Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protease serine 11E

Gene

TMPRSS11E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.By similarity

Enzyme regulationi

Inhibited by SERPINA5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei232Charge relay system1 Publication1
Active sitei277Charge relay system1 Publication1
Active sitei373Charge relay system1 Publication1

GO - Molecular functioni

GO - Biological processi

  • cognition Source: UniProtKB
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000087128-MONOMER.

Protein family/group databases

MEROPSiS01.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serine 11E (EC:3.4.21.-)
Alternative name(s):
Serine protease DESC1
Transmembrane protease serine 11E2
Cleaved into the following 2 chains:
Gene namesi
Name:TMPRSS11E
Synonyms:DESC1, TMPRSS11E2
ORF Names:UNQ742/PRO1461
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24465. TMPRSS11E.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type II membrane protein By similarity
Chain Transmembrane protease serine 11E catalytic chain :
  • Secreted By similarity

  • Note: Activated by cleavage and secreted.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini41 – 423ExtracellularSequence analysisAdd BLAST383

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi28983.
OpenTargetsiENSG00000087128.
PharmGKBiPA142670729.
PA162406637.

Polymorphism and mutation databases

BioMutaiTMPRSS11E.
DMDMi57015324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000278911 – 191Transmembrane protease serine 11E non-catalytic chainSequence analysisAdd BLAST191
ChainiPRO_0000027892192 – 423Transmembrane protease serine 11E catalytic chainSequence analysisAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi177 ↔ 297Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
Disulfide bondi217 ↔ 233PROSITE-ProRule annotation1 Publication
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi342 ↔ 358PROSITE-ProRule annotation1 Publication
Disulfide bondi369 ↔ 398PROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiQ9UL52.
PaxDbiQ9UL52.
PeptideAtlasiQ9UL52.
PRIDEiQ9UL52.

PTM databases

iPTMnetiQ9UL52.
PhosphoSitePlusiQ9UL52.

Expressioni

Tissue specificityi

Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.1 Publication

Gene expression databases

BgeeiENSG00000087128.
CleanExiHS_TMPRSS11E.
ExpressionAtlasiQ9UL52. baseline and differential.
GenevisibleiQ9UL52. HS.

Organism-specific databases

HPAiHPA051062.

Interactioni

Subunit structurei

Forms a heterodimer with SERPINA5 and SERPINE1.

Protein-protein interaction databases

IntActiQ9UL52. 1 interactor.
STRINGi9606.ENSP00000307519.

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi206 – 211Combined sources6
Beta strandi214 – 223Combined sources10
Beta strandi226 – 229Combined sources4
Helixi231 – 234Combined sources4
Helixi240 – 242Combined sources3
Beta strandi243 – 251Combined sources9
Beta strandi255 – 265Combined sources11
Beta strandi279 – 285Combined sources7
Beta strandi291 – 293Combined sources3
Beta strandi310 – 316Combined sources7
Beta strandi330 – 337Combined sources8
Helixi339 – 342Combined sources4
Turni345 – 350Combined sources6
Beta strandi356 – 360Combined sources5
Beta strandi365 – 367Combined sources3
Beta strandi376 – 380Combined sources5
Beta strandi386 – 394Combined sources9
Beta strandi396 – 400Combined sources5
Beta strandi405 – 409Combined sources5
Helixi411 – 413Combined sources3
Helixi414 – 421Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OQ5X-ray1.61A192-423[»]
ProteinModelPortaliQ9UL52.
SMRiQ9UL52.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UL52.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 167SEAPROSITE-ProRule annotationAdd BLAST119
Domaini192 – 422Peptidase S1PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 1 SEA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ9UL52.
KOiK09642.
OMAiYEGISKC.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UL52.
TreeFamiTF351684.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UL52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYRPDVVRA RKRVCWEPWV IGLVIFISLI VLAVCIGLTV HYVRYNQKKT
60 70 80 90 100
YNYYSTLSFT TDKLYAEFGR EASNNFTEMS QRLESMVKNA FYKSPLREEF
110 120 130 140 150
VKSQVIKFSQ QKHGVLAHML LICRFHSTED PETVDKIVQL VLHEKLQDAV
160 170 180 190 200
GPPKVDPHSV KIKKINKTET DSYLNHCCGT RRSKTLGQSL RIVGGTEVEE
210 220 230 240 250
GEWPWQASLQ WDGSHRCGAT LINATWLVSA AHCFTTYKNP ARWTASFGVT
260 270 280 290 300
IKPSKMKRGL RRIIVHEKYK HPSHDYDISL AELSSPVPYT NAVHRVCLPD
310 320 330 340 350
ASYEFQPGDV MFVTGFGALK NDGYSQNHLR QAQVTLIDAT TCNEPQAYND
360 370 380 390 400
AITPRMLCAG SLEGKTDACQ GDSGGPLVSS DARDIWYLAG IVSWGDECAK
410 420
PNKPGVYTRV TALRDWITSK TGI
Length:423
Mass (Da):47,696
Last modified:January 4, 2005 - v2
Checksum:iEB1476807C0B613D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158H → Q in AC019173 (PubMed:15815621).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051847303Y → C.Corresponds to variant rs976002dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064819 mRNA. Translation: AAF04328.1.
AY359017 mRNA. Translation: AAQ89376.1.
AC140484 Genomic DNA. No translation available.
AC019173 Genomic DNA. No translation available.
BC113412 mRNA. Translation: AAI13413.1.
BC113414 mRNA. Translation: AAI13415.1.
CCDSiCCDS33993.1.
RefSeqiNP_054777.2. NM_014058.3.
UniGeneiHs.201877.

