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Protein

Zinc finger protein 214

Gene

ZNF214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 297C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri303 – 325C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149050-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 214
Alternative name(s):
BWSCR2-associated zinc finger protein 1
Short name:
BAZ-1
Gene namesi
Name:ZNF214
Synonyms:BAZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13006. ZNF214.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7761.
OpenTargetsiENSG00000149050.
PharmGKBiPA37585.

Polymorphism and mutation databases

BioMutaiZNF214.
DMDMi296453038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474581 – 606Zinc finger protein 214Add BLAST606

Proteomic databases

PaxDbiQ9UL59.
PeptideAtlasiQ9UL59.
PRIDEiQ9UL59.

PTM databases

iPTMnetiQ9UL59.
PhosphoSitePlusiQ9UL59.

Expressioni

Gene expression databases

BgeeiENSG00000149050.
CleanExiHS_ZNF214.
GenevisibleiQ9UL59. HS.

Organism-specific databases

HPAiHPA055391.

Interactioni

Protein-protein interaction databases

BioGridi113544. 12 interactors.
STRINGi9606.ENSP00000278314.

Structurei

3D structure databases

ProteinModelPortaliQ9UL59.
SMRiQ9UL59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83KRABPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 297C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri303 – 325C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UL59.
KOiK09228.
OMAiKCHEYYK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UL59.
TreeFamiTF350845.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UL59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTFEDVTI IFTWEEWKFL DSSQKRLYRE VMWENYTNVM SVENWNESYK
60 70 80 90 100
SQEEKFRYLE YENFSYWQGW WNAGAQMYEN QNYGETVQGT DSKDLTQQDR
110 120 130 140 150
SQCQEWLILS TQVPGYGNYE LTFESKSLRN LKYKNFMPWQ SLETKTTQDY
160 170 180 190 200
GREIYMSGSH GFQGGRYRLG ISRKNLSMEK EQKLIVQHSY IPVEEALPQY
210 220 230 240 250
VGVICQEDLL RDSMEEKYCG CNKCKGIYYW NSRCVFHKRN QPGENLCQCS
260 270 280 290 300
ICKACFSQRS DLYRHPRNHI GKKLYGCDEV DGNFHQSSGV HFHQRVHIGE
310 320 330 340 350
VPYSCNACGK SFSQISSLHN HQRVHTEEKF YKIECDKDLS RNSLLHIHQR
360 370 380 390 400
LHIGEKPFKC NQCGKSFNRS SVLHVHQRVH TGEKPYKCDE CGKGFSQSSN
410 420 430 440 450
LRIHQLVHTG EKSYKCEDCG KGFTQRSNLQ IHQRVHTGEK PYKCDDCGKD
460 470 480 490 500
FSHSSDLRIH QRVHTGEKPY TCPECGKGFS KSSKLHTHQR VHTGEKPYKC
510 520 530 540 550
EECGKGFSQR SHLLIHQRVH TGEKPYKCHD CGKGFSHSSN LHIHQRVHTG
560 570 580 590 600
EKPYQCAKCG KGFSHSSALR IHQRVHAGEK PYKCREYYKG FDHNSHLHNN

HRRGNL
Length:606
Mass (Da):70,992
Last modified:May 18, 2010 - v2
Checksum:iD0CBA2E0F9E3EAB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252C → R in AAF00004 (PubMed:10762538).Curated1
Sequence conflicti252C → R in BAG36248 (PubMed:14702039).Curated1
Sequence conflicti252C → R in AAI36773 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05740366Y → C.Corresponds to variant rs1156526dbSNPEnsembl.1
Natural variantiVAR_019975128L → H.Corresponds to variant rs1156525dbSNPEnsembl.1
Natural variantiVAR_057404160H → R.Corresponds to variant rs16921097dbSNPEnsembl.1
Natural variantiVAR_019976185I → R.Corresponds to variant rs2239734dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056617 mRNA. Translation: AAF00004.1.
AK313462 mRNA. Translation: BAG36248.1.
AC100875 Genomic DNA. No translation available.
BC136772 mRNA. Translation: AAI36773.1.
CCDSiCCDS31418.1.
RefSeqiNP_037381.2. NM_013249.2.
XP_005253185.1. XM_005253128.3.
XP_006718371.1. XM_006718308.3.
UniGeneiHs.733636.

Genome annotation databases

EnsembliENST00000278314; ENSP00000278314; ENSG00000149050.
ENST00000536068; ENSP00000445373; ENSG00000149050.
GeneIDi7761.
KEGGihsa:7761.
UCSCiuc001mfa.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056617 mRNA. Translation: AAF00004.1.
AK313462 mRNA. Translation: BAG36248.1.
AC100875 Genomic DNA. No translation available.
BC136772 mRNA. Translation: AAI36773.1.
CCDSiCCDS31418.1.
RefSeqiNP_037381.2. NM_013249.2.
XP_005253185.1. XM_005253128.3.
XP_006718371.1. XM_006718308.3.
UniGeneiHs.733636.

3D structure databases

ProteinModelPortaliQ9UL59.
SMRiQ9UL59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113544. 12 interactors.
STRINGi9606.ENSP00000278314.

PTM databases

iPTMnetiQ9UL59.
PhosphoSitePlusiQ9UL59.

Polymorphism and mutation databases

BioMutaiZNF214.
DMDMi296453038.

Proteomic databases

PaxDbiQ9UL59.
PeptideAtlasiQ9UL59.
PRIDEiQ9UL59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278314; ENSP00000278314; ENSG00000149050.
ENST00000536068; ENSP00000445373; ENSG00000149050.
GeneIDi7761.
KEGGihsa:7761.
UCSCiuc001mfa.3. human.

Organism-specific databases

CTDi7761.
DisGeNETi7761.
GeneCardsiZNF214.
HGNCiHGNC:13006. ZNF214.
HPAiHPA055391.
MIMi605015. gene.
neXtProtiNX_Q9UL59.
OpenTargetsiENSG00000149050.
PharmGKBiPA37585.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9UL59.
KOiK09228.
OMAiKCHEYYK.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9UL59.
TreeFamiTF350845.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149050-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7761.
PROiQ9UL59.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149050.
CleanExiHS_ZNF214.
GenevisibleiQ9UL59. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN214_HUMAN
AccessioniPrimary (citable) accession number: Q9UL59
Secondary accession number(s): B2R8Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.