Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin transcription factor 1-like protein

Gene

MYT1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendroglia in the CNS (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 6544CCHHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 54044CCHHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 58444CCHHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri896 – 93944CCHHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri945 – 98844CCHHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri998 – 104144CCHHC-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin transcription factor 1-like protein
Short name:
MyT1-L
Short name:
MyT1L
Gene namesi
Name:MYT1L
Synonyms:KIAA1106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7623. MYT1L.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal dominant 39 (MRD39)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features.
See also OMIM:616521

Keywords - Diseasei

Autism spectrum disorder, Mental retardation

Organism-specific databases

MIMi616521. phenotype.
PharmGKBiPA31427.

Polymorphism and mutation databases

BioMutaiMYT1L.
DMDMi327478568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11861186Myelin transcription factor 1-like proteinPRO_0000096673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei250 – 2501PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UL68.
PaxDbiQ9UL68.
PeptideAtlasiQ9UL68.
PRIDEiQ9UL68.

PTM databases

iPTMnetiQ9UL68.
PhosphoSiteiQ9UL68.

Expressioni

Gene expression databases

BgeeiENSG00000186487.
CleanExiHS_MYT1L.
ExpressionAtlasiQ9UL68. baseline and differential.
GenevisibleiQ9UL68. HS.

Organism-specific databases

HPAiHPA051866.

Interactioni

Protein-protein interaction databases

BioGridi116679. 2 interactions.
IntActiQ9UL68. 5 interactions.
STRINGi9606.ENSP00000396103.

Structurei

3D structure databases

ProteinModelPortaliQ9UL68.
SMRiQ9UL68. Positions 28-60, 502-577, 902-1044.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1056 – 113075Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 16973Asp/Glu-richAdd
BLAST
Compositional biasi686 – 71934Ser-richAdd
BLAST

Sequence similaritiesi

Contains 6 CCHHC-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 6544CCHHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri497 – 54044CCHHC-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri541 – 58444CCHHC-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri896 – 93944CCHHC-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri945 – 98844CCHHC-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri998 – 104144CCHHC-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3803. Eukaryota.
ENOG410ZPWS. LUCA.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiQ9UL68.
OMAiLSEGDCW.
OrthoDBiEOG091G0135.
PhylomeDBiQ9UL68.
TreeFamiTF317299.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]
PROSITEiPS51802. ZF_CCHHC. 6 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UL68-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVDTEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC DDSDGTEDMD
110 120 130 140 150
EKEEDEGEEY SEDNDEPGDE DEEDEEGDRE EEEEIEEEDE DDDEDGEDVE
160 170 180 190 200
DEEEEEEEEE EEEEEEENED HQMNCHNTRI MQDTEKDDNN NDEYDNYDEL
210 220 230 240 250
VAKSLLNLGK IAEDAAYRAR TESEMNSNTS NSLEDDSDKN ENLGRKSELS
260 270 280 290 300
LDLDSDVVRE TVDSLKLLAQ GHGVVLSENM NDRNYADSMS QQDSRNMNYV
310 320 330 340 350
MLGKPMNNGL MEKMVEESDE EVCLSSLECL RNQCFDLARK LSETNPQERN
360 370 380 390 400
PQQNMNIRQH VRPEEDFPGR TPDRNYSDML NLMRLEEQLS PRSRVFASCA
410 420 430 440 450
KEDGCHERDD DTTSVNSDRS EEVFDMTKGN LTLLEKAIAL ETERAKAMRE
460 470 480 490 500
KMAMEAGRRD NMRSYEDQSP RQLPGEDRKP KSSDSHVKKP YYGKDPSRTE
510 520 530 540 550
KKESKCPTPG CDGTGHVTGL YPHHRSLSGC PHKDRVPPEI LAMHESVLKC
560 570 580 590 600
PTPGCTGRGH VNSNRNSHRS LSGCPIAAAE KLAKAQEKHQ SCDVSKSSQA
610 620 630 640 650
SDRVLRPMCF VKQLEIPQYG YRNNVPTTTP RSNLAKELEK YSKTSFEYNS
660 670 680 690 700
YDNHTYGKRA IAPKVQTRDI SPKGYDDAKR YCKDPSPSSS STSSYAPSSS
710 720 730 740 750
SNLSCGGGSS ASSTCSKSSF DYTHDMEAAH MAATAILNLS TRCREMPQNL
760 770 780 790 800
STKPQDLCAT RNPDMEVDEN GTLDLSMNKQ RPRDSCCPIL TPLEPMSPQQ
810 820 830 840 850
QAVMNNRCFQ LGEGDCWDLP VDYTKMKPRR IDEDESKDIT PEDLDPFQEA
860 870 880 890 900
LEERRYPGEV TIPSPKPKYP QCKESKKDLI TLSGCPLADK SIRSMLATSS
910 920 930 940 950
QELKCPTPGC DGSGHITGNY ASHRSLSGCP RAKKSGIRIA QSKEDKEDQE
960 970 980 990 1000
PIRCPVPGCD GQGHITGKYA SHRSASGCPL AAKRQKDGYL NGSQFSWKSV
1010 1020 1030 1040 1050
KTEGMSCPTP GCDGSGHVSG SFLTHRSLSG CPRATSAMKK AKLSGEQMLT
1060 1070 1080 1090 1100
IKQRASNGIE NDEEIKQLDE EIKELNESNS QMEADMIKLR TQITTMESNL
1110 1120 1130 1140 1150
KTIEEENKVI EQQNESLLHE LANLSQSLIH SLANIQLPHM DPINEQNFDA
1160 1170 1180
YVTTLTEMYT NQDRYQSPEN KALLENIKQA VRGIQV
Length:1,186
Mass (Da):133,043
Last modified:April 5, 2011 - v3
Checksum:iAEF068692263FA8C
GO
Isoform 2 (identifier: Q9UL68-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-159: Missing.
     493-494: Missing.

