780        790        800
KPQDLCATRN PDMEVDENGT LDLSMNKQRP RDSCCPILTP LEPMSPQQQA 
       810        820        830        840        850
VMNNRCFQLG EGDCWDLPVD YTKMKPRRID EDESKDITPE DLDPFQEALE 
       860        870        880        890        900
ERRYPGEVTI PSPKPKYPQC KESKKDLITL SGCPLADKSI RSMLATSSQE 
       910        920        930        940        950
LKCPTPGCDG SGHITGNYAS HRSLSGCPRA KKSGIRIAQS KEDKEDQEPI 
       960        970        980        990       1000
RCPVPGCDGQ GHITGKYASH RSASGCPLAA KRQKDGYLNG SQFSWKSVKT 
      1010       1020       1030       1040       1050
EGMSCPTPGC DGSGHVSGSF LTHRSLSGCP RATSAMKKAK LSGEQMLTIK 
      1060       1070       1080       1090       1100
QRASNGIEND EEIKQLDEEI KELNESNSQM EADMIKLRTQ ITTMESNLKT 
      1110       1120       1130       1140       1150
IEEENKVIEQ QNESLLHELA NLSQSLIHSL ANIQLPHMDP INEQNFDAYV 
      1160       1170       1180 
TTLTEMYTNQ DRYQSPENKA LLENIKQAVR GIQV

Show »

Length:1,184

Mass (Da):132,858

Checksum:ⁱ6EA2551E3046F395

GO

Sequence cautionⁱ

The sequence AAF14051 differs from that shown. Reason: Frameshift at position 1185.Curated

The sequence BAA83058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	191	N → S in AAF14051 (Ref. 1) Curated	1
Sequence conflictⁱ	935	S → R in AAF14051 (Ref. 1) Curated	1
Sequence conflictⁱ	987	D → E in AAF14051 (Ref. 1) Curated	1
Sequence conflictⁱ	1110	I → V in AAF14051 (Ref. 1) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_015722	1 – 1004	Missing in isoform 3. 1 PublicationAdd BLAST	1004
Alternative sequenceⁱVSP_015723	108 – 159	Missing in isoform 2. 2 PublicationsAdd BLAST	52
Alternative sequenceⁱVSP_015724	493 – 494	Missing in isoform 2 and isoform 4. 2 Publications	2
Alternative sequenceⁱVSP_015725	1092	Q → QVT in isoform 3. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF036943 mRNA. Translation: AAF14051.1. Frameshift. AB029029 mRNA. Translation: BAA83058.2. Different initiation. AC008276 Genomic DNA. No translation available. AC009232 Genomic DNA. No translation available. AC009471 Genomic DNA. No translation available. AC011301 Genomic DNA. No translation available. AC093390 Genomic DNA. No translation available. AC106046 Genomic DNA. No translation available. BC071612 mRNA. Translation: AAH71612.1. BC137272 mRNA. Translation: AAI37273.1. BC137273 mRNA. Translation: AAI37274.1. BC150281 mRNA. Translation: AAI50282.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46222.1. [Q9UL68-4] CCDS77378.1. [Q9UL68-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001289981.1. NM_001303052.1. [Q9UL68-1] NP_001316773.1. NM_001329844.1. [Q9UL68-1] NP_001316774.1. NM_001329845.1. [Q9UL68-1] NP_001316776.1. NM_001329847.1. [Q9UL68-4] NP_001316777.1. NM_001329848.1. [Q9UL68-4] NP_055840.2. NM_015025.3. [Q9UL68-4]
UniGeneⁱ	Hs.434418. Hs.669852.

