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Q9UL46

- PSME2_HUMAN

UniProt

Q9UL46 - PSME2_HUMAN

Protein

Proteasome activator complex subunit 2

Gene

PSME2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 4 (18 May 2010)
      Previous versions | rss
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    Functioni

    Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

    GO - Biological processi

    1. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. apoptotic process Source: Reactome
    6. cellular nitrogen compound metabolic process Source: Reactome
    7. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
    8. G1/S transition of mitotic cell cycle Source: Reactome
    9. gene expression Source: Reactome
    10. mitotic cell cycle Source: Reactome
    11. mRNA metabolic process Source: Reactome
    12. negative regulation of apoptotic process Source: Reactome
    13. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    14. positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    15. protein polyubiquitination Source: Reactome
    16. regulation of apoptotic process Source: Reactome
    17. regulation of cellular amino acid metabolic process Source: Reactome
    18. regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: Reactome
    19. RNA metabolic process Source: Reactome
    20. small molecule metabolic process Source: Reactome
    21. viral process Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome activator complex subunit 2
    Alternative name(s):
    11S regulator complex subunit beta
    Short name:
    REG-beta
    Activator of multicatalytic protease subunit 2
    Proteasome activator 28 subunit beta
    Short name:
    PA28b
    Short name:
    PA28beta
    Gene namesi
    Name:PSME2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:9569. PSME2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. proteasome activator complex Source: InterPro
    6. proteasome complex Source: ProtInc

    Keywords - Cellular componenti

    Proteasome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33915.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 239238Proteasome activator complex subunit 2PRO_0000161785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei10 – 101Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UL46.
    PaxDbiQ9UL46.
    PRIDEiQ9UL46.

    2D gel databases

    OGPiQ9UL46.
    REPRODUCTION-2DPAGEIPI00384051.

    PTM databases

    PhosphoSiteiQ9UL46.

    Expressioni

    Inductioni

    By IFNG/IFN-gamma.

    Gene expression databases

    BgeeiQ9UL46.
    CleanExiHS_PSME2.
    GenevestigatoriQ9UL46.

    Interactioni

    Subunit structurei

    Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

    Protein-protein interaction databases

    BioGridi111693. 41 interactions.
    IntActiQ9UL46. 13 interactions.
    MINTiMINT-1478095.
    STRINGi9606.ENSP00000216802.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UL46.
    SMRiQ9UL46. Positions 7-66, 97-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PA28 family.Curated

    Phylogenomic databases

    eggNOGiNOG280316.
    HOGENOMiHOG000282822.
    HOVERGENiHBG053745.
    KOiK06697.
    OMAiDGFQTNI.
    PhylomeDBiQ9UL46.
    TreeFamiTF106236.

    Family and domain databases

    Gene3Di1.20.120.180. 1 hit.
    1.20.5.120. 1 hit.
    InterProiIPR009077. Proteasome_activ_pa28.
    IPR003186. Proteasome_activ_pa28_C.
    IPR003185. Proteasome_activ_pa28_N.
    [Graphical view]
    PANTHERiPTHR10660. PTHR10660. 1 hit.
    PfamiPF02251. PA28_alpha. 1 hit.
    PF02252. PA28_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF47216. SSF47216. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UL46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED    50
    SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVHK CGFLPGNEKV 100
    LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV 150
    NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG 200
    ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY 239
    Length:239
    Mass (Da):27,402
    Last modified:May 18, 2010 - v4
    Checksum:i98A30D83B3F93A91
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti229 – 2291N → T in BAA08205. (PubMed:7789512)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891H → P.3 Publications
    Corresponds to variant rs7146672 [ dbSNP | Ensembl ].
    VAR_063111

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079558 Genomic DNA. Translation: AAF02218.1.
    D45248 mRNA. Translation: BAA08205.1.
    AL136295 Genomic DNA. No translation available.
    BC004368 mRNA. Translation: AAH04368.1.
    BC019885 mRNA. Translation: AAH19885.1.
    BC072025 mRNA. Translation: AAH72025.1.
    CCDSiCCDS9614.1.
    PIRiI53518.
    RefSeqiNP_002809.2. NM_002818.2.
    UniGeneiHs.434081.
    Hs.512410.

    Genome annotation databases

    EnsembliENST00000216802; ENSP00000216802; ENSG00000100911.
    GeneIDi5721.
    KEGGihsa:5721.
    UCSCiuc001wmj.3. human.