Note: No experimental confirmation available.
Show »
Length:1,132
Mass (Da):126,617
Checksum:i0864D75EB5CAA8CE
GO
Isoform 3 (identifier: Q9UL68-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1004: Missing.
     1092-1092: Q → QVT

Note: No experimental confirmation available.
Show »
Length:184
Mass (Da):20,620
Checksum:i40104F07E2F61130
GO
Isoform 4 (identifier: Q9UL68-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-494: Missing.

Show »
Length:1,184
Mass (Da):132,858
Checksum:i6EA2551E3046F395
GO

Sequence cautioni

The sequence AAF14051 differs from that shown. Reason: Frameshift at position 1185. Curated
The sequence BAA83058 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911N → S in AAF14051 (Ref. 1) Curated
Sequence conflicti935 – 9351S → R in AAF14051 (Ref. 1) Curated
Sequence conflicti987 – 9871D → E in AAF14051 (Ref. 1) Curated
Sequence conflicti1110 – 11101I → V in AAF14051 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10041004Missing in isoform 3. 1 PublicationVSP_015722Add
BLAST
Alternative sequencei108 – 15952Missing in isoform 2. 2 PublicationsVSP_015723Add
BLAST
Alternative sequencei493 – 4942Missing in isoform 2 and isoform 4. 2 PublicationsVSP_015724
Alternative sequencei1092 – 10921Q → QVT in isoform 3. 1 PublicationVSP_015725

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036943 mRNA. Translation: AAF14051.1. Frameshift.
AB029029 mRNA. Translation: BAA83058.2. Different initiation.
AC008276 Genomic DNA. No translation available.
AC009232 Genomic DNA. No translation available.
AC009471 Genomic DNA. No translation available.
AC011301 Genomic DNA. No translation available.
AC093390 Genomic DNA. No translation available.
AC106046 Genomic DNA. No translation available.
BC071612 mRNA. Translation: AAH71612.1.
BC137272 mRNA. Translation: AAI37273.1.
BC137273 mRNA. Translation: AAI37274.1.
BC150281 mRNA. Translation: AAI50282.1.
CCDSiCCDS46222.1. [Q9UL68-4]
CCDS77378.1. [Q9UL68-1]
RefSeqiNP_001289981.1. NM_001303052.1. [Q9UL68-1]
NP_055840.2. NM_015025.3. [Q9UL68-4]
UniGeneiHs.434418.
Hs.669852.

