Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Short transient receptor potential channel 5

Gene

TRPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.By similarity1 Publication

Enzyme regulationi

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.1 Publication

GO - Molecular functioni

  • calcium channel activity Source: UniProtKB
  • inositol 1,4,5 trisphosphate binding Source: Ensembl
  • store-operated calcium channel activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072315-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Protein family/group databases

TCDBi1.A.4.1.7. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 5
Short name:
TrpC5
Alternative name(s):
Transient receptor protein 5
Short name:
TRP-5
Short name:
hTRP-5
Short name:
hTRP5
Gene namesi
Name:TRPC5
Synonyms:TRP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12337. TRPC5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 330CytoplasmicSequence analysisAdd BLAST330
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 398ExtracellularSequence analysisAdd BLAST47
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 470ExtracellularSequence analysisAdd BLAST12
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 512CytoplasmicSequence analysisAdd BLAST21
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 603ExtracellularSequence analysisAdd BLAST70
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 973CytoplasmicSequence analysisAdd BLAST349

GO - Cellular componenti

  • calcium channel complex Source: UniProtKB
  • cytoplasm Source: Ensembl
  • dendrite Source: Ensembl
  • growth cone Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane raft Source: Ensembl
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7224.
OpenTargetsiENSG00000072315.
PharmGKBiPA37010.

Chemistry databases

ChEMBLiCHEMBL1250411.
GuidetoPHARMACOLOGYi490.

Polymorphism and mutation databases

BioMutaiTRPC5.
DMDMi10720321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153181 – 973Short transient receptor potential channel 5Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UL62.
MaxQBiQ9UL62.
PaxDbiQ9UL62.
PeptideAtlasiQ9UL62.
PRIDEiQ9UL62.

PTM databases

iPTMnetiQ9UL62.
PhosphoSitePlusiQ9UL62.

Expressioni

Tissue specificityi

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.1 Publication

Gene expression databases

BgeeiENSG00000072315.
CleanExiHS_TRPC5.
GenevisibleiQ9UL62. HS.

Interactioni

Subunit structurei

Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat).By similarity5 Publications

Protein-protein interaction databases

BioGridi113075. 18 interactors.
IntActiQ9UL62. 1 interactor.
STRINGi9606.ENSP00000262839.

Structurei

3D structure databases

ProteinModelPortaliQ9UL62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 60ANK 1Add BLAST30
Repeati69 – 97ANK 2Add BLAST29
Repeati98 – 124ANK 3Add BLAST27
Repeati141 – 170ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni971 – 973Essential for binding to NHERF PDZ domainBy similarity3

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9UL62.
KOiK04968.
OMAiNCSKSEI.
OrthoDBiEOG091G029I.
PhylomeDBiQ9UL62.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UL62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRR PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRRNLRSFT
710 720 730 740 750
ERNADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTHEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKHPRSF STSSTELSQR DDNNDGSGGA RAKSKSVSFN
810 820 830 840 850
LGCKKKTCHG PPLIRTMPRS SGAQGKSKAE SSSKRSFMGP SLKKLGLLFS
860 870 880 890 900
KFNGHMSEPS SEPMYTISDG IVQQHCMWQD IRYSQMEKGK AEACSQSEIN
910 920 930 940 950
LSEVELGEVQ GAAQSSECPL ACSSSLHCAS SICSSNSKLL DSSEDVFETW
960 970
GEACDLLMHK WGDGQEEQVT TRL
Length:973
Mass (Da):111,412
Last modified:May 1, 2000 - v1
Checksum:iFBC8CBF17BE42166
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069415667P → T Found in a patient with severe delayed speech, autism spectrum and Gilles de la Tourette disorders. 1 Publication1
Natural variantiVAR_052369702R → H.Corresponds to variant rs36047478dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054568 mRNA. Translation: AAF00002.1.
AC005191 Genomic DNA. Translation: AAC24563.1.
AL049563, AC005191 Genomic DNA. Translation: CAI43017.1.
CH471120 Genomic DNA. Translation: EAX02630.1.
BC137271 mRNA. Translation: AAI37272.1.
BC137274 mRNA. Translation: AAI37275.1.
CCDSiCCDS14561.1.
RefSeqiNP_036603.1. NM_012471.2.
XP_016885263.1. XM_017029774.1.
UniGeneiHs.657709.

Genome annotation databases

EnsembliENST00000262839; ENSP00000262839; ENSG00000072315.
GeneIDi7224.
KEGGihsa:7224.
UCSCiuc004epl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054568 mRNA. Translation: AAF00002.1.
AC005191 Genomic DNA. Translation: AAC24563.1.
AL049563, AC005191 Genomic DNA. Translation: CAI43017.1.
CH471120 Genomic DNA. Translation: EAX02630.1.
BC137271 mRNA. Translation: AAI37272.1.
BC137274 mRNA. Translation: AAI37275.1.
CCDSiCCDS14561.1.
RefSeqiNP_036603.1. NM_012471.2.
XP_016885263.1. XM_017029774.1.
UniGeneiHs.657709.

3D structure databases

ProteinModelPortaliQ9UL62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113075. 18 interactors.
IntActiQ9UL62. 1 interactor.
STRINGi9606.ENSP00000262839.

Chemistry databases

ChEMBLiCHEMBL1250411.
GuidetoPHARMACOLOGYi490.

Protein family/group databases

TCDBi1.A.4.1.7. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9UL62.
PhosphoSitePlusiQ9UL62.

Polymorphism and mutation databases

BioMutaiTRPC5.
DMDMi10720321.

Proteomic databases

EPDiQ9UL62.
MaxQBiQ9UL62.
PaxDbiQ9UL62.
PeptideAtlasiQ9UL62.
PRIDEiQ9UL62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262839; ENSP00000262839; ENSG00000072315.
GeneIDi7224.
KEGGihsa:7224.
UCSCiuc004epl.2. human.

Organism-specific databases

CTDi7224.
DisGeNETi7224.
GeneCardsiTRPC5.
HGNCiHGNC:12337. TRPC5.
MIMi300334. gene.
neXtProtiNX_Q9UL62.
OpenTargetsiENSG00000072315.
PharmGKBiPA37010.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiQ9UL62.
KOiK04968.
OMAiNCSKSEI.
OrthoDBiEOG091G029I.
PhylomeDBiQ9UL62.
TreeFamiTF313147.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072315-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiTRPC5. human.
GeneWikiiTRPC5.
GenomeRNAii7224.
PROiQ9UL62.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072315.
CleanExiHS_TRPC5.
GenevisibleiQ9UL62. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC5_HUMAN
AccessioniPrimary (citable) accession number: Q9UL62
Secondary accession number(s): B2RP53
, O75233, Q5JXY8, Q9Y514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.