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Q9UL52

- TM11E_HUMAN

UniProt

Q9UL52 - TM11E_HUMAN

Protein

Transmembrane protease serine 11E

Gene

TMPRSS11E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position By similarity.By similarity

    Enzyme regulationi

    Inhibited by SERPINA5.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei232 – 2321Charge relay system1 Publication
    Active sitei277 – 2771Charge relay system1 Publication
    Active sitei373 – 3731Charge relay system1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type peptidase activity Source: UniProtKB

    GO - Biological processi

    1. cognition Source: UniProt
    2. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.021.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protease serine 11E (EC:3.4.21.-)
    Alternative name(s):
    Serine protease DESC1
    Transmembrane protease serine 11E2
    Cleaved into the following 2 chains:
    Gene namesi
    Name:TMPRSS11E
    Synonyms:DESC1, TMPRSS11E2
    ORF Names:UNQ742/PRO1461
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24465. TMPRSS11E.

    Subcellular locationi

    Transmembrane protease serine 11E catalytic chain : Secreted By similarity
    Note: Activated by cleavage and secreted.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670729.
    PA162406637.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191Transmembrane protease serine 11E non-catalytic chainSequence AnalysisPRO_0000027891Add
    BLAST
    Chaini192 – 423232Transmembrane protease serine 11E catalytic chainSequence AnalysisPRO_0000027892Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi177 ↔ 297Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotation
    Disulfide bondi217 ↔ 2331 PublicationPROSITE-ProRule annotation
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi342 ↔ 3581 PublicationPROSITE-ProRule annotation
    Disulfide bondi369 ↔ 3981 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9UL52.
    PRIDEiQ9UL52.

    PTM databases

    PhosphoSiteiQ9UL52.

    Expressioni

    Tissue specificityi

    Expression can only be detected in tissues derived from the head and neck, and in skin, prostate and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ9UL52.
    BgeeiQ9UL52.
    CleanExiHS_TMPRSS11E.
    GenevestigatoriQ9UL52.

    Organism-specific databases

    HPAiHPA051062.

    Interactioni

    Subunit structurei

    Forms a heterodimer with SERPINA5 and SERPINE1.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000307519.

    Structurei

    Secondary structure

    1
    423
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi206 – 2116
    Beta strandi214 – 22310
    Beta strandi226 – 2294
    Helixi231 – 2344
    Helixi240 – 2423
    Beta strandi243 – 2519
    Beta strandi255 – 26511
    Beta strandi279 – 2857
    Beta strandi291 – 2933
    Beta strandi310 – 3167
    Beta strandi330 – 3378
    Helixi339 – 3424
    Turni345 – 3506
    Beta strandi356 – 3605
    Beta strandi365 – 3673
    Beta strandi376 – 3805
    Beta strandi386 – 3949
    Beta strandi396 – 4005
    Beta strandi405 – 4095
    Helixi411 – 4133
    Helixi414 – 4218

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2OQ5X-ray1.61A192-423[»]
    ProteinModelPortaliQ9UL52.
    SMRiQ9UL52. Positions 48-124, 164-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UL52.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 423383ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 167119SEAPROSITE-ProRule annotationAdd
    BLAST
    Domaini192 – 422231Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 1 SEA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251823.
    HOVERGENiHBG013304.
    InParanoidiA6NL71.
    KOiK09642.
    OMAiYEGISKC.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ9UL52.
    TreeFamiTF351684.

    Family and domain databases

    Gene3Di3.30.70.960. 1 hit.
    InterProiIPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEiPS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UL52-1 [UniParc]FASTAAdd to Basket

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    MMYRPDVVRA RKRVCWEPWV IGLVIFISLI VLAVCIGLTV HYVRYNQKKT    50
    YNYYSTLSFT TDKLYAEFGR EASNNFTEMS QRLESMVKNA FYKSPLREEF 100
    VKSQVIKFSQ QKHGVLAHML LICRFHSTED PETVDKIVQL VLHEKLQDAV 150
    GPPKVDPHSV KIKKINKTET DSYLNHCCGT RRSKTLGQSL RIVGGTEVEE 200
    GEWPWQASLQ WDGSHRCGAT LINATWLVSA AHCFTTYKNP ARWTASFGVT 250
    IKPSKMKRGL RRIIVHEKYK HPSHDYDISL AELSSPVPYT NAVHRVCLPD 300
    ASYEFQPGDV MFVTGFGALK NDGYSQNHLR QAQVTLIDAT TCNEPQAYND 350
    AITPRMLCAG SLEGKTDACQ GDSGGPLVSS DARDIWYLAG IVSWGDECAK 400
    PNKPGVYTRV TALRDWITSK TGI 423
    Length:423
    Mass (Da):47,696
    Last modified:January 4, 2005 - v2
    Checksum:iEB1476807C0B613D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581H → Q in AC019173. (PubMed:15815621)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031Y → C.
    Corresponds to variant rs976002 [ dbSNP | Ensembl ].
    VAR_051847

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064819 mRNA. Translation: AAF04328.1.
    AY359017 mRNA. Translation: AAQ89376.1.
    AC140484 Genomic DNA. No translation available.
    AC019173 Genomic DNA. No translation available.
    BC113412 mRNA. Translation: AAI13413.1.
    BC113414 mRNA. Translation: AAI13415.1.
    CCDSiCCDS33993.1.
    RefSeqiNP_054777.2. NM_014058.3.
    UniGeneiHs.201877.

    Genome annotation databases

    EnsembliENST00000305363; ENSP00000307519; ENSG00000087128.
    GeneIDi28983.
    KEGGihsa:28983.
    UCSCiuc003hdz.4. human.

    Polymorphism databases

    DMDMi57015324.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064819 mRNA. Translation: AAF04328.1 .
    AY359017 mRNA. Translation: AAQ89376.1 .
    AC140484 Genomic DNA. No translation available.
    AC019173 Genomic DNA. No translation available.
    BC113412 mRNA. Translation: AAI13413.1 .
    BC113414 mRNA. Translation: AAI13415.1 .
    CCDSi CCDS33993.1.
    RefSeqi NP_054777.2. NM_014058.3.
    UniGenei Hs.201877.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2OQ5 X-ray 1.61 A 192-423 [» ]
    ProteinModelPortali Q9UL52.
    SMRi Q9UL52. Positions 48-124, 164-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000307519.

    Protein family/group databases

    MEROPSi S01.021.

    PTM databases

    PhosphoSitei Q9UL52.

    Polymorphism databases

    DMDMi 57015324.

    Proteomic databases

    PaxDbi Q9UL52.
    PRIDEi Q9UL52.

    Protocols and materials databases

    DNASUi 28983.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305363 ; ENSP00000307519 ; ENSG00000087128 .
    GeneIDi 28983.
    KEGGi hsa:28983.
    UCSCi uc003hdz.4. human.

    Organism-specific databases

    CTDi 28983.
    GeneCardsi GC04P069313.
    HGNCi HGNC:24465. TMPRSS11E.
    HPAi HPA051062.
    MIMi 610399. gene.
    neXtProti NX_Q9UL52.
    PharmGKBi PA142670729.
    PA162406637.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251823.
    HOVERGENi HBG013304.
    InParanoidi A6NL71.
    KOi K09642.
    OMAi YEGISKC.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q9UL52.
    TreeFami TF351684.

    Miscellaneous databases

    EvolutionaryTracei Q9UL52.
    GenomeRNAii 28983.
    NextBioi 51877.
    PROi Q9UL52.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UL52.
    Bgeei Q9UL52.
    CleanExi HS_TMPRSS11E.
    Genevestigatori Q9UL52.

    Family and domain databases

    Gene3Di 3.30.70.960. 1 hit.
    InterProi IPR017329. Pept_S1A_HAT/DESC1.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR000082. SEA_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01390. SEA. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037941. TMPRSS11ABCDE. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF82671. SSF82671. 1 hit.
    PROSITEi PS50024. SEA. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck."
      Lang J.C., Schuller D.E.
      Br. J. Cancer 84:237-243(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma."
      Wakita T., Hayashi T., Nishioka J., Tamaru H., Akita N., Asanuma K., Kamada H., Gabazza E.C., Ido M., Kawamura J., Suzuki K.
      Int. J. Cancer 108:516-523(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, HETERODIMER WITH SERPINA5.
    6. "Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family."
      Kyrieleis O.J., Huber R., Ong E., Oehler R., Hunter M., Madison E.L., Jacob U.
      FEBS J. 274:2148-2160(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.61 ANGSTROMS) OF 192-423, ACTIVE SITE, DISULFIDE BONDS.

    Entry informationi

    Entry nameiTM11E_HUMAN
    AccessioniPrimary (citable) accession number: Q9UL52
    Secondary accession number(s): A6NL71, Q14DC8, Q6UW31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3