Genome annotation databases

EnsembliENST00000399161; ENSP00000382114; ENSG00000186487. [Q9UL68-1]
ENST00000407844; ENSP00000384219; ENSG00000186487. [Q9UL68-3]
ENST00000428368; ENSP00000396103; ENSG00000186487. [Q9UL68-4]
GeneIDi23040.
KEGGihsa:23040.
UCSCiuc002qxd.4. human. [Q9UL68-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036943 mRNA. Translation: AAF14051.1. Frameshift.
AB029029 mRNA. Translation: BAA83058.2. Different initiation.
AC008276 Genomic DNA. No translation available.
AC009232 Genomic DNA. No translation available.
AC009471 Genomic DNA. No translation available.
AC011301 Genomic DNA. No translation available.
AC093390 Genomic DNA. No translation available.
AC106046 Genomic DNA. No translation available.
BC071612 mRNA. Translation: AAH71612.1.
BC137272 mRNA. Translation: AAI37273.1.
BC137273 mRNA. Translation: AAI37274.1.
BC150281 mRNA. Translation: AAI50282.1.
CCDSiCCDS46222.1. [Q9UL68-4]
CCDS77378.1. [Q9UL68-1]
RefSeqiNP_001289981.1. NM_001303052.1. [Q9UL68-1]
NP_055840.2. NM_015025.3. [Q9UL68-4]
UniGeneiHs.434418.
Hs.669852.

3D structure databases

ProteinModelPortaliQ9UL68.
SMRiQ9UL68. Positions 28-60, 502-577, 902-1044.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116679. 2 interactions.
IntActiQ9UL68. 5 interactions.
STRINGi9606.ENSP00000396103.

PTM databases

iPTMnetiQ9UL68.
PhosphoSiteiQ9UL68.

Polymorphism and mutation databases

BioMutaiMYT1L.
DMDMi327478568.

Proteomic databases

MaxQBiQ9UL68.
PaxDbiQ9UL68.
PeptideAtlasiQ9UL68.
PRIDEiQ9UL68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399161; ENSP00000382114; ENSG00000186487. [Q9UL68-1]
ENST00000407844; ENSP00000384219; ENSG00000186487. [Q9UL68-3]
ENST00000428368; ENSP00000396103; ENSG00000186487. [Q9UL68-4]
GeneIDi23040.
KEGGihsa:23040.
UCSCiuc002qxd.4. human. [Q9UL68-1]

Organism-specific databases

CTDi23040.
GeneCardsiMYT1L.
HGNCiHGNC:7623. MYT1L.
HPAiHPA051866.
MIMi613084. gene.
616521. phenotype.
neXtProtiNX_Q9UL68.
PharmGKBiPA31427.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3803. Eukaryota.
ENOG410ZPWS. LUCA.
GeneTreeiENSGT00440000038465.
HOGENOMiHOG000234099.
HOVERGENiHBG006433.
InParanoidiQ9UL68.
OMAiLSEGDCW.
OrthoDBiEOG091G0135.
PhylomeDBiQ9UL68.
TreeFamiTF317299.

Miscellaneous databases

ChiTaRSiMYT1L. human.
GenomeRNAii23040.
PROiQ9UL68.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186487.
CleanExiHS_MYT1L.
ExpressionAtlasiQ9UL68. baseline and differential.
GenevisibleiQ9UL68. HS.

Family and domain databases

InterProiIPR013681. Myelin_TF.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF08474. MYT1. 1 hit.
PF01530. zf-C2HC. 6 hits.
[Graphical view]
PROSITEiPS51802. ZF_CCHHC. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYT1L_HUMAN
AccessioniPrimary (citable) accession number: Q9UL68
Secondary accession number(s): A7E2C7
, B2RP54, Q6IQ17, Q9UPP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.