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Protein

Short transient receptor potential channel 5

Gene

TRPC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.By similarity1 Publication

Enzyme regulationi

Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.1 Publication

GO - Molecular functioni

  • actin binding Source: Ensembl
  • actinin binding Source: Ensembl
  • ATPase binding Source: Ensembl
  • calcium channel activity Source: UniProtKB
  • clathrin binding Source: Ensembl
  • inositol 1,4,5 trisphosphate binding Source: Ensembl
  • store-operated calcium channel activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling

Protein family/group databases

TCDBi1.A.4.1.7 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 5
Short name:
TrpC5
Alternative name(s):
Transient receptor protein 5
Short name:
TRP-5
Short name:
hTRP-5
Short name:
hTRP5
Gene namesi
Name:TRPC5
Synonyms:TRP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000072315.3
HGNCiHGNC:12337 TRPC5
MIMi300334 gene
neXtProtiNX_Q9UL62

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 330CytoplasmicSequence analysisAdd BLAST330
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 398ExtracellularSequence analysisAdd BLAST47
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 437CytoplasmicSequence analysisAdd BLAST18
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 470ExtracellularSequence analysisAdd BLAST12
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 512CytoplasmicSequence analysisAdd BLAST21
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 603ExtracellularSequence analysisAdd BLAST70
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Topological domaini625 – 973CytoplasmicSequence analysisAdd BLAST349

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7224
OpenTargetsiENSG00000072315
PharmGKBiPA37010

Chemistry databases

ChEMBLiCHEMBL1250411
GuidetoPHARMACOLOGYi490

Polymorphism and mutation databases

BioMutaiTRPC5
DMDMi10720321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153181 – 973Short transient receptor potential channel 5Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UL62
PaxDbiQ9UL62
PeptideAtlasiQ9UL62
PRIDEiQ9UL62

PTM databases

iPTMnetiQ9UL62
PhosphoSitePlusiQ9UL62

Expressioni

Tissue specificityi

Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.1 Publication

Gene expression databases

BgeeiENSG00000072315
CleanExiHS_TRPC5
GenevisibleiQ9UL62 HS

Interactioni

Subunit structurei

Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat).By similarity5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113075, 18 interactors
IntActiQ9UL62, 1 interactor
STRINGi9606.ENSP00000262839

Structurei

3D structure databases

ProteinModelPortaliQ9UL62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 60ANK 1Add BLAST30
Repeati69 – 97ANK 2Add BLAST29
Repeati98 – 124ANK 3Add BLAST27
Repeati141 – 170ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni971 – 973Essential for binding to NHERF PDZ domainBy similarity3

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiQ9UL62
KOiK04968
OMAiSCMKWRR
OrthoDBiEOG091G029I
PhylomeDBiQ9UL62
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005461 TRPC5_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF24 PTHR10117:SF24, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01646 TRPCHANNEL5
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UL62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLNAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRR PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRRNLRSFT
710 720 730 740 750
ERNADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTHEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKHPRSF STSSTELSQR DDNNDGSGGA RAKSKSVSFN
810 820 830 840 850
LGCKKKTCHG PPLIRTMPRS SGAQGKSKAE SSSKRSFMGP SLKKLGLLFS
860 870 880 890 900
KFNGHMSEPS SEPMYTISDG IVQQHCMWQD IRYSQMEKGK AEACSQSEIN
910 920 930 940 950
LSEVELGEVQ GAAQSSECPL ACSSSLHCAS SICSSNSKLL DSSEDVFETW
960 970
GEACDLLMHK WGDGQEEQVT TRL
Length:973
Mass (Da):111,412
Last modified:May 1, 2000 - v1
Checksum:iFBC8CBF17BE42166
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069415667P → T Found in a patient with severe delayed speech, autism spectrum and Gilles de la Tourette disorders. 1 Publication1
Natural variantiVAR_052369702R → H. Corresponds to variant dbSNP:rs36047478Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054568 mRNA Translation: AAF00002.1
AC005191 Genomic DNA Translation: AAC24563.1
AL049563, AC005191 Genomic DNA Translation: CAI43017.1
CH471120 Genomic DNA Translation: EAX02630.1
BC137271 mRNA Translation: AAI37272.1
BC137274 mRNA Translation: AAI37275.1
CCDSiCCDS14561.1
RefSeqiNP_036603.1, NM_012471.2
XP_016885263.1, XM_017029774.1
UniGeneiHs.657709

Genome annotation databases

EnsembliENST00000262839; ENSP00000262839; ENSG00000072315
GeneIDi7224
KEGGihsa:7224
UCSCiuc004epl.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRPC5_HUMAN
AccessioniPrimary (citable) accession number: Q9UL62
Secondary accession number(s): B2RP53
, O75233, Q5JXY8, Q9Y514
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health