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Protein

Zinc finger protein 214

Gene

ZNF214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 297C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri303 – 325C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 214
Alternative name(s):
BWSCR2-associated zinc finger protein 1
Short name:
BAZ-1
Gene namesi
Name:ZNF214
Synonyms:BAZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149050.9
HGNCiHGNC:13006 ZNF214
MIMi605015 gene
neXtProtiNX_Q9UL59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7761
OpenTargetsiENSG00000149050
PharmGKBiPA37585

Polymorphism and mutation databases

BioMutaiZNF214
DMDMi296453038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474581 – 606Zinc finger protein 214Add BLAST606

Proteomic databases

PaxDbiQ9UL59
PeptideAtlasiQ9UL59
PRIDEiQ9UL59

PTM databases

iPTMnetiQ9UL59
PhosphoSitePlusiQ9UL59

Expressioni

Gene expression databases

BgeeiENSG00000149050
CleanExiHS_ZNF214
GenevisibleiQ9UL59 HS

Organism-specific databases

HPAiHPA055391

Interactioni

Protein-protein interaction databases

BioGridi113544, 15 interactors
STRINGi9606.ENSP00000278314

Structurei

3D structure databases

ProteinModelPortaliQ9UL59
SMRiQ9UL59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83KRABPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 297C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri303 – 325C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri526 – 548C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 576C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9UL59
KOiK09228
OMAiKCHEYYK
OrthoDBiEOG091G02KC
PhylomeDBiQ9UL59
TreeFamiTF350845

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

Q9UL59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTFEDVTI IFTWEEWKFL DSSQKRLYRE VMWENYTNVM SVENWNESYK
60 70 80 90 100
SQEEKFRYLE YENFSYWQGW WNAGAQMYEN QNYGETVQGT DSKDLTQQDR
110 120 130 140 150
SQCQEWLILS TQVPGYGNYE LTFESKSLRN LKYKNFMPWQ SLETKTTQDY
160 170 180 190 200
GREIYMSGSH GFQGGRYRLG ISRKNLSMEK EQKLIVQHSY IPVEEALPQY
210 220 230 240 250
VGVICQEDLL RDSMEEKYCG CNKCKGIYYW NSRCVFHKRN QPGENLCQCS
260 270 280 290 300
ICKACFSQRS DLYRHPRNHI GKKLYGCDEV DGNFHQSSGV HFHQRVHIGE
310 320 330 340 350
VPYSCNACGK SFSQISSLHN HQRVHTEEKF YKIECDKDLS RNSLLHIHQR
360 370 380 390 400
LHIGEKPFKC NQCGKSFNRS SVLHVHQRVH TGEKPYKCDE CGKGFSQSSN
410 420 430 440 450
LRIHQLVHTG EKSYKCEDCG KGFTQRSNLQ IHQRVHTGEK PYKCDDCGKD
460 470 480 490 500
FSHSSDLRIH QRVHTGEKPY TCPECGKGFS KSSKLHTHQR VHTGEKPYKC
510 520 530 540 550
EECGKGFSQR SHLLIHQRVH TGEKPYKCHD CGKGFSHSSN LHIHQRVHTG
560 570 580 590 600
EKPYQCAKCG KGFSHSSALR IHQRVHAGEK PYKCREYYKG FDHNSHLHNN

HRRGNL
Length:606
Mass (Da):70,992
Last modified:May 18, 2010 - v2
Checksum:iD0CBA2E0F9E3EAB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti252C → R in AAF00004 (PubMed:10762538).Curated1
Sequence conflicti252C → R in BAG36248 (PubMed:14702039).Curated1
Sequence conflicti252C → R in AAI36773 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05740366Y → C. Corresponds to variant dbSNP:rs1156526Ensembl.1
Natural variantiVAR_019975128L → H. Corresponds to variant dbSNP:rs1156525Ensembl.1
Natural variantiVAR_057404160H → R. Corresponds to variant dbSNP:rs16921097Ensembl.1
Natural variantiVAR_019976185I → R. Corresponds to variant dbSNP:rs2239734Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056617 mRNA Translation: AAF00004.1
AK313462 mRNA Translation: BAG36248.1
AC100875 Genomic DNA No translation available.
BC136772 mRNA Translation: AAI36773.1
CCDSiCCDS31418.1
RefSeqiNP_037381.2, NM_013249.2
XP_005253185.1, XM_005253128.3
XP_006718371.1, XM_006718308.3
UniGeneiHs.445849
Hs.562382
Hs.733636

Genome annotation databases

EnsembliENST00000278314; ENSP00000278314; ENSG00000149050
ENST00000536068; ENSP00000445373; ENSG00000149050
GeneIDi7761
KEGGihsa:7761
UCSCiuc001mfa.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN214_HUMAN
AccessioniPrimary (citable) accession number: Q9UL59
Secondary accession number(s): B2R8Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health