Genome annotation databases

EnsembliENST00000305363; ENSP00000307519; ENSG00000087128.
GeneIDi28983.
KEGGihsa:28983.
UCSCiuc003hdz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064819 mRNA. Translation: AAF04328.1.
AY359017 mRNA. Translation: AAQ89376.1.
AC140484 Genomic DNA. No translation available.
AC019173 Genomic DNA. No translation available.
BC113412 mRNA. Translation: AAI13413.1.
BC113414 mRNA. Translation: AAI13415.1.
CCDSiCCDS33993.1.
RefSeqiNP_054777.2. NM_014058.3.
UniGeneiHs.201877.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OQ5X-ray1.61A192-423[»]
ProteinModelPortaliQ9UL52.
SMRiQ9UL52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UL52. 1 interactor.
STRINGi9606.ENSP00000307519.

Protein family/group databases

MEROPSiS01.021.

PTM databases

iPTMnetiQ9UL52.
PhosphoSitePlusiQ9UL52.

Polymorphism and mutation databases

BioMutaiTMPRSS11E.
DMDMi57015324.

Proteomic databases

EPDiQ9UL52.
PaxDbiQ9UL52.
PeptideAtlasiQ9UL52.
PRIDEiQ9UL52.

Protocols and materials databases

DNASUi28983.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305363; ENSP00000307519; ENSG00000087128.
GeneIDi28983.
KEGGihsa:28983.
UCSCiuc003hdz.4. human.

Organism-specific databases

CTDi28983.
DisGeNETi28983.
GeneCardsiTMPRSS11E.
HGNCiHGNC:24465. TMPRSS11E.
HPAiHPA051062.
MIMi610399. gene.
neXtProtiNX_Q9UL52.
OpenTargetsiENSG00000087128.
PharmGKBiPA142670729.
PA162406637.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000251823.
HOVERGENiHBG013304.
InParanoidiQ9UL52.
KOiK09642.
OMAiYEGISKC.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UL52.
TreeFamiTF351684.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000087128-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9UL52.
GenomeRNAii28983.
PROiQ9UL52.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087128.
CleanExiHS_TMPRSS11E.
ExpressionAtlasiQ9UL52. baseline and differential.
GenevisibleiQ9UL52. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
Gene3Di3.30.70.960. 1 hit.
InterProiIPR017329. Pept_S1A_HAT/DESC1.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000082. SEA_dom.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF01390. SEA. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF82671. SSF82671. 1 hit.
PROSITEiPS50024. SEA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM11E_HUMAN
AccessioniPrimary (citable) accession number: Q9UL52
Secondary accession number(s): A6NL71, Q14DC8, Q6UW31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 4, 2005
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.