Genome annotation databases

Ensemblⁱ	ENST00000399161; ENSP00000382114; ENSG00000186487. [Q9UL68-1] ENST00000407844; ENSP00000384219; ENSG00000186487. [Q9UL68-3] ENST00000428368; ENSP00000396103; ENSG00000186487. [Q9UL68-4]
GeneIDⁱ	23040.
KEGGⁱ	hsa:23040.
UCSC genome browser More...UCSCⁱ	uc002qxd.4. human. [Q9UL68-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF036943 mRNA. Translation: AAF14051.1. Frameshift. AB029029 mRNA. Translation: BAA83058.2. Different initiation. AC008276 Genomic DNA. No translation available. AC009232 Genomic DNA. No translation available. AC009471 Genomic DNA. No translation available. AC011301 Genomic DNA. No translation available. AC093390 Genomic DNA. No translation available. AC106046 Genomic DNA. No translation available. BC071612 mRNA. Translation: AAH71612.1. BC137272 mRNA. Translation: AAI37273.1. BC137273 mRNA. Translation: AAI37274.1. BC150281 mRNA. Translation: AAI50282.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46222.1. [Q9UL68-4] CCDS77378.1. [Q9UL68-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001289981.1. NM_001303052.1. [Q9UL68-1] NP_001316773.1. NM_001329844.1. [Q9UL68-1] NP_001316774.1. NM_001329845.1. [Q9UL68-1] NP_001316776.1. NM_001329847.1. [Q9UL68-4] NP_001316777.1. NM_001329848.1. [Q9UL68-4] NP_055840.2. NM_015025.3. [Q9UL68-4]
UniGeneⁱ	Hs.434418. Hs.669852.

3D structure databases

ProteinModelPortalⁱ	Q9UL68.
SMRⁱ	Q9UL68.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116679. 3 interactors.
IntActⁱ	Q9UL68. 5 interactors.
STRINGⁱ	9606.ENSP00000396103.

PTM databases

iPTMnetⁱ	Q9UL68.
PhosphoSitePlusⁱ	Q9UL68.

Polymorphism and mutation databases

BioMutaⁱ	MYT1L.
DMDMⁱ	327478568.

Proteomic databases

PaxDbⁱ	Q9UL68.
PeptideAtlas More...PeptideAtlasⁱ	Q9UL68.
PRIDEⁱ	Q9UL68.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000399161; ENSP00000382114; ENSG00000186487. [Q9UL68-1] ENST00000407844; ENSP00000384219; ENSG00000186487. [Q9UL68-3] ENST00000428368; ENSP00000396103; ENSG00000186487. [Q9UL68-4]
GeneIDⁱ	23040.
KEGGⁱ	hsa:23040.
UCSC genome browser More...UCSCⁱ	uc002qxd.4. human. [Q9UL68-1]

Organism-specific databases

CTDⁱ	23040.
DisGeNET More...DisGeNETⁱ	23040.
GeneCardsⁱ	MYT1L.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7623. MYT1L.
MalaCards human disease database More...MalaCardsⁱ	MYT1L.
MIMⁱ	613084. gene. 616521. phenotype.
neXtProtⁱ	NX_Q9UL68.
Open Targets More...OpenTargetsⁱ	ENSG00000186487.
PharmGKBⁱ	PA31427.
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3803. Eukaryota. ENOG410ZPWS. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000038465.
HOGENOMⁱ	HOG000234099.
HOVERGENⁱ	HBG006433.
InParanoidⁱ	Q9UL68.
OMAⁱ	PYYGKDP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0135.
PhylomeDBⁱ	Q9UL68.
TreeFamⁱ	TF317299.

Miscellaneous databases

ChiTaRSⁱ	MYT1L. human.
GenomeRNAiⁱ	23040.
Protein Ontology More...PROⁱ	PR:Q9UL68.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186487.
CleanExⁱ	HS_MYT1L.
ExpressionAtlasⁱ	Q9UL68. baseline and differential.
Genevisibleⁱ	Q9UL68. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013681. Myelin_TF. IPR002515. Znf_C2HC.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08474. MYT1. 1 hit. PF01530. zf-C2HC. 6 hits.
SUPFAMⁱ	SSF103637. SSF103637. 6 hits.
PROSITEⁱ	View protein in PROSITE PS51802. ZF_CCHHC. 6 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYT1L_HUMAN
Accessionⁱ	Q9UL68Primary (citable) accession number: Q9UL68 Secondary accession number(s): A7E2C7 , B2RP54, Q6IQ17, Q9UPP6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	April 5, 2011
	Last modified:	July 5, 2017
	This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UL68 (MYT1L_HUMAN)

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Myelin transcription factor 1-like protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (4)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