    Polymorphism databases

    DMDMi296453017.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF079558 Genomic DNA. Translation: AAF02218.1 .
    D45248 mRNA. Translation: BAA08205.1 .
    AL136295 Genomic DNA. No translation available.
    BC004368 mRNA. Translation: AAH04368.1 .
    BC019885 mRNA. Translation: AAH19885.1 .
    BC072025 mRNA. Translation: AAH72025.1 .
    CCDSi CCDS9614.1.
    PIRi I53518.
    RefSeqi NP_002809.2. NM_002818.2.
    UniGenei Hs.434081.
    Hs.512410.

    3D structure databases

    ProteinModelPortali Q9UL46.
    SMRi Q9UL46. Positions 7-66, 97-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111693. 41 interactions.
    IntActi Q9UL46. 13 interactions.
    MINTi MINT-1478095.
    STRINGi 9606.ENSP00000216802.

    PTM databases

    PhosphoSitei Q9UL46.

    Polymorphism databases

    DMDMi 296453017.

    2D gel databases

    OGPi Q9UL46.
    REPRODUCTION-2DPAGE IPI00384051.

    Proteomic databases

    MaxQBi Q9UL46.
    PaxDbi Q9UL46.
    PRIDEi Q9UL46.

    Protocols and materials databases

    DNASUi 5721.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216802 ; ENSP00000216802 ; ENSG00000100911 .
    GeneIDi 5721.
    KEGGi hsa:5721.
    UCSCi uc001wmj.3. human.

    Organism-specific databases

    CTDi 5721.
    GeneCardsi GC14M024612.
    HGNCi HGNC:9569. PSME2.
    MIMi 602161. gene.
    neXtProti NX_Q9UL46.
    PharmGKBi PA33915.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG280316.
    HOGENOMi HOG000282822.
    HOVERGENi HBG053745.
    KOi K06697.
    OMAi DGFQTNI.
    PhylomeDBi Q9UL46.
    TreeFami TF106236.

    Enzyme and pathway databases

    Reactomei REACT_111056. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_111178. ER-Phagosome pathway.
    REACT_1156. Orc1 removal from chromatin.
    REACT_118656. Activation of NF-kappaB in B cells.
    REACT_1221. CDK-mediated phosphorylation and removal of Cdc6.
    REACT_13464. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_13565. Regulation of ornithine decarboxylase (ODC).
    REACT_150471. Separation of Sister Chromatids.
    REACT_1614. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
    REACT_172638. Asymmetric localization of PCP proteins.
    REACT_1949. CDT1 association with the CDC6:ORC:origin complex.
    REACT_200766. degradation of AXIN.
    REACT_200841. degradation of DVL.
    REACT_20549. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_25325. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_4. Ubiquitin-dependent degradation of Cyclin D1.
    REACT_6761. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    REACT_6785. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_6821. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_6871. APC/C:Cdc20 mediated degradation of Securin.
    REACT_75842. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_9003. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_9031. Vpu mediated degradation of CD4.
    REACT_9453. Vif-mediated degradation of APOBEC3G.

    Miscellaneous databases

    ChiTaRSi PSME2. human.
    GeneWikii PSME2.
    GenomeRNAii 5721.
    NextBioi 22238.
    PROi Q9UL46.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UL46.
    CleanExi HS_PSME2.
    Genevestigatori Q9UL46.

    Family and domain databases

    Gene3Di 1.20.120.180. 1 hit.
    1.20.5.120. 1 hit.
    InterProi IPR009077. Proteasome_activ_pa28.
    IPR003186. Proteasome_activ_pa28_C.
    IPR003185. Proteasome_activ_pa28_N.
    [Graphical view ]
    PANTHERi PTHR10660. PTHR10660. 1 hit.
    Pfami PF02251. PA28_alpha. 1 hit.
    PF02252. PA28_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47216. SSF47216. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organization of the genes encoding the human proteasome activators PA28alpha and beta."
      McCusker D., Wilson M., Trowsdale J.
      Immunogenetics 49:438-445(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-89.
    2. "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome."
      Ahn J.Y., Tanahashi N., Akiyama K., Hisamatsu H., Noda C., Tanaka K., Chung C.H., Shibmara N., Willy P.J., Mott J.D., Slaughter C.A., DeMartino G.N.
      FEBS Lett. 366:37-42(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-89.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-89.
      Tissue: Liver, Pancreas and Placenta.
    5. Bienvenut W.V.
      Submitted (OCT-2004) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-61; 91-115; 132-145; 155-171; 181-226 AND 232-239, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    6. "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
      Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.
      Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPSME2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UL46
    Secondary accession number(s): Q15129
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 132